Diabetes management (London, England)最新文献_第6页

Mechanisms in the adaptation of maternal β-cells during pregnancy. 妊娠期母体β细胞的适应机制。

Diabetes management (London, England) Pub Date : 2011-03-01 DOI: 10.2217/dmt.10.24

Sara Ernst, Cem Demirci, Shelley Valle, Silvia Velazquez-Garcia, Adolfo Garcia-Ocaña

{"title":"Mechanisms in the adaptation of maternal β-cells during pregnancy.","authors":"Sara Ernst, Cem Demirci, Shelley Valle, Silvia Velazquez-Garcia, Adolfo Garcia-Ocaña","doi":"10.2217/dmt.10.24","DOIUrl":"https://doi.org/10.2217/dmt.10.24","url":null,"abstract":"Pancreatic β-cell mass adapts to changing insulin demands in the body. One of the most amazing reversible β-cell adaptations occurs during pregnancy and postpartum conditions. During pregnancy, the increase in maternal insulin resistance is compensated by maternal β-cell hyperplasia and hyperfunctionality to maintain normal blood glucose. Although the cellular mechanisms involved in maternal β-cell expansion have been studied in detail in rodents, human studies are very sparse. A summary of these studies in rodents and humans is described below. Since β-cell mass expands during pregnancy, unraveling the endocrine/paracrine/autocrine molecular mechanisms responsible for these effects can be of great importance for predicting and treating gestational diabetes and for finding new cues that induce β-cell regeneration in diabetes. In addition to the well known implication of lactogens during maternal β-cell expansion, additional participants are being discovered such as serotonin and HGF. Transcription factors, such as hepatocyte nuclear factor-4α and the forkhead box protein-M1, and cell cycle regulators, such as menin, p27 and p18, are important intracellular signals responsible for these effects. In this article, we summarize and discuss novel studies uncovering molecular mechanisms involved in the maternal β-cell adaptive expansion during pregnancy.","PeriodicalId":89355,"journal":{"name":"Diabetes management (London, England)","volume":"1 2","pages":"239-248"},"PeriodicalIF":0.0,"publicationDate":"2011-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/dmt.10.24","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30079789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 86

Recurrence of autoimmunity in pancreas transplant patients: research update. 胰腺移植患者自身免疫复发的研究进展

Diabetes management (London, England) Pub Date : 2011-03-01 DOI: 10.2217/dmt.10.21

Alberto Pugliese, Helena K Reijonen, Jerry Nepom, George W Burke

引用次数: 38

Health literacy in diabetes care: explanation, evidence and equipment. 糖尿病护理中的健康素养:解释、证据和设备。

Diabetes management (London, England) Pub Date : 2011-03-01 DOI: 10.2217/dmt.11.5

Kerri L Cavanaugh

引用次数: 99

Assessing fear of hypoglycemia in children with Type 1 diabetes and their parents. 评估1型糖尿病儿童及其父母对低血糖的恐惧。

Diabetes management (London, England) Pub Date : 2011-01-01 DOI: 10.2217/DMT.11.60

Linda Gonder-Frederick, Maren Nyer, Jaclyn A Shepard, Karen Vajda, William Clarke

{"title":"Assessing fear of hypoglycemia in children with Type 1 diabetes and their parents.","authors":"Linda Gonder-Frederick, Maren Nyer, Jaclyn A Shepard, Karen Vajda, William Clarke","doi":"10.2217/DMT.11.60","DOIUrl":"https://doi.org/10.2217/DMT.11.60","url":null,"abstract":"This article summarizes the literature on fear of hypoglycemia in pediatric Type 1 diabetes and the assessment of this fear in both children with Type 1 diabetes and their parents. The most common instrument for assessing fear of hypoglycemia in this population is the children's and parent's versions of the Hypoglycemia Fear Survey (HFS), although studies using other assessment measures are also reviewed. Studies using this survey have identified variables contributing to fear of hypoglycemia in children with Type 1 diabetes and their parents, such as history of frequent or traumatic hypoglycemia, as well as trait anxiety. In addition to this summary of the literature, new data are presented supporting the reliability of hypoglycemic fear assessment in younger children and comparing fear of hypoglycemia in children in different age groups (6-18 years old) and their parents. Also reviewed are studies investigating the relationship between fear of hypoglycemia and diabetes control, which have yielded inconsistent results. Given the potential importance of fear of hypoglycemia in pediatric diabetes, there has been limited research in this area.","PeriodicalId":89355,"journal":{"name":"Diabetes management (London, England)","volume":"1 6","pages":"627-639"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/DMT.11.60","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30334689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 133

2020 Conference Announcementon Diabetes and Obesity 2020年糖尿病和肥胖会议公告

Diabetes management (London, England) Pub Date : 1900-01-01 DOI: 10.37532/1758-1907.2021.11(5).226

N. Chalisa

引用次数: 0