Biology, Medicine, & Natural Product Chemistry最新文献_第6页

The Role of Gene Therapy in the Treatments of Type 1 Diabetes Mellitus: a review 基因治疗在1型糖尿病治疗中的作用

Biology, Medicine, & Natural Product Chemistry Pub Date : 2020-11-10 DOI: 10.14421/biomedich.2020.92.57-64

Harem O. Smail

引用次数: 2

Prevalence of Psychoactive Substance Use Among Nigerian Male Commercial Vehicle Drivers Selected from The Three Major Ethnic Groups in Nigeria 从尼日利亚三个主要民族中选出的尼日利亚男性商用车司机中精神活性物质使用的流行率

Biology, Medicine, & Natural Product Chemistry Pub Date : 2020-07-26 DOI: 10.14421/biomedich.2020.91.47-55

T. Egwuatu, O. Iroanya, Khalid Olajide Adekoya

{"title":"Prevalence of Psychoactive Substance Use Among Nigerian Male Commercial Vehicle Drivers Selected from The Three Major Ethnic Groups in Nigeria","authors":"T. Egwuatu, O. Iroanya, Khalid Olajide Adekoya","doi":"10.14421/biomedich.2020.91.47-55","DOIUrl":"https://doi.org/10.14421/biomedich.2020.91.47-55","url":null,"abstract":"The use of psychoactive substances for several reasons by commercial vehicle drivers has been documented as a major cause of increased incidences of traffic accidents globally. The study aimed at determining the prevalence of psychoactive substance use among Nigerian male commercial vehicle drivers randomly selected from the three major ethnic groups in Nigeria (Igbo, Hausa and Yoruba). A structured questionnaire which included data on sociodemographic status and psychoactive drug use history was introduced to all participants. Generic Multi-Drug Urine Dip Card Test Kit and Shimadzu chromatograph system (Shimadzu Corporation, Kyoto, Japan) were used for toxicological analyses. Out of the 264 Nigerian male commercial vehicle drivers who participated in this study, 111(42.0 %) had used illicit drugs in recent times, 55(20.8 %) took drugs for improved energy and 90(34.1 %) felt high after using illicit drugs. Marijuana was the most abused substance; 77(29.2 %) followed by benzodiazepine; 34(12.9) across all ethnicities studied. Across all ethnicities, HPLC revealed that the Hausa drivers had the highest concentration of psychoactive substances in their urine samples. These findings, reiterates the need for the Nigerian anti-drug agency to develop new strategies in conducting a repressive drug war and extending the same to bus stations.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48869200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Isolation and Characterization of Sesquiterpenes from Stem Bark of Warburgia ugandensis Sprague 水杨茎皮中倍半萜的分离与鉴定

Biology, Medicine, & Natural Product Chemistry Pub Date : 2020-05-17 DOI: 10.14421/biomedich.2020.91.39-46

Teshome Gonfa Hordofa

引用次数: 1

Toxicological Effects of Ethanolic Stem Bark Extract of Xylopia Aethiopica on Testicular Oxidative Stress Markers and Histology of Male Rats 木皮乙醇提取物对雄性大鼠睾丸氧化应激标志物及组织学的毒理学影响

Biology, Medicine, & Natural Product Chemistry Pub Date : 2020-05-11 DOI: 10.14421/biomedich.2020.91.33-37

Elias Adikwu, B. E. Ehigiator

{"title":"Toxicological Effects of Ethanolic Stem Bark Extract of Xylopia Aethiopica on Testicular Oxidative Stress Markers and Histology of Male Rats","authors":"Elias Adikwu, B. E. Ehigiator","doi":"10.14421/biomedich.2020.91.33-37","DOIUrl":"https://doi.org/10.14421/biomedich.2020.91.33-37","url":null,"abstract":"Impairment in testicular function can occur through perturbations in testicular oxidative stress markers and histology. Xylopia aethiopica (XE) is used to enhance fertility in males, but with information gap on its effect on testicular oxidative stress markers and histology. The present study assessed the effects of ethanolic stem bark extract of Xylopia aethiopica (EEXA) on testicular oxidative stress markers and histology of male albino rats. Sixty adult male albino rats (200g-250g) were randomly grouped into 4 (A-D) of 15 rats per group. The rats in the control group A (A1-A3) were administered per oral (p.o) with water (0.2 mL/day) for 15, 30 and 60 days respectively. The rats in groups B (B1-B3), C(C1-C3) and D (D1-D3) were administered p.o with EEXA (200, 400 and 800 mg/kg/day) for 15, 30 and 60 days respectively. The rats were anesthetized at the termination of EEXA administration and were dissected and testes removed. The testes were weighed and evaluated for oxidative stress markers and histology. Testicular weights were decreased in a dose and-time dependent fashion in EEXA-treated rats. Significant decreases in testicular superoxide dismutase, glutathione, catalase, and glutathione peroxidase levels with significant increases in malondialdehyde levels in a dose and time-dependent fashion were observed in rats administered with EEXA. Testicular histology showed cellular necrosis, degeneration and loss of interstitial tissues in rats administered with EEXA. This study observed that EEXA perturbed testicular oxidative markers and histology. Its use may impair testicular function.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44343133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antioxidant Activities of the Leaf Extract and Fractions of Dryopteris filix-mas (L.) Schott could be Attributed to The Abundance of Polyphenol Compounds 鳞毛蕨叶提取物和级分的抗氧化活性可归因于丰富的多酚类化合物

Biology, Medicine, & Natural Product Chemistry Pub Date : 2020-04-16 DOI: 10.14421/biomedich.2020.91.1-6

E. Erhirhie, E. Ilodigwe, D. Ajaghaku, B. O. Umeokoli, Peter M Eze, F. Okoye

{"title":"Antioxidant Activities of the Leaf Extract and Fractions of Dryopteris filix-mas (L.) Schott could be Attributed to The Abundance of Polyphenol Compounds","authors":"E. Erhirhie, E. Ilodigwe, D. Ajaghaku, B. O. Umeokoli, Peter M Eze, F. Okoye","doi":"10.14421/biomedich.2020.91.1-6","DOIUrl":"https://doi.org/10.14421/biomedich.2020.91.1-6","url":null,"abstract":"Dryopteris filix mas ( D filix-mas ) is wildly used in ethnomedicine for the management of rheumatoid arthritis, wounds and other diseases. We investigated the anti-oxidant activities of its leaf extract, and chromatographic fractions. The ethanol leaf extract was partitioned into four fractions; n-hexane, ethyl acetate, n-butanol and water. Ferric reducing anti-oxidant power (FRAP), 1, 1-diphenyl-2-picrylhydrazil (DPPH) and nitric oxide (NO) scavenging in vitro assays were carried out on the extract and fractions at 6.25, 12.5, 25, 50, 100, 200, 400 and 800 µg/mL. The most active fraction (ethyl acetate fraction) was further purified using chromatographic techniques to isolate its major compound whose structure was elucidated using ID nuclear magnetic resonance (NMR) and mass spectrometry. The ethyl acetate fraction produced the highest free radical scavenging activity among the other fractions. The fraction (VLC-E7) from which the bioactive compound, quercetin-3-O-αL-rhamnopyranoside , was isolated had the best FRAP and DPPH scavenging activities with EC 50 and IC 50 values of 88.81 ± 3.41 and 26.87 ± 0.24 respectively more than the ethyl acetate fraction. This study revealed that the polyphenol flavonoid, quercetin-3-O-αL-rhamnopyranoside could be responsible for antioxidant activity of ethno-medicinal property of D filix-mas leaf.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49144742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Effect of Cassava Peel Starch Addition to Bioplastic Biodegradation Based On Chitosan On Soil and River Water Media 木薯淀粉对壳聚糖生物降解土壤和河水的影响

Biology, Medicine, & Natural Product Chemistry Pub Date : 2020-04-16 DOI: 10.14421/biomedich.2020.91.7-13

M. Syuhada, Sintia Ainus Sofa, E. Sedyadi

{"title":"The Effect of Cassava Peel Starch Addition to Bioplastic Biodegradation Based On Chitosan On Soil and River Water Media","authors":"M. Syuhada, Sintia Ainus Sofa, E. Sedyadi","doi":"10.14421/biomedich.2020.91.7-13","DOIUrl":"https://doi.org/10.14421/biomedich.2020.91.7-13","url":null,"abstract":"The study of the relationship between starch addition to biodegradation of bioplastics has been carried out. This study aims to understand the biodegradability of chitosan-based bioplastics with additional cassava peel starch on soil and river water media. This research was conducted through four stages, namely making starch from cassava peel waste, making bioplastics using the blending and castingwet processes method with variations of starch 5, 10, 15 and 20 ml. Testing physical mechanical properties including water resistance, thickness, tensile strength, elongation, and modulus young. Testing the characteristics of bioplastics functional groups was carried out using FTIR (Fourier Transform Infrared) and biodegradation testing of bioplastics carried out on soil and river water media. The results of bioplastics research with variation 5 ml produce good mechanical physical properties. Bioplastics produced water resistance value of 45.03%, thickness of 0.0190 mm, tensile strength of 49.93 MPa, elongation of 3.068% and Young modulus of 1627.63 MPa. Bioplastics biodegradation test was observed by measuring the decrease in sample mass. The biodegradation test results in soil and river water media respectively showed a decrease in bioplastic mass up to 63% and 54%. The biodegradation rate of the calculation results on soil media is −0,1502 and in river water media is −0,0948.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42577028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Analysis of Body Posture using Rapid Entire Body Assessment (REBA) and Rapid Upper Limb Assessment (RULA) to Improve the Posture of Sand Paper Machine Operators and Reduce the Risk of Low Back Pain 使用快速全身评估（REBA）和快速上肢评估（RULA）分析身体姿势以改善砂纸操作员的姿势并降低腰痛风险

Biology, Medicine, & Natural Product Chemistry Pub Date : 2020-04-16 DOI: 10.14421/biomedich.2020.91.21-25

Trio Yonathan Teja Kusuma

{"title":"Analysis of Body Posture using Rapid Entire Body Assessment (REBA) and Rapid Upper Limb Assessment (RULA) to Improve the Posture of Sand Paper Machine Operators and Reduce the Risk of Low Back Pain","authors":"Trio Yonathan Teja Kusuma","doi":"10.14421/biomedich.2020.91.21-25","DOIUrl":"https://doi.org/10.14421/biomedich.2020.91.21-25","url":null,"abstract":"The metal casting industry, Nitikan is a micro business whose production process is carried out manually. The equipment used is simple and without considering the user's health. This can be seen in the product finishing process that uses a sanding machine. The equipment is not designed according to the user's posture so the operator bends in doing work movements, of course this is very risky to experience lower back pain injuries. This study aims to analyze the work activities of the finishing process using the Rapid Entire Body Assessment (REBA) and Rapid Upper Limb Assessment (RULA) approach and design work tools that can be applied to improve work posture. The results of data processing and analysis obtained a Rapid Entire Body Assessment score on a sandpaper machine single head of 5 and a Rapid Upper Limb Assessment score of 4, the score indicates that the work position has the potential to experience a risk of low back pain, so there must be an improvement in work posture. Work posture improvement is done by designing a tool in the form of a sandpaper machine that takes into account ergonomic dimensions to reduce the risk of lower back injury. The final result after the improvement is obtained Rapid Entire Body Assessment score of 3 and Rapid Upper Limb Assessment score of 4. This shows that the risk of lower back injuries can be minimized.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43876285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Mathematical Model of the Covid-19 Cases in Indonesia (Under and Without Lockdown Enforcement) 印度尼西亚Covid-19病例的数学模型(有和没有封锁执行)

Biology, Medicine, & Natural Product Chemistry Pub Date : 2020-04-16 DOI: 10.14421/biomedich.2020.91.15-19

S. Sugiyanto, M. Abrori

引用次数: 15

The Potential of Chrysin of Oroxylum indicum L. to Induce Carbonic Anhydrase (CA) to Improve Cattle Fertility 牛白杨黄素诱导碳酸酐酶(CA)提高牛生育力的潜力

Biology, Medicine, & Natural Product Chemistry Pub Date : 2020-04-16 DOI: 10.14421/biomedich.2020.91.27-32

M. Amin, Muhammad Najib Fahmi, Muh. Makhrus Ali Ridho, Nurul Fitri, U. Lestari, Dina Maulina, I. F. Amin

{"title":"The Potential of Chrysin of Oroxylum indicum L. to Induce Carbonic Anhydrase (CA) to Improve Cattle Fertility","authors":"M. Amin, Muhammad Najib Fahmi, Muh. Makhrus Ali Ridho, Nurul Fitri, U. Lestari, Dina Maulina, I. F. Amin","doi":"10.14421/biomedich.2020.91.27-32","DOIUrl":"https://doi.org/10.14421/biomedich.2020.91.27-32","url":null,"abstract":"The Artificial Insemination (AI) aims to develop the potential of the cattle reproduction comprehensively. The success of AI results is highly dependent on the level of livestock fertility. Therefore, improv the quality and quantity of semen could be done by hormone induction. However, hormone prices are expensive. This problem could be overcome using alternative way with the natural compound containing chrysin which might has the same function. The purpose of the study was analyze the potential of chrysin compound from Bungli plant ( Oroxylum indicum ) as fertilizer of males through bioinformatics approach. Methods performed through data search by webserver with the following stages: (1) Pubchem, (2) Swiss (3) Target Prediction, (4) Uniprot, (5) Protein Data Bank and (6) docking software using PyRx, PyMOL and Discovery Studio. The results showed that the chrysin compound interact with carbonic anhydrase (CA) expressed from the testes of the cattle, through van der Waals and Pi-Alkyl bonds. Chrysin is effective as CA ligand inducers based on affinity bonds (-8.4 kcal/mole) and more negatively than flavonol as a control compound with binding affinity (-6.2 kcal/mol). This suggests that chrysin is an effective compound as a potential drug for improved livestock fertility.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46835622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Anthropometer Development for Improving the Measurement Quality of Human Body Dimensions 为提高人体尺寸测量质量而开发的数字人体测量仪

Biology, Medicine, & Natural Product Chemistry Pub Date : 2019-10-31 DOI: 10.14421/biomedich.2019.82.27-32

Trio Yonathan Teja Kusuma, A. Wirabhuana, Faurosi Syafa’atul Yusuf

引用次数: 0