Biology, Medicine, & Natural Product Chemistry最新文献

Prevalence of Enterobacteriaceae Producing Extended Spectrum Beta-Lactamase (ESBL) in Broiler Meat (Gallus domesticus) Sold in Regional Markets of West Surabaya 西泗水地区市场上销售的肉鸡肉中产生广谱β -内酰胺酶(ESBL)的肠杆菌科细菌的流行情况

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-11-09 DOI: 10.14421/biomedich.2023.122.607-610

Kadek Rio Risnanda, Masfufatun Masfufatun, Agusniar Furkani Listyawati, Kuntaman Kuntaman, Akhmad Sudibya

{"title":"Prevalence of Enterobacteriaceae Producing Extended Spectrum Beta-Lactamase (ESBL) in Broiler Meat (Gallus domesticus) Sold in Regional Markets of West Surabaya","authors":"Kadek Rio Risnanda, Masfufatun Masfufatun, Agusniar Furkani Listyawati, Kuntaman Kuntaman, Akhmad Sudibya","doi":"10.14421/biomedich.2023.122.607-610","DOIUrl":"https://doi.org/10.14421/biomedich.2023.122.607-610","url":null,"abstract":"Broiler meat is a foodstuff that is easily damaged by bacterial growth. Several pathogenic bacteria from the Enterobacteriaceae family have also been found as contaminants in chicken meat. While Extended Spectrum Beta-Lactamases (ESBL) are enzymes that have the ability to hydrolyze antibiotics of the penicillin class, first, second, and third generation cephalosporins as well as the monobactam group. Based on this phenomenon, the researchers wanted to examine the prevalence of the ESBL-producing Enterobacteriaceae family in broiler chicken (Gallus domesticus) meat sold in the West Surabaya market. This research is a descriptive observational type using a cross-sectional approach. The population in this study was broiler chicken meat taken from broiler traders in several markets in West Surabaya which had met the inclusion and exclusion criteria with a large sample of 50 samples. Then the data were analyzed using the chi-square test. The results of the analysis showed that 13 samples produced ESBL. The prevalence of Enterobacteriaceae bacteria producing ESBL in broiler chicken (Gallus domesticus) meat in several markets in West Surabaya is 26% of the 50 samples used. The results of the chi-square test showed that there was no significant difference between locations where ESBL was found.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135192689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin Bioavailability Evaluation on Standardized Herbal Medicine Containing Guava Leaf Extract with HPLC 番石榴叶提取物标准药材槲皮素生物利用度的HPLC评价

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-11-07 DOI: 10.14421/biomedich.2023.122.593-599

Rizky Yulion, Yulianis Yulianis, Suntri Suntri

{"title":"Quercetin Bioavailability Evaluation on Standardized Herbal Medicine Containing Guava Leaf Extract with HPLC","authors":"Rizky Yulion, Yulianis Yulianis, Suntri Suntri","doi":"10.14421/biomedich.2023.122.593-599","DOIUrl":"https://doi.org/10.14421/biomedich.2023.122.593-599","url":null,"abstract":"Standardized herbal medicines are classified as one of Indonesia's natural medicine ingredients in addition to herbal medicine and phytopharmaceuticals. The safety and efficacy of standardized herbal medicines are scientifically proven through preclinical trials, and raw materials and products have been standardized. One includes standardized herbal medicines is diapet, psidii, lelap, fitolac, and glucogarp. To determine the bioavailability of standardized herbal products containing guava leaf extract (Psidium guajava L.). which uses single and combined natural materials. The method used is experimental with a crossover design. Blood samples are taken from the marginalis vein of the rabbit ear at 0.5 hours; 1; 2; 4; and 6. The level of quercetin in the blood is determined by the reverse-phase HPLC method. The mobile phase used is methanol:aquabidest (59:41,v/v), stationary phase octadecyl silica (C18), flow rate 1 mL/min, UV-Vis detector 370 nm, and injection volume 20 ?L. The value of bioavailability parameters obtained in the parameters Cpmax, Tmax, and AUC of product A is 1.486454 ?g / ml; 1.4 hours and 10.2615291 ?g/ml/h, product B is 1.29224019 ?g/ml; 1.5 hours and 11.30810501 ?g/ml/hour. Based on the results of this study, it can be concluded that the bioavailability profile of the two products is not much different, so it is expected that the effects caused are the same.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135540721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Anti-inflammatory Activity of Bamboo Tali Leaf (Gigantochloa apus) Ethanol Extract 竹叶乙醇提取物的体外抗炎活性研究

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-11-07 DOI: 10.14421/biomedich.2023.122.601-606

Nurul Hidayah, Mutista Hafshah

{"title":"In Vitro Anti-inflammatory Activity of Bamboo Tali Leaf (Gigantochloa apus) Ethanol Extract","authors":"Nurul Hidayah, Mutista Hafshah","doi":"10.14421/biomedich.2023.122.601-606","DOIUrl":"https://doi.org/10.14421/biomedich.2023.122.601-606","url":null,"abstract":"Inflammation is a physiological process that serves as a defense mechanism for the body against foreign substances, bacteria, or irritants. Inflammation can be cured with anti-inflammatory drugs. One of the plants that has the potential to be an anti-inflammatory agent is the bamboo leaf. This research aims to analyze the content of secondary metabolites, determine the inhibition value and IC50 value of the anti-inflammatory activity of the ethanol extract of bamboo tali leaves. Bamboo tali leaves were macerated using 96% ethanol and subjected to phytochemical screening. The extract was then tested for anti-inflammatory activity in vitro with the Bovine Serum Albumin (BSA) protein denaturation inhibition method. Bamboo tali leaf ethanol extract contains flavonoids, alkaloids, saponins, and phenols. The anti-inflammatory activity of the ethanol extract of bamboo tali leaves with concentrations of 28, 42, 56, 70, and 84 ppm had an inhibition percentage value of 23.14 ± 0.008%; 34.30 0.026%; 54.51 0.060%; 69.07 ± 0.006%; and 87.02 ± 0.021% with an IC50 value of 52.991 ppm. These results indicate that the ethanol extract of bamboo tali leaves has the potential to be an anti-inflammatory with a strong IC50 value below 100 ppm.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135540716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico Study on Structural Inhibition of Bacterial DNA Gyrase by Major Secondary Metabolites Found in Grape Seed Extract 葡萄籽提取物中主要次生代谢物对细菌DNA回转酶结构抑制的硅晶研究

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-11-07 DOI: 10.14421/biomedich.2023.122.585-592

Haritha Lawan, Hashitha Tharakee

{"title":"In silico Study on Structural Inhibition of Bacterial DNA Gyrase by Major Secondary Metabolites Found in Grape Seed Extract","authors":"Haritha Lawan, Hashitha Tharakee","doi":"10.14421/biomedich.2023.122.585-592","DOIUrl":"https://doi.org/10.14421/biomedich.2023.122.585-592","url":null,"abstract":"In the early 20th century, during the era of investigating and identifying essential “vitamins”, scientific research focused on grape seed extracts and their bioactive components, particularly polyphenols. Extensive studies have demonstrated that grape seed extract, rich in proanthocyanidins, offers protection against a wide spectrum of diseases, encompassing inflammation, cardiac ailments, peptic ulcers, hypertension, diabetes, cancer, and microbial infections. To explore potential secondary metabolites within grape seed extract that could serve as structural inhibitors of bacterial DNA Gyrase, molecular docking studies were performed. The docking results revealed that two phytochemicals, namely (-)-catechin and Procyanidin-B2, exhibited the highest potency in inhibiting DNA gyrase subunit B. Subsequent in silico physicochemical and pharmacokinetic parameter predictions were conducted using specialized web servers for the examined phytochemicals. Notably, (-)-catechin displayed superior inhibitory and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) characteristics, suggesting its potential for utilization in synthesizing novel antibacterial compounds.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135540710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analgesic and Antipyretic Activity of Sweet Orange Peel Methanol Extract 甜橙皮甲醇提取物的镇痛解热作用

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-10-05 DOI: 10.14421/biomedich.2023.122.577-584

Elsa Debora Silalahi, I Nyoman Ehrich Lister, Edy Fachrial

{"title":"Analgesic and Antipyretic Activity of Sweet Orange Peel Methanol Extract","authors":"Elsa Debora Silalahi, I Nyoman Ehrich Lister, Edy Fachrial","doi":"10.14421/biomedich.2023.122.577-584","DOIUrl":"https://doi.org/10.14421/biomedich.2023.122.577-584","url":null,"abstract":"An analgesic-antipyretic drug widely used is paracetamol, which has various health benefits and several adverse effects. Therefore, various natural products have been extensively studied as alternative analgesic-antipyretics, one of which is sweet orange peel. This study aimed to investigate sweet orange peel's analgesic and antipyretic activity by in vivo methods. This experimental study evaluated the analgesic and antipyretic effects of sweet orange peel extract extracted by the maceration method. The analgesic effect was evaluated by tail immersion (Maximum Possible Analgesia) and acetic acid-induced writhing method (total abdominal writhing). Meanwhile, the antipyretic effect was evaluated by the brewer yeast-induced hyperpyrexia (body temperature) method. This study showed that sweet orange peel methanol extract significantly increased the maximum possible analgesia value (132.79%) and reduced the number of abdominal writhing (44.05%) at the highest dose of 750 mg/kg BW. It indicated analgesic activity from sweet orange peels. Meanwhile, the antipyretic effect of sweet orange peel methanol extract was observed from 1-4 hours after administration, and the highest percentage inhibition of body temperature 4 hours after administration was found in a moderate dose, that was 5.98% (P value: 0.042). Therefore, it can be concluded that sweet orange peel methanol extract has analgesic and antipyretic effects with an optimal dose range of 500-750 mg/kg BW.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134976342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Potential of a Sumbawa Herbal Oil-Based Oleogel as Burn Wound Dressing 松巴哇草药油基油凝胶作为烧伤创面敷料的潜力

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-09-25 DOI: 10.14421/biomedich.2023.122.559-562

Andi Irma Yuniar, Nurul Wahidah Yasid, Syarifah Fatimah Nissatuljannah, Armanto Makmun, Syamsu Rijal

{"title":"The Potential of a Sumbawa Herbal Oil-Based Oleogel as Burn Wound Dressing","authors":"Andi Irma Yuniar, Nurul Wahidah Yasid, Syarifah Fatimah Nissatuljannah, Armanto Makmun, Syamsu Rijal","doi":"10.14421/biomedich.2023.122.559-562","DOIUrl":"https://doi.org/10.14421/biomedich.2023.122.559-562","url":null,"abstract":"This study aimed to innovate the current Sumbawa oil preparation which is still in the form of liquid into an oleogel so that it is easier to apply and more practical for distribution and storage. Phytochemical analysis of Sumbawa oil showed the contents of phenols, flavonoids, and alkaloids. By adding hydroxyethyl cellulose (HEC) as a gelling agent and glycerin as a humectant, Sumbawa oil can be served in the form of an oleogel. The pH measurement of the Sumbawa oil oleogel at levels of 90%, 95%, and 100% ranged from 7.0–7.3 which is the ideal acidity level for the wound healing process. In the antimicrobial activity test with S. aureus and E. coli, the zone of inhibition ranged from 12.1–14.7 mm which is considered strong. Meanwhile, in in vitro testing of the anti-inflammatory activity using the human red blood cell membrane stabilization method, the stability level of each was obtained to be 78% for 100% Sumbawa oil, 74% for oleogel with 95% Sumbawa oil, and 73% for oleogel with 90% Sumbawa oil. The oleogel morphology observation using a scanning electron microscope showed a good gelation process at 5% and 10% HEC levels.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135865892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Physical, Chemical, and Organoleptic Properties of Functional Drink Turkey Berry (Solanum torvum swartz) with the Addition of Butterfly Pea Flower (Clitoria ternatea linn) and Emprit Ginger (Zingiber officinale var. Amarum) 添加蝴蝶豌豆花(Clitoria ternatea linn)和Emprit姜(Zingiber officinale var. Amarum)的功能性饮料火鸡莓(Solanum torvum swartz)的物理、化学和感官特性研究

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-09-25 DOI: 10.14421/biomedich.2023.122.563-575

Rista Anggriani, Nina Nurazizah Purnomo Putri, Vritta Amroini Wahyudi

{"title":"Study of Physical, Chemical, and Organoleptic Properties of Functional Drink Turkey Berry (Solanum torvum swartz) with the Addition of Butterfly Pea Flower (Clitoria ternatea linn) and Emprit Ginger (Zingiber officinale var. Amarum)","authors":"Rista Anggriani, Nina Nurazizah Purnomo Putri, Vritta Amroini Wahyudi","doi":"10.14421/biomedich.2023.122.563-575","DOIUrl":"https://doi.org/10.14421/biomedich.2023.122.563-575","url":null,"abstract":"Turkey berry (Solanum torvum Swartz) is a wild plant often found in Indonesia and its usage is still limited. Turkey berry has a high potential as a source of antioxidants, which can be consumed as a functional drink. Ginger and butterfly pea flowers were selected as additional ingredients in composite drinks to enhance the quality of the functional drink in terms of function and sensory characteristics. This study aimed to determine the effects of variations in the concentration of turkey berry, butterfly pea flower, and ginger on the physical, chemical, and organoleptic characteristics. The design method used a Simple Randomized Block Design with four treatment combinations to be analyzed in three repetitions. Data were analyzed using Analysis of Variance (ANOVA) to determine the effects of the treatment. The results showed that turkey berry, in combination with ginger and butterfly pea flower, had a significant effect on the physicochemical and organoleptic characteristics, including pH, total phenolic content, total flavonoid content, antioxidants, color, aroma, taste, and preference.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Correlation Between Widal Diagnostic Test, Total Leukocyte Count, and Platelet Count in Suspected Typhoid Fever Patients at RS Aura Syifa Kediri RS区疑似伤寒患者维达尔诊断试验与白细胞总计数、血小板计数的相关性研究

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-09-22 DOI: 10.14421/biomedich.2023.122.555-558

Novi Loviana, Lisa Savitri, Rochmad Krissanjaya, Elfred Rinaldo Kasimo

{"title":"The Correlation Between Widal Diagnostic Test, Total Leukocyte Count, and Platelet Count in Suspected Typhoid Fever Patients at RS Aura Syifa Kediri","authors":"Novi Loviana, Lisa Savitri, Rochmad Krissanjaya, Elfred Rinaldo Kasimo","doi":"10.14421/biomedich.2023.122.555-558","DOIUrl":"https://doi.org/10.14421/biomedich.2023.122.555-558","url":null,"abstract":"Typhoid fever is an acute systemic infectious disease that is related to poor personal hygiene and environmental sanitation. The diagnosis of typhoid fever is established through laboratory examinations, including serological, hematological, and bacteriological tests. This research aims to determine the correlation between the Widal diagnostic test and the total leukocyte count and platelet count in suspected typhoid fever patients at RS Aura Syifa Kediri. The study design used in this research is quantitative descriptive analysis with a cross-sectional approach. The data was collected retrospectively from secondary sources, specifically medical records of patients from August 1, 2021, to March 31, 2022, at RS Aura Syifa Kediri. The total population comprised 157 patients, and a purposive sampling method was used to select 41 patients who met the inclusion and exclusion criteria. The statistical analysis using the Spearman correlation test resulted in p-values ≥ α = 0.05 for the following correlations: Widal test O with leukocytes (0.538 ≥ 0.05), Widal test H with leukocytes (0.915 ≥ 0.05), Widal test O with platelets (0.476 ≥ 0.05), and Widal test H with platelets (0.965 ≥ 0.05). These findings indicate that there is no significant correlation between the Widal test O and H with the platelet count in patients with typhoid fever. Therefore, it can be concluded that there is no significant relationship between the Widal test O and H results and the platelet count in typhoid fever patients.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136098798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant Activity Test (DPPH) and Cytotoxicity of Jengkol Peel Ethanol Extract (Pithecellobium jiringa) on Shrimp Larvae (Artemia salina Leach) 枸杞皮乙醇提取物对盐碱对虾幼虫的抗氧化活性(DPPH)及细胞毒性试验

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-09-20 DOI: 10.14421/biomedich.2023.122.533-537

Glen Arya Wibowo, Tika Afriani, Azimatur Rahmi

引用次数: 0

Standardization of Golden Sea Cucumber (Stichopus hermanii) Extracts from Pelapis Island, Kayong Regency, West Kalimantan 西加里曼丹加永县佩拉皮斯岛金海参提取物的标准化

Biology, Medicine, & Natural Product Chemistry Pub Date : 2023-09-20 DOI: 10.14421/biomedich.2023.122.539-545

Rusmini Rusmini, Wintari Taurina, Mohamad Andrie

{"title":"Standardization of Golden Sea Cucumber (Stichopus hermanii) Extracts from Pelapis Island, Kayong Regency, West Kalimantan","authors":"Rusmini Rusmini, Wintari Taurina, Mohamad Andrie","doi":"10.14421/biomedich.2023.122.539-545","DOIUrl":"https://doi.org/10.14421/biomedich.2023.122.539-545","url":null,"abstract":"Stichopus hermanii can be used as a medicinal material, a source of animal protein, and wound healing medicine products. Extracts as raw materials for products must go through a standardization process to ensure pharmaceutical reproducibility, a therapeutic quality, and to ensure a consistent and uniform final composition. The purpose of this research was to determine the test results of the standardization parameters of Stichopus hermanii extract from Pelapis Island, West Kalimantan as raw material for wound healing herbal medicinal preparations. Preparation of extracts using the maceration method with 96% ethanol. The extract was standardized with specific parameters, including organoleptic, water and ethanol soluble content, phytochemical screening, and protein content, and non-specific parameters, including drying shrinkage, water content, ash content, and acid insoluble ash content. The test results obtained were a water-soluble content of 61.89%, ethanol-soluble content of 41.81%, protein content of 7.62%, drying shrinkage of 38.81%, water content of 20.58%, ash content of 37.95%, and acid insoluble ash content of 2.07%.","PeriodicalId":8882,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136378099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0