Anti-infective agents in medicinal chemistry最新文献

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Pharmacology of Current and Investigational Human Immunodeficiency virus (HIV) Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Adults 目前和正在研究的成人人类免疫缺陷病毒(HIV)核苷/核苷酸逆转录酶抑制剂的药理学
Anti-infective agents in medicinal chemistry Pub Date : 2007-06-30 DOI: 10.2174/187152107781023656
Laura Waters and Marta Boffito
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引用次数: 2
Antibacterial Peptides - A Bright Future or a False Hope 抗菌肽——光明的未来还是虚假的希望
Anti-infective agents in medicinal chemistry Pub Date : 2007-06-30 DOI: 10.2174/187152107781023665
R. Bucki, I. Levental, P. Janmey
{"title":"Antibacterial Peptides - A Bright Future or a False Hope","authors":"R. Bucki, I. Levental, P. Janmey","doi":"10.2174/187152107781023665","DOIUrl":"https://doi.org/10.2174/187152107781023665","url":null,"abstract":"The increasing number of antibiotic resistant bacterial strains presents an emerging world health problem that demands continued effort to develop new antibacterial compounds. Endogenous antibacterial peptides (ABPs) that are constitutively and/or inducibly produced in tissues exposed to external surroundings represent new candidates for devel- opment of such compounds. Most ABPs target bacterial membranes initially by electrostatic interactions between posi- tively charged amino acids and negatively charged molecules present on bacterial walls, followed by compromise of the permeability barrier of bacterial membranes through the formation of pores, leading to rapid cell death and efficient bacte- rial elimination. Other mechanisms, such as the inhibition of bacterial protein and DNA synthesis or receptor-mediated stimulation of host defense mechanisms are also ascribed to these molecules. The activities of ABPs correlate positively with a gradient of hydrophobicity along the peptide backbone, net positive charge at neutral pH, and secondary structure. More than 850 sequences with antibacterial activity have been described, and this number continues to grow with the ad- dition of newly discovered, as well as synthetic, peptides. Many strategies, including increasing net positive charge, in- creasing net hydrophobicity, conjugation of peptides with lipophilic acids, incorporation of carbonate bonds, and synthesis of their hybrids and truncated sequences that omit hemolytic regions, have been proposed to increase efficiency of syn- thetic ABPs. Additionally peptide-mimicking molecules such as cationic steroid antibiotics (CSAs) may be useful alterna- tives to natural ABPs. Current challenges for practical application of ABPs are the high cost of synthesis/isolation, inacti- vation by blood plasma, confinement by anionic polyelectrolytes, and possible unknown toxicity.","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"6 1","pages":"175-184"},"PeriodicalIF":0.0,"publicationDate":"2007-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68021026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Mass Spectrometry, Proteomics, Data Mining Strategies and Their Applications in Infectious Disease Research. 质谱,蛋白质组学,数据挖掘策略及其在传染病研究中的应用。
Anti-infective agents in medicinal chemistry Pub Date : 2007-03-31 DOI: 10.2174/187152107780361689
A. Evangelou, L. Gortzak-Uzan, I. Jurisica, T. Kislinger
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引用次数: 2
Medicinal Use of Lincosamides and Microbial Resistance to Them 林可胺类药物的药用及微生物耐药性
Anti-infective agents in medicinal chemistry Pub Date : 2007-03-31 DOI: 10.2174/187152107780361670
T. Řezanka, J. Spížek, K. Sigler
{"title":"Medicinal Use of Lincosamides and Microbial Resistance to Them","authors":"T. Řezanka, J. Spížek, K. Sigler","doi":"10.2174/187152107780361670","DOIUrl":"https://doi.org/10.2174/187152107780361670","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"6 1","pages":"133-144"},"PeriodicalIF":0.0,"publicationDate":"2007-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152107780361670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68020877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Aminoglycosidic Aminocyclitol Antibiotics-A Wonder, But Toxic Drugs:Developments and Clinical Implications 氨基糖苷类氨基环醇抗生素——一种神奇但有毒的药物:发展和临床意义
Anti-infective agents in medicinal chemistry Pub Date : 2007-03-31 DOI: 10.2174/187152107780361643
M. Shahid
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引用次数: 10
Inactivation of Pathogenic Microorganisms by Photodynamic Techniques:Mechanistic Aspects and Perspective Applications. 病原微生物的光动力失活技术:机理方面和前景应用。
Anti-infective agents in medicinal chemistry Pub Date : 2007-03-31 DOI: 10.2174/187152107780361652
Giulio Jori and Olimpia Coppellotti
{"title":"Inactivation of Pathogenic Microorganisms by Photodynamic Techniques:Mechanistic Aspects and Perspective Applications.","authors":"Giulio Jori and Olimpia Coppellotti","doi":"10.2174/187152107780361652","DOIUrl":"https://doi.org/10.2174/187152107780361652","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"6 1","pages":"119-131"},"PeriodicalIF":0.0,"publicationDate":"2007-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68020843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 74
Revitalized Strategies Against Multi-Resistant Bacteria: Antimicrobial Photodynamic Therapy and Bacteriophage Therapy 对抗多重耐药细菌的新策略:抗菌素光动力疗法和噬菌体疗法
Anti-infective agents in medicinal chemistry Pub Date : 2007-03-31 DOI: 10.2174/187152107780361634
T. Maisch
{"title":"Revitalized Strategies Against Multi-Resistant Bacteria: Antimicrobial Photodynamic Therapy and Bacteriophage Therapy","authors":"T. Maisch","doi":"10.2174/187152107780361634","DOIUrl":"https://doi.org/10.2174/187152107780361634","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"6 1","pages":"145-150"},"PeriodicalIF":0.0,"publicationDate":"2007-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152107780361634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68020793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Unique Applications of Novel Antifungal Drug Combinations 新型抗真菌药物组合的独特应用
Anti-infective agents in medicinal chemistry Pub Date : 2007-01-01 DOI: 10.2174/187152107779314142
C. Heitman
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引用次数: 20
Recent Synthesis of Marine Natural Products with Antibacterial Activities 具有抗菌活性的海洋天然产物的合成研究进展
Anti-infective agents in medicinal chemistry Pub Date : 2007-01-01 DOI: 10.2174/187152107779314151
I. Mancini, A. Defant, G. Guella
{"title":"Recent Synthesis of Marine Natural Products with Antibacterial Activities","authors":"I. Mancini, A. Defant, G. Guella","doi":"10.2174/187152107779314151","DOIUrl":"https://doi.org/10.2174/187152107779314151","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"6 1","pages":"17-48"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152107779314151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68020737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 36
The First Years of Linezolid Experience in Clinical Practice: A Balance and Future Implications 利奈唑胺在临床实践中的第一年经验:平衡和未来的影响
Anti-infective agents in medicinal chemistry Pub Date : 2007-01-01 DOI: 10.2174/187152107779314098
R. Manfredi, L. Calza
{"title":"The First Years of Linezolid Experience in Clinical Practice: A Balance and Future Implications","authors":"R. Manfredi, L. Calza","doi":"10.2174/187152107779314098","DOIUrl":"https://doi.org/10.2174/187152107779314098","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"6 1","pages":"63-70"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152107779314098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68020656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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