Asian Journal of Organic & Medicinal Chemistry最新文献

Association of Cathepsin K and Tartrate- Resistant Acid Phosphatase-5b in Different Stages of Rheumatoid Arthritis Patients in South Indian Population 组织蛋白酶K和酒石酸盐抗性酸性磷酸酶5b在南印度人群不同阶段类风湿关节炎患者中的相关性

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2023-11-02 DOI: 10.14233/ajomc.2023.ajomc-p27954

Sharmil Thangavel, Ezhilarasi Krishnamoorthy, Shyam Sundar Jaganathan, Abirami M. Padmanaban, Shila Samuel

{"title":"Association of Cathepsin K and Tartrate- Resistant Acid Phosphatase-5b in Different Stages of Rheumatoid Arthritis Patients in South Indian Population","authors":"Sharmil Thangavel, Ezhilarasi Krishnamoorthy, Shyam Sundar Jaganathan, Abirami M. Padmanaban, Shila Samuel","doi":"10.14233/ajomc.2023.ajomc-p27954","DOIUrl":"https://doi.org/10.14233/ajomc.2023.ajomc-p27954","url":null,"abstract":"The aim of the study was to identify effective biomarkers of changes in bone mineral density (BMD) at different stages of rheumatoid arthritis patients from South Indian population, using disease activity score in 28 joints (DAS28) which is being used as a measurement for assessing disease activity in patients with rheumatoid arthritis. The study was carried out in 92 rheumatoid arthritis patients. Serum level of tartrateresistant acid phosphatase-5b (TRAP-5b) and cathepsin K was measured using ELISA. Serum rheumatoid factor (RF) and C-reactive protein (CRP) was recorded by the attending rheumatologists. The C-reactive protein (CRP) was quantified using a latex immunoturbidimetric method. The rheumatoid arthritis (RA) was measured by turbidimetric immunoassay method. The bone mineral density (BMD) T-score was calculated according to WHO guidelines. Reverse transcription PCR (RT-PCR) was used to determine the expression of cathepsin K. The rheumatoid arthritis (RA) patients were categorized into three groups based on the DAS28 score as inactive (DAS ≤ 3.2), moderately active (DAS > 3.2 ≤ 5.1) and very active (DAS > 5.1) at the time of admission. Out of 92 patients, 16 (17.4%) patients had inactive disease condition, 42 (45.6%) patients had moderately active disease condition and 34 (37%) patients had very active disease condition. The mean BMD was significantly lower in very active (0.28 ± 0.04; p < 0.001) as compared with moderately active (0.71 ± 0.13; p < 0.001) and inactive (1.21 ± 0.14). TRAP5b and cathepsin K showed significant increases in very active group (p < 0.001) as compared with moderately active (p < 0.001) and inactive groups. In conclusion, The biomarker TRAP-5b and cathepsin K identified in this study may become a new and highly specific biomarker for rheumatoid arthritis","PeriodicalId":8846,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"4 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135975082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly Novel Diastereoselective Synthesis of (E)-1-Aryl-1-alkenes 高度新颖的非对映选择性合成(E)-1-芳基-1-烯烃

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2023-11-02 DOI: 10.14233/ajomc.2023.ajomc-p27959

Narayan G. Bhat, Percal Lopez

引用次数: 0

Alkenylcopper Reagents Prepared from Stereodefined Alkenylboronate Esters. Reaction with Allylic Halides as a Convenient Route to Stereodefined 1,4-Dienes 由立体硼酸烯基酯制备的烯基铜试剂。与烯丙基卤化物反应制备立体1,4-二烯的便捷途径

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2023-11-02 DOI: 10.14233/ajomc.2023.ajomc-p27957

Narayan G. Bhat

引用次数: 0

Synthesis, DFT Calculations, DNA Binding and Molecular Docking Studies on BiologicallyActive N-((3-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)naphthyl Derivatives 生物活性N-((3-(4-甲氧基苯基)-1-苯基- 1h -吡唑-4-基)亚甲基)萘基衍生物的合成、DFT计算、DNA结合及分子对接研究

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-12-31 DOI: 10.14233/ajomc.2021.ajomc-p351

P. Sandhya, K. S. Femina, A. Pradeep

引用次数: 0

Synthesis, Characterization and in vitro Anticancer Studies of New Co(II), Ni(II), Cu(II) andZn(II) Complexes of (E)-4-((Quinoline-8-ylimino)methyl)benzene-1,2,3-triol Ligand 新型Co(II)、Ni(II)、Cu(II)和zn (II)配合物(E)-4-((喹啉-8-酰基)甲基)苯-1,2,3-三醇配体的合成、表征及体外抗癌研究

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-12-31 DOI: 10.14233/ajomc.2021.ajomc-p345

A. Sanjeev, N. Naresh Reddy, M. Kumara Swamy, Rohini Rondla, S. R. Reddy, P. Muralidhar Reddy

{"title":"Synthesis, Characterization and in vitro Anticancer Studies of New Co(II), Ni(II), Cu(II) and\u0000Zn(II) Complexes of (E)-4-((Quinoline-8-ylimino)methyl)benzene-1,2,3-triol Ligand","authors":"A. Sanjeev, N. Naresh Reddy, M. Kumara Swamy, Rohini Rondla, S. R. Reddy, P. Muralidhar Reddy","doi":"10.14233/ajomc.2021.ajomc-p345","DOIUrl":"https://doi.org/10.14233/ajomc.2021.ajomc-p345","url":null,"abstract":"Herein, a new tridentate (NNO) Schiff base ligand, (E)-4-[(quinoline-8-ylimino)methyl]benzene-1,2,3-\u0000triol derived from the condensation of 8-aminoquinoline with 2,3,4-trihydroxy benzaldehyde is reported.\u0000The ligand was complexed with certain metal ions like Co(II) (1), Ni(II) (2), Cu(II) (3), Zn(II) (4) and\u0000were characterized by various spectroscopic and analytical techniques such as FT-IR, UV-Vis, 1H\u0000NMR, 13C NMR, ESI-Mass, ESR, elemental analysis and magnetic susceptibility. Spectral data revealed\u0000octahedral geometry for cobalt(II), nickel(II), copper(II) complexes and tetrahedral geometry for zinc(II)\u0000complex. All the metal(II) complexes along with the Schiff base ligand were screened for their anticancer\u0000activities. The CT-DNA binding studies revealed high binding propensity for metal complexes with\u0000Kb values 1.50 × 104 M-1 for 1; 3.62 × 104 M-1 for 2; 2.53 × 104 M-1 for 3 and 1.8 × 104 M-1 for 4,\u0000respectively. Anticancer studies against A549 & MCF-7 demonstrated excellent antiproliferative activity\u0000with IC50 values in the range 17.62-48.82 μM. A standard drug cisplatin was employed to compare the\u0000activity of metal complexes. The complexes exhibited remarkable antitumour activity due to their\u0000high binding ability with DNA. It is interesting to observe that the complexes did not produce any\u0000cytotoxicity towards the normal cell lines.","PeriodicalId":8846,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80233929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eco-friendly Synthesis of Some New Benzylidene-iminothiazolyl-pyrazol-3-ol Derivatives viaOne-Pot Multicomponent Reaction and Evaluation of Antioxidant Activities 一锅多组分反应环境友好合成新型苄基-亚氨基噻唑-吡唑-3-醇衍生物及抗氧化活性评价

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-12-31 DOI: 10.14233/ajomc.2021.ajomc-p348

Ajay N Ambhore

引用次数: 0

Cytotoxicity and Antibacterial Studies of Newly Synthesized NovelHeterocylcic Pyridine Derivative and its Metal Complexes 新合成的新型杂环吡啶衍生物及其金属配合物的细胞毒性和抗菌研究

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-12-31 DOI: 10.14233/ajomc.2021.ajomc-p343

B.R. Chaitanya Kumar, K. Sudhakar Babu, J. Latha

{"title":"Cytotoxicity and Antibacterial Studies of Newly Synthesized Novel\u0000Heterocylcic Pyridine Derivative and its Metal Complexes","authors":"B.R. Chaitanya Kumar, K. Sudhakar Babu, J. Latha","doi":"10.14233/ajomc.2021.ajomc-p343","DOIUrl":"https://doi.org/10.14233/ajomc.2021.ajomc-p343","url":null,"abstract":"A pyridine derivative 2-((E)-1-(2-hydrazinyl-4-methyl-6-phenyl-pyridine-3-carboyl)ethyl)pyridine-4-\u0000carbonitrile (CPHPC) ligand and its 3d-metal(II) complexes has been synthesized (where [M = Co(II),\u0000Ni(II) and Cu(II)]. The physico-chemical, analytical data, UV-Vis, FT-IR, 1H NMR and ESR spectrum\u0000methods were used to characterize all of the synthesized complexes. Spectral investigations of metal(II)\u0000complexes revealed that the metal ion is surrounded by an octahedral geometry. Low conductance\u0000values indicated that the metal(II) complexes behave as non-electrolyte. The cytotoxic activity on\u0000lung cancer cell lines and hepatic cancer cell lines A549 and HepG2, respectively, with the ligand and\u0000their metal complexes were tested with MTT assay. The ligand and its metal complexes were tested\u0000for diverse harmful bacterial strains using the agar well diffusion method on Gram-negative bacteria\u0000such as Pseudomonas desmolyticum, Escherichia coli and Klebsiella aerogenes, as well as Gram-positive\u0000bacteria Staphylococcus aureus.","PeriodicalId":8846,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73803111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Silver Nanoparticle Using Bioactive Phenolic Compound Extracts ofLeucas aspera and Leucas cephalotes and Evaluation of its Antibacterial Activity 用白桦和白桦生物活性酚类化合物提取物合成纳米银及其抗菌活性评价

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-12-31 DOI: 10.14233/ajomc.2021.ajomc-p355

M. Kausar, B. Manjunatha, C. Purvika, Mizba Farkana

{"title":"Synthesis of Silver Nanoparticle Using Bioactive Phenolic Compound Extracts of\u0000Leucas aspera and Leucas cephalotes and Evaluation of its Antibacterial Activity","authors":"M. Kausar, B. Manjunatha, C. Purvika, Mizba Farkana","doi":"10.14233/ajomc.2021.ajomc-p355","DOIUrl":"https://doi.org/10.14233/ajomc.2021.ajomc-p355","url":null,"abstract":"The present study was carried out to investigate the antibacterial activity of the bioactive phenolic extract\u0000from Leucas aspera and Leucas cephalotes. The phenolic compounds were extracted using water:\u0000ethanol (1:3, v/v) by hydroethanolic extraction method. The hydroethanolic extracts were subjected to\u0000qualitative and FTIR analysis as a confirmatory step for the presence of phenolics. Synthesis of silver\u0000nanoparticle from both plants was carried out by acid hydrolysis method and subjected to UV-visible\u0000spectrophotometry, SEM, TEM and XRD analysis, for confirmation of tagged bioactive compound to\u0000AgNO3. The nanoparticle size distribution ranged between 50-94 nm in L. aspera and 40-67 nm in L.\u0000cephalotes. The antibacterial study was carried out using both crude phenolic extract and synthesized\u0000nanoparticles and tested against 5 pathogens namely Escherichia coli (ATCC® 8739™), Pseudomonas\u0000aeruginosa (ATCC® 25619™), Staphylococcus aureus (ATCC® 6538™), Bacillus subtilis (ATCC®\u000011774™) and Klebsiella pneumonia (ATCC® 13882™) for their antibacterial activity. From present\u0000study, the crude extract of L. cephalotes showed good antibacterial effect against test pathogen species\u0000wherein highest inhibition was observed in, P. aeruginosa, followed by B. subtilis and S. aureus with\u0000an average zone of inhibition of 23, 14 and 12 mm, E. coli and K. pneumonia measured 9 and 7 mm.\u0000The crude extract of L. aspera showed the highest inhibition in P. aeruginosa followed by S. aureus\u0000and E. coli with an average zone of inhibition of 12,11 and 10 mm B. subtilis and K. pneumonia\u0000measured 8 and 7 mm. Statistical analysis was calculated using One way ANOVA and was found to be\u0000statistically significant with p < 0.05.","PeriodicalId":8846,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79716419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Docking Studies of Dihydropyridazin-3(2H)-oneDerivatives as Anticonvulsant Agents 抗惊厥药二氢吡嗪-3(2H)- 1衍生物的分子对接研究

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-12-31 DOI: 10.14233/ajomc.2021.ajomc-p349

S. Prasad, S. L. Khokra, M. Devgun

引用次数: 0

A Gift of Good Health from Mother Nature: PresentingMoringa oleifera, a Plant with Multiple Anticancer Activities 大自然赐予健康的礼物:介绍具有多种抗癌活性的植物辣木

Asian Journal of Organic & Medicinal Chemistry Pub Date : 2021-12-31 DOI: 10.14233/ajomc.2021.ajomc-p350

M. Das Sarma

引用次数: 0