Signal transduction最新文献_第5页

From the Bremen Drop Tower to the international space station ISS – Ways to weightlessness in the German space life sciences program 从不来梅发射塔到国际空间站——德国太空生命科学项目的失重之路

Signal transduction Pub Date : 2006-12-01 DOI: 10.1002/SITA.200600108

G. Ruyters, U. Friedrich

{"title":"From the Bremen Drop Tower to the international space station ISS – Ways to weightlessness in the German space life sciences program","authors":"G. Ruyters, U. Friedrich","doi":"10.1002/SITA.200600108","DOIUrl":"https://doi.org/10.1002/SITA.200600108","url":null,"abstract":"Investigations on the effects of gravity on living systems, especially the perception and transduction of this important environmental parameter, are in the focus of the German Space Life Sciences Program since several years. This program is managed – like all other space activities – by the German Aerospace Center DLR in its role as the German Space Agency. Funding of scientists, placing contracts to industry for the development of necessary space research facilities, and providing flight opportunities for performing space experiments including international coordination with other space agencies are the main responsibilities of the agency. In the present contribution the special features of the various flight opportunities, which are made available by DLR for life sciences research, are described in some detail. By this, scientists should become aware of the interesting possibilities to perform space research in the frame of the German Space Life Sciences Program, while other contributions in this special publications will focus on the results obtained, especially in the area of gravity signal transduction.","PeriodicalId":88702,"journal":{"name":"Signal transduction","volume":"113 1","pages":"397-405"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/SITA.200600108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50950941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Gravity‐sensing and gravity‐related signaling pathways in unicellular model systems of protists and plants 原生生物和植物单细胞模式系统中的重力感应和重力相关信号通路

Signal transduction Pub Date : 2006-12-01 DOI: 10.1002/SITA.200600106

R. Hemmersbach, M. Braun

引用次数: 23

Effects of different gravity conditions on self organizing biological systems 不同重力条件对自组织生物系统的影响

Signal transduction Pub Date : 2006-12-01 DOI: 10.1002/SITA.200600101

M. Wiedemann, Alexandra Piffel, W. Hanke

{"title":"Effects of different gravity conditions on self organizing biological systems","authors":"M. Wiedemann, Alexandra Piffel, W. Hanke","doi":"10.1002/SITA.200600101","DOIUrl":"https://doi.org/10.1002/SITA.200600101","url":null,"abstract":"The effects of different gravity conditions on the retinal Spreading Depression (rSD) were investigated. The rSD, an excitation depression wave in retinal tissue is used as an example of self organization and pattern formation in the central nervous system (CNS). The properties of such phenomena depend critically on the parameters of the system, small changes in the system can thus induce significant changes in the propagation properties of the SD. Gravity is a small but permanently stimulus on earth, absence of gravity and amplification respectively may have severe consequences for the function of the brain as an excitable medium. Microgravity experiments were performed on a TEXUS sounding rocket mission (5 min μg) and two DLR parabolic flight missions (20 s μg), hypergravity experiments were performed in the centrifuge in the lab. In this presentation we summarize the effects of altered gravity conditions on different parameters of the rSD. The results are discussed also in their relation to other earlier experiments with propagating action potentials under different gravity conditions. For both self organized biological systems a gravity dependence could be shown.","PeriodicalId":88702,"journal":{"name":"Signal transduction","volume":"44 1","pages":"414-421"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/SITA.200600101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50951209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Interacting signal transduction chains in gravity-stimulated maize roots 重力刺激下玉米根系的相互作用信号转导链

Signal transduction Pub Date : 2006-12-01 DOI: 10.1002/SITA.200600109

A. Hahn, R. Firn, H. Edelmann

引用次数: 12

Graviresponses in fungi and slime molds 真菌和黏菌的重力反应

Signal transduction Pub Date : 2006-12-01 DOI: 10.1002/SITA.200600111

B. Hock, D. Häder

引用次数: 4

Editorial: Calcium, cytokines, and maturation factors during T cell activation 编辑:钙、细胞因子和成熟因子在T细胞活化中的作用

Signal transduction Pub Date : 2006-08-01 DOI: 10.1002/SITA.200690027

R. Hass

引用次数: 0

Calcium release-activated calcium channels as signal transducers in T-cells 钙释放激活钙通道在t细胞中的信号转导作用

Signal transduction Pub Date : 2006-08-01 DOI: 10.1002/SITA.200600092

D. Griesemer, Birgit Löffler, Carsten Kummerow, Ariel Quintana, E. Schwarz, M. Hoth

{"title":"Calcium release-activated calcium channels as signal transducers in T-cells","authors":"D. Griesemer, Birgit Löffler, Carsten Kummerow, Ariel Quintana, E. Schwarz, M. Hoth","doi":"10.1002/SITA.200600092","DOIUrl":"https://doi.org/10.1002/SITA.200600092","url":null,"abstract":"Stimulation of T-cell receptors by professional antigen presenting cells initiates several signaling cascades which finally lead to T-cell activation and proliferation. One of the cascades induces a rise of the cytoplasmic IP3 concentration, which releases Ca2+ from the endoplasmic reticulum. This Ca2+ release alone, however, is not sufficient to activate Ca2+ dependent signal transduction and gene transcription in T-cells. For T-cell activation and proliferation, a sustained Ca2+ entry over the plasma membrane is needed. This Ca2+ entry is called storeoperated Ca2+ (SOC) entry, because it is activated by depletion of the Ca2+ stores. The first and best-characterized member of the SOC channels is the Ca2+ release-activated Ca2+ (CRAC) channel which is the predominant Ca2+ influx pathway in T-cells. CRAC channels are highly selective for Ca2+ over all other cations and are responsible for the Ca2+ entry and subsequent sustained elevation of the intracellular Ca2+ concentration which is required for T-cell activation. We discuss the role of CRAC channels for T-cell activation and their potential to determine the quality and quantity of the T-cell response.","PeriodicalId":88702,"journal":{"name":"Signal transduction","volume":"15 1","pages":"233-239"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/SITA.200600092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50951048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: TGF‐β signaling 编辑:TGF‐β信号

Signal transduction Pub Date : 2006-08-01 DOI: 10.1002/SITA.200690034

H. Ungefroren

引用次数: 4

Blimp‐1 is expressed in human and mouse T cell subsets and leads to loss of IL‐2 production and to defective proliferation Blimp‐1在人和小鼠T细胞亚群中表达，导致IL‐2生成缺失和增殖缺陷

Signal transduction Pub Date : 2006-08-01 DOI: 10.1002/SITA.200500062

B. Santner‐Nanan, F. Berberich-Siebelt, Zheng Xiao, Niklas Poser, H. Sennefelder, S. Rauthe, D. Vallabhapurapu, I. Berberich, A. Schimpl, H. Kreth, R. Nanan

{"title":"Blimp‐1 is expressed in human and mouse T cell subsets and leads to loss of IL‐2 production and to defective proliferation","authors":"B. Santner‐Nanan, F. Berberich-Siebelt, Zheng Xiao, Niklas Poser, H. Sennefelder, S. Rauthe, D. Vallabhapurapu, I. Berberich, A. Schimpl, H. Kreth, R. Nanan","doi":"10.1002/SITA.200500062","DOIUrl":"https://doi.org/10.1002/SITA.200500062","url":null,"abstract":"The transcriptional repressor Blimp-1 regulates terminal differentiation of B-lymphocytes and myeloid cells. We now show that Blimp-1 is also expressed in human and murine primary T lymphocytes. Blimp-1 expression is highest in freshly isolated primary T cells with an antigen experienced phenotype. Th2 and CD4+CD25+ cells exhibited higher levels of Blimp-1 mRNA than Th1 cells. However, ectopic expression of Blimp-1 by retroviral transduction neither altered the frequency of IFN-γ or IL-4 producing cells nor did it induce suppressor activity. In non-polarized cells, retroviral transduction of Blimp-1 led to a marked reduction in IL-2 secretion, to an inability to proliferate and to reduced viability. Our data suggest that Blimp-1 is physiologically expressed in T lymphocytes during late stages of differentiation, induces down regulation of IL-2 production and a shortened life span and might thus contribute to a limitation of T cell immune responses.","PeriodicalId":88702,"journal":{"name":"Signal transduction","volume":"33 5","pages":"268-279"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/SITA.200500062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50950456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Competition and cooperation: Signal transduction by CD28 and CTLA-4 竞争与合作:CD28和CTLA-4的信号转导

Signal transduction Pub Date : 2006-08-01 DOI: 10.1002/SITA.200500081

H. Hoff, G. Burmester, M. Brunner‐Weinzierl

引用次数: 5