Biochemical Society transactions最新文献_第6页

Understanding carboxysomes to enhance carbon fixation in crops. 了解羧酶体促进作物固碳的作用。

IF 4.3 3区生物学

Biochemical Society transactions Pub Date : 2025-06-30 DOI: 10.1042/BST20253072

Nghiem Dinh Nguyen, Loraine M Rourke, Alexandra Cleaver, Joseph Brock, Benedict M Long, Dean G Price

引用次数: 0

How do different cell populations orchestrate myelin regeneration? 不同的细胞群如何协调髓磷脂再生？

IF 4.3 3区生物学

Biochemical Society transactions Pub Date : 2025-06-30 DOI: 10.1042/BST20231085

Sara Grassi, Alessandro Prinetti

{"title":"How do different cell populations orchestrate myelin regeneration?","authors":"Sara Grassi, Alessandro Prinetti","doi":"10.1042/BST20231085","DOIUrl":"10.1042/BST20231085","url":null,"abstract":"Approximately 35 in 100,000 people are affected by diseases associated with loss of myelin, generally described as demyelinating diseases. Demyelinating diseases encompass many different pathological conditions characterized by heterogeneous and sometimes disease-specific etiopathological mechanisms. While several approaches aimed at ameliorating the symptoms and the progression of some of these diseases exist, the most effective cure for all demyelinating diseases would be regeneration of lost myelin. Myelin regeneration occurs spontaneously in the central nervous system in response to myelin damage but is inefficient for a variety of reasons, especially in human patients. In this review, we will discuss the contributions of different cell populations to the creation of conditions permissive for effective remyelination and to the formation of new myelin after injury. Moreover, we would like to highlight the importance of sphingolipids in the network of interactions between these cell populations. Mutations in genes encoding sphingolipid metabolic enzymes (such as GALC) represent a major risk factor for multiple sclerosis, and alterations in sphingolipid metabolism in specific cell types contribute to myelin damage. On the other hand, sphingolipid signaling, in particular through sphingosine 1 phosphate, directly affects the process of myelin regeneration, with distinct effects on different cellular populations.","PeriodicalId":8841,"journal":{"name":"Biochemical Society transactions","volume":" ","pages":"653-669"},"PeriodicalIF":4.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connecting tubules: mechanisms of endoplasmic reticulum membrane fusion. 连接小管：内质网膜融合机制。

IF 4.3 3区生物学

Biochemical Society transactions Pub Date : 2025-06-30 DOI: 10.1042/BST20253043

Eunhong Jang, Youngsoo Jun

引用次数: 0

Regulation of adipogenesis by nucleotides. 核苷酸对脂肪形成的调控。

IF 4.3 3区生物学

Biochemical Society transactions Pub Date : 2025-06-30 DOI: 10.1042/BST20253045

Julia A Pinette, Heather G Bryant, Jacob W Myers, Elma Zaganjor

引用次数: 0

Extracellular membrane particles en route to the nucleus - exploring the VOR complex. 胞外膜颗粒在通往细胞核的途中-探索VOR复合体。

IF 3.8 3区生物学

Biochemical Society transactions Pub Date : 2025-06-30 DOI: 10.1042/BST20253005

Aurelio Lorico, Mark F Santos, Jana Karbanová, Denis Corbeil

{"title":"Extracellular membrane particles en route to the nucleus - exploring the VOR complex.","authors":"Aurelio Lorico, Mark F Santos, Jana Karbanová, Denis Corbeil","doi":"10.1042/BST20253005","DOIUrl":"10.1042/BST20253005","url":null,"abstract":"Intercellular communication is an essential hallmark of multicellular organisms for their development and adult tissue homeostasis. Over the past two decades, attention has been focused on communication mechanisms based on various membrane structures, as illustrated by the burst of scientific literature in the field of extracellular vesicles (EVs). These lipid bilayer-bound nano- or microparticles, as vehicle-like devices, act as regulators in various biological and physiological processes. When EVs are internalized by recipient cells, their membrane and cytoplasmic cargoes can interfere with cellular activities, affecting pathways that regulate cell proliferation, differentiation, and migration. In cancer, EVs can transfer oncogenic factors, stimulate neo-angiogenesis and immunosuppression, reprogram stromal cells, and confer drug resistance traits, thereby remodeling the surrounding microenvironment. Although the mechanisms underlying EV biogenesis and uptake are now better understood, little is known about the spatiotemporal mechanism(s) of their actions after internalization. In this respect, we have shown that a fraction of endocytosed EVs reaches the nuclear compartment via the VOR (VAP-A-ORP3-Rab7) complex-mediated docking of late endosomes to the outer nuclear membrane in the nucleoplasmic reticulum, positioning and facilitating the transfer of EV cargoes into the nucleoplasm via nuclear pores. Here, we highlight the EV heterogeneity, the cellular pathways governing EV release and uptake by donor and recipient cells, respectively, and focus on a novel intracellular pathway leading to the nuclear transfer of EV cargoes. We will discuss how to intercept it, which could open up new avenues for clinical applications in which EVs and other small extracellular particles (e.g., retroviruses) are implicated.","PeriodicalId":8841,"journal":{"name":"Biochemical Society transactions","volume":" ","pages":"529-546"},"PeriodicalIF":3.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in understanding the mechanisms of the human papillomavirus oncoproteins. 人乳头瘤病毒癌蛋白机制的研究进展。

IF 3.8 3区生物学

Biochemical Society transactions Pub Date : 2025-06-30 DOI: 10.1042/BST20253041

Denise Ijeoma Obanya, Louisa M Wootton, Ethan L Morgan

引用次数: 0

Cdk activation by phosphorylation: linking growth signals to cell cycle control. 磷酸化激活Cdk：将生长信号与细胞周期控制联系起来。

IF 3.8 3区生物学

Biochemical Society transactions Pub Date : 2025-05-09 DOI: 10.1042/BST20253004

Heidi M Blank, Eun-Gyu No, Michael Polymenis

引用次数: 0

Recent advances in understanding the role of extracellular vesicles from probiotics in intestinal immunity signaling. 益生菌胞外囊泡在肠道免疫信号传导中的作用研究进展。

IF 3.8 3区生物学

Biochemical Society transactions Pub Date : 2025-04-30 DOI: 10.1042/BST20240150

Atsushi Kurata, Koichi Uegaki

引用次数: 0

Single-molecule study of the dynamics of the molecular chaperone Hsp70 during the functional cycle. 分子伴侣蛋白Hsp70在功能周期中的单分子动力学研究。

IF 3.8 3区生物学

Biochemical Society transactions Pub Date : 2025-04-30 DOI: 10.1042/BST20230831

Huimin Hu, Ming Yang, Sarah Perrett, Si Wu

{"title":"Single-molecule study of the dynamics of the molecular chaperone Hsp70 during the functional cycle.","authors":"Huimin Hu, Ming Yang, Sarah Perrett, Si Wu","doi":"10.1042/BST20230831","DOIUrl":"10.1042/BST20230831","url":null,"abstract":"The 70-kDa heat shock protein, Hsp70, is a key chaperone involved in cellular protein homeostasis. The structure of the Hsp70 protein family is highly conserved, including a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). ATP binding and hydrolysis in the NBD of Hsp70 regulates the binding and release of substrates in the SBD via interdomain allosteric communication. Growing evidence shows that the conformational dynamics of Hsp70 are crucial for its function, which are difficult to probe by traditional bulk-based methods. Single-molecule techniques are emerging as powerful tools to explore the dynamics of proteins that are obscured in bulk measurements. In this review, we summarize recent progress in the study of the molecular dynamics of Hsp70 and its interactions with cochaperones and substrates using single-molecule fluorescence spectroscopy and single-molecule force spectroscopy. We discuss how the application of single-molecule techniques facilitates a deeper understanding of the mechanistic details of the chaperone functions of Hsp70.","PeriodicalId":8841,"journal":{"name":"Biochemical Society transactions","volume":"53 2","pages":"461-471"},"PeriodicalIF":3.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of neuronal ankyrin localization and function by post-translational modifications. 翻译后修饰对神经元锚蛋白定位和功能的调控。

IF 3.8 3区生物学

Biochemical Society transactions Pub Date : 2025-04-30 DOI: 10.1042/BST20253016

Kalynn M Bird, Paul M Jenkins

{"title":"Regulation of neuronal ankyrin localization and function by post-translational modifications.","authors":"Kalynn M Bird, Paul M Jenkins","doi":"10.1042/BST20253016","DOIUrl":"10.1042/BST20253016","url":null,"abstract":"Ankyrins are a family of intracellular scaffolding proteins that control the subcellular localization of a host of critically important signaling proteins within neurons, including many proteins associated with neurological disease. Ankyrin proteins are a vital component of the neuron. These scaffolding proteins must be spatially and temporally arranged to interact with their binding partners and facilitate proper neuronal signaling. Dysfunction of ankyrins is associated with neurodevelopmental disorders such as epilepsy and autism spectrum disorder. Despite the high degree of sequence similarity between ankyrin proteins, they display almost completely nonoverlapping localization and function. How ankyrins localize to the correct subcellular compartments to interact with their binding partners and complete their distinct roles remains poorly understood. Emerging evidence suggests that post-translational modifications may play a key part in this process. Some of the post-translational modifications that have been identified to regulate ankyrins are phosphorylation, ubiquitination, and palmitoylation. These modifications affect proper interactions, function, and localization of ankyrin proteins, which highlights their potential role in disease. This review will give an overview of neuronal ankyrins, and how post-translational modifications could be utilized to regulate protein localization and function in the context of neurological disease.","PeriodicalId":8841,"journal":{"name":"Biochemical Society transactions","volume":"53 2","pages":"497-507"},"PeriodicalIF":3.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0