Signal transduction最新文献

Effector enzymes coupled to GTP-binding proteins: Adenylyl cyclase and phospholipase C 与gtp结合蛋白偶联的效应酶:腺苷酸环化酶和磷脂酶C

Signal transduction Pub Date : 2009-01-01 DOI: 10.1016/B978-0-12-369441-6.00005-2

B. Gomperts, I. Kramer, P. Tatham

引用次数: 2

Lysophosphatidic acid LPA1 receptor close‐up 溶血磷脂酸LPA1受体闭合

Signal transduction Pub Date : 2007-12-01 DOI: 10.1002/SITA.200700138

S. E. Avendaño-Vázquez, Alejandro Cabrera-Wrooman, Christian C Colín-Santana, J. García-Sáinz

{"title":"Lysophosphatidic acid LPA1 receptor close‐up","authors":"S. E. Avendaño-Vázquez, Alejandro Cabrera-Wrooman, Christian C Colín-Santana, J. García-Sáinz","doi":"10.1002/SITA.200700138","DOIUrl":"https://doi.org/10.1002/SITA.200700138","url":null,"abstract":"Lysophosphatidic acid is a local hormone / autacoid / growth factor, which induces a plethora of actions in the majority of cells in our organism. These actions include, among many others, the following: cell migration, proliferation and surviving, induction of gene transcription, platelet aggregation, smooth muscle contraction, myelinization, neurotransmitter release, cytoskeletal reorganization during the stress fiber formation, establishment of focal adhesions, neurite retraction, and cell rounding. The actions of lysophosphatidic acid are mediated through a family of G protein coupled receptors that includes five receptor subtypes, i.e. LPA1,–5 receptors. These receptors couple to different G proteins, mainly Gi, Gq and G12/13 and their signaling pathways, besides there is evidence that they can transactivate EGF receptors to mediate some of their actions. The LPA1 receptor was the first subtype to be cloned for this lysophospholipid. It plays an important role in development, is expressed in many cells and tissues and has been the most extensively studied. The present review presents current knowledge on the structure, function and regulation of this receptor subtype, its possible involvement in pathological conditions and suggests certain areas in which current knowledge is insufficient and further research is required.","PeriodicalId":88702,"journal":{"name":"Signal transduction","volume":"61 3","pages":"351-363"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/SITA.200700138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50951450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Editorial: Signal transduction in Mexico 社论:墨西哥的信号转导

Signal transduction Pub Date : 2007-12-01 DOI: 10.1002/SITA.200890001

J. García-Sáinz, Y. Rosenstein

引用次数: 1

Early biochemical events in leukocyte activation through receptors for IgG 白细胞通过IgG受体激活的早期生化事件

Signal transduction Pub Date : 2007-12-01 DOI: 10.1002/SITA.200700143

E. Ortega, I. Soto-Cruz

引用次数: 3

Fc receptor and integrin signaling in phagocytes 吞噬细胞中Fc受体与整合素信号传导

Signal transduction Pub Date : 2007-12-01 DOI: 10.1002/SITA.200700141

C. Rosales

引用次数: 25

Signaling through the high affinity IgE receptor and conditions able to modify IgE‐antigen responsiveness of mast cells 通过高亲和力IgE受体的信号传导和能够改变肥大细胞IgE抗原反应性的条件

Signal transduction Pub Date : 2007-12-01 DOI: 10.1002/SITA.200700142

C. González-Espinosa, J. Medina-Tamayo, E. Sánchez-Miranda, Juan Pablo Benitez-Garrido, Alejandro Martin Avila-Hernandez, A. Padilla, Jonathan Garcia-Roman

{"title":"Signaling through the high affinity IgE receptor and conditions able to modify IgE‐antigen responsiveness of mast cells","authors":"C. González-Espinosa, J. Medina-Tamayo, E. Sánchez-Miranda, Juan Pablo Benitez-Garrido, Alejandro Martin Avila-Hernandez, A. Padilla, Jonathan Garcia-Roman","doi":"10.1002/SITA.200700142","DOIUrl":"https://doi.org/10.1002/SITA.200700142","url":null,"abstract":"Signaling through the high affinity receptor for IgE (FceRI) on mast cells comprises an intricate network of protein-protein modifications and interactions leading to mast cell degranulation, lipid-derived mediator production and cytokine release. Depending on the tissue where mast cells are activated, mediator release can induce distinct allergy symptoms. FceRI receptor mainly couples to at least two Src family kinases (Lyn and Fyn), which are responsible for the initiation of the signaling cascade. Distinct membrane bound adapters couple the initial signal to the formation of particular multi-molecular complexes that, in turn, will mediate a specific final response. In this review we summarize the molecular mechanisms initiated by the FceRI receptor on mast cells that have been involved in cytokine expression. At the same time, some conditions where the main signal transduction mechanism is modified will be analyzed in order to understand how locally produced mediators could alter IgE-antigen-induced allergic responses.","PeriodicalId":88702,"journal":{"name":"Signal transduction","volume":"16 5","pages":"402-414"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/SITA.200700142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50951673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

CD43 – One molecule, many tales to recount CD43 -一个分子，许多故事要讲述

Signal transduction Pub Date : 2007-12-01 DOI: 10.1002/SITA.200700140

G. Pedraza-Alva, Y. Rosenstein

引用次数: 15

The role of the Jak‐Stat pathway in chemokine‐mediated signaling in T lymphocytes Jak - Stat通路在趋化因子介导的T淋巴细胞信号传导中的作用

Signal transduction Pub Date : 2007-12-01 DOI: 10.1002/SITA.200700144

G. Soldevila, E. García-Zepeda

{"title":"The role of the Jak‐Stat pathway in chemokine‐mediated signaling in T lymphocytes","authors":"G. Soldevila, E. García-Zepeda","doi":"10.1002/SITA.200700144","DOIUrl":"https://doi.org/10.1002/SITA.200700144","url":null,"abstract":"Chemokines are low molecular weight soluble mediators that control leukocyte trafficking during lymphocyte homeostasis and inflammation. Chemokine-mediated signaling is triggered upon chemokine binding to seven transmembrane G protein-coupled receptors. Multiple signaling pathways are activated leading to cytoskeleton rearrangements, gene transcription and receptor internalization or degradation Among the signaling molecules involved in chemokine mediated signaling, the Jak-Stat pathway has been shown to be activated very early after chemokine stimulation. There is growing evidence showing the involvement of particular Jaks and Stats, in chemokine receptor signaling both in cell lines and primary cells. Jak/Stat phosphorylation is detected soon after chemokine receptor dimerization or in response to chemokines. Also, pharmacological inhibition of Jaks, or the use of Jak deficient lymphocytes results in inhibition of chemokine-mediated responses, such as chemotaxis or integrin-mediated adhesion. This review summarizes the current data describing the involvement of the Jak-Stat pathway in chemokine-mediated signaling in T lymphocytes and discusses the potential crosstalk with other TCR and cytokine-mediated signaling pathways.","PeriodicalId":88702,"journal":{"name":"Signal transduction","volume":"36 3","pages":"427-438"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/SITA.200700144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50951376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Histamine H3 receptors and their role in basal ganglia physiology and pathophysiology 组胺H3受体及其在基底神经节生理和病理生理中的作用

Signal transduction Pub Date : 2007-12-01 DOI: 10.1002/SITA.200700139

J. Arias-Montaño

{"title":"Histamine H3 receptors and their role in basal ganglia physiology and pathophysiology","authors":"J. Arias-Montaño","doi":"10.1002/SITA.200700139","DOIUrl":"https://doi.org/10.1002/SITA.200700139","url":null,"abstract":"Through interaction with G protein-coupled receptors, histamine regulates pre- and post-synaptically a number of brain functions such as wakefulness, locomotor activity, autonomic and vestibular functions, feeding, drinking, analgesia and memory. Four such receptors have been cloned to date, and three of them (H1, H2, and H3) are widely distributed in the central nervous system, which contains the great majority of histamine H3 receptors (H3Rs). These receptors are expressed at high densities in the basal ganglia, a group of subcortical neuronal nuclei intimately involved in the regulation of posture and movement. In this review the main characteristics of H3Rs (structure, isoforms, constitutive activity and signaling) are briefly described, to then summarize our own work regarding the H3R-mediated regulation of synaptic transmission in the basal ganglia. Finally, the possible participation of H3Rs in the pathophysiology of Parkinson's disease is discussed. Based on the information herein reviewed it is concluded that H3Rs play a relevant role in basal ganglia function both in normal and pathological conditions, and that H3R agonists and antagonists may have potential use in the treatment of both Parkinson's disease and the complications of the current pharmacological therapies of the disorder.","PeriodicalId":88702,"journal":{"name":"Signal transduction","volume":"23 1","pages":"364-371"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/SITA.200700139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50951463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Novel monoclonal antibodies for the investigation of PCH family proteins 用于PCH家族蛋白研究的新型单克隆抗体

Signal transduction Pub Date : 2007-08-01 DOI: 10.1002/SITA.200600130

M. Lettau, A. Beyer, O. Janssen

{"title":"Novel monoclonal antibodies for the investigation of PCH family proteins","authors":"M. Lettau, A. Beyer, O. Janssen","doi":"10.1002/SITA.200600130","DOIUrl":"https://doi.org/10.1002/SITA.200600130","url":null,"abstract":"The pombe Cdc15 homology (PCH) protein family (also termed FCH/SH3 family) comprises 5 subgroups of structurally related polypeptides. The protein kinase C and casein kinase substrate in neurons 1 (PACSIN1), the CD2-binding protein 1 (CD2BP1) and the Cdc42-interacting protein 4 (CIP4) represent members of three individual subgroups. PCH proteins in general are supposed to link cytoskeletal elements to membrane trafficking machineries. In various cellular systems, PCH proteins are involved in lysosomal targeting, vesicular transport, and endocytotic as well as exocytotic processes. However, the specific molecular networks around individual PCH proteins and their localization in different cell populations need to be identified. We have recently reported that several members of the PCH family interact with the death factor FasL (CD178). This interaction is mediated via the SH3 domains of PCH proteins binding to the proline-rich cytoplasmatic region of FasL. To analyze the role of endogenous PCH proteins in the context of FasL or other interactors, novel molecular tools are needed. We developed a set of monoclonal antibodies against three individual PCH family members. These novel reagents will help to analyze the presence and function of endogenous PCH proteins in lymphocytes and other cell types.","PeriodicalId":88702,"journal":{"name":"Signal transduction","volume":"131 S4","pages":"320-328"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/SITA.200600130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50951101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3