Korean diabetes journal最新文献

{"title":"Letter: The Relationship between Lung Function and Metabolic Syndrome in Obese and Non-Obese Korean Adult Males (Korean Diabetes J 2010;34:253-60).","authors":"Bo Kyung Koo","doi":"10.4093/kdj.2010.34.5.327","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.5.327","url":null,"abstract":"We appreciate the comments on our study \"The Relationship between Lung Function and Metabolic Syndrome in Obese and Non-Obese Korean Adult Males,\" which was published in Korean Diabetes J 2010;34:253-260. \u0000 \u0000We reported that insulin resistance, and other metabolic risk factors appear to be related to forced vital capacity (FVC), irrespective of obesity in Korean males. \u0000 \u0000The age, height, and disease were the major determinants of ventilatory function [1]. In our study, there was a significant difference of age between metabolic syndrome (MetS) and non-MetS. So, we studied the relationship between MetS and FVC after adjusting for age. After adjusting age, there was still a significant difference in FVC between MetS and non-MetS groups (93.1 ± 12.1 vs. 97.0 ± 11.5, P < 0.05). Furthermore, insulin resistance and other metabolic components such as waist circumference were independently associated with FVC in a multi-linear regression analysis after adjusting for age and height, the major determinants of ventilatory function, and this was consistent with previous studies [2-5]. \u0000 \u0000It has been reported that lung function is affected by several factors such as body composition and fat distribution, physical activity level, handgrip strength and respiratory muscle power [6-9]. Our study was performed on a limited cross-section of the population, so we could not control the potential biases due to differences in physical activity or respiratory muscle power. \u0000 \u0000However, several studies have reported that insulin resistance is independently associated with lung function [3,10]. These studies reported that the lung function is still inversely associated with insulin resistance after adjusting for compounding factors such as age, height, smoking, and physical activity. Furthermore, Lazarus et al. [11,12] reported that skeletal muscle weakness served as a marker for future risk of insulin resistance, and that impaired lung function can aid in the prediction of development of insulin resistance. They suggested that some metabolic change that eventually leads to insulin resistance may initially induce diminished muscle strength and diminished ventilatory function [12]. So diminished muscle strength may be not confounding factor, but an early marker of insulin resistance. \u0000 \u0000Several reports have suggested that impaired lung function is associated with glucose intolerance, hypertension, and cardiovascular disease, and that lung function is a reliable long-term predictor of mortality in the general population. \u0000 \u0000We suggested that decreased FVC is associated with increased metabolic risk and insulin resistance in Korean males. Further prospective study to elucidate the relationship between lung function and metabolic risk is needed.","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 5","pages":"327-8"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.5.327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29469304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of diet in good and poor glycemic control groups in elderly patients with type 2 diabetes mellitus.","authors":"Mi-Hye Woo,&nbsp;Soojin Park,&nbsp;Jeong-Taek Woo,&nbsp;Ryowon Choue","doi":"10.4093/kdj.2010.34.5.303","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.5.303","url":null,"abstract":"<p><strong>Background: </strong>Identification of dietary patterns is important for glycemic management in elderly patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>Elderly T2DM patients (> 65 years of age, n = 48) were categorized based on their concentration of glycated hemoglobin (HbA(1c)). Subjects with HbA(1c) levels below 7% were placed in the good control (GC) group and those with HbA(1c) levels equal to or above 8% were placed in the poor control (PC) group. Anthropometric data, blood parameters, and dietary intake records were compared between the groups. Statistical analysis included Student's t-test, chi-square test, and Pearson correlation coefficient test.</p><p><strong>Results: </strong>Anthropometric data, including body mass index (24.7 ± 2.9 kg/m(2)), did not differ between the GC and PC groups. Significant abnormalities in blood glucose levels (P < 0.01), lean body mass (P < 0.01), and plasma protein and albumin levels (P < 0.05, P < 0.01) were found in the PC group. In contrast to the GC group, the PC group depended on carbohydrate (P = 0.014) rather than protein (P = 0.013) or fat (P = 0.005) as a major source of energy, and had a lower index of nutritional quality for nutrients such as protein (P = 0.001), and all vitamins and minerals (P < 0.001, 0.01, or 0.05 for individual nutrients), except vitamin C, in their usual diet. Negative correlations between HbA(1c) levels and protein (r = -0.338, P < 0.05) or fat (r = -0.385, P < 0.01) intakes were also found.</p><p><strong>Conclusions: </strong>Healthcare professionals should encourage elderly diabetic patients to consume a balanced diet to maintain good glycemic control.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 5","pages":"303-11"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.5.303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29468881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of pyruvate dehydrogenase kinase 4 in regulation of blood glucose levels.","authors":"Nam Ho Jeoung,&nbsp;Robert A Harris","doi":"10.4093/kdj.2010.34.5.274","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.5.274","url":null,"abstract":"<p><p>In the well-fed state a relatively high activity of the pyruvate dehydrogenase complex (PDC) reduces blood glucose levels by directing the carbon of pyruvate into the citric acid cycle. In the fasted state a relatively low activity of the PDC helps maintain blood glucose levels by conserving pyruvate and other three carbon compounds for gluconeogenesis. The relative activities of the pyruvate dehydrogenase kinases (PDKs) and the opposing pyruvate dehydrogenase phosphatases determine the activity of PDC in the fed and fasted states. Up regulation of PDK4 is largely responsible for inactivation of PDC in the fasted state. PDK4 knockout mice have lower fasting blood glucose levels than wild type mice, proving that up regulation of PDK4 is important for normal glucose homeostasis. In type 2 diabetes, up regulation of PDK4 also inactivates PDC, which promotes gluconeogenesis and thereby contributes to the hyperglycemia characteristic of this disease. When fed a high fat diet, wild type mice develop fasting hyperglycemia but PDK4 knockout mice remain euglycemic, proving that up regulation of PDK4 contributes to hyperglycemia in diabetes. These finding suggest PDK4 inhibitors might prove useful in the treatment of type 2 diabetes.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 5","pages":"274-83"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.5.274","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29468877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone mineral density in prediabetic men.","authors":"Ju Hee Lee,&nbsp;Yun Hyeong Lee,&nbsp;Kyoung Hye Jung,&nbsp;Min Kyeong Kim,&nbsp;Hye Won Jang,&nbsp;Tae Kyun Kim,&nbsp;Hyun Jin Kim,&nbsp;Young Suk Jo,&nbsp;Minho Shong,&nbsp;Tae Yong Lee,&nbsp;Bon Jeong Ku","doi":"10.4093/kdj.2010.34.5.294","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.5.294","url":null,"abstract":"<p><strong>Background: </strong>There are many studies regarding the effects of insulin on bone metabolism and changes in bone mineral density (BMD) in the setting of diabetes. The effect of prediabetes on BMD is not known.</p><p><strong>Methods: </strong>A total of 802 men participated in the Korea Rural Genomic Cohort Study (in Geumsan County). According to the results of an oral glucose tolerance test, subjects were classified into normal, prediabetic, and diabetic categories. One hundred twenty-four subjects diagnosed with type 2 diabetes were excluded, leaving 678 subjects for the study inclusion. BMD was estimated with a quantitative ultrasonometer.</p><p><strong>Results: </strong>The average BMD T scores of normal and prediabetic subjects were -1.34 ± 1.42 and -1.33 ± 1.30, respectively; there was no significant difference in the BMD T scores between these groups. The BMD T score was inversely associated with age and positively correlated with body weight, body mass index, total cholesterol, low density lipoprotein cholesterol, and HbA1c. On multiple linear regression analysis, low density lipoprotein cholesterol was the only statistically significant variable for prediabetes (β = 0.007, P = 0.005). On the stepwise regression analysis, age (β = -0.026, P < 0.001), the body mass index (β = 0.079, P < 0.001), and low density lipoprotein cholesterol (β = 0.004, P = 0.016) were significant variables for prediabetes.</p><p><strong>Conclusions: </strong>There was no significant difference in the BMD T score between the normal and prediabetic subjects. Further studies are needed regarding the association of fracture risk and changes in BMD with the development of overt diabetes.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 5","pages":"294-302"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.5.294","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29468880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Tribbles-Related Protein 3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells.","authors":"Young Yun Jang,&nbsp;Nam Keong Kim,&nbsp;Mi Kyung Kim,&nbsp;Ho Young Lee,&nbsp;Sang Jin Kim,&nbsp;Hye Soon Kim,&nbsp;Hye-Young Seo,&nbsp;In Kyu Lee,&nbsp;Keun Gyu Park","doi":"10.4093/kdj.2010.34.5.312","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.5.312","url":null,"abstract":"<p><strong>Background: </strong>The highly developed endoplasmic reticulum (ER) structure in pancreatic beta cells is heavily involved in insulin biosynthesis. Thus, any perturbation in ER function inevitably impacts insulin biosynthesis. Recent studies showed that the expression of tribbles-related protein 3 (TRB3), a mammalian homolog of Drosophilia tribbles, in various cell types is induced by ER stress. Here, we examined whether ER stress induces TRB3 expression in INS-1 cells and found that TRB3 mediates ER stress-induced suppression of insulin gene expression.</p><p><strong>Methods: </strong>The effects of tunicamycin and thapsigargin on insulin and TRB3 expression in INS-1 cells were measured by Northern and Western blot analysis, respectively. The effects of adenovirus-mediated overexpression of TRB3 on insulin, PDX-1 and MafA gene expression in INS-1 cells were measured by Northern blot analysis. The effect of TRB3 on insulin promoter was measured by transient transfection study with constructs of human insulin promoter.</p><p><strong>Results: </strong>The treatment of INS-1 cells with tunicamycin and thapsigargin decreased insulin mRNA expression, but increased TRB3 protein expression. Adenovirus-mediated overexpression of TRB3 decreased insulin gene expression in a dose-dependent manner. A transient transfection study showed that TRB3 inhibited insulin promoter activity, suggesting that TRB3 inhibited insulin gene expression at transcriptional level. Adenovirus-mediated overexpression of TRB3 also decreased PDX-1 mRNA expression, but did not influence MafA mRNA expression.</p><p><strong>Conclusions: </strong>This study showed that ER stress induced TRB3 expression, but decreased both insulin and PDX-1 gene expression in INS-1 cells. Our data suggest that TRB3 plays an important role in ER stress-induced beta cell dysfunction.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 5","pages":"312-9"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.5.312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29468882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response: The Relationship between Lung Function and Metabolic Syndrome in Obese and Non-Obese Korean Adult Males (Korean Diabetes J 2010;34:253-60).","authors":"Soo Kyoung Kim,&nbsp;Jae Hyeon Kim","doi":"10.4093/kdj.2010.34.5.329","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.5.329","url":null,"abstract":"Corresponding author: Jae Hyeon Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Korea E-mail: jaehyeonkim@paran.com We appreciate the comments on our study “The Relationship between Lung Function and Metabolic Syndrome in Obese and Non-Obese Korean Adult Males,” which was published in Korean Diabetes J 2010;34:253-260. We reported that insulin resistance, and other metabolic risk factors appear to be related to forced vital capacity (FVC), irrespective of obesity in Korean males. The age, height, and disease were the major determinants of ventilatory function [1]. In our study, there was a significant difference of age between metabolic syndrome (MetS) and non-MetS. So, we studied the relationship between MetS and FVC after adjusting for age. After adjusting age, there was still a significant difference in FVC between MetS and non-MetS groups (93.1 ± 12.1 vs. 97.0 ± 11.5, P < 0.05). Furthermore, insulin resistance and other metabolic components such as waist circumference were independently associated with FVC in a multi-linear regression analysis after adjusting for age and height, the major determinants of ventilatory function, and this was consistent with previous studies [2–5]. It has been reported that lung function is affected by several factors such as body composition and fat distribution, physical activity level, handgrip strength and respiratory muscle power [6–9]. Our study was performed on a limited cross-section of the population, so we could not control the potential biases due to differences in physical activity or respiratory muscle power. However, several studies have reported that insulin resistance is independently associated with lung function [3,10]. These studies reported that the lung function is still inversely associated with insulin resistance after adjusting for compounding factors such as age, height, smoking, and physical activity. Furthermore, Lazarus et al. [11,12] reported that skeletal muscle weakness served as a marker for future risk of insulin resistance, and that impaired lung function can aid in the prediction of development of insulin resistance. They suggested that some metabolic change that eventually leads to insulin resistance may initially induce diminished muscle strength and diminished ventilatory function [12]. So diminished muscle strength may be not confounding factor, but an early marker of insulin resistance. Several reports have suggested that impaired lung function is associated with glucose intolerance, hypertension, and cardiovascular disease, and that lung function is a reliable longterm predictor of mortality in the general population . We suggested that decreased FVC is associated with increased metabolic risk and insulin resistance in Korean males. Further prospective study to elucidate the relationship between lung function and metabolic risk is nee","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 5","pages":"329-30"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.5.329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29469305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of brachial-ankle pulse wave velocity with acute postprandial hyperglycemia in korean prediabetic and diabetic subjects.","authors":"Chul Woo Ahn","doi":"10.4093/kdj.2010.34.5.284","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.5.284","url":null,"abstract":"Subjects with diabetes have accelerated atherosclerotic vascular lesions. The risk of having coronary, cerebral, and peripheral arterial diseases is higher in diabetic subjects than in non-diabetic subjects [1]. Atherosclerosis involves a combination of fatty degeneration and vessel stiffening of the arterial wall. Sclerotic changes are more difficult to assess than atherosis and, because of this, it have attracted less attention. For example, the standard evaluation of atheromatous by histopathology and serial angiography is a sensitive method that does not detect sclerotic changes [2]. In animal studies, a direct relationship has been established between regression of atherosclerosis and an increase in arterial distensibility [3,4]. \u0000 \u0000Pulse wave velocity (PWV) is known to be an indicator of arterial stiffness [5,6], and has been regarded as a marker of vascular damage [7,8]. Recent studies have demonstrated that PWV is not only a marker of vascular damages, but also a prognostic predictor when it is measured using noninvasive automatic devices [9,10]. Therefore, PWV can be potentially used for screening vascular damage in a large population [6,11]. Recently, an instrument was developed to measure brachial-ankle PWV (baPWV) by using a volume-rendering [12]. Nakamura et al. have found that the length of abdominal aorta that is affected by calcification, which is a known risk factor for cardiovascular morbidity and mortality, also independently predicted baPWV [13]. Accordingly, baPWV could be used as a new measure of vascular damage that may predispose an individual to cardiovascular events. baPWV was mainly affected by age, systolic blood pressure and sex. Many other factors, such as body weight, body mass index (BMI), waist to hip ratio, HbA1c, microalbuminuria, triglyceride, ϒGTP, and duration of diabetes mellitus , also affected baPWV [14]. \u0000 \u0000Long-term glycemic control is known to be correlated with the changes of baPWV in type 2 diabetic subjects who frequently have accompanying insulin resistance for 12 months [15]. In addition, hyperinsulinemia contributes to the development of arterial stiffness, which is assessed by measuring the baPWV, in the early stages of type 2 diabetes mellitus [16]. Glycemic control and the hyperinsulinemic state are important factors that determine the PWV in diabetic subjects. In a study of university students in Japan, baPWV was significantly higher in obese (BMI > 30 kg/m2) male subjects than in the overweight (25 < BMI < 30 kg/m2) subjects and higher in the males with nonalcoholic fatty liver disease (NAFLD) than in those without NAFLD [17]. \u0000 \u0000In the present study, the investigators measured baPWV, fasting, 30- and 120-minute post-challenge glucose levels, as well as other metabolic parameters, in 633 subjects with fasting hyperglycemia. Among the participants, 62.9% were prediabetic, and 31.7% were diagnosed with having diabetes. The mean baPWV value was significantly higher in subjects with diabetes, whe","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 5","pages":"284-6"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.5.284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29468878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus.","authors":"Dae Joon Jeong,&nbsp;Dong Gyu Lee,&nbsp;Hee-Jung Kim,&nbsp;Eun Hee Cho,&nbsp;Sang-Wook Kim","doi":"10.4093/kdj.2010.34.5.320","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.5.320","url":null,"abstract":"<p><strong>Background: </strong>Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized calcification in infancy and an increased risk of developing type 2 diabetes mellitus (T2DM). We hypothesized that the ENPP1 K121Q variant may be associated with increased coronary artery calcification in T2DM patients.</p><p><strong>Methods: </strong>The study subjects were aged 34 to 85 years and showed no evidence of clinical cardiovascular disease prior to recruitment. A total of 140 patients with T2DM were assessed for their coronary artery calcium (CAC) scores and ENPP1 K121Q polymorphisms were identified.</p><p><strong>Results: </strong>The prevalence of subjects carrying the KQ genotype was 12.9% (n = 18). There were no 121QQ homozygotes. Patients with the KQ genotype did not show a significantly higher CAC score (122 vs. 18; P = 0.858). We matched each patient with the KQ genotype to a respective control with the KK genotype by gender, age, and duration of diabetes. When compared to matched controls, we observed no significant difference in CAC score (P = 0.959).</p><p><strong>Conclusions: </strong>The ENPP1 K121Q polymorphism does not appear to be associated with coronary artery calcification in patients with T2DM.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 5","pages":"320-6"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.5.320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29468883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ubiquitous Diabetes Management System via Interactive Communication Based on Information Technologies: Clinical Effects and Perspectives.","authors":"Jae-Hyoung Cho, Hun-Sung Kim, Jae-Hoon Han, Jin-Hee Lee, Jeong-Ah Oh, Yoon-Hee Choi, Kun-Ho Yoon","doi":"10.4093/kdj.2010.34.5.267","DOIUrl":"10.4093/kdj.2010.34.5.267","url":null,"abstract":"<p><p>New diabetes management systems based on interactive communication have been introduced recently, accompanying rapid advances in information technology; these systems are referred to as \"ubiquitous diabetes management systems.\" In such ubiquitous systems, patients and medical teams can communicate via Internet or telecommunications, with patients uploading their glucose data and personal information, and medical teams sending optimal feedback. Clinical evidence from both long-term and short-term trials has been reported by some researchers. Such systems appear to be effective not only in reducing the levels of HbA1c but also in stabilizing glucose control. However, most notably, evidence for the cost-effectiveness of such a system should be demonstrated before it can be propagated out to the general population in actual clinical practice. To establish a cost-effective model, various types of clinical decision supporting software designed to reduce the labor time of physicians must first be developed. A number of sensors and devices for monitoring patients' data are expected to be available in the near future; thus, methods for automatic interconnections between devices and web charts were also developed. Further investigations to demonstrate the clinical outcomes of such a system should be conducted, hopefully leading to a new paradigm of diabetes management.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 5","pages":"267-73"},"PeriodicalIF":0.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bf/b5/kdj-34-267.PMC2972485.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29468876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of adiponectin/leptin ratio with homeostasis model assessment insulin resistance index and metabolic syndrome in apparently healthy korean male adults.","authors":"Chan-Hee Jung,&nbsp;Eun-Jung Rhee,&nbsp;Ji-Hoon Choi,&nbsp;Ji-Cheol Bae,&nbsp;Seung-Hyun Yoo,&nbsp;Won-Jun Kim,&nbsp;Cheol-Young Park,&nbsp;Ji Oh Mok,&nbsp;Chul Hee Kim,&nbsp;Won-Young Lee,&nbsp;Ki-Won Oh,&nbsp;Sung-Woo Park,&nbsp;Sun-Woo Kim","doi":"10.4093/kdj.2010.34.4.237","DOIUrl":"https://doi.org/10.4093/kdj.2010.34.4.237","url":null,"abstract":"<p><strong>Background: </strong>We investigated the relationships of adiponectin/leptin (A/L) ratio with cardiovascular risk factors, insulin resistance index, and metabolic syndrome (MS) in apparently healthy Korean male adults.</p><p><strong>Methods: </strong>Sixty-eight male subjects were enrolled among the participants of an annual health check-up program (mean age, 55.1 years). Percent body fat (%) was measured using a bioelectric impedance analyzer. Serum leptin level was measured via radioimmunoassay, and adiponectin level was measured using an enzyme-linked immunosorbent assay. Homeostasis model assessment (HOMA)-insulin resistance (IR) index was calculated, and the presence of metabolic syndrome was assessed.</p><p><strong>Results: </strong>Adiponectin, leptin, and A/L ratio showed significant correlations with percent body fat, lipid profile, and HOMA-IR. Mean leptin and HOMA-IR levels were significantly higher, while A/L ratio was significantly lower in subjects with MS. With increasing number of MS components, the mean values of leptin and HOMA-IR increased and the A/L ratio decreased. In multiple regression analysis, HOMA-IR was significantly correlated with triglyceride, fasting glucose, and A/L ratio, while A/L ratio was significantly correlated with body mass index and HOMA-IR. HOMA-IR and A/L ratio were significant predictors for each other after adjustment for other factors.</p><p><strong>Conclusion: </strong>A/L ratio correlated well with lipid profile, HOMA-IR, and the presence and number of MS components in Korean male subjects.</p>","PeriodicalId":88924,"journal":{"name":"Korean diabetes journal","volume":"34 4","pages":"237-43"},"PeriodicalIF":0.0,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4093/kdj.2010.34.4.237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40063831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}