Screening for pancreatic cancer: what can cyst fluid analysis tell us?

Walter G Park
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引用次数: 7

Abstract

Pancreatic cysts are increasingly recognized as a dilemma in clinical practice because of their uncertain risk of malignancy. Because diagnosis by cytology is insensitive, current guidelines suggest using radiographic and clinical criteria to determine the appropriateness of surgery or surveillance, although this is far from perfect. Several cyst fluid biomarkers have been reported to aid diagnosis, and to date, carcinoembryonic antigen is the most accurate in detecting potentially cancerous mucinous cysts, but not in detecting malignant cysts. Recent studies have highlighted novel cyst fluid biomarkers based on DNA analysis, protein expression profiling, and secreted proteins that, if validated, may improve diagnosis and management.

Abstract Image

胰腺癌筛查:囊肿液分析能告诉我们什么?
胰腺囊肿由于其恶性肿瘤的危险性不确定,越来越被认为是临床实践中的一个难题。由于细胞学诊断不敏感,目前的指南建议使用放射学和临床标准来确定手术或监测的适当性,尽管这还远远不够完美。据报道,一些囊肿液体生物标志物有助于诊断,迄今为止,癌胚抗原在检测潜在的癌性粘液囊肿方面是最准确的,但在检测恶性囊肿方面却不是。最近的研究强调了基于DNA分析、蛋白质表达谱和分泌蛋白的新型囊肿液生物标志物,如果得到验证,可能会改善诊断和管理。
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