F1000 medicine reports最新文献_第4页

Screening for pancreatic cancer: what can cyst fluid analysis tell us? 胰腺癌筛查:囊肿液分析能告诉我们什么?

F1000 medicine reports Pub Date : 2011-02-01 DOI: 10.3410/M3-3

Walter G Park

引用次数: 7

Medication-assisted treatment for opioid dependence: making a difference in prisons. 阿片类药物依赖的药物辅助治疗：在监狱中发挥作用。

F1000 medicine reports Pub Date : 2011-01-14 DOI: 10.3410/M3-1

Anna Pecoraro, George E Woody

引用次数: 0

The allergy gene: how a mutation in a skin protein revealed a link between eczema and asthma. 过敏基因:皮肤蛋白的突变如何揭示湿疹和哮喘之间的联系。

F1000 medicine reports Pub Date : 2011-01-14 DOI: 10.3410/M3-2

W H Irwin McLean

{"title":"The allergy gene: how a mutation in a skin protein revealed a link between eczema and asthma.","authors":"W H Irwin McLean","doi":"10.3410/M3-2","DOIUrl":"https://doi.org/10.3410/M3-2","url":null,"abstract":"Ichthyosis vulgaris is a common genetic skin disorder characterized by dry, scaly skin. About 1% of the European population have the full presentation of ichthyosis vulgaris; up to 10% have a milder, subclinical form. Atopic eczema is the most common, inflammatory skin condition, affecting 20% of children. It is often accompanied by a number of other allergies, including atopic asthma. Atopic eczema is a complex trait, where predisposing genes in combination with environmental stimuli produce the disease. Recently, we reported the first loss-of-function genetic mutations in the filaggrin gene as the cause of ichthyosis vulgaris. We noted people with ichthyosis vulgaris also have atopic eczema (and vice versa) and that the filaggrin gene sits in a known atopic eczema susceptibility locus. We went on to confirm that filaggrin mutations, carried by up to 10% of the population, are the major genetic predisposing factor for atopic eczema and the various allergies associated with atopic eczema. Filaggrin is a highly abundant protein expressed in the uppermost part of the epidermis that is critical to the formation and hydration of the stratum corneum-the outermost dead cell layers responsible for the barrier function of the skin. Filaggrin deficiency leads to a \"leaky\" skin barrier that allows higher than normal water loss (explaining the dry, scaly skin), as well as allowing entry of allergens through the epidermis where they trigger inflammatory and allergic immune responses (atopic eczema and allergies). This work has placed the skin barrier at the center stage of eczema and allergy research and has kick-started new therapy development programs aimed at repairing or enhancing skin-barrier function as a means of treating or preventing these very common diseases.","PeriodicalId":88480,"journal":{"name":"F1000 medicine reports","volume":"3 ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2011-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8a/50/medrep-03-02.PMC3042307.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29737858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Emerging fungal infections in immunocompromised patients. 免疫功能低下患者的新发真菌感染。

F1000 medicine reports Pub Date : 2011-01-01 Epub Date: 2011-07-01 DOI: 10.3410/M3-14

Chian-Yong Low, Coleman Rotstein

引用次数: 255

Molecular insights into Parkinson's disease. 帕金森氏症的分子研究。

F1000 medicine reports Pub Date : 2011-01-01 Epub Date: 2011-04-01 DOI: 10.3410/M3-7

Bobby Thomas, M Flint Beal

引用次数: 88

Alloantigen-based AIDS vaccine: revisiting a "rightfully" discarded promising strategy. 基于同种异体抗原的艾滋病疫苗:重新审视一个“正当”被抛弃的有希望的策略。

F1000 medicine reports Pub Date : 2011-01-01 Epub Date: 2011-06-01 DOI: 10.3410/M3-12

Gene M Shearer, Adriano Boasso

引用次数: 9

The new face of ovarian cancer modeling: better prospects for detection and treatment. 卵巢癌建模的新面貌:更好的检测和治疗前景。

F1000 medicine reports Pub Date : 2011-01-01 Epub Date: 2011-11-01 DOI: 10.3410/M3-22

Alison M Karst, Ronny Drapkin

引用次数: 21

The role of blood flow in determining the sites of atherosclerotic plaques. 血流在确定动脉粥样硬化斑块位置中的作用。

F1000 medicine reports Pub Date : 2011-01-01 Epub Date: 2011-03-01 DOI: 10.3410/M3-5

Christina M Warboys, Narges Amini, Amalia de Luca, Paul C Evans

{"title":"The role of blood flow in determining the sites of atherosclerotic plaques.","authors":"Christina M Warboys, Narges Amini, Amalia de Luca, Paul C Evans","doi":"10.3410/M3-5","DOIUrl":"https://doi.org/10.3410/M3-5","url":null,"abstract":"Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids and inflammatory cells along the inner walls of arteries, and is an underlying cause of cardiovascular disease. Atherosclerotic lesions develop predominantly at branches, bends, and bifurcations in the arterial tree because these sites are exposed to low or disturbed blood flow, which exerts low/oscillatory shear stress on the vessel wall. This mechanical environment alters endothelial cell physiology by enhancing inflammatory activation. In contrast, regions of the arterial tree that are exposed to uniform, unidirectional blood flow and experience high shear stress are protected from inflammation and lesion development. Shear stress is sensed by the endothelium via mechanoreceptors and is subsequently transduced into biochemical signals resulting in modulation of proinflammatory signaling pathways. In this article, we address the molecular mechanisms behind the spatial localization of vascular inflammation and atherosclerosis, with particular focus on studies by our own group of two key proinflammatory signaling pathways, the mitogen-activated protein kinase pathway and the nuclear factor-kappa-B pathway.","PeriodicalId":88480,"journal":{"name":"F1000 medicine reports","volume":"3 ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3410/M3-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29922270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 106

MicroRNAs in cardiovascular disease. 微rna在心血管疾病中的作用。

F1000 medicine reports Pub Date : 2011-01-01 Epub Date: 2011-05-03 DOI: 10.3410/M3-10

Terry S Elton, Mahmood Khan, Dmitry Terentyev

引用次数: 9

Anti-addiction vaccines. 戒毒疫苗。

F1000 medicine reports Pub Date : 2011-01-01 Epub Date: 2011-10-03 DOI: 10.3410/M3-20

Xiaoyun Shen, Frank M Orson, Thomas R Kosten

引用次数: 8