The open addiction journal最新文献_第6页

Editorial: Extinction of Drug-Seeking Behavior 社论:药物寻求行为的消失

The open addiction journal Pub Date : 2010-05-04 DOI: 10.2174/1874941001003020055

M. Olive

{"title":"Editorial: Extinction of Drug-Seeking Behavior","authors":"M. Olive","doi":"10.2174/1874941001003020055","DOIUrl":"https://doi.org/10.2174/1874941001003020055","url":null,"abstract":"Some of the key defining characteristics of drug addiction (substance dependence) is the persistence of drug-seeking behavior despite attempts at abstinence, adverse health and legal consequences, and impaired social, occupational or academic functioning [1]. From a behavior modification standpoint, extinction refers to the gradual and intentional reduction of a maladaptive behavior, such as drug-seeking or drug self-administration behavior. From a cognitive-behavioral therapeutic perspective, extinction refers to a gradual and intentional reduction in psychological and/or physiological responses, such as autonomic nervous system activation and drug craving, to drug-associated stimuli. In the latter sense, extinction is essentially a “desensitization” process that is performed via cue exposure therapy (CET). During CET, addicts are presented with pictures of or actual physical exposure to drug-related stimuli such as drug paraphernalia (i.e., crack pipes), drug-related olfactory stimuli (i.e., the aroma of alcohol or cigarette smoke), or even drug self-administration contextual environments. Over time, the conditioned psychological and physiological responses to drug-associated stimuli extinguish. Similar cue exposure therapy procedures, such as exposure plus response prevention, are successfully used for the treatment of anxiety disorders including disabling phobias, obsessive-compulsive disorder, and post-traumatic stress disorder.","PeriodicalId":89289,"journal":{"name":"The open addiction journal","volume":"3 1","pages":"55-56"},"PeriodicalIF":0.0,"publicationDate":"2010-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68096813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroanatomical Structures Underlying the Extinction of Drug-Seeking Behavior~!2009-09-18~!2010-01-24~!2010-04-09~! 药物寻求行为消失背后的神经解剖结构2009-09-18 2010-01-24 2010-04-09

The open addiction journal Pub Date : 2010-05-04 DOI: 10.2174/1874941001003020063

R. M. Cleva, J. Gass

引用次数: 6

The Role of N-Acetylcysteine in Inhibiting Responding During Extinction in Rats Trained to Self-Administer Cocaine. n -乙酰半胱氨酸在自我给药大鼠灭绝过程中抑制反应的作用。

The open addiction journal Pub Date : 2010-05-04 DOI: 10.2174/1874941001003020088

S. Larowe, P. Kalivas

引用次数: 8

The Potent Effect of Environmental Context on Relapse to Alcohol-Seeking After Extinction. 环境背景对灭绝后嗜酒复发的有力影响。

The open addiction journal Pub Date : 2010-05-04 DOI: 10.2174/1874941001003020076

P. Janak, N. Chaudhri

{"title":"The Potent Effect of Environmental Context on Relapse to Alcohol-Seeking After Extinction.","authors":"P. Janak, N. Chaudhri","doi":"10.2174/1874941001003020076","DOIUrl":"https://doi.org/10.2174/1874941001003020076","url":null,"abstract":"Environments in which the pharmacological effects of alcohol have been experienced become potent triggers for relapse in abstinent humans. Animal models developed to study the effect of environmental contexts on relapse to alcohol-seeking behavior demonstrate that alcohol-seeking is renewed by exposure to an alcohol-associated context, following the extinction of alcohol-seeking in a different context. Hence, contexts in which alcohol conditioning and extinction learning occur can be critical determinants for whether or not alcohol-seeking behavior is observed. This review summarizes preclinical research to date examining the role of alcohol contexts on the reinstatement of extinguished responding for alcohol. Behavioral studies have elucidated factors that are important for eliciting context-dependent relapse, and have uncovered novel interactions between alcohol-seeking driven by discrete alcohol cues in different contexts. Neuropharmacological studies provide substantial evidence for a role of dopaminergic systems in context-dependent reinstatement, and growing support for opioidergic mechanisms as well. Several key limbic brain regions have been identified in the modulation of alcohol-seeking by context, supporting a proposed neural circuit that includes the hippocampus, nucleus accumbens, basolateral amygdala, lateral hypothalamus, and the paraventricular thalamus.","PeriodicalId":89289,"journal":{"name":"The open addiction journal","volume":"3 1","pages":"76-87"},"PeriodicalIF":0.0,"publicationDate":"2010-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68096880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48

Progress in Cue Exposure Therapy for the Treatment of Addictive Disorders: A Review Update~!2009-11-25~!2010-02-08~!2010-04-09~! 提示暴露疗法治疗成瘾性疾病的进展:综述更新2009-11-25 2010-02-08 2010-04-09

The open addiction journal Pub Date : 2010-05-04 DOI: 10.2174/1874941001003020092

T. Martin, S. Larowe, R. Malcolm

引用次数: 26

Extinction Learning as a Model of Drug Treatment and Relapse: A Behavioral Overview~!2009-12-19~!2010-02-03~!2010-04-09~! 作为药物治疗和复发模型的消退学习:行为学综述2009-12-19 2010-02-03 2010-04-09

The open addiction journal Pub Date : 2010-05-04 DOI: 10.2174/1874941001003020057

J. Widholm

引用次数: 3

Predictors of Early and Late Escalation of Smokeless Tobacco Use and Cigarette Smoking Among Swedish Adolescents 瑞典青少年中无烟烟草使用和吸烟的早期和晚期升级的预测因素

The open addiction journal Pub Date : 2010-04-07 DOI: 10.2174/1874941001003010050

K. Rosendahl, M. Galanti

引用次数: 4

Interpersonal Self-Perception and Memories on Parental Rearing in Alcohol Dependent Patients and Outpatient Controls 酒精依赖患者与门诊对照中父母教养对人际自我知觉与记忆的影响

The open addiction journal Pub Date : 2010-01-19 DOI: 10.2174/1874941001003010043

A. Jong, P. Jacobs

引用次数: 4

The ACID-Survey: Methodology and Design of an Online Survey to Assess Alcohol and Recreational Cocaine Use and its Consequences for Traffic Safety 酸调查:在线调查的方法和设计，以评估酒精和娱乐性可卡因使用及其对交通安全的影响

The open addiction journal Pub Date : 2010-01-13 DOI: 10.2174/1874941001003010024

J. Verster, Y. Kuerten, B. Olivier, M. Laar

引用次数: 9

Absinthe, Absinthism and Thujone - New Insight into the Spirit's Impact on Public Health 苦艾酒、苦艾酒和图琼酒——精神对公众健康影响的新见解

The open addiction journal Pub Date : 2010-01-13 DOI: 10.2174/1874941001003010032

D. Lachenmeier, David Nathan-Maister, Theodore A Breaux, J. Luauté, J. Emmert

{"title":"Absinthe, Absinthism and Thujone - New Insight into the Spirit's Impact on Public Health","authors":"D. Lachenmeier, David Nathan-Maister, Theodore A Breaux, J. Luauté, J. Emmert","doi":"10.2174/1874941001003010032","DOIUrl":"https://doi.org/10.2174/1874941001003010032","url":null,"abstract":"Absinthe, a strong alcoholic aperitif, is notorious for containing the compound 'thujone', which has been commonly regarded as its 'active ingredient'. It has been widely theorized that the thujone content of vintage absinthe made it harmful to public health, and caused the distinct syndrome absinthism, which was extensively described in the literature prior to the spirit's ban in 1915. The interdisciplinary research presented in this paper shows that 1) absinthism cannot be distinguished from common alcoholism in the medical research literature of the time, and that 2) due to the physical chemistry of the distillation process, the thujone content of vintage absinthe was considerably lower than previously estimated and corresponds to levels generally recognized as safe, as proven by analyses of absinthes from the pre-ban era. Due to the re-legalization of absinthe in the European Union and more recently in the United States, potential public health concerns have re-emerged, not expressly based on worries about thujone content or absinthism, but on alcohol-related harm and youth protection issues, exacerbated by marketing strategies promoting absinthe using false and discredited claims pertaining to thujone and stubbornly persistant myths.","PeriodicalId":89289,"journal":{"name":"The open addiction journal","volume":"3 1","pages":"32-38"},"PeriodicalIF":0.0,"publicationDate":"2010-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68096127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12