ISRN surgeryPub Date : 2013-08-05eCollection Date: 2013-01-01DOI: 10.1155/2013/960424
Theodosios Theodosopoulos, Dionysios Dellaportas, Anneza I Yiallourou, George Gkiokas, George Polymeneas, Alexios Fotopoulos
{"title":"Pancreatic Remnant Occlusion after Whipple's Procedure: An Alternative Oncologically Safe Method.","authors":"Theodosios Theodosopoulos, Dionysios Dellaportas, Anneza I Yiallourou, George Gkiokas, George Polymeneas, Alexios Fotopoulos","doi":"10.1155/2013/960424","DOIUrl":"https://doi.org/10.1155/2013/960424","url":null,"abstract":"<p><p>Introduction. To present our experience regarding the use of pancreatic stump occlusion technique as an alternative management of the pancreatic remnant after pancreatoduodenectomy (PD). Methods. Between 2002 and 2009, hospital records of 93 patients who had undergone a Whipple's procedure for either pancreatic-periampullary cancer or chronic pancreatitis were retrospectively studied. In 37 patients the pancreatic duct was occluded by stapling and running suture without anastomosis of the pancreatic remnant, whereas in 56 patients a pancreaticojejunostomy was performed. Operative data, postoperative complications, oncological parameters, and survival rates were recorded. Results. 2/37 patients of the occlusion group and 9/56 patients of the anastomosis group were treated for chronic pancreatitis, whereas 35/37 and 47/56 patients for periampullary malignancies. The duration of surgery for the anastomosis group was significantly longer (mean time 220 versus 180 minutes). Mean hospitalization time was 6 days for both groups. The occlusion group had a lower morbidity rate (24% versus 32%). With regard to postoperative complications, a slightly higher incidence of pancreatic fistulas was observed in the anastomosis group. Conclusions. Pancreatic remnant occlusion is a safe, technically feasible, and reducing postoperative complications alternative approach of the pancreatic stump during Whipple's procedure. </p>","PeriodicalId":89400,"journal":{"name":"ISRN surgery","volume":"2013 ","pages":"960424"},"PeriodicalIF":0.0,"publicationDate":"2013-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/960424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31692817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ISRN surgeryPub Date : 2013-06-16Print Date: 2013-01-01DOI: 10.1155/2013/508719
Alexis Luna, Pere Rebasa, Sandra Montmany, Salvador Navarro
{"title":"Learning curve for d2 lymphadenectomy in gastric cancer.","authors":"Alexis Luna, Pere Rebasa, Sandra Montmany, Salvador Navarro","doi":"10.1155/2013/508719","DOIUrl":"https://doi.org/10.1155/2013/508719","url":null,"abstract":"<p><p>Background. D2 lymphadenectomy is a demanding technique which is associated with high morbidity in the West. We report our experience with D2 lymphadenectomy after a training period in Japan. Methods. Prospective, descriptive study in 133 consecutive patients undergoing radical gastrectomy for gastric adenocarcinoma from 2005 to 2011. We analysed the number of lymph nodes removed, observed morbidity/mortality compared with the predictions of POSSUM and O-POSSUM, survival, and disease-free interval for patients with D1 and D2 lymphadenectomy. Results. The morbidity rate in patients with D1 lymphadenectomy was 59.4%. For D2 it was 47.7%. The mortality rate in patients with D1 was 6.7%. In the D2 group it was 6.8%. Median survival was 42.9 months in D1 and 55 months in D2. The disease-free interval was 49 months for D1 and 58 months for D2. Conclusion. The learning curve for D2 lymphadenectomy presents acceptable rates of morbidity and mortality, providing that the technique is learnt at a center with extensive experience. </p>","PeriodicalId":89400,"journal":{"name":"ISRN surgery","volume":"2013 ","pages":"508719"},"PeriodicalIF":0.0,"publicationDate":"2013-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/508719","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31571474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ISRN surgeryPub Date : 2013-06-13Print Date: 2013-01-01DOI: 10.1155/2013/191543
Cattleya Thongrong, Pornthep Kasemsiri, Ricardo L Carrau, Sergio D Bergese
{"title":"Control of bleeding in endoscopic skull base surgery: current concepts to improve hemostasis.","authors":"Cattleya Thongrong, Pornthep Kasemsiri, Ricardo L Carrau, Sergio D Bergese","doi":"10.1155/2013/191543","DOIUrl":"https://doi.org/10.1155/2013/191543","url":null,"abstract":"<p><p>Hemostasis is critical for adequate anatomical visualization during endoscopic endonasal skull base surgery. Reduction of intraoperative bleeding should be considered during the treatment planning and continued throughout the perioperative period. Preoperative preparations include the optimization of comorbidities and cessation of drugs that may inhibit coagulation. Intraoperative considerations comprise anesthetic and surgical aspects. Controlled hypotension is the main anesthetic technique to reduce bleeding; however, there is controversy regarding its effectiveness; what the appropriate mean arterial pressure is and how to maintain it. In extradural cases, we advocate a mean arterial pressure of 65-70 mm Hg to reduce bleeding while preventing ischemic complications. For dealing intradural lesion, controlled hypotension should be cautious. We do not advocate a marked blood pressure reduction, as this often affects the perfusion of neural structures. Further reduction could lead to stroke or loss of cranial nerve function. From the surgical perspective, there are novel technologies and techniques that reduce bleeding, thus, improving the visualization of the surgical field. </p>","PeriodicalId":89400,"journal":{"name":"ISRN surgery","volume":"2013 ","pages":"191543"},"PeriodicalIF":0.0,"publicationDate":"2013-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/191543","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31572054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ISRN surgeryPub Date : 2013-06-05Print Date: 2013-01-01DOI: 10.1155/2013/156347
Bahtiyar Ertor, Serdar Topaloglu, Adnan Calik, Umit Cobanoglu, Ali Ahmetoglu, Huseyin Ak, Erdem Karabulut, Mithat Kerim Arslan
{"title":"The effects of bile duct obstruction on liver volume: an experimental study.","authors":"Bahtiyar Ertor, Serdar Topaloglu, Adnan Calik, Umit Cobanoglu, Ali Ahmetoglu, Huseyin Ak, Erdem Karabulut, Mithat Kerim Arslan","doi":"10.1155/2013/156347","DOIUrl":"https://doi.org/10.1155/2013/156347","url":null,"abstract":"<p><p>Objectives. This study is aimed at investigating alterations in liver volume during obstructive jaundice in rat liver. Materials and Methods. Thirty-six rats were divided into four groups. Abdominal tomography was performed for baseline volumetric analyses. The main bile ducts were ligated (BDL). Volumetric analyses were repeated 3 days after BDL in group 1, 7 days after BDL in group 2, 15 days after BDL in group 3, and 25 days after BDL in group 4, and total hepatectomy was performed in all animals. Control group (n = 4) was created with the rats that died before bile duct ligation. Results. There was no difference found in liver volume in group 1 compared to control animals. The liver volume was increased 7 days after BDL (P = 0.01). It was increased up to 60% of baseline values 25 days after BDL (P = 0.002). Wet liver weights of animals were also increased compared to control group. Liver weights were increased up to 40% percent of baseline values in group 4 (P = 0.002). Conclusions. Liver volume and weight were increased after BDL. Liver surgery in patients with huge liver mass is generally associated with significant difficulty. The surgeon should be aware of the time-dependent alteration in liver volume after obstructive jaundice. </p>","PeriodicalId":89400,"journal":{"name":"ISRN surgery","volume":"2013 ","pages":"156347"},"PeriodicalIF":0.0,"publicationDate":"2013-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/156347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31569395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ISRN surgeryPub Date : 2013-05-28Print Date: 2013-01-01DOI: 10.1155/2013/238067
Corey R Deeken, Brent D Matthews
{"title":"Characterization of the Mechanical Strength, Resorption Properties, and Histologic Characteristics of a Fully Absorbable Material (Poly-4-hydroxybutyrate-PHASIX Mesh) in a Porcine Model of Hernia Repair.","authors":"Corey R Deeken, Brent D Matthews","doi":"10.1155/2013/238067","DOIUrl":"https://doi.org/10.1155/2013/238067","url":null,"abstract":"<p><p>Purpose. Poly-4-hydroxybutyrate (P4HB) is a naturally derived, absorbable polymer. P4HB has been manufactured into PHASIX Mesh and P4HB Plug designs for soft tissue repair. The objective of this study was to evaluate mechanical strength, resorption properties, and histologic characteristics in a porcine model. Methods. Bilateral defects were created in the abdominal wall of n = 20 Yucatan minipigs and repaired in a bridged fashion with PHASIX Mesh or P4HB Plug fixated with SorbaFix or permanent suture, respectively. Mechanical strength, resorption properties, and histologic characteristics were evaluated at 6, 12, 26, and 52 weeks (n = 5 each). Results. PHASIX Mesh and P4HB Plug repairs exhibited similar burst strength, stiffness, and molecular weight at all time points, with no significant differences detected between the two devices (P > 0.05). PHASIX Mesh and P4HB Plug repairs also demonstrated significantly greater burst strength and stiffness than native abdominal wall at all time points (P < 0.05), and material resorption increased significantly over time (P < 0.001). Inflammatory infiltrates were mononuclear, and both devices exhibited mild to moderate granulation tissue/vascularization. Conclusions. PHASIX Mesh and P4HB Plug demonstrated significant mechanical strength compared to native abdominal wall, despite significant material resorption over time. Histological assessment revealed a comparable mild inflammatory response and mild to moderate granulation tissue/vascularization.</p>","PeriodicalId":89400,"journal":{"name":"ISRN surgery","volume":"2013 ","pages":"238067"},"PeriodicalIF":0.0,"publicationDate":"2013-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/238067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31517981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ISRN surgeryPub Date : 2013-05-25Print Date: 2013-01-01DOI: 10.1155/2013/536081
Ye Xin Koh, Adrian Kah Heng Chiow, Aik Yong Chok, Lip Seng Lee, Siong San Tan, Salleh Ibrahim
{"title":"Recurrent pyogenic cholangitis: disease characteristics and patterns of recurrence.","authors":"Ye Xin Koh, Adrian Kah Heng Chiow, Aik Yong Chok, Lip Seng Lee, Siong San Tan, Salleh Ibrahim","doi":"10.1155/2013/536081","DOIUrl":"10.1155/2013/536081","url":null,"abstract":"<p><p>Recurrent pyogenic cholangitis (RPC) is characterized by repeated infections of the biliary system with the formation of stones and strictures. The management aims are to treat acute cholangitis, clear the biliary ductal debris and calculi, and eliminate predisposing factors of bile stasis. Operative options include hepatectomy and biliary drainage procedures or a combination of both; nonoperative options include endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (PTC) guided procedures. This current study compares the operative and the nonoperative management outcomes in patients with RPC in 80 consecutive patients. In addition, we aim to evaluate our approach to the management of RPC over the past decade, according to the various degrees of severity and extent of the disease, and identify the patterns of recurrence in this complex clinical condition. Initial failure rate in terms of residual stone of operative compared with nonoperative treatment was 10.2% versus 32.3% (P = 0.020). Long-term failure rate for operative compared with non-operative treatment was 20.4% versus 61.3% (P = 0.010). Based on multivariate logistic regression, the only significant factors associated with failure were bilaterality of disease (OR: 8.101, P = 0.007) and nonoperative treatment (OR: 26.843, P = 0.001). The median time to failure of the operative group was 48 months as compared to 20 months in the nonoperative group (P < 0.010). Thus operative treatment is a durable option in long-term resolution of disease. Hepatectomy is the preferred option to prevent recurrent disease. However, biliary drainage procedures are also an effective treatment option. The utility of nonoperative treatment can achieve a reasonable duration of disease free interval with minimal complications, albeit inferior to operative management.</p>","PeriodicalId":89400,"journal":{"name":"ISRN surgery","volume":"2013 ","pages":"536081"},"PeriodicalIF":0.0,"publicationDate":"2013-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31502959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ISRN surgeryPub Date : 2013-05-23Print Date: 2013-01-01DOI: 10.1155/2013/862549
Erin M Hanna, Guy R Voeller, J Scott Roth, Jeffrey R Scott, Darcy H Gagne, David A Iannitti
{"title":"Evaluation of ECHO PS Positioning System in a Porcine Model of Simulated Laparoscopic Ventral Hernia Repair.","authors":"Erin M Hanna, Guy R Voeller, J Scott Roth, Jeffrey R Scott, Darcy H Gagne, David A Iannitti","doi":"10.1155/2013/862549","DOIUrl":"https://doi.org/10.1155/2013/862549","url":null,"abstract":"<p><p>Purpose. Operative efficiency improvements for laparoscopic ventral hernia repair (LVHR) have focused on reducing operative time while maintaining overall repair efficacy. Our objective was to evaluate procedure time and positioning accuracy of an inflatable mesh positioning device (Echo PS Positioning System), as compared to a standard transfascial suture technique, using a porcine model of simulated LVHR. Methods. The study population consisted of seventeen general surgeons (n = 17) that performed simulated LVHR on seventeen (n = 17) female Yorkshire pigs using two implantation techniques: (1) Ventralight ST Mesh + Echo PS Positioning System (Echo PS) and (2) Ventralight ST Mesh + transfascial sutures (TSs). Procedure time and mesh centering accuracy overtop of a simulated surgical defect were evaluated. Results. Echo PS demonstrated a 38.9% reduction in the overall procedure time, as compared to TS. During mesh preparation and positioning, Echo PS demonstrated a 60.5% reduction in procedure time (P < 0.0001). Although a trend toward improved centering accuracy was observed for Echo PS (16.2%), this was not significantly different than TS. Conclusions. Echo PS demonstrated a significant reduction in overall simulated LVHR procedure time, particularly during mesh preparation/positioning. These operative time savings may translate into reduced operating room costs and improved surgeon/operating room efficiency.</p>","PeriodicalId":89400,"journal":{"name":"ISRN surgery","volume":"2013 ","pages":"862549"},"PeriodicalIF":0.0,"publicationDate":"2013-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/862549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31502961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ISRN surgeryPub Date : 2013-05-16Print Date: 2013-01-01DOI: 10.1155/2013/625093
Airazat M Kazaryan, Bård I Røsok, Bjørn Edwin
{"title":"Morbidity assessment in surgery: refinement proposal based on a concept of perioperative adverse events.","authors":"Airazat M Kazaryan, Bård I Røsok, Bjørn Edwin","doi":"10.1155/2013/625093","DOIUrl":"https://doi.org/10.1155/2013/625093","url":null,"abstract":"<p><p>Background. Morbidity is a cornerstone assessing surgical treatment; nevertheless surgeons have not reached extensive consensus on this problem. Methods and Findings. Clavien, Dindo, and Strasberg with coauthors (1992, 2004, 2009, and 2010) made significant efforts to the standardization of surgical morbidity (Clavien-Dindo-Strasberg classification, last revision, the Accordion classification). However, this classification includes only postoperative complications and has two principal shortcomings: disregard of intraoperative events and confusing terminology. Postoperative events have a major impact on patient well-being. However, intraoperative events should also be recorded and reported even if they do not evidently affect the patient's postoperative well-being. The term surgical complication applied in the Clavien-Dindo-Strasberg classification may be regarded as an incident resulting in a complication caused by technical failure of surgery, in contrast to the so-called medical complications. Therefore, the term surgical complication contributes to misinterpretation of perioperative morbidity. The term perioperative adverse events comprising both intraoperative unfavourable incidents and postoperative complications could be regarded as better alternative. In 2005, Satava suggested a simple grading to evaluate intraoperative surgical errors. Based on that approach, we have elaborated a 3-grade classification of intraoperative incidents so that it can be used to grade intraoperative events of any type of surgery. Refinements have been made to the Accordion classification of postoperative complications. Interpretation. The proposed systematization of perioperative adverse events utilizing the combined application of two appraisal tools, that is, the elaborated classification of intraoperative incidents on the basis of the Satava approach to surgical error evaluation together with the modified Accordion classification of postoperative complication, appears to be an effective tool for comprehensive assessment of surgical outcomes. This concept was validated in regard to various surgical procedures. Broad implementation of this approach will promote the development of surgical science and practice.</p>","PeriodicalId":89400,"journal":{"name":"ISRN surgery","volume":"2013 ","pages":"625093"},"PeriodicalIF":0.0,"publicationDate":"2013-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/625093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31502960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ISRN surgeryPub Date : 2013-05-15Print Date: 2013-01-01DOI: 10.1155/2013/248126
Mehmet Emin Gunes, Gungor Uzum, Oguz Koc, Yiğit Duzkoylu, Meltem Kucukyilmaz, Yavuz Selim Sari, Vahit Tunalı, Sennur Kose
{"title":"A modified method in laparoscopic peritoneal catheter implantation: the combination of preperitoneal tunneling and pelvic fixation.","authors":"Mehmet Emin Gunes, Gungor Uzum, Oguz Koc, Yiğit Duzkoylu, Meltem Kucukyilmaz, Yavuz Selim Sari, Vahit Tunalı, Sennur Kose","doi":"10.1155/2013/248126","DOIUrl":"https://doi.org/10.1155/2013/248126","url":null,"abstract":"<p><p>Introduction. Continuous ambulatory peritoneal dialysis (CAPD) is widely accepted for the management of end-stage renal disease (ESRD). Although not as widely used as hemodialysis, CAPD has clear advantages, especially those related to patient satisfaction and simplicity. Peritoneal dialysis (PD) catheter insertion can be accomplished by several different techniques. In this study, we aimed to evaluate our results obtained with peritoneal dialysis catheter placement by combination of pelvic fixation plus preperitoneal tunneling. Material and Methods. Laparoscopic peritoneal catheter implantation by combining preperitoneal tunneling and pelvic fixation methods was performed in 82 consecutive patients with end-stage renal disease. Sex, age, primary disease etiology, complications, mean duration of surgery, mean duration of hospital stay, morbidity, mortality, and catheter survival rates and surgical technique used were assessed. Analysis of catheter survival was performed using the Kaplan-Meier method. Results. Mean follow-up period was 28.35 ± 14.5 months (range of 13-44 months). Mean operative time was 28 ± 6 minutes, and mean duration of hospital stay was 3 ± 1 days. There were no conversions from laparoscopy to other insertion methods. None of the patients developed serious complications during surgery or the postoperative period. No infections of the exit site or subcutaneous tunnel, hemorrhagic complications, abdominal wall hernias, or extrusion of the superficial catheter cuff was detected. No mortality occurred in this series of patients. Catheter survival was found to be 92% at 3 years followup. Conclusions. During one-year followup, we had seven patients of migrated catheters due to separation of pelvic fixation suture from peritoneal surface, but they were reimplanted and fixated again laparoscopically with success. Over a three-year followup period, catheter survival was found to be 92%. In the literature, similar catheter survival rates without combination of the two techniques are reported. As a conclusion, although laparoscopic placement of PD catheters avoids many perioperative and early complications, as well as increasing catheter free survival period and quality of life, our results comparing to other studies in the literature indicate that different laparoscopic placement methods are still in debate, and further studies are necessary to make a more accurate decision.</p>","PeriodicalId":89400,"journal":{"name":"ISRN surgery","volume":"2013 ","pages":"248126"},"PeriodicalIF":0.0,"publicationDate":"2013-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/248126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31502958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ISRN surgeryPub Date : 2013-04-11Print Date: 2013-01-01DOI: 10.1155/2013/652895
Andrew F Lamm, Ameer L Elaimy, Wayne T Lamoreaux, Alexander R Mackay, Robert K Fairbanks, John J Demakas, Barton S Cooke, Christopher M Lee
{"title":"A review of the clinical outcomes for patients diagnosed with brainstem metastasis and treated with stereotactic radiosurgery.","authors":"Andrew F Lamm, Ameer L Elaimy, Wayne T Lamoreaux, Alexander R Mackay, Robert K Fairbanks, John J Demakas, Barton S Cooke, Christopher M Lee","doi":"10.1155/2013/652895","DOIUrl":"https://doi.org/10.1155/2013/652895","url":null,"abstract":"<p><p>Only 3%-5% of all brain metastases are located in the brainstem. We present a comprehensive review of the clinical outcomes from modern studies that treated patients with brainstem metastasis using either a Gamma Knife or a linear accelerator-based stereotactic radiosurgery. The median survival time of patients was compared to better understand what clinical or treatment factors are predictive of improved survival. This information can then be utilized to optimize patient care. The data suggests that higher prescribed marginal dose and the associated greater local control of brainstem lesions are associated with longer patient survival. Further research is necessary to better describe the most effective dose for individual brainstem lesions and to tailor optimum therapy to specific patient subgroups.</p>","PeriodicalId":89400,"journal":{"name":"ISRN surgery","volume":"2013 ","pages":"652895"},"PeriodicalIF":0.0,"publicationDate":"2013-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/652895","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31444814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}