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Biomedical & environmental mass spectrometry最新文献

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Characterization of glutathione conjugates by fast atom bombardment/tandem mass spectrometry. 快速原子轰击/串联质谱法表征谷胱甘肽缀合物。
Biomedical & environmental mass spectrometry Pub Date : 1988-06-01 DOI: 10.1002/bms.1200151107
P E Haroldsen, M H Reilly, H Hughes, S J Gaskell, C J Porter
{"title":"Characterization of glutathione conjugates by fast atom bombardment/tandem mass spectrometry.","authors":"P E Haroldsen,&nbsp;M H Reilly,&nbsp;H Hughes,&nbsp;S J Gaskell,&nbsp;C J Porter","doi":"10.1002/bms.1200151107","DOIUrl":"https://doi.org/10.1002/bms.1200151107","url":null,"abstract":"<p><p>The collisionally activated decomposition of [M + H]+ ions, generated by fast atom bombardment (FAB) of glutathione conjugates, has been studied by tandem mass spectrometry (MS/MS) using hybrid sector/quadrupole instruments. Abundant fragments of diagnostic utility were present in the daughter ion spectra. Common fragmentation modes were observed but their relative importance was strongly dependent on the nature of the conjugated species. As an example of a general approach to the characterization of glutathione conjugates in biological samples, the acetaminophen-glutathione conjugate was identified in rat bile, following coadministration of (2H0)- and (2H3)acetaminophen, using the experimental sequence: (i) conventional FAB mass spectrometric analysis, (ii) MS/MS using constant neutral loss (129 u) scanning to identify parent ions corresponding to glutathione conjugates, (iii) MS/MS to yield daughter ion spectra of parents so identified and corresponding to (2H0)- and (2H3)-labeled conjugates.</p>","PeriodicalId":8924,"journal":{"name":"Biomedical & environmental mass spectrometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/bms.1200151107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14521760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 58
Analysis of glutathione conjugates and related compounds by thermospray mass spectrometry. 热喷雾质谱法分析谷胱甘肽偶联物及相关化合物。
Biomedical & environmental mass spectrometry Pub Date : 1988-06-01 DOI: 10.1002/bms.1200151108
C E Parker, J S de Wit, R W Smith, M B Gopinathan, O Hernandez, K B Tomer, C H Vestal, J M Sanders, J R Bend
{"title":"Analysis of glutathione conjugates and related compounds by thermospray mass spectrometry.","authors":"C E Parker,&nbsp;J S de Wit,&nbsp;R W Smith,&nbsp;M B Gopinathan,&nbsp;O Hernandez,&nbsp;K B Tomer,&nbsp;C H Vestal,&nbsp;J M Sanders,&nbsp;J R Bend","doi":"10.1002/bms.1200151108","DOIUrl":"https://doi.org/10.1002/bms.1200151108","url":null,"abstract":"<p><p>A series of 17 cysteine, N-acetyl cysteine, glutathione, and N-trifluoroacetyl glutathione conjugates have been prepared, and their thermospray (TSP) spectra have been recorded in the positive and negative ion modes. The compounds undergo extensive fragmentation, which primarily occurs at the carbon-sulfur bonds. For most of the compounds, positive ion TSP is more sensitive than negative ion thermospray. Probably due to the thermal lability of these adducts, the quality of the spectra obtained are dependent on source conditions, requiring fine control of the vaporization/desolvation process.</p>","PeriodicalId":8924,"journal":{"name":"Biomedical & environmental mass spectrometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/bms.1200151108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14521761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Volumes 6-10, 1979-1983. Cumulative indexes and contents. 第6-10卷，1979-1983年。累积索引和内容。
Biomedical & environmental mass spectrometry Pub Date : 1985-01-01
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引用次数: 0
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