Health outcomes research in medicine最新文献

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Incidence of Exacerbations and Hospitalizations Is Reduced and Time to Exacerbations Is Prolonged with Mometasone Furoate Dry Powder Inhaler Versus Beclomethasone Dipropionate Hydrofluoroalkane Aerosol in Patients with Mild Asthma 轻度哮喘患者糠酸莫米松干粉吸入器与二丙酸倍氯米松氢氟烷烃气雾剂的急性发作和住院发生率降低,急性发作时间延长
Health outcomes research in medicine Pub Date : 2010-12-01 DOI: 10.1016/j.ehrm.2010.08.001
Prakash Navaratnam RPh, MPH, PhD , Eduardo Urdaneta MD , John McLaughlin MSPH , Howard S. Friedman PhD, MMS
{"title":"Incidence of Exacerbations and Hospitalizations Is Reduced and Time to Exacerbations Is Prolonged with Mometasone Furoate Dry Powder Inhaler Versus Beclomethasone Dipropionate Hydrofluoroalkane Aerosol in Patients with Mild Asthma","authors":"Prakash Navaratnam RPh, MPH, PhD ,&nbsp;Eduardo Urdaneta MD ,&nbsp;John McLaughlin MSPH ,&nbsp;Howard S. Friedman PhD, MMS","doi":"10.1016/j.ehrm.2010.08.001","DOIUrl":"10.1016/j.ehrm.2010.08.001","url":null,"abstract":"<div><h3>Objective</h3><p><span><span>To compare the incidence and time to onset of exacerbations among mild asthmatic non-controller-naive patients who began treatment with </span>mometasone furoate via a </span>dry powder inhaler (MF-DPI) or a beclomethasone dipropionate-hydrofluoroalkane (BDP-HFA) aerosol inhaler.</p></div><div><h3>Study Design</h3><p>An administrative claims database was retrospectively examined from January 1, 2005 through June 30, 2008. Patients with mild asthma aged 12-65 years who were US residents and enrolled in their health plan for ≥1 year before and after the index date for MF-DPI or BDP-HFA treatment initiation were included (n<!--> <!-->=<!--> <span><span>1273 matched patients per cohort). Primary evaluations included the incidence of and time to any asthma exacerbations and several asthma exacerbation subtypes. Multivariate generalized </span>linear regression<span> modeling analyses were used to compare the postindex incidence of exacerbations between cohorts. Cox regression analyses were conducted to control for the impact of input variables and evaluate the time to exacerbations.</span></span></p></div><div><h3>Results</h3><p>Significantly fewer MF-DPI patients experienced an exacerbation compared with BDP-HFA patients (9.7% vs 11.5%, respectively; <em>P</em> <!-->=<!--> <!-->.0002). At all time points examined, fewer MF-DPI patients compared with BDP-HFA patients experienced any exacerbation or an exacerbation requiring inpatient hospitalization. The difference between cohorts in the incidence of inpatient exacerbations increased over time. MF-DPI patients experienced prolonged time to any asthma exacerbation (hazard ratio<!--> <!-->=<!--> <!-->0.77; <em>P</em> <!-->=<!--> <!-->.0414) or exacerbations requiring inpatient hospitalization (hazard ratio<!--> <!-->=<!--> <!-->0.51; <em>P</em> <!-->=<!--> <!-->.0191) compared with BDP-HFA patients.</p></div><div><h3>Conclusion</h3><p>These analyses suggest that patients (previously receiving asthma-related therapy) with mild asthma receiving MF-DPI are at lower risk for asthma exacerbations compared with those receiving BDP-HFA.</p></div>","PeriodicalId":88882,"journal":{"name":"Health outcomes research in medicine","volume":"1 2","pages":"Pages e93-e102"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehrm.2010.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54245347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An Editorial 一篇社论
Health outcomes research in medicine Pub Date : 2010-12-01 DOI: 10.1016/j.ehrm.2010.09.001
Bryan R. Luce PhD, MBA (Associate Editor, Health Policy and Comparative Effectiveness)
{"title":"An Editorial","authors":"Bryan R. Luce PhD, MBA (Associate Editor, Health Policy and Comparative Effectiveness)","doi":"10.1016/j.ehrm.2010.09.001","DOIUrl":"https://doi.org/10.1016/j.ehrm.2010.09.001","url":null,"abstract":"","PeriodicalId":88882,"journal":{"name":"Health outcomes research in medicine","volume":"1 2","pages":"Pages e67-e68"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehrm.2010.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137406830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Analysis of Item Response Theory-based Short-form Depression Severity Scales Based on the HDRS and MADRS 基于项目反应理论的基于HDRS和MADRS的短格式抑郁严重程度量表的编制与分析
Health outcomes research in medicine Pub Date : 2010-12-01 DOI: 10.1016/j.ehrm.2009.11.001
Dennis A. Revicki PhD , Wen-Hung Chen PhD , Lori Frank PhD , Douglas Feltner MD , Robert Morlock PhD
{"title":"Development and Analysis of Item Response Theory-based Short-form Depression Severity Scales Based on the HDRS and MADRS","authors":"Dennis A. Revicki PhD ,&nbsp;Wen-Hung Chen PhD ,&nbsp;Lori Frank PhD ,&nbsp;Douglas Feltner MD ,&nbsp;Robert Morlock PhD","doi":"10.1016/j.ehrm.2009.11.001","DOIUrl":"10.1016/j.ehrm.2009.11.001","url":null,"abstract":"<div><h3>Objectives</h3><p><span>The Hamilton Depression Rating Scale (HDRS) is the most frequently used primary endpoint for antidepressant </span>clinical trials<span>. This study developed and evaluated the psychometric<span> characteristics of 3 item response theory (IRT)-based short-form depression severity scales based on combinations of the HDRS and Montgomery-Asberg Depression Rating Scale (MADRS) items.</span></span></p></div><div><h3>Study Design</h3><p>A secondary analysis was completed using data from 1027 subjects with major depressive disorder participating in 2 antidepressant clinical trials. Data were collected using the HDRS and MADRS throughout the 6-week clinical trials. Maier, Bech, and Gibbons brief depression scales were calculated based on the HDRS.</p></div><div><h3>Results</h3><p>Three short-form depression severity (DS) scales were developed based on clinician recommendations and IRT analyses, (DS-1, 7 items; DS-2, 8 items; DS-3, 10 items). Internal consistency reliability of the short forms was 0.87 to 0.93. DS were more reliable across the range of the depression than the HDRS or MADRS. The DS scales were correlated 0.27 to 0.29 with HDRS, 0.55 to 0.85 with MADRS, and −0.25 to −0.34 with Quality of Enjoyment and Satisfaction Questionnaire scores at baseline. In 1 clinical trial, none of the depression outcome measures demonstrated statistically significant differences between the paroxetine and placebo groups. In the second clinical trial, there were significant between-group differences in DS-1 (<em>P</em> <!-->=<!--> <!-->.004; ES<!--> <!-->=<!--> <!-->0.46), DS-2 (<em>P</em> &lt;.001; ES<!--> <!-->=<!--> <!-->0.59), DS-3 (<em>P</em> &lt;.001; ES<!--> <!-->=<!--> <!-->0.63), Bech (<em>P</em> <!-->=<!--> <!-->.007; ES<!--> <!-->=<!--> <!-->0.43), Maier (<em>P</em> <!-->=<!--> <!-->.009; ES<!--> <!-->=<!--> <!-->0.41), Gibbon (<em>P</em> <!-->=<!--> <!-->.003; ES<!--> <!-->=<!--> <!-->0.47), HDRS (<em>P</em> <!-->=<!--> <!-->.007; ES<!--> <!-->=<!--> <!-->0.43), and MADRS (<em>P</em> <!-->=<!--> <!-->.001; ES<!--> <!-->=<!--> <!-->0.54) scores.</p></div><div><h3>Conclusions</h3><p>The IRT-based short-form depression measures were reliable, valid, and responsive in patients<span> with major depressive disorder. Effect sizes were comparable or better to other depression severity scales.</span></p></div>","PeriodicalId":88882,"journal":{"name":"Health outcomes research in medicine","volume":"1 2","pages":"Pages e111-e122"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehrm.2009.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54245248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Understanding Brain Damage and Sleep Apnea: A Review 理解脑损伤和睡眠呼吸暂停:综述
Health outcomes research in medicine Pub Date : 2010-12-01 DOI: 10.1016/j.ehrm.2010.09.004
Susan Zafarlotfi PhD , Mohammed Quadri , Jacob Borodovsky
{"title":"Understanding Brain Damage and Sleep Apnea: A Review","authors":"Susan Zafarlotfi PhD ,&nbsp;Mohammed Quadri ,&nbsp;Jacob Borodovsky","doi":"10.1016/j.ehrm.2010.09.004","DOIUrl":"10.1016/j.ehrm.2010.09.004","url":null,"abstract":"<div><p><span>Sleep disturbances affect practically every segment of society, permeating across all ethnic, socioeconomic, and age groups. According to the American Academy of Sleep Medicine<span>, there are more than 90 different sleep disorders. One of the most commonly diagnosed sleep disorders is sleep apnea. There are 3 types of sleep apnea: central, mixed, and obstructive sleep apnea (OSA). Sleep-disordered breathing is extremely prevalent in the brain-injured patient population. OSA is the most common type of apnea and is easily alleviated with </span></span>continuous positive airway pressure<span>. However, if left untreated, OSA can induce and exacerbate cognitive deficits<span> and other metabolic disorders<span>. It has been established that OSA is a risk factor for cerebrovascular accidents and cardiovascular outcomes. Patients with brain injury have existing lesions that are exposed to episodic/intermittent hypoxia if accompanied by OSA. The ubiquitous nature of OSA poses a threat to brain-injured patients, and treatment of sleep apnea is warranted to avoid further complications that might prolong recovery and time in rehabilitation. The purpose of this article is to increase awareness among physicians in order to improve the management of patients with brain injury and OSA. We will review the current concepts, prevalence, and ramifications of sleep apnea in brain-injured patients and their cognitive function.</span></span></span></p></div>","PeriodicalId":88882,"journal":{"name":"Health outcomes research in medicine","volume":"1 2","pages":"Pages e103-e110"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehrm.2010.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54245367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Variations in CRC Screening Practice: Would This Patient Be Screened? CRC筛查实践的变化:该患者会被筛查吗?
Health outcomes research in medicine Pub Date : 2010-12-01 DOI: 10.1016/j.ehrm.2010.09.002
Sarah B. Wackerbarth PhD , Yelena N. Tarasenko MPH, MPA , Jennifer M. Joyce MD , Steven A. Haist MD, MS, FACP
{"title":"Variations in CRC Screening Practice: Would This Patient Be Screened?","authors":"Sarah B. Wackerbarth PhD ,&nbsp;Yelena N. Tarasenko MPH, MPA ,&nbsp;Jennifer M. Joyce MD ,&nbsp;Steven A. Haist MD, MS, FACP","doi":"10.1016/j.ehrm.2010.09.002","DOIUrl":"10.1016/j.ehrm.2010.09.002","url":null,"abstract":"<div><h3>Purpose</h3><p>Screening rates for colorectal cancer (CRC) in the United States were below the goal of 50% outlined in Healthy People 2010. Physician recommendation is an important predictor of patient compliance. We compared physician CRC screening decision processes (as depicted in decision trees) and examined how variations in decision processes affected decision outcomes. Further, we examined whether those variations could be attributed to physicians’ characteristics and guidelines’ utilization.</p></div><div><h3>Methods</h3><p><span>We conducted semi-structured interviews with primary care physicians, developed decision trees, compared trees, used trees to predict the recommendation for 8 sample patients, and used </span>regression analysis to identify predictors of variation.</p></div><div><h3>Results</h3><p>Most of the physicians (77.3%) self-reported following clinical guidelines for CRC screening. Physicians considered an average of 5.9 decision criteria (range 2-12) in making their screening recommendations. Frequently cited criteria included patient age and family history. We documented variation for 3 of 8 sample patients. Regression analysis indicated that complexity of decision process, gender, age, and experience of physicians contributed to recommendations on screening. In addition, the self-report adherence to guidelines did not influence whether a physician would recommend CRC screening.</p></div><div><h3>Conclusions</h3><p>This study supports the notion that variation in practice is a function of decision processes. Therefore, studying decision processes may facilitate efforts to improve patient outcomes.</p></div>","PeriodicalId":88882,"journal":{"name":"Health outcomes research in medicine","volume":"1 2","pages":"Pages e81-e91"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehrm.2010.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54245353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcultural and Measurement Evaluation of the Asthma Quality-of-Life Questionnaire 哮喘生活质量问卷的跨文化及测量评估
Health outcomes research in medicine Pub Date : 2010-12-01 DOI: 10.1016/j.ehrm.2010.09.003
Angela E. Williams BSc , Lydiane Agier MSc , Ingela Wiklund PhD , Lucy Frith MSc , Nadeem Gul MSc , Elizabeth Juniper MSc F
{"title":"Transcultural and Measurement Evaluation of the Asthma Quality-of-Life Questionnaire","authors":"Angela E. Williams BSc ,&nbsp;Lydiane Agier MSc ,&nbsp;Ingela Wiklund PhD ,&nbsp;Lucy Frith MSc ,&nbsp;Nadeem Gul MSc ,&nbsp;Elizabeth Juniper MSc F","doi":"10.1016/j.ehrm.2010.09.003","DOIUrl":"10.1016/j.ehrm.2010.09.003","url":null,"abstract":"<div><h3>Objective</h3><p>This analysis compared Asthma Quality-of-Life Questionnaire (AQLQ) data from across 16 countries (17 languages) to evaluate suitability to combine data in analyses.</p></div><div><h3>Study Design</h3><p>AQLQ data from the Gaining Optimal Asthma Control study was used for the analyses; 1832 patients had an overall AQLQ score at baseline and week 12. The original North American English version, for Canadian patients only, was the reference language (RL). AQLQ scores range from 1-7, where a high score indicates no impairment. Values within 0.5 of the RL were considered comparable.</p></div><div><h3>Results</h3><p><span><span>The number of patients varied from 27 (Canadian French) to 257 (Mandarin Chinese). Mean age ranged from 27.6 (Spain Spanish) to 52.9 years (Norway Norwegian). Mean overall AQLQ score (SD) at baseline in the RL was 4.59 (0.94). All but 3 languages reported scores within 0.5 of the RL. Mean change from baseline in the overall AQLQ score in the RL was 0.89 (1.06). Baseline overall AQLQ scores were all within 0.5 of the RL. Cronbach alpha ranged from 0.93 to 0.97 (RL 0.94). Correlation with baseline Asthma Control Questionnaire (ACQ) and the </span>forced expiratory volume in 1</span> <!-->second (FEV<sub>1</sub>) ranged from −0.76 to −0.58 (RL −0.69) and −0.02 to 0.41 (RL 0.08), respectively. Similarly, correlations with change from baseline for ACQ and FEV<sub>1</sub><span> ranged from −0.83 to −0.61 (RL −0.77) and −0.11 to 0.56 (RL 0.03). Effect sizes were all &gt;0.50, ranging from 0.59 (Norway Norwegian) to 1.10 (New Zealand English) (RL 0.85).</span></p></div><div><h3>Conclusions</h3><p>The finding that internal consistency, construct validity, and responsiveness were demonstrated across languages and similar to the RL supports the combining of data for analyses.</p></div>","PeriodicalId":88882,"journal":{"name":"Health outcomes research in medicine","volume":"1 2","pages":"Pages e69-e79"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehrm.2010.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54245360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Readability and Missing Data Rates in CAHPS 2.0 Medicare Survey in African American and White Medicare Respondents CAHPS 2.0在非裔美国人和白人医疗保险调查对象中的可读性和数据缺失率
Health outcomes research in medicine Pub Date : 2010-07-01 DOI: 10.1016/j.ehrm.2010.03.001
Marie Ngetiko Fongwa RN, MPH, PhD , Claude M. Setodji PhD , Sylvia H. Paz PhD , Leo S. Morales MD, PhD , W.N. Steers PhD , Ron D. Hays PhD
{"title":"Readability and Missing Data Rates in CAHPS 2.0 Medicare Survey in African American and White Medicare Respondents","authors":"Marie Ngetiko Fongwa RN, MPH, PhD ,&nbsp;Claude M. Setodji PhD ,&nbsp;Sylvia H. Paz PhD ,&nbsp;Leo S. Morales MD, PhD ,&nbsp;W.N. Steers PhD ,&nbsp;Ron D. Hays PhD","doi":"10.1016/j.ehrm.2010.03.001","DOIUrl":"10.1016/j.ehrm.2010.03.001","url":null,"abstract":"<div><h3>Purpose</h3><p>To examine associations between readability of survey items and missing data rates in a sample of white and African-American Medicare enrollees in managed care plans.</p></div><div><h3>Methods</h3><p>Consumer Assessment of Healthcare Provider and Systems (CAHPS) 2.0 health plan survey data collected from 139,284 respondents (127,524 whites and 11,760 African Americans) in 321 health plans. Product-moment correlations were computed between Flesch-Kincaid (F-K) readability estimates and the CAHPS item-missing data rates.</p></div><div><h3>Results</h3><p>F-K reading levels for items ranged from 4.8 to 17.7 with a mean of 8.9 across items. Missing data rates ranged from 1% to 10%, with African Americans having significantly higher missing data rates. Correlations between missing data rates and item-level readability were statistically significant for whites (r<!--> <!-->=<!--> <!-->0.33, <em>P</em> <!-->=<!--> <!-->.0515) and African Americans (r<!--> <!-->=<!--> <!-->0.37, <em>P</em> <!-->=<!--> <!-->.0284).</p></div><div><h3>Conclusions</h3><p>The significant associations between missing data rates and item-level readability estimates indicate that the completion of survey items varies by their readability. Enhancing the readability of survey items can improve the inclusion of survey data collected from different respondents.</p></div>","PeriodicalId":88882,"journal":{"name":"Health outcomes research in medicine","volume":"1 1","pages":"Pages e39-e49"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehrm.2010.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30904669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
The Effect of the Vermont Diabetes Information System on Inpatient and Emergency Department Use: Results from a Randomized Trial 佛蒙特州糖尿病信息系统对住院和急诊科使用的影响:一项随机试验的结果
Health outcomes research in medicine Pub Date : 2010-07-01 DOI: 10.1016/j.ehrm.2010.03.002
Shamima Khan MBA, PhD , Charles D. MacLean MDCM , Benjamin Littenberg MD
{"title":"The Effect of the Vermont Diabetes Information System on Inpatient and Emergency Department Use: Results from a Randomized Trial","authors":"Shamima Khan MBA, PhD ,&nbsp;Charles D. MacLean MDCM ,&nbsp;Benjamin Littenberg MD","doi":"10.1016/j.ehrm.2010.03.002","DOIUrl":"10.1016/j.ehrm.2010.03.002","url":null,"abstract":"<div><h3>Objective</h3><p>To describe the effect of the Vermont Diabetes Information System (VDIS) on hospital and emergency department use.</p></div><div><h3>Data Source</h3><p>Statewide discharge database.</p></div><div><h3>Study Design</h3><p>Randomized controlled trial<span> of a decision support system for 7412 adults with diabetes and their 64 primary care providers.</span></p></div><div><h3>Data Collection/Data Extraction</h3><p>Charges and dates for hospital admissions and emergency department care in Vermont during an average of 32 months of observation. Data from New York hospitals were not available.</p></div><div><h3>Results</h3><p>Patients randomized to VDIS were admitted to the hospital less often than control subjects (0.17 admissions vs 0.20; <em>P</em> <!-->=<!--> <!-->.01) and generated lower hospital charges ($3113 vs $3480; <em>P</em> <!-->=<!--> <!-->.019). VDIS patients also had lower emergency department utilization (0.27 visits vs 0.36; <em>P</em> &lt;.0001) and charges ($304 vs $414; <em>P</em> &lt;.0001). The intervention was particularly effective in men and in older subjects.</p></div><div><h3>Conclusions</h3><p>Despite data limitations that tended to reduce the apparent effect of the system, this randomized, controlled trial showed that VDIS reduces hospitalization and emergency department utilization and expenses.</p></div>","PeriodicalId":88882,"journal":{"name":"Health outcomes research in medicine","volume":"1 1","pages":"Pages e61-e66"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehrm.2010.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29379633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Preferences of Patients and Oncologists for Advanced Ovarian Cancer Treatment-Related Health States 晚期卵巢癌患者和肿瘤学家对治疗相关健康状态的偏好
Health outcomes research in medicine Pub Date : 2010-07-01 DOI: 10.1016/j.ehrm.2010.02.001
Lisa M. Hess PhD , Daniel C. Malone PhD , Pamela G. Reed PhD , Grant Skrepnek PhD , Karen Weihs MD
{"title":"Preferences of Patients and Oncologists for Advanced Ovarian Cancer Treatment-Related Health States","authors":"Lisa M. Hess PhD ,&nbsp;Daniel C. Malone PhD ,&nbsp;Pamela G. Reed PhD ,&nbsp;Grant Skrepnek PhD ,&nbsp;Karen Weihs MD","doi":"10.1016/j.ehrm.2010.02.001","DOIUrl":"10.1016/j.ehrm.2010.02.001","url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of this study was to compare expected utility preferences of various health outcomes of chemotherapy treatment among ovarian-cancer patients receiving chemotherapy, ovarian cancer patients who were post-treatment (eg, under surveillance), and oncologists who treat this disease.</p></div><div><h3>Methods</h3><p><span>Participants were asked to score 6 hypothetical ovarian cancer treatment-related health states using both a rating scale and the standard gamble. Scores were obtained in the range of 0.0 (death) to 1.0 (perfect health) for each hypothetical health state, with a difference of 0.10 being practically meaningful, and were analyzed by </span>analysis of variance.</p></div><div><h3>Results</h3><p>Seventy-five eligible participants were included in this study (41 ovarian-cancer patients and 34 oncologists). Patients and physicians reported similar responses in the rating scale exercise (<em>F</em> <!-->=<!--> <!-->0.854, <em>P</em> <!-->=<!--> <span>.43). However, when the health states were presented with an element of uncertainty via the standard gamble exercise, patients who were under surveillance reported significantly different expected utilities of the health states from physicians and from patients who were receiving treatment, demonstrating greater risk aversion than the other groups (</span><em>F</em> <!-->=<!--> <!-->4.270, <em>P</em> <!-->=<!--> <!-->.018).</p></div><div><h3>Conclusions</h3><p>This study suggests that there are significant differences in expected utility preferences among patients who are under surveillance as opposed to oncologists or patients receiving treatment, despite similarities in rating scale values. These findings suggest a need to further evaluate these differences in expected utility preferences in the context of decision in the setting of recurrent disease, where a patient under surveillance must make decisions related to re-initiation of therapy at a time when her preferences are likely to significantly differ from those of oncologists.</p></div>","PeriodicalId":88882,"journal":{"name":"Health outcomes research in medicine","volume":"1 1","pages":"Pages e51-e59"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehrm.2010.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54245259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The Momentum for Health Outcomes Research in Medicine 医学健康结果研究的势头
Health outcomes research in medicine Pub Date : 2010-07-01 DOI: 10.1016/j.ehrm.2010.07.001
Donald E. Stull PhD (Editor-in-Chief)
{"title":"The Momentum for Health Outcomes Research in Medicine","authors":"Donald E. Stull PhD (Editor-in-Chief)","doi":"10.1016/j.ehrm.2010.07.001","DOIUrl":"10.1016/j.ehrm.2010.07.001","url":null,"abstract":"","PeriodicalId":88882,"journal":{"name":"Health outcomes research in medicine","volume":"1 1","pages":"Pages e1-e3"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehrm.2010.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54245340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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