{"title":"Advanced approaches for Obesity and Endocrinology","authors":"Khomassuridze","doi":"10.37532/1758-1907.2020.10(4).E102","DOIUrl":"https://doi.org/10.37532/1758-1907.2020.10(4).E102","url":null,"abstract":"It is a great platform to share a new things on obesity and diabetes and it is organizing with the International Researchers, Doctors, Scientists, Endocrinologists, Diabetologists, Health care professionals, Delegates and Students across the globe will assemble on the venue and justify the phenomenon, the theme “Advanced approaches for Obesity and Endocrinology.Overweight and obesity has proceeded as one of the most regular global issues as it is affecting more than a billion adults worldwide. Both general and abdominal obesity have been shown as risk factors contributing for morbidity and mortality. Major global organizations have focused today on speedy treatment and prevention strategies for this epidemic which has been recognized to pose drastic threat to public health. Obesity results in reduced quality of life. This global health issue is becoming more prevalent among women and in lower social classes or immigrants; while over weight is increasing especially among children.","PeriodicalId":89355,"journal":{"name":"Diabetes management (London, England)","volume":"19 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69923190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The potential role of male bone marrow mesenchymal stem cells of diabetic female rats","authors":"K. El-Said, Amany Abdel hamid Ezz, Amira Mohamed","doi":"10.37532/1758-1907.2020.10(2).137-146","DOIUrl":"https://doi.org/10.37532/1758-1907.2020.10(2).137-146","url":null,"abstract":"Background: Diabetes Mellitus is a metabolic defect that has the ability to produce an irreversible injury, abnormality of function and defect of several organs. Stem cell treatment posses a fantastic hope for the remedy damaged tissues or organs, and it is one of the utmost hopeful remedy for diabetic people. Thus, the current research direct to highlights of the potency function of MSCs of diabetic female rats. Methodology: Male albino bone marrow mesenchymal stem cells have been isolated and confirmed by their adhesion, spindle shape and also by cluster differentiation marker. Streptozotocin-induced diabetic female rats were intravenous injected by 1 x 105 MSCs (cell/rat). Results: MSCs group is capable of lowering blood glucose level, the activities of α-amylase, and S. L-MDA. However, hepatic glycogen contents showed an incredible increase when compared with the STZ-diabetic female nontreated rats. The histopathological and immuno-histochemical photo results confirmed that MSCs group noteworthy diminutive the degenerative alteration in pancreatic β-cells islet. Conclusions: Using bone marrow MSCs in remedy of STZ-diabetic female rats have the ability to recover odd biochemical parameters to normal or near normal level in STZ-induced diabetes model. But, MSCs needs more research and it may be more effective by injection more than one dose.","PeriodicalId":89355,"journal":{"name":"Diabetes management (London, England)","volume":"10 1","pages":"10-20"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69923088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glimpses of Diabetes Management","authors":"L. Kao","doi":"10.37532/1758-1907.2020.10(4).E105","DOIUrl":"https://doi.org/10.37532/1758-1907.2020.10(4).E105","url":null,"abstract":"Diabetes Management presents findings, analysis and commentary on the battle with Type I and Type II diabetes. Articles published in Diabetes Management address improvements in current therapeutics and patient compliance together with perspectives on future prospects. Coverage focuses on the key objective of stabilizing blood glucose levels in individuals with either form of the disease, and the associated issues of patient co-operation and education. The journal also reflects the frontiers of current research, such as attempts to recreate pancreatic cells through stem cell technology or islet cell transplantation, the development of a vaccine for Type 1 disease and the potential for biomarkers to be used for the detection. The increasing understanding of the molecular basis of the disease and associated genetics will play an important part in future diabetes management.","PeriodicalId":89355,"journal":{"name":"Diabetes management (London, England)","volume":"10 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69923011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abigail D Peairs, Amy S Shah, Suzanne Summer, Melody Hess, Sarah C Couch
{"title":"Effects of the dietary approaches to stop hypertension (DASH) diet on glucose variability in youth with Type 1 diabetes.","authors":"Abigail D Peairs, Amy S Shah, Suzanne Summer, Melody Hess, Sarah C Couch","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Glucose variability (GV) independently increases risk for vascular events in patients with diabetes. The Dietary Approaches to Stop Hypertension (DASH) dietary pattern emphasizes fruits, vegetables, whole grains, lean meats, and low fat dairy and has the potential to reduce postprandial blood glucose (BG) excursions, however, its effect on GV is not known. The purpose of this work was to assess feasibility and collect preliminary data on the efficacy of the DASH diet on GV in adolescents with type 1 diabetes (T1D).</p><p><strong>Methods: </strong>Twenty one adolescents recruited from the Diabetes Center of Cincinnati Children's Hospital Medical Center with T1D (11-17y) participated in one of two phases of a controlled feeding study. The first phase tested the acceptability and blood glucose response to a traditional DASH diet (DASH) and the second phase tested a DASH diet specifically modified for diabetes (DASH-D) to improve glucose response to meals. For each phase, participants consumed first their usual diet, and then a controlled DASH diet while wearing continuous glucose monitoring (CGM) systems for 3 days of each diet. All foods were provided to the patients during the DASH dietary periods and 24 h dietary recalls were conducted during the usual diet periods to assess daily intake.</p><p><strong>Results: </strong>Sixteen participants (14.1 +/- 2.2y) were included in final analyses (DASH n=7, DASH-D n=9). Both DASH diets were significantly higher in fruits, vegetables, fiber, vitamin A, and % energy from protein than usual intakes. DASH was higher in carbohydrate (CHO) (60 <i>vs.</i> 50%) and lower in fat (21 <i>vs.</i> 36%) than usual intake, resulting in higher GV (Standard Deviation and Lability Index) and more low BG excursions (3 ± 2.8 <i>vs.</i> 7.1 ± 3.3, p=0.024). DASH-D was modified to better match CHO and fat content of patients' usual intakes in phase 1 (50/30/20 for CHO/fat/pro respectively, which resulted in no difference in GV between DASH-D and usual intake. There were also trends for lower average BG (144.1 <i>vs.</i> 168.9, p=0.072) and less percentage of time spent in the hyperglycemic range (39.3 ± 25.5 <i>vs.</i> 54.1 ± 19.4, p=0.07) on DASH-D compared to usual intake.</p><p><strong>Conclusion: </strong>The DASH dietary pattern tended to result in less hyperglycemia and an overall lower BG compared to usual care. Modifying a traditional DASH diet by increasing heart healthy fats improves glycemic response to DASH and may be beneficial for long term cardiovascular benefits in youth with T1D.</p>","PeriodicalId":89355,"journal":{"name":"Diabetes management (London, England)","volume":"7 5","pages":"383-391"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763547/pdf/nihms922515.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35735956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Steven S Coughlin, Christos Hatzigeorgiou, Judith Anglin, Ding Xie, Gina M Besenyi, Gianluca De Leo, Jessica Stewart, Thad Wilkins
{"title":"Healthy lifestyle intervention for adult clinic patients with type 2 diabetes mellitus.","authors":"Steven S Coughlin, Christos Hatzigeorgiou, Judith Anglin, Ding Xie, Gina M Besenyi, Gianluca De Leo, Jessica Stewart, Thad Wilkins","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Diet and exercise therapy have been reported to be effective in improving blood glucose control and are an important part of treatment of type 2 diabetes mellitus.</p><p><strong>Objective: </strong>The goal of this study is to examine the efficacy of a healthy lifestyle intervention for adult clinic patients with type 2 diabetes mellitus, as measured by Hgb-A1c, cardiovascular indicators, physical activity, weight, and BMI. Also of interest are optimal strategies for subject recruitment, the number of intervention sessions attended, and participant use of the Fitbit watch to monitor their physical activity and track food and beverage consumption.</p><p><strong>Methods: </strong>A pre/post-test design will be used in this pilot study. Non-institutionalized adult patients (n=50) aged 18-65 years who have been seen at the Augusta Health outpatient clinics (General Internal Medicine or Family Medicine) for type 2 diabetes in the past 12 months, and who are interested in reducing their risk of disease recurrence through healthy lifestyle behaviors, will be eligible to participate. At orientation visit, eligible individuals will be asked to provide written informed consent. Consenting volunteers (n=50) will be asked to complete the baseline and 6-month follow-up questionnaire and to participate in 12 weekly group sessions of 90 min duration, involving physical activity and to meet with a dietitian (baseline, one month, 90 days) to receive individualized advice on diet and nutrition. The technology-based intervention will use wrist-worn Fitbit Blaze physical activity monitoring devices.</p><p><strong>Conclusions: </strong>This pilot study will provide important information about the feasibility and preliminary efficacy of a healthy lifestyle intervention for adult clinic patients with type 2 diabetes mellitus. The use of consumer-facing devices such as the Fitbit watch has the potential advantage over the use of research accelerometers, pedometers, or actigraphs in increasing the likelihood that the intervention will be sustainable after the study ends.</p>","PeriodicalId":89355,"journal":{"name":"Diabetes management (London, England)","volume":"7 2","pages":"197-204"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545882/pdf/nihms885043.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Korey K Hood, Marisa Hilliard, Gretchen Piatt, Carolyn E Ievers-Landis
{"title":"Effective strategies for encouraging behavior change in people with diabetes.","authors":"Korey K Hood, Marisa Hilliard, Gretchen Piatt, Carolyn E Ievers-Landis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Behavioral management of diabetes leads to better health outcomes. This paper reviews the available literature on facilitators of behavior change in people with diabetes and highlights approaches and strategies diabetes care providers can utilize. The research and clinical evidence points to the critical nature of considering the content and structure of recommendations, and utilizing problem solving and teamwork approaches. Furthermore, close attention to individual and community factors will optimize behavior change. These factors include health literacy, community infrastructure, support within the family, and whether there are co-occurring eating and mood issues. Recommendations are provided to optimize communication and embed behavior change approaches in clinical and community encounters.</p>","PeriodicalId":89355,"journal":{"name":"Diabetes management (London, England)","volume":"5 6","pages":"499-510"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086609/pdf/nihms797813.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36389475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding hypoglycemia in hospitalized patients.","authors":"Raphael D Hulkower, Rena M Pollack, Joel Zonszein","doi":"10.2217/DMT.13.73","DOIUrl":"https://doi.org/10.2217/DMT.13.73","url":null,"abstract":"<p><p>Controlling blood glucose in hospitalized patients is important as both hyperglycemia and hypoglycemia are associated with increased cost, length of stay, morbidity and mortality. A limiting factor in stringent control is the concern of iatrogenic hypoglycemia. The association of hypoglycemia with mortality has led to clinical guideline changes recommending more conservative glycemic control than had previously been suggested, with the use of patient specific approaches when appropriate. Healthier, stable patients may be managed with stricter control while the elderly and severely ill may be managed less aggressively. While the avoidance of hypoglycemia is essential in clinical practice, recent studies suggest that a higher mortality rate occurs in spontaneous rather than iatrogenic hypoglycemia. Therefore, inpatient hypoglycemia may be viewed more as a biomarker of disease rather than a true cause of fatality.</p>","PeriodicalId":89355,"journal":{"name":"Diabetes management (London, England)","volume":"4 2","pages":"165-176"},"PeriodicalIF":0.0,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/DMT.13.73","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32647877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}