Biomatter Pub Date : 2016-01-01 Epub Date: 2016-10-14 DOI: 10.1080/21592535.2016.1231276

Tanit Haddad, Samantha Noel, Benoît Liberelle, Rouwayda El Ayoubi, Abdellah Ajji, Gregory De Crescenzo

引用次数: 0

Enhanced bioactivity of glass ionomer cement by incorporating calcium silicates 通过掺入硅酸钙提高玻璃离子水门合剂的生物活性

Biomatter Pub Date : 2016-01-01 DOI: 10.1080/21592535.2015.1123842

Song Chen, Yixiao Cai, H. Engqvist, W. Xia

引用次数: 18

Effect of grain sizes on mechanical properties and biodegradation behavior of pure iron for cardiovascular stent application. 晶粒尺寸对心血管支架用纯铁力学性能和生物降解行为的影响。

Biomatter Pub Date : 2016-01-01 DOI: 10.4161/21592527.2014.959874

Camillus Sunday Obayi, Ranna Tolouei, Afghany Mostavan, Carlo Paternoster, Stephane Turgeon, Boniface Adeleh Okorie, Daniel Oray Obikwelu, Diego Mantovani

{"title":"Effect of grain sizes on mechanical properties and biodegradation behavior of pure iron for cardiovascular stent application.","authors":"Camillus Sunday Obayi, Ranna Tolouei, Afghany Mostavan, Carlo Paternoster, Stephane Turgeon, Boniface Adeleh Okorie, Daniel Oray Obikwelu, Diego Mantovani","doi":"10.4161/21592527.2014.959874","DOIUrl":"https://doi.org/10.4161/21592527.2014.959874","url":null,"abstract":"Pure iron has been demonstrated as a potential candidate for biodegradable metal stents due to its appropriate biocompatibility, suitable mechanical properties and uniform biodegradation behavior. The competing parameters that control the safety and the performance of BMS include proper strength-ductility combination, biocompatibility along with matching rate of corrosion with healing rate of arteries. Being a micrometre-scale biomedical device, the mentioned variables have been found to be governed by the average grain size of the bulk material. Thermo-mechanical processing techniques of the cold rolling and annealing were used to grain-refine the pure iron. Pure Fe samples were unidirectionally cold rolled and then isochronally annealed at different temperatures with the intention of inducing different ranges of grain size. The effect of thermo-mechanical treatment on mechanical properties and corrosion rates of the samples were investigated, correspondingly. Mechanical properties of pure Fe samples improved significantly with decrease in grain size while the corrosion rate decreased marginally with decrease in the average grain sizes. These findings could lead to the optimization of the properties to attain an adequate biodegradation-strength-ductility balance. ","PeriodicalId":8891,"journal":{"name":"Biomatter","volume":"6 ","pages":"e959874"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/21592527.2014.959874","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32888170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 62

The effect of oligo(trimethylene carbonate) addition on the stiffness of acrylic bone cement 低聚碳酸三亚甲基对丙烯酸骨水泥刚度的影响

Biomatter Pub Date : 2016-01-01 DOI: 10.1080/21592535.2015.1133394

C. Persson, Alejandro López, H. Fathali, A. Hoess, R. Rojas, M. Ott, J. Hilborn, H. Engqvist

{"title":"The effect of oligo(trimethylene carbonate) addition on the stiffness of acrylic bone cement","authors":"C. Persson, Alejandro López, H. Fathali, A. Hoess, R. Rojas, M. Ott, J. Hilborn, H. Engqvist","doi":"10.1080/21592535.2015.1133394","DOIUrl":"https://doi.org/10.1080/21592535.2015.1133394","url":null,"abstract":"ABSTRACT With the increasing elderly population an increase in the number of bony fractures associated to age-related diseases such as osteoporosis also follows. The relatively high stiffness of the acrylic bone cements used in these patients has been suggested to give raise to a suboptimal load distribution surrounding the cement in vivo, and hence contribute to clinical complications, such as additional fractures. The aim of this study was to develop a low-modulus bone cement, based on currently used, commercially available poly(methyl methacrylate) (PMMA) cements for vertebroplasty. To this end, acrylate end-functionalized oligo(trimethylene carbonate) (oTMC) was incorporated into the cements, and the resulting compressive mechanical properties were evaluated, as well as the cytotoxic and handling properties of selected formulations. Sixteen wt%oTMC was needed in the vertebroplastic cement Osteopal V to achieve an elastic modulus of 1063 MPa (SD 74), which gave a corresponding compressive strength of 46.1 MPa (SD 1.9). Cement extracts taken at 1 and 12 hours gave a reduced MG-63 cell viability in most cases, while extracts taken at 24 hours had no significant effect on cell behavior. The modification also gave an increase in setting time, from 14.7 min (SD 1.7) to 18.0 min (SD 0.9), and a decrease in maximum polymerization temperature, from 41.5°C (SD 3.4) to 30.7°C (SD 1.4). While further evaluation of other relevant properties, such as injectability and in vivo biocompatibility, remains to be done, the results presented herein are promising in terms of approaching clinically applicable bone cements with a lower stiffness.","PeriodicalId":8891,"journal":{"name":"Biomatter","volume":"137 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77223770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Small-sized granules of biphasic bone substitutes support fast implant bed vascularization. 小颗粒双相骨替代物支持快速种植床血管化。

Biomatter Pub Date : 2015-01-01 DOI: 10.1080/21592535.2015.1056943

M Barbeck, M Dard, M Kokkinopoulou, J Markl, P Booms, R A Sader, C J Kirkpatrick, S Ghanaati

{"title":"Small-sized granules of biphasic bone substitutes support fast implant bed vascularization.","authors":"M Barbeck, M Dard, M Kokkinopoulou, J Markl, P Booms, R A Sader, C J Kirkpatrick, S Ghanaati","doi":"10.1080/21592535.2015.1056943","DOIUrl":"https://doi.org/10.1080/21592535.2015.1056943","url":null,"abstract":"The present study investigated the influence of granule size of 2 biphasic bone substitutes (BoneCeramic® 400-700 μm and 500-1000 μm) on the induction of multinucleated giant cells (MNGCs) and implant bed vascularization in a subcutaneous implantation model in rats. Furthermore, degradation mechanisms and particle phagocytosis of both materials were examined by transmission electron microscopy (TEM). Both granule types induced tissue reactions involving primarily mononuclear cells and only small numbers of MNGCs. Higher numbers of MNGCs were detected in the group with small granules starting on day 30, while higher vascularization was observed only at day 10 in this group. TEM analysis revealed that both mono- and multinucleated cells were involved in the phagocytosis of the materials. Additionally, the results allowed recognition of the MNGCs as the foreign body giant cell phenotype. Histomorphometrical analysis of the size of phagocytosed particles showed no differences between the 2 granule types. The results indicate that granule size seems to have impact on early implant bed vascularization and also on the induction of MNGCs in the late phase of the tissue reaction. Furthermore, the results revealed that a synthetic bone substitute material can induce tissue reactions similar to those of some xenogeneic materials, thus pointing to a need to elucidate their \"ideal\" physical characteristics. The results also show that granule size in the range studied did not alter phagocytosis by mononuclear cells. Finally, the investigation substantiates the differentiation of material-induced MNGCs, which are of the foreign body giant cell type. ","PeriodicalId":8891,"journal":{"name":"Biomatter","volume":"5 ","pages":"e1056943"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21592535.2015.1056943","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33276146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Cell infiltration into a 3D electrospun fiber and hydrogel hybrid scaffold implanted in the brain. 细胞浸润到3D电纺丝纤维和水凝胶混合支架植入大脑。

Biomatter Pub Date : 2015-01-01 DOI: 10.1080/21592535.2015.1005527

Christopher J Rivet, Kun Zhou, Ryan J Gilbert, David I Finkelstein, John S Forsythe

{"title":"Cell infiltration into a 3D electrospun fiber and hydrogel hybrid scaffold implanted in the brain.","authors":"Christopher J Rivet, Kun Zhou, Ryan J Gilbert, David I Finkelstein, John S Forsythe","doi":"10.1080/21592535.2015.1005527","DOIUrl":"https://doi.org/10.1080/21592535.2015.1005527","url":null,"abstract":"Tissue engineering scaffolds are often designed without appropriate consideration for the translational potential of the material. Solid scaffolds implanted into central nervous system (CNS) tissue to promote regeneration may require tissue resection to accommodate implantation. Or alternatively, the solid scaffold may be cut or shaped to better fit an irregular injury geometry, but some features of the augmented scaffold may fail to integreate with surrounding tissue reducing regeneration potential. To create a biomaterial able to completely fill the irregular geometry of CNS injury and yet still provide sufficient cell migratory cues, an injectable, hybrid scaffold was created to present the physical architecture of electrospun fibers in an agarose/methylcellulose hydrogel. When injected into the rat striatum, infiltrating macrophages/microglia and resident astrocytes are able to locate the fibers and utilize their cues for migration into the hybrid matrix. Thus, hydrogels containing electrospun fibers may be an appropriate platform to encourage regeneration of the injured brain. ","PeriodicalId":8891,"journal":{"name":"Biomatter","volume":"5 ","pages":"e1005527"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21592535.2015.1005527","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33202429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 49

Strontium ranelate improves the interaction of osteoblastic cells with titanium substrates: Increase in cell proliferation, differentiation and matrix mineralization. 雷奈酸锶改善成骨细胞与钛基质的相互作用:增加细胞增殖、分化和基质矿化。

Biomatter Pub Date : 2015-01-01 DOI: 10.1080/21592535.2015.1027847

William Querido, Marcos Farina, Karine Anselme

{"title":"Strontium ranelate improves the interaction of osteoblastic cells with titanium substrates: Increase in cell proliferation, differentiation and matrix mineralization.","authors":"William Querido, Marcos Farina, Karine Anselme","doi":"10.1080/21592535.2015.1027847","DOIUrl":"https://doi.org/10.1080/21592535.2015.1027847","url":null,"abstract":"We describe direct effects of strontium ranelate on the interaction of osteoblastic cells with different titanium substrates. Our goal was to better understand the potential of this drug for improving the efficacy of bone implants. Treatment was done with 0.12 and 0.5 mM Sr(2+) of strontium ranelate in cell culture. We analyzed cell response to the drug on titanium substrates with surface topographies obtained using acid etching, electro-erosion processing, sandblasting, and machine-tooling. Treatment preserved the initial cell adhesion to the substrates, cell shape parameters (area, aspect ratio, circularity, and solidity), and the orientation of cells on grooved surfaces. However, both concentrations of the drug increased cell proliferation in all substrates. Moreover, a dose-dependent increase in alkaline phosphatase activity and in the production of mineralized matrix with typical features of bone tissue was shown. The observed effects were similar in the different substrates. In conclusion, strontium ranelate improved the interaction of osteoblastic cells with titanium substrates, increasing cell proliferation and differentiation into mature osteoblasts and the production of bone-like mineralized matrix for all substrates. This study highlights a promising role of strontium ranelate on enhancing the clinical success of bone implants, particularly in patients with osteoporosis.","PeriodicalId":8891,"journal":{"name":"Biomatter","volume":"5 ","pages":"e1027847"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21592535.2015.1027847","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34289979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Development of a novel carrier optimized for cell sheet transplantation. 细胞片移植优化载体的研制。

Biomatter Pub Date : 2015-01-01 DOI: 10.1080/21592535.2015.1027846

Yosuke Amagai, Kaoru Karasawa, Jung Kyungsook, Akira Matsuda, Masanori Kojima, Jun Watanabe, Toyoji Hibi, Hiroshi Matsuda, Akane Tanaka

引用次数: 8

On the potential for fibronectin/phosphorylcholine coatings on PTFE substrates to jointly modulate endothelial cell adhesion and hemocompatibility properties. 聚四氟乙烯基纤维连接蛋白/磷胆碱涂层联合调节内皮细胞粘附和血液相容性的潜力。

Biomatter Pub Date : 2015-01-01 DOI: 10.4161/21592535.2014.979679

Vanessa Montaño-Machado, Pascale Chevallier, Diego Mantovani, Emmanuel Pauthe

{"title":"On the potential for fibronectin/phosphorylcholine coatings on PTFE substrates to jointly modulate endothelial cell adhesion and hemocompatibility properties.","authors":"Vanessa Montaño-Machado, Pascale Chevallier, Diego Mantovani, Emmanuel Pauthe","doi":"10.4161/21592535.2014.979679","DOIUrl":"https://doi.org/10.4161/21592535.2014.979679","url":null,"abstract":"The use of biomolecules as coatings on biomaterials is recognized to constitute a promising approach to modulate the biological response of the host. In this work, we propose a coating composed by 2 biomolecules susceptible to provide complementary properties for cardiovascular applications: fibronectin (FN) to enhance endothelialization, and phosphorylcholine (PRC) for its non thrombogenic properties. Polytetrafluoroethylene (PTFE) was selected as model substrate mainly because it is largely used in cardiovascular applications. Two approaches were investigated: 1) a sequential adsorption of the 2 biomolecules and 2) an adsorption of the protein followed by the grafting of phosphorylcholine via chemical activation. All coatings were characterized by immunofluorescence staining, X-Ray Photoelectron Spectroscopy and Scanning Electron Microscopy analyses. Assays with endothelial cells showed improvement on cell adhesion, spreading and metabolic activity on FN-PRC coatings compared with the uncoated PTFE. Platelets adhesion and activation were both reduced on the coated surfaces when compared with uncoated PTFE. Moreover, clotting time tests exhibited better hemocompatibility properties of the surfaces after a sequential adsorption of FN and PRC. In conclusion, FN-PRC coating improves cell adhesion and non-thrombogenic properties, thus revealing a certain potential for the development of this combined deposition strategy in cardiovascular applications. ","PeriodicalId":8891,"journal":{"name":"Biomatter","volume":"5 ","pages":"e979679"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/21592535.2014.979679","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33142122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Platinum metallization for MEMS application MEMS应用的铂金属化

Biomatter Pub Date : 2014-04-17 DOI: 10.4161/biom.28822

V. Guarnieri, L. Biazi, R. Marchiori, A. Lago

{"title":"Platinum metallization for MEMS application","authors":"V. Guarnieri, L. Biazi, R. Marchiori, A. Lago","doi":"10.4161/biom.28822","DOIUrl":"https://doi.org/10.4161/biom.28822","url":null,"abstract":"The adherence of Platinum thin film on Si/SiO2 wafer was studies using Chromium, Titanium or Alumina (Cr, Ti, Al2O3) as interlayer. The adhesion of Pt is a fundamental property in different areas, for example in MEMS devices, which operate at high temperature conditions, as well as in biomedical applications, where the problem of adhesion of a Pt film to the substrate is known as a major challenge in several industrial applications health and in biomedical devices, such as for example in the stents.1-4 We investigated the properties of Chromium, Titanium, and Alumina (Cr, Ti, and Al2O3) used as adhesion layers of Platinum (Pt) electrode. Thin films of Chromium, Titanium and Alumina were deposited on Silicon/Silicon dioxide (Si/SiO2) wafer by electron beam. We introduced Al2O3 as a new adhesion layer to test the behavior of the Pt film at higher temperature using a ceramic adhesion thin film. Electric behaviors were measured for different annealing temperatures to know the performance for Cr/Pt, Ti/Pt, and Al2O3/Pt metallic film in the gas sensor application. All these metal layers showed a good adhesion onto Si/SiO2 and also good Au wire bondability at room temperature, but for higher temperature than 400 °C the thin Cr/Pt and Ti/Pt films showed poor adhesion due to the atomic inter-diffusion between Platinum and the metal adhesion layers.5 The proposed Al2O3/Pt ceramic-metal layers confirmed a better adherence for the higher temperatures tested.","PeriodicalId":8891,"journal":{"name":"Biomatter","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89547433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

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