Biomedical & environmental mass spectrometry最新文献

Dimethylisopropylsilyl ether derivative in gas chromatography/mass spectrometry of 11-dehydrothromboxane B2. 11-脱氢血栓素B2的二甲基异丙基硅醚衍生物气相色谱/质谱分析。

Biomedical & environmental mass spectrometry Pub Date : 1989-11-25 DOI: 10.1248/CPB.37.3015

M. Ishibashi, K. Watanabe, N. Harima, S. Krolik

引用次数: 6

Determination of the new aromatic retinoic acid Ro 13-7410 in plasma by two-dimensional gas chromatography negative ion chemical ionization mass spectrometry with selected-ion monitoring. 选择离子监测的二维气相色谱-负离子化学电离质谱法测定血浆中新型芳香族维甲酸Ro 13-7410。

Biomedical & environmental mass spectrometry Pub Date : 1989-07-01 DOI: 10.1002/bms.1200180703

H J Egger, U B Ranalder, E U Koelle, M Klaus

{"title":"Determination of the new aromatic retinoic acid Ro 13-7410 in plasma by two-dimensional gas chromatography negative ion chemical ionization mass spectrometry with selected-ion monitoring.","authors":"H J Egger, U B Ranalder, E U Koelle, M Klaus","doi":"10.1002/bms.1200180703","DOIUrl":"https://doi.org/10.1002/bms.1200180703","url":null,"abstract":"A highly sensitive and specific method for the determination of the aromatic retinoic acid Ro 13-7410 in plasma at the picogram per millilitre level is described. The method involves extraction of plasma using Extrelut-1 columns, purification of the extract with Bond Elut-NH2 cartridges, derivatization with pentafluorobenzyl bromide, and subsequent analysis by two-dimensional capillary gas chromatography using the zone-cutting technique, stable isotope dilution and selective negative ion monitoring chemical ionization mass spectrometry. A tetradeuterated analogue is used as internal standard. Quantification is possible down to 25 pg/ml using 1 ml of plasma. The coefficients of variation of the method as calculated from quality control samples are 8.5 and 4.2% at the 100 and 400 pg/ml levels. The method has been applied to the analysis of plasma of volunteers following an oral dose of 40 micrograms Ro 13-7410 and plasma of dogs following an intravenous and oral dose of 25 and 50 micrograms, respectively.","PeriodicalId":8924,"journal":{"name":"Biomedical & environmental mass spectrometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/bms.1200180703","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13914121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Deuterated ritanserin analysis by gas chromatography/mass spectrometry: a sensitive technique to study human ritanserin pharmacokinetics. 气相色谱/质谱法分析氘化利坦色林:一种研究人利坦色林药动学的灵敏技术。

Biomedical & environmental mass spectrometry Pub Date : 1989-07-01 DOI: 10.1002/bms.1200180709

P Timmerman, R Woestenborghs, H Lenoir, J Heykants

{"title":"Deuterated ritanserin analysis by gas chromatography/mass spectrometry: a sensitive technique to study human ritanserin pharmacokinetics.","authors":"P Timmerman, R Woestenborghs, H Lenoir, J Heykants","doi":"10.1002/bms.1200180709","DOIUrl":"https://doi.org/10.1002/bms.1200180709","url":null,"abstract":"Ritanserin, a new selective serotonin-S2 antagonist, was labelled in one 4-fluorophenyl moiety to obtain a (2H4)-labelled analogue having the following isotopic distribution: 2H0: 0.0%, 2H1: 0.1%, 2H2: 1.9%, 2H3: 5.8%, 2H4: 92.2%. (2H0/2H4) Ritanserin and the internal standard were isolated from the plasma by liquid/liquid extraction and analysed by selected-ion monitoring gas chromatography/mass spectrometry in the 70 eV electron impact mode. A detection limit of 0.1 ng ml-1 could be obtained for both (2H0) and (2H4)ritanserin. The precision (per cent coefficient of variation) and accuracy (per cent relative error) of the method were 4.1% and 4.1%, respectively. The method was used to determine the plasma levels of ritanserin and tetradeuterated ritanserin in three healthy male subjects receiving an equimolar mixture of 5:5 mg (2H0/2H4)ritanserin. The pharmacokinetics of both isotopomers proved to be identical, indicating the absence of an isotope effect, so that this technique might be very promising for use in bioequivalence studies.","PeriodicalId":8924,"journal":{"name":"Biomedical & environmental mass spectrometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/bms.1200180709","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13650578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Identification and determination of tert-alkylphenols in carp from the Trenton Channel of the Detroit River, Michigan, USA. 美国密歇根州底特律河特伦顿海峡鲤鱼中叔烷基酚的鉴定与测定。

Biomedical & environmental mass spectrometry Pub Date : 1989-07-01 DOI: 10.1002/bms.1200180706

H Shiraishi, D S Carter, R A Hites

引用次数: 35

Stable isotope dilution analysis of n-hexanoylglycine, 3-phenylpropionylglycine and suberylglycine in human urine using chemical ionization gas chromatography/mass spectrometry selected ion monitoring. 化学电离气相色谱/质谱选择离子监测分析人尿中正己甘氨酸、3-苯基丙酰甘氨酸和亚基甘氨酸的稳定同位素稀释。

Biomedical & environmental mass spectrometry Pub Date : 1989-07-01 DOI: 10.1002/bms.1200180705

P Rinaldo, J J O'Shea, R D Welch, K Tanaka

{"title":"Stable isotope dilution analysis of n-hexanoylglycine, 3-phenylpropionylglycine and suberylglycine in human urine using chemical ionization gas chromatography/mass spectrometry selected ion monitoring.","authors":"P Rinaldo, J J O'Shea, R D Welch, K Tanaka","doi":"10.1002/bms.1200180705","DOIUrl":"https://doi.org/10.1002/bms.1200180705","url":null,"abstract":"We describe a gas chromatographic/mass spectrometric method for the accurate determination of n-hexanoylglycine, 3-phenylpropionylglycine and suberylglycine in urine for the diagnosis of hereditary medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. These acylglycines had previously been detected in urine from patients with MCAD deficiency, but their diagnostic values were unknown because of a lack of appropriate analytical methods. n-Hexanoyl(1,2-13C)glycine, 3-phenylpropionyl(2-13C,15N)glycine and suberyl(2-13C,15N)glycine were synthesized and used as internal standards. Ammonia chemical ionization was utilized to generate intense [M + H]+ ions for selected-ion monitoring quantification. The whole procedure is fast and can be performed by a low-resolution gas chromatographic/mass spectrometric system, giving accurate results over a range of three orders of magnitude (0.0167-16.7 micrograms/ml). The results from the analyses of 54 urine samples from 21 MCAD-deficient patients and various control samples using this method established that n-hexanoyglycine and 3-phenylpropionylglycine were highly diagnostic for this disease, while suberylglycine was found less specific.","PeriodicalId":8924,"journal":{"name":"Biomedical & environmental mass spectrometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/bms.1200180705","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13914122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

A rapid liquid-solid extraction procedure for the quantification of clenbuterol in urine. 快速液固萃取法定量测定尿中盐酸克仑特罗。

Biomedical & environmental mass spectrometry Pub Date : 1988-11-01 DOI: 10.1002/bms.1200170512

J Schmid, A Bücheler

引用次数: 10

Quantitation of clenbuterol in biological fluids using ammonia CI and automated capillary GCMS. 氨CI和自动毛细管气相色谱法定量生物体液中的克仑特罗。

Biomedical & environmental mass spectrometry Pub Date : 1988-11-01 DOI: 10.1002/bms.1200170513

H J Förster, K L Rominger, E Ecker, H Peil, A Wittrock

引用次数: 19

Proceedings of the International Symposium on Applied Mass Spectrometry in the Health Sciences. Barcelona, Spain, 28-30 September 1987. 质谱在健康科学中的应用国际研讨会论文集。1987年9月28日至30日，西班牙巴塞罗那。

Biomedical & environmental mass spectrometry Pub Date : 1988-10-01

引用次数: 0

Measurement of phenylacetic acid in cerebrospinal fluid and plasma using combined gas chromatography/electron capture chemical ionization mass spectrometry. 联合气相色谱/电子俘获化学电离质谱法测定脑脊液和血浆中的苯乙酸。

Biomedical & environmental mass spectrometry Pub Date : 1988-09-01 DOI: 10.1002/bms.1200170310

K F Faull, N Pascoe, K A Greene, J F Maddaluno, J Lunde, R J King

引用次数: 9

Potassium ion ionization of desorbed species (K+IDS): a rapid method for the screening of urine for organic acidemias. 解吸态钾离子电离(K+IDS):一种快速筛选尿液有机酸血症的方法。

Biomedical & environmental mass spectrometry Pub Date : 1988-09-01 DOI: 10.1002/bms.1200170311

D B Kassel, J Allison

{"title":"Potassium ion ionization of desorbed species (K+IDS): a rapid method for the screening of urine for organic acidemias.","authors":"D B Kassel, J Allison","doi":"10.1002/bms.1200170311","DOIUrl":"https://doi.org/10.1002/bms.1200170311","url":null,"abstract":"A new desorption/ionization mass spectrometric technique, K+ ionization of desorbed species (K+IDS), is evaluated as a rapid method for differentiating various organic acidemias, conditions in which excessive levels of organic acid metabolites are present in plasma or urine as a result of some inborn error of metabolism. This method requires no derivatization of the isolated organic acids, unlike that required for gas chromatographic and gas chromatographic/mass spectrometric analyses. 'Batch' mass spectrometric analysis is achieved by deposition of the complex organic acid mixture (from urine) onto a K+IDS probe. Rapid heating results in the emission of alkali ions (Na+ or K+) from a thermionic emitter and the intact desorption of analyte. Subsequent gas-phase addition produces a mass spectrum showing alkali ion adducts of the components, providing molecular weight and relative concentration information. This rapid desorption/ionization technique requires no matrix, and analysis times are exceedingly short relative to those required in gas chromatographic/mass spectrometric analyses. Results suggest that differential diagnosis of some of the more commonly occurring organic acidemias (e.g. isovaleric acidemia, maple syrup urine disease, etc.) may be made.","PeriodicalId":8924,"journal":{"name":"Biomedical & environmental mass spectrometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/bms.1200170311","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14345578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4