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Michael Neuberger (1953-2013), in memoriam 纪念迈克尔·纽伯格(1953-2013)
Inmunologia (Barcelona, Spain : 1987) Pub Date : 2014-01-01 DOI: 10.1016/j.inmuno.2013.11.001
África González-Fernández , Almudena R. Ramiro , Fernando Díaz-Espada
{"title":"Michael Neuberger (1953-2013), in memoriam","authors":"África González-Fernández , Almudena R. Ramiro , Fernando Díaz-Espada","doi":"10.1016/j.inmuno.2013.11.001","DOIUrl":"10.1016/j.inmuno.2013.11.001","url":null,"abstract":"","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"33 1","pages":"Pages 34-37"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2013.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54644135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Informe de actividades de la Sociedad Española de Inmunología 2013 西班牙免疫学学会2013年活动报告
Inmunologia (Barcelona, Spain : 1987) Pub Date : 2014-01-01 DOI: 10.1016/j.inmuno.2014.01.002
José R. Regueiro
{"title":"Informe de actividades de la Sociedad Española de Inmunología 2013","authors":"José R. Regueiro","doi":"10.1016/j.inmuno.2014.01.002","DOIUrl":"10.1016/j.inmuno.2014.01.002","url":null,"abstract":"","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"33 1","pages":"Pages 1-5"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2014.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54644375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Analysis of immunological patents filed under the Patent Cooperation Treaty (2004–2011) 专利合作条约下的免疫学专利分析(2004-2011年)
Inmunologia (Barcelona, Spain : 1987) Pub Date : 2014-01-01 DOI: 10.1016/j.inmuno.2013.07.002
Elena Campos Jiménez, Adolfo Campos Ferrer
{"title":"Analysis of immunological patents filed under the Patent Cooperation Treaty (2004–2011)","authors":"Elena Campos Jiménez, Adolfo Campos Ferrer","doi":"10.1016/j.inmuno.2013.07.002","DOIUrl":"10.1016/j.inmuno.2013.07.002","url":null,"abstract":"","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"33 1","pages":"Pages 21-26"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2013.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54643839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Las células natural killer y su papel en la respuesta inmunitaria durante la infección por el virus de la inmunodeficiencia humana tipo-1 自然杀伤细胞及其在1型人类免疫缺陷病毒感染期间免疫反应中的作用
Inmunologia (Barcelona, Spain : 1987) Pub Date : 2014-01-01 DOI: 10.1016/j.inmuno.2013.11.002
Natalia A. Taborda , Juan C. Hernández , Carlos J. Montoya , María T. Rugeles
{"title":"Las células natural killer y su papel en la respuesta inmunitaria durante la infección por el virus de la inmunodeficiencia humana tipo-1","authors":"Natalia A. Taborda ,&nbsp;Juan C. Hernández ,&nbsp;Carlos J. Montoya ,&nbsp;María T. Rugeles","doi":"10.1016/j.inmuno.2013.11.002","DOIUrl":"10.1016/j.inmuno.2013.11.002","url":null,"abstract":"<div><p>During human immunodeficiency virus type-1 (HIV-1) infection there are several changes in the frequency, phenotype and function of NK cells, altering their antiviral response. This is correlated with increased viral loads, and AIDS progression. However, studies in individuals with natural resistance to HIV-1 infection have shown that NK cells are very important in controlling viral replication, not only for their antiviral activity, but also because of their effects on the activity of other innate immune cells, such as dendritic cells. NK cells do not have antigen receptors, but it has been recently reported that they can specifically respond to HIV-1 peptides. Although the mechanism is not fully elucidated, this finding open more options in the study of new therapeutic or preventative strategies against HIV-1 infection.</p></div>","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"33 1","pages":"Pages 11-20"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2013.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54644172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Expression of the FUT2 gene and CD44 marker in patients with oral lesions 口腔病变患者FUT2基因和CD44标志物的表达
Inmunologia (Barcelona, Spain : 1987) Pub Date : 2013-10-01 DOI: 10.1016/j.inmuno.2013.04.003
María Alejandra Ensinck, Melissa Valles, Natalia Lebensohn, Carlos Cotorruelo, Claudia Biondi
{"title":"Expression of the FUT2 gene and CD44 marker in patients with oral lesions","authors":"María Alejandra Ensinck,&nbsp;Melissa Valles,&nbsp;Natalia Lebensohn,&nbsp;Carlos Cotorruelo,&nbsp;Claudia Biondi","doi":"10.1016/j.inmuno.2013.04.003","DOIUrl":"10.1016/j.inmuno.2013.04.003","url":null,"abstract":"<div><p>The aim of this work was to investigate the <em>FUT 2</em><span> gene, the secretor status and the expression of CD44 protein in epithelial cells obtain from saliva samples from patients with oral lesions (benign, pre-cancerous and cancerous lesions, </span><em>n</em> <!-->=<!--> <!-->94). We analyzed polymorphisms of the <em>FUT2</em> gene by allele specific oligonucleotide–polymerase chain reaction. The <em>FUT2</em> gene encodes the α(1,2) fucosyltransferase (Se enzyme) that regulates the expression of ABH antigens in secretions. Generally speaking, being a non-secretor has several disadvantages with regard to metabolism and immune function. In this study, we found that oral pre-cancerous and cancerous lesions were increased among individuals with non-secretor status and nonsense mutation 428G<em>→A.</em> Fifty-one percent of the patients with oral pre-malignant and malignant lesions were non-secretors, in contrast with the healthy population (OR<!--> <!-->=<!--> <!-->3.44). We observed a marginal association between secretor status and these lesions. Our study suggests that the lack of wild type <em>FUT2</em> gene and a non-secretor status appear to be an associated risk marker for the development of oral cancer in patients with oral lesions.</p><p>One of the genes involved in tumour processes is <em>CD44</em>, which appears to be one of the most promising candidates as a cancer diagnosis marker. We investigated, using confocal microscopy, the expression of CD44 protein in epithelial cells obtained from saliva samples from patients with oral lesions. The results obtained showed fluorescence corresponding to the presence of CD44 protein in samples from patients diagnosed with cancer and pre-cancer. These findings indicate that overexpression of CD44 molecule analyzed could be considered as a marker of risk in individuals with oral lesions.</p></div>","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"32 4","pages":"Pages 123-128"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2013.04.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54643534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Una nueva página web para todos 一个面向所有人的新网站
Inmunologia (Barcelona, Spain : 1987) Pub Date : 2013-10-01 DOI: 10.1016/j.inmuno.2013.10.002
David Sancho , Oscar de la Calle-Martín , Alfredo Corell , José R. Regueiro , Roger Colobran
{"title":"Una nueva página web para todos","authors":"David Sancho ,&nbsp;Oscar de la Calle-Martín ,&nbsp;Alfredo Corell ,&nbsp;José R. Regueiro ,&nbsp;Roger Colobran","doi":"10.1016/j.inmuno.2013.10.002","DOIUrl":"10.1016/j.inmuno.2013.10.002","url":null,"abstract":"","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"32 4","pages":"Pages 121-122"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2013.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54643704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Linfocitos B reguladores en enfermedades humanas y modelos murinos de autoinmunidad 调节B细胞在人类疾病和小鼠自身免疫模型中的作用
Inmunologia (Barcelona, Spain : 1987) Pub Date : 2013-10-01 DOI: 10.1016/j.inmuno.2013.06.001
Héctor Rincón-Arévalo, Lina Yassin-Noreña, Gloria Vásquez, Diana Castaño
{"title":"Linfocitos B reguladores en enfermedades humanas y modelos murinos de autoinmunidad","authors":"Héctor Rincón-Arévalo,&nbsp;Lina Yassin-Noreña,&nbsp;Gloria Vásquez,&nbsp;Diana Castaño","doi":"10.1016/j.inmuno.2013.06.001","DOIUrl":"10.1016/j.inmuno.2013.06.001","url":null,"abstract":"<div><p>B lymphocytes belong to the adaptive immune system and they are responsible for humoral responses. In recent years, it has been demonstrated the existence of B cells with regulatory capacity (Breg) in humans and mouse models. The regulatory function of these B cells is explained by the production of IL-10 and the reduction of IFN-γ, TNF-α and IL-17 secretion by CD4 + T cells; in addition, Breg cells promote the differentiation of T lymphocytes into a regulatory phenotype and induce the remission of autoimmune manifestations in different murine models. In humans, alterations in number and function of Breg cells have been reported in systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases. Therefore, it has been suggested that Breg cells have an important role in the immunopathology of autoimmune diseases and may be a potential target for future treatments.</p></div>","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"32 4","pages":"Pages 129-138"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2013.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54643086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Taller de Autoinmunidad 2013 de la Sociedad Española de Inmunología. Anticuerpos anticitoplasma de neutrófilo (ANCA) 2013年西班牙免疫学会自身免疫研讨会。抗中性粒细胞细胞质抗体(ANCA)
Inmunologia (Barcelona, Spain : 1987) Pub Date : 2013-10-01 DOI: 10.1016/j.inmuno.2013.09.002
M. Rosa Julià Benique , Pedro Martínez García , Eduardo Villegas Martín , Ángela Carrasco Sayalero , Alfonso Sánchez Ibarrola , Esther Ocaña Pérez , Goitzane Marcaida Benito , Juana Rodríguez Delgado , María José Martínez Becerra , Paz Laporta Martín , Luis Fernández Pereira , María Aránzazu Pacho de Lucas , Carmen Jiménez Garófano , Odette Vinyas Gomis , Mila Garcia , Romina Dieli Crimi , Pablo Eiras Martínez , Jordi Bas , Cecilia Muñoz Calleja , Margarita García Marcos , María José Amengual Guedan
{"title":"Taller de Autoinmunidad 2013 de la Sociedad Española de Inmunología. Anticuerpos anticitoplasma de neutrófilo (ANCA)","authors":"M. Rosa Julià Benique ,&nbsp;Pedro Martínez García ,&nbsp;Eduardo Villegas Martín ,&nbsp;Ángela Carrasco Sayalero ,&nbsp;Alfonso Sánchez Ibarrola ,&nbsp;Esther Ocaña Pérez ,&nbsp;Goitzane Marcaida Benito ,&nbsp;Juana Rodríguez Delgado ,&nbsp;María José Martínez Becerra ,&nbsp;Paz Laporta Martín ,&nbsp;Luis Fernández Pereira ,&nbsp;María Aránzazu Pacho de Lucas ,&nbsp;Carmen Jiménez Garófano ,&nbsp;Odette Vinyas Gomis ,&nbsp;Mila Garcia ,&nbsp;Romina Dieli Crimi ,&nbsp;Pablo Eiras Martínez ,&nbsp;Jordi Bas ,&nbsp;Cecilia Muñoz Calleja ,&nbsp;Margarita García Marcos ,&nbsp;María José Amengual Guedan","doi":"10.1016/j.inmuno.2013.09.002","DOIUrl":"10.1016/j.inmuno.2013.09.002","url":null,"abstract":"","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"32 4","pages":"Pages 148-156"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2013.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54643575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modelos de reconocimiento inmunológico: tolerancia e inmunidad en el marco de la evolución del conocimiento científico 免疫识别模型:科学知识进化框架下的耐受和免疫
Inmunologia (Barcelona, Spain : 1987) Pub Date : 2013-10-01 DOI: 10.1016/j.inmuno.2013.09.001
Silvia Sánchez-Ramón , Daniela Butnaru
{"title":"Modelos de reconocimiento inmunológico: tolerancia e inmunidad en el marco de la evolución del conocimiento científico","authors":"Silvia Sánchez-Ramón ,&nbsp;Daniela Butnaru","doi":"10.1016/j.inmuno.2013.09.001","DOIUrl":"10.1016/j.inmuno.2013.09.001","url":null,"abstract":"<div><p>The immune system (IS) is an exquisite machine involved in the maintenance of the integrity of the organism, and in the regulation of its own function to adapt its diverse strategies of molecular recognition within a dynamical framework. These strategies are modulated by the nature of the antigenic stimulus, the internal status of its components, and the local microenvironment, which will determine an immune response of immunity or tolerance. Throughout the history of Immunology, the archetypical «self/non-self» axiom of the immune recognition, in direct reference to the identity of the individual, has been consistently used, which should be nevertheless displaced by its numerous exceptions. We present a review of the theoretical models of the IS functioning from its basic property of antigenic recognition. We discuss the need to develop new models that enable to comprehend the IS functioning as an indissoluble integrated system with psychoneurological and endocrine systems.</p></div>","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"32 4","pages":"Pages 139-147"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2013.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54643910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Importancia de la actividad asistencial de Inmunología Clínica con Asistencia Directa a Pacientes para el futuro de la especialidad de Inmunología 临床免疫学援助活动与直接帮助患者对免疫学专业未来的重要性
Inmunologia (Barcelona, Spain : 1987) Pub Date : 2013-07-01 DOI: 10.1016/j.inmuno.2012.12.001
Javier Carbone
{"title":"Importancia de la actividad asistencial de Inmunología Clínica con Asistencia Directa a Pacientes para el futuro de la especialidad de Inmunología","authors":"Javier Carbone","doi":"10.1016/j.inmuno.2012.12.001","DOIUrl":"10.1016/j.inmuno.2012.12.001","url":null,"abstract":"","PeriodicalId":88896,"journal":{"name":"Inmunologia (Barcelona, Spain : 1987)","volume":"32 3","pages":"Pages 117-120"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.inmuno.2012.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54642849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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