Diabetes management (London, England)最新文献_第5页

Looking forward to transition: perspectives on transition from pediatric to adult diabetes care. 展望转变:从儿科到成人糖尿病护理转变的观点。

Diabetes management (London, England) Pub Date : 2013-07-01 DOI: 10.2217/dmt.13.27

Jennifer K Raymond, Danny C Duke, Lisa Shimomaeda, Michael A Harris

引用次数: 12

Viruses and Type 1 diabetes: a dynamic labile equilibrium. 病毒与 1 型糖尿病：一种动态的易变平衡。

Diabetes management (London, England) Pub Date : 2013-05-01 DOI: 10.2217/dmt.13.17

Darius A Schneider, Matthias G von Herrath

引用次数: 0

Targeting sirtuins for the treatment of diabetes. 靶向sirtuins治疗糖尿病。

Diabetes management (London, England) Pub Date : 2013-05-01 DOI: 10.2217/dmt.13.6

Frank K Huynh, Kathleen A Hershberger, Matthew D Hirschey

引用次数: 47

Dissecting gene-environment contributions to Type 2 diabetes. 剖析基因环境对2型糖尿病的影响。

Diabetes management (London, England) Pub Date : 2012-09-01 DOI: 10.2217/dmt.12.47

Braxton D Mitchell, Robert L Hanson

引用次数: 0

Sirtuin biology and relevance to diabetes treatment. Sirtuin生物学及其与糖尿病治疗的相关性。

Diabetes management (London, England) Pub Date : 2012-05-01 DOI: 10.2217/dmt.12.16

X Charlie Dong

{"title":"Sirtuin biology and relevance to diabetes treatment.","authors":"X Charlie Dong","doi":"10.2217/dmt.12.16","DOIUrl":"https://doi.org/10.2217/dmt.12.16","url":null,"abstract":"Sirtuins are a group of NAD(+)-dependent enzymes that post-translationally modify histones and other proteins. Among seven mammalian sirtuins, SIRT1 has been the most extensively studied and has been demonstrated to play a critical role in all major metabolic organs and tissues. SIRT1 regulates glucose and lipid homeostasis in the liver, modulates insulin secretion in pancreatic islets, controls insulin sensitivity and glucose uptake in skeletal muscle, increases adiponectin expression in white adipose tissue and controls food intake and energy expenditure in the brain. Recently, SIRT3 has been demonstrated to modulate insulin sensitivity in skeletal muscle and systemic metabolism, and Sirt3-null mice manifest characteristics of metabolic syndrome on a high-fat diet. Thus, it is reasonable to believe that enhancing the activities of SIRT1 and SIRT3 may be beneficial for Type 2 diabetes. Although it is controversial, the SIRT1 activator SRT1720 has been reported to be effective in improving glucose metabolism and insulin sensitivity in animal models. More research needs to be conducted so that we can better understand the physiological functions and molecular mechanisms of sirtuins in order to therapeutically target these enzymes for diabetes treatment.","PeriodicalId":89355,"journal":{"name":"Diabetes management (London, England)","volume":"2 3","pages":"243-257"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/dmt.12.16","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30944454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

β-cell preservation and regeneration for diabetes treatment: where are we now? β细胞保存和再生用于糖尿病治疗:我们现在在哪里?

Diabetes management (London, England) Pub Date : 2012-05-01 DOI: 10.2217/dmt.12.21

Michael J Karadimos, Archana Kapoor, Ilham El Khattabi, Arun Sharma

引用次数: 3

Personalized medicine in Type 2 diabetes: what does the future hold? 2型糖尿病的个体化治疗:未来会怎样?

Diabetes management (London, England) Pub Date : 2012-05-01 DOI: 10.2217/dmt.12.15

Richard W Grant, Deborah J Wexler

引用次数: 17

Diabetes prevention: global health policy and perspectives from the ground. 糖尿病预防：全球卫生政策和实地视角。

Diabetes management (London, England) Pub Date : 2012-01-01 DOI: 10.2217/dmt.12.34

Michael Bergman, Martin Buysschaert, Peter Eh Schwarz, Ann Albright, Km Venkat Narayan, Derek Yach

{"title":"Diabetes prevention: global health policy and perspectives from the ground.","authors":"Michael Bergman, Martin Buysschaert, Peter Eh Schwarz, Ann Albright, Km Venkat Narayan, Derek Yach","doi":"10.2217/dmt.12.34","DOIUrl":"10.2217/dmt.12.34","url":null,"abstract":"Type 2 diabetes and other noncommunicable diseases are a growing public health challenge globally. An estimated 285 million people, corresponding to 6.4% of the world's adult population, has diabetes, which is expected to reach 552 million by the International Diabetes Federation in 2030. A much larger segment of the world's population, approximating 79 million individuals in the USA alone, has prediabetes. Globally, a relatively small percentage of those with diabetes or prediabetes are diagnosed with the potential for developing chronic complications. To address this epidemic, governments, in concert with the private sector, need to set policies that promote healthy nutritional and agricultural policies, favor modifications in the environment that encourage greater physical activity and make prevention affordable for all citizens at high risk. The public health sector has the charge of translating evidence-based findings into practical, accessible and cost-effective programs and monitoring the process to continuously improve prevention initiatives. The clinical sector has the formidable challenge of screening and identifying those at high risk and referring them to accredited intervention programs. There is a need to explore additional cost-effective interventions that are customized to meet individual needs that can be offered at the community and clinical levels. Thus, all three sectors, government, public health and clinical, each have a critical role in this process and by working in a partnership, ought to create the necessary synergies essential for making substantial forays in the prevention of Type 2 diabetes.","PeriodicalId":89355,"journal":{"name":"Diabetes management (London, England)","volume":"2 4","pages":"309-321"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556601/pdf/nihms-718230.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34146280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Addressing diabetes racial and ethnic disparities: lessons learned from quality improvement collaboratives. 解决糖尿病种族和民族差异:从质量改进合作中吸取的经验教训。

Diabetes management (London, England) Pub Date : 2011-11-01 DOI: 10.2217/dmt.11.48

Abigail E Wilkes, Kristine Bordenave, Lisa Vinci, Monica E Peek

引用次数: 0

Update on diagnosis, pathogenesis and management of ketosis-prone Type 2 diabetes mellitus. 易发生酮症的2型糖尿病的诊断、发病机制和治疗进展。

Diabetes management (London, England) Pub Date : 2011-11-01 DOI: 10.2217/DMT.11.57

Dawn Smiley, Prakash Chandra, Guillermo E Umpierrez

引用次数: 0