The open psychiatry journal最新文献_第2页

Adolescents in Primary Care with Sub-Threshold Depressed Mood Screened for Participation in a Depression Prevention Study: Co-Morbidity and Factors Associated with Depressive Symptoms~!2010-02-08~!2010-04-05~!2010-04-23~! 在初级保健机构接受亚阈值抑郁情绪筛查的青少年参与抑郁症预防研究:抑郁症状的共发病及相关因素2010-02-08 2010-04-05 2010-04-23

The open psychiatry journal Pub Date : 2010-05-04 DOI: 10.2174/1874354401004010010

Benjamin W. Voorhees, S. Melkonian, Monika Marko, J. Humensky, J. Fogel

引用次数: 0

Anhedonia in Unipolar Major Depressive Disorder: A Review~!2009-10-26~!2010-02-18~!2010-04-08~! 单极重性抑郁障碍的快感缺乏研究进展2009-10-26 2010-02-18 2010-04-08

The open psychiatry journal Pub Date : 2010-04-08 DOI: 10.2174/1874354401004010001

G. Dichter

引用次数: 58

Adolescents in Primary Care with Sub-Threshold Depressed Mood Screened for Participation in a Depression Prevention Study: Co-Morbidity and Factors Associated with Depressive Symptoms. 在初级保健中接受亚阈值抑郁情绪筛查的青少年参与抑郁症预防研究:与抑郁症状相关的共发病和因素

The open psychiatry journal Pub Date : 2010-01-01 DOI: 10.2174/1874300501004010010

B. V. Van Voorhees, S. Melkonian, Monika Marko, J. Humensky, J. Fogel

{"title":"Adolescents in Primary Care with Sub-Threshold Depressed Mood Screened for Participation in a Depression Prevention Study: Co-Morbidity and Factors Associated with Depressive Symptoms.","authors":"B. V. Van Voorhees, S. Melkonian, Monika Marko, J. Humensky, J. Fogel","doi":"10.2174/1874300501004010010","DOIUrl":"https://doi.org/10.2174/1874300501004010010","url":null,"abstract":"PURPOSE Adolescents in primary care with sub-threshold depression symptoms may be candidates for early intervention to prevent onset of full major depressive disorder. Little is known about this population. METHOD We screened consecutive adolescents (ages 14-21) in 13 primary care sites for presence of depression symptoms for \"at least a few days\" or \"nearly every day\" in the last two weeks for possible enrollment in a primary care/Internet-based depression prevention intervention (CATCH-IT). We report illness severity, prevalence of self-harm ideation, prevalence correlates (automatic negative thoughts, generalized self-efficacy, perceived social support from family and friends) and co-occurring symptoms of other mental disorders with depressed mood. RESULTS Twenty-one percent (N=293) of those screened reported a core symptom of depressive disorder of which 83 enrolled in the study and were analyzed. The sample was 40% ethnic minority with a mean zip code household income of $40,249 (SD=$14,500). Reporting at least one symptom of another mental disorder was common for anxiety (48%, N=40), substance abuse (31%, N=15), conduct disorder (71%, N=53), as were self-harm ideation (16%, N=12) and reporting school impairment (100%, N=83). Prevalence correlates for current depressive symptoms included low self-efficacy, automatic negative thoughts, perceived low peer acceptance, and school impairment. CONCLUSIONS Adolescents with sub-threshold depressed mood have frequent co-morbid symptoms that may need to be considered in developing prevention interventions. Early intervention targets to reduce depressed mood include pessimistic thinking, low self-efficacy, low peer acceptance, and school impairment.","PeriodicalId":88755,"journal":{"name":"The open psychiatry journal","volume":"43 1","pages":"10-18"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74216224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Adolescents in Primary Care with Sub-Threshold Depressed Mood Screened for Participation in a Depression Prevention Study: Co-Morbidity and Factors Associated with Depressive Symptoms. 在初级保健中接受亚阈值抑郁情绪筛查的青少年参与抑郁症预防研究:与抑郁症状相关的共发病和因素

The open psychiatry journal Pub Date : 2010-01-01

Benjamin W Van Voorhees, Stephanie Melkonian, Monika Marko, Jennifer Humensky, Joshua Fogel

{"title":"Adolescents in Primary Care with Sub-Threshold Depressed Mood Screened for Participation in a Depression Prevention Study: Co-Morbidity and Factors Associated with Depressive Symptoms.","authors":"Benjamin W Van Voorhees, Stephanie Melkonian, Monika Marko, Jennifer Humensky, Joshua Fogel","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: Adolescents in primary care with sub-threshold depression symptoms may be candidates for early intervention to prevent onset of full major depressive disorder. Little is known about this population.Method: We screened consecutive adolescents (ages 14-21) in 13 primary care sites for presence of depression symptoms for \"at least a few days\" or \"nearly every day\" in the last two weeks for possible enrollment in a primary care/Internet-based depression prevention intervention (CATCH-IT). We report illness severity, prevalence of self-harm ideation, prevalence correlates (automatic negative thoughts, generalized self-efficacy, perceived social support from family and friends) and co-occurring symptoms of other mental disorders with depressed mood.Results: Twenty-one percent (N=293) of those screened reported a core symptom of depressive disorder of which 83 enrolled in the study and were analyzed. The sample was 40% ethnic minority with a mean zip code household income of $40,249 (SD=$14,500). Reporting at least one symptom of another mental disorder was common for anxiety (48%, N=40), substance abuse (31%, N=15), conduct disorder (71%, N=53), as were self-harm ideation (16%, N=12) and reporting school impairment (100%, N=83). Prevalence correlates for current depressive symptoms included low self-efficacy, automatic negative thoughts, perceived low peer acceptance, and school impairment.Conclusions: Adolescents with sub-threshold depressed mood have frequent co-morbid symptoms that may need to be considered in developing prevention interventions. Early intervention targets to reduce depressed mood include pessimistic thinking, low self-efficacy, low peer acceptance, and school impairment.","PeriodicalId":88755,"journal":{"name":"The open psychiatry journal","volume":"4 ","pages":"10-18"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686117/pdf/nihms469440.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31529444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Patient Satisfaction with the Feedback After aNeuropsychological Assessment 神经心理评估后患者满意度反馈的预测因素

The open psychiatry journal Pub Date : 2009-08-20 DOI: 10.2174/1874354400903010050

Ylva Holst, H. Nyman, J. Larsson

引用次数: 8

Premenstrual Syndrome and Premenstrual Dysphoric Disorder: Symptoms and Cluster Influences 经前综合征和经前烦躁障碍:症状和群集影响

The open psychiatry journal Pub Date : 2009-08-04 DOI: 10.2174/1874354400903010039

F. Pérez-López, P. Chedraui, G. Pérez-Roncero, M. T. López-Baena, J. L. Cuadros-López

{"title":"Premenstrual Syndrome and Premenstrual Dysphoric Disorder: Symptoms and Cluster Influences","authors":"F. Pérez-López, P. Chedraui, G. Pérez-Roncero, M. T. López-Baena, J. L. Cuadros-López","doi":"10.2174/1874354400903010039","DOIUrl":"https://doi.org/10.2174/1874354400903010039","url":null,"abstract":"Many women in their reproductive years experience some mood, behavioral, or physical symptoms in the week prior to menses. Women experiencing mild symptoms may have a wide variability in the level of symptom burden, whereas a minority suffers severe and debilitating symptoms. Severe premenstrual syndrome (PMS) affects 3% to 5% of women of reproductive age and has been classified under the Diagnostic and Statistical Manual of Mental Disorders (DSM IV) as premenstrual dysphoric disorder (PMDD). Both disorders are characterized mainly by symptoms confined to the premenstrual period, which reduce not only patients' quality of life, but also their working activities. Women suffering PMDD experience severe dysphoric mood, and a greater desire and actual intake of certain foods, demonstrating impaired cognitive performance during the luteal phase. Several theories have been proposed to explain the underlying mechanisms of PMS and PMDD with complex bio-psycho-social factors involved. Although precise causes are unknown, the late luteal phase could be associated with diverse psychosomatic and behavioral symptoms appearing premenstrually which should be appropriately treated. Notwithstanding this high prevalence, no specific symptoms or signs appear, nor have any recognizable anatomical factors been identified in women suffering PMS or PMDD, and hence, no universal treatment yet exists. Despite this, therapeutic progress has been reached, although the ideal treatment has not yet been obtained due to the many clusters involved.","PeriodicalId":88755,"journal":{"name":"The open psychiatry journal","volume":"17 1","pages":"39-49"},"PeriodicalIF":0.0,"publicationDate":"2009-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81817649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Depression Across the Species 物种间的抑郁症

The open psychiatry journal Pub Date : 2009-06-18 DOI: 10.2174/1874354400903010033

Á. Dias, Ana Karina Santos, Margareth Yuri Takeuchi, C. H. Adania

引用次数: 3

Bayesian Monitoring and Bootstrap Trial Simulation: A New Paradigm to Implement Adaptive Trial Design for Testing Antidepressant Drugs 贝叶斯监测和自举试验模拟:抗抑郁药物自适应试验设计的新范式

The open psychiatry journal Pub Date : 2009-06-02 DOI: 10.2174/1874354400903000020

E. Merlo-Pich, P. Bettica, R. Gomeni

{"title":"Bayesian Monitoring and Bootstrap Trial Simulation: A New Paradigm to Implement Adaptive Trial Design for Testing Antidepressant Drugs","authors":"E. Merlo-Pich, P. Bettica, R. Gomeni","doi":"10.2174/1874354400903000020","DOIUrl":"https://doi.org/10.2174/1874354400903000020","url":null,"abstract":"A novel methodology is proposed for continuous monitoring of efficacy data in ongoing antidepressant clinical trials and for decision making to support progression or discontinuation of the trial or one of the treatment arms. The Posterior Probability of Superiority (PPS) resulting from the application of Monte Carlo Markov Chain approach to a longitudinal model describing the time course of placebo and antidepressant drugs was used to estimate criteria to discontinue a treatment arm or the trial for futility, and to predict the treatment effect at study-end while the trial was still ongoing. The decision to stop the study was based on PPS, Predictive Power and on risk analysis based on a non-parametric bootstrap trial simulation. The performance of the Bayesian monitoring was evaluated by the retrospective analysis of 3 clinical trials. The Bootstrap-based methodology was compared to the Conditional Power and the Predictive Probability approaches. The application of the proposed methodology showed the possibility to stop a trial for futility when about 50% of total information was available and to detect signal of a treatment effect when limited information (<40%) was available. The comparisons with the Condition Power and the Predictive Probability approaches indicated that the Bayesian Bootstrap method, based on data-driven assumptions for priors, provided a better control for the risk of inappropriate decisions. The results suggest that the proposed methodology to monitor the accumulating information and to provide a scenario- based risk analysis could constitute a valuable approach to re-engineer the development process of novel drugs.","PeriodicalId":88755,"journal":{"name":"The open psychiatry journal","volume":"34 1","pages":"20-32"},"PeriodicalIF":0.0,"publicationDate":"2009-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81632410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Does Assertive Community Treatment Work with Forensic Populations? Review and Recommendations 自信的社区治疗对法医群体有效吗?检讨及建议

The open psychiatry journal Pub Date : 2009-05-05 DOI: 10.2174/1874354400903010013

J. Jennings

{"title":"Does Assertive Community Treatment Work with Forensic Populations? Review and Recommendations","authors":"J. Jennings","doi":"10.2174/1874354400903010013","DOIUrl":"https://doi.org/10.2174/1874354400903010013","url":null,"abstract":"Several variations of the Assertive Community Treatment model have been tried with forensic and offender populations, including Forensic Assertive Community Treatment (FACT), Forensic Intensive Case Management (FICM) and Integrated Dual Diagnosis Treatment (IDDT). Based on a comprehensive review of multiple reviews and research studies, it appears that the field is converging on the conclusion that ACT may have a positive impact on mental health for forensic patients, but that it is probably ineffective or minimally effective in reducing criminal recidivism. The author argues that emerging research from the \"forensic continuum of care model\" and correctional re-entry treatment programs suggests that the community aftercare component is vital with offending populations and that aftercare programs like ACT can be enhanced by a \"pre-treatment\" residential treatment precursor. Specifically, the provision of enriched or extended residential treatment - in which forensic patients have adequate time to learn, practice and master life management skills - can maximize the effectiveness of follow-up ACT. Most FACT and FICM approaches have lacked this \"continuum\" feature.","PeriodicalId":88755,"journal":{"name":"The open psychiatry journal","volume":"24 1","pages":"13-19"},"PeriodicalIF":0.0,"publicationDate":"2009-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83306776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Suicidal Behavior and the Serotonin Transporter Gene Polymorphism (5-HTTLPR) with Novel Subtypes, in Danish Schizophrenic Patients 丹麦精神分裂症患者自杀行为和5-羟色胺转运蛋白基因多态性(5-HTTLPR)的新亚型

The open psychiatry journal Pub Date : 2009-04-20 DOI: 10.2174/1874354400903010009

August G. Wang, H. Rasmussen, H. Sørensen, Marianne Hvid, Claus Breddam, B. Hansen, V. Bille, O. Garsdal, A. Jacoby, K. Søeby, H. Dam, L. Krogsbøll, S. Timm, T. Werge

{"title":"Suicidal Behavior and the Serotonin Transporter Gene Polymorphism (5-HTTLPR) with Novel Subtypes, in Danish Schizophrenic Patients","authors":"August G. Wang, H. Rasmussen, H. Sørensen, Marianne Hvid, Claus Breddam, B. Hansen, V. Bille, O. Garsdal, A. Jacoby, K. Søeby, H. Dam, L. Krogsbøll, S. Timm, T. Werge","doi":"10.2174/1874354400903010009","DOIUrl":"https://doi.org/10.2174/1874354400903010009","url":null,"abstract":"Background: Literature reports a genetic component for suicidal behavior, especially of determinant/violent type. One of the candidates has been the polymorphism 5-HTTLPR in the serotonin promoter. Employing a between group design, we wished to test the association between suicidal behavior and serotonin-related polymorphisms. Method: 350 Danish patients with average 14 years' duration of illness and with well researched history of suicidal behavior participated. Three groups were identified: 1. without suicidal behavior, 2. with suicidal behavior of non- determinant/non-violent methods, and 3. suicidal behavior with determinant/violent methods. We used the common alleles S and L as well as the new aspect with allelic subtypes SA, SG, LA.LG to constitute 3 functional genotypes: SS, SL and LL. We also included duration of illness, age at onset and sex in our study as potential covariates. Results: We tested suicidal behavior types 2 and 3 versus type 1 for distribution differences as well as for possible trend. We did not find any statistical significant relations. Conclusions: We could not find support for a relevant relation between the polymorphisms in the serotonin promoter and suicidal behavior in our schizophrenic patient sample.","PeriodicalId":88755,"journal":{"name":"The open psychiatry journal","volume":"46 1","pages":"9-12"},"PeriodicalIF":0.0,"publicationDate":"2009-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82358694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3