Peter J Castagna, Matthew Calamia, Scott Roye, Steven G Greening, Thompson E Davis
{"title":"The effects of childhood inattention and anxiety on executive functioning: inhibition, updating, and shifting.","authors":"Peter J Castagna, Matthew Calamia, Scott Roye, Steven G Greening, Thompson E Davis","doi":"10.1007/s12402-019-00306-7","DOIUrl":"https://doi.org/10.1007/s12402-019-00306-7","url":null,"abstract":"<p><p>Although anxiety and attention-deficit/hyperactivity disorder (ADHD) symptoms are highly comorbid, research has generally examined the executive functioning (EF) deficits associated with each of these symptoms independently. The purpose of this study was to examine the unique and interactive effects of anxiety and ADHD symptoms (first respectively, then collectively) on multiple dimensions of EF (i.e., inhibition, updating, and shifting, respectively). A sample of 142 youth from the community (age range 8-17 years; M<sub>age</sub> = 11.87 ± 2.94 years) completed the Delis-Kaplan Executive Function System and dimensional measures of anxiety, inattention, and hyperactivity/impulsivity. It was hypothesized that anxiety would moderate the effect of ADHD symptomatology on EF. Multiple regression models examined anxiety and ADHD symptom domains as predictors of EF. When examining ADHD symptom domains separately, anxiety moderated the relationship between inattention and both updating and shifting; the association between hyperactivity/impulsivity and updating was also moderated by anxiety. Within the full model including both ADHD symptom domains, results indicated that anxiety moderated the relationship between inattention and shifting. Analyses of ADHD symptoms in separate and combined models demonstrated a similar pattern: Increased inattention was associated with worse EF and when anxiety was a significant moderator, and increased ADHD symptoms were associated with worse EF only for those with high levels of anxiety. These results highlight the utility of including anxiety in studies examining the relationship between ADHD and EF. EF is related to multiple aspects of daily functioning (e.g., academic achievement), and EF deficits are often targeted in interventions for ADHD.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 4","pages":"423-432"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-019-00306-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37417851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John Bernstein, Scott Roye, Matthew Calamia, Alyssa De Vito
{"title":"Utility of a novel simulator paradigm in the assessment of driving ability in individuals with and without attention-deficit hyperactivity disorder.","authors":"John Bernstein, Scott Roye, Matthew Calamia, Alyssa De Vito","doi":"10.1007/s12402-019-00303-w","DOIUrl":"https://doi.org/10.1007/s12402-019-00303-w","url":null,"abstract":"<p><p>This study aimed to evaluate the utility of a novel, more cost-effective driving simulator, Assetto Corsa (AC), in detecting differences in driving performance between individuals with and without ADHD. Driving simulators are a useful means of assessing driving performance in those with attention-deficit hyperactivity disorder (ADHD); however, they are frequently expensive and thus unavailable to many researchers. A total of 87 participants (16 with ADHD, 71 without) completed an AC driving simulator task. They also completed computerized measures of attention and executive functioning and a questionnaire assessing self-reported driving behaviors and anger, ADHD and related symptoms, and mind wandering. Relative to those without ADHD, participants with ADHD reached higher average ground speeds and more greatly utilized the throttle. They also applied higher maximum pressure to the throttle and brake pedals. Within the full sample, greater mind wandering was associated with average and maximum throttle pressure and maximum ground speed. Findings confirm prior works indicative of a deleterious effect of ADHD diagnosis on simulator performance and may be attributed to a combination of impulsivity and mind wandering.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 4","pages":"403-411"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-019-00303-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37148129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sebastiaan Dovis, Marija Maric, Pier J M Prins, Saskia Van der Oord
{"title":"Correction to: Does executive function capacity moderate the outcome of executive function training in children with ADHD?","authors":"Sebastiaan Dovis, Marija Maric, Pier J M Prins, Saskia Van der Oord","doi":"10.1007/s12402-019-00310-x","DOIUrl":"https://doi.org/10.1007/s12402-019-00310-x","url":null,"abstract":"<p><p>The original version of this article unfortunately contained a mistake. The captions of Figures 1 and 2 were swapped.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 4","pages":"461-462"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-019-00310-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37352183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Attention and behavioral control skills in Iranian school children.","authors":"Behnaz Kiani, Habib Hadianfard, John T Mitchell","doi":"10.1007/s12402-019-00289-5","DOIUrl":"https://doi.org/10.1007/s12402-019-00289-5","url":null,"abstract":"<p><p>This study assessed quality of life, emotional and behavioral problems, prosocial behavior, and functional impairment in a sample of Iranian children based on their attention and behavioral control skills. The sample consisted of 280 male and female children aged between 6 and 12 years old who were divided into strong, moderate, and weak groups based on parental ratings of attention and behavioral control skills on the strengths and weaknesses of ADHD symptom and normal behavior rating scale (SWAN). In addition, parents completed the pediatric quality of life inventory version 4.0 generic core scales (PedsQL 4.0), the strengths and difficulties questionnaire, and the Weiss functional impairment rating scale-parent report (WFIRS-P). The strong group generally showed better quality of life than the weak group. The strong group was better than the moderate group, and the moderate group was better than the weak group on school functioning. The weak group had more conduct problems and hyperactivity/inattention and less prosocial behavior than the moderate group and the strong group. The moderate group had more hyperactivity/inattention than the strong group. The weak group showed more impairment than the moderate group and the strong group on all subscales and the total scale of the WFIRS-P. The quality of life, behavioral problems, prosocial behavior, and functional impairment can be different in children based on their attention and behavioral control skills.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 3","pages":"263-270"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-019-00289-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36946846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How relevant is higher-order language deficit (HOLD) to children with complex presentations of attention-deficit hyperactivity disorder?","authors":"Rebecca Randell, Luke Somerville-Brown, Wai Chen","doi":"10.1007/s12402-018-0279-4","DOIUrl":"https://doi.org/10.1007/s12402-018-0279-4","url":null,"abstract":"<p><p>Attention-deficit hyperactivity disorder (ADHD) is frequently associated with language impairment, autism spectrum disorder (ASD) symptoms and higher-order language deficit (HOLD); yet, their complex relationship is poorly understood. HOLD encompasses deficits in using language for reasoning, problem-solving, causal and critical thinking. This study evaluates the roles of HOLD in children with ADHD. We hypothesise that both our subgroups (ADHD-only and ADHD + 'ASD traits') will have HOLD difficulties, though to a differing degree, as children with ADHD are compromised by executive function deficits, and those with additional ASD traits are further impaired by pragmatic language deficits. Data were reviewed from 36 children with ADHD (± 'ASD traits'), who attended the tier 4 statewide specialist clinic for ADHD patients non-responsive to community care. HOLD was assessed by the Test of Problem Solving-3 Elementary (TOPS-3). The age of the sample ranged from 6 to 12 years with a male-to-female ratio of 8:1. The rate of HOLD in our sample was 47.2% (published controls = 16%). Likewise, the rates of Making Inferences (50.0%, p < 0.001), Sequencing (44.4%, p < 0.001), Negative Questions (33.3%, p = 0.278), Problem-Solving (38.9%, p = 0.022), Predicting (27.8%, p = 0.022) and Determining Causes (30.6%, p = 0.022) were all elevated. When stratified, the rates in ADHD-only group and ADHD + 'ASD traits' group were 37.5% and 55.0%, respectively. Children with ADHD + 'ASD traits' had greater 'Sequencing' deficit. Our exploratory study confirms that HOLD is more common in children with ADHD, including deficits in Making Inferences, Sequencing, Problem-Solving, Predicting, Determining Causes and understanding Negative Questions. Our findings provide preliminary support for the potentially important role played by HOLD in neurodevelopmental disorders.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 3","pages":"325-332"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-018-0279-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36635657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew Stickley, Roman Koposov, Yoko Kamio, Hidetoshi Takahashi, Ai Koyanagi, Yosuke Inoue, Aki Yazawa, Vladislav Ruchkin
{"title":"Attention deficit/hyperactivity disorder and future expectations in Russian adolescents.","authors":"Andrew Stickley, Roman Koposov, Yoko Kamio, Hidetoshi Takahashi, Ai Koyanagi, Yosuke Inoue, Aki Yazawa, Vladislav Ruchkin","doi":"10.1007/s12402-019-00292-w","DOIUrl":"https://doi.org/10.1007/s12402-019-00292-w","url":null,"abstract":"<p><p>In recent years, there has been an increasing focus on the role of future expectations-the extent to which a future outcome is deemed likely-in the health and well-being of adolescents, with research linking future expectations to outcomes such as an increased likelihood of engaging in risky health behaviors. As yet, however, there has been no research on future expectations and attention deficit/hyperactivity disorder (ADHD) in adolescence. To address this research gap, the current study examined the association between ADHD symptoms/possible ADHD status and future expectations in a school-based sample of adolescents. Data were analyzed from 537 Russian adolescents (aged 12-17) with teacher-reported ADHD symptoms and self-reported future expectations. Logistic regression analysis was used to examine associations. In fully adjusted analyses, inattention symptoms/possible ADHD inattentive status was associated with lower future educational expectations, while a possible ADHD hyperactivity status was associated with increased odds for negative future expectations relating to work, family and succeeding in what is most important. The findings of this study suggest that greater ADHD symptoms/possible ADHD status in adolescence may be linked to an increased risk for negative future expectations across a variety of different life domains.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 3","pages":"279-287"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-019-00292-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37201536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD): a meta-analysis.","authors":"Evangelia Kotsi, Elisavet Kotsi, Despina N Perrea","doi":"10.1007/s12402-018-0276-7","DOIUrl":"https://doi.org/10.1007/s12402-018-0276-7","url":null,"abstract":"<p><p>The aim of this article was to assess the differences in serum 25(OH)D levels between children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and healthy controls. We used the PubMed (1966-2017), Scopus (2004-2017), ClinicalTrials.gov (2008-2017), Cochrane Central Register of Controlled Trials CENTRAL (2000-2017), and Google Scholar (2004-2017) databases. Statistical meta-analysis was performed with RevMan 5.3. Εight studies were finally included in the present meta-analysis with a total number of 11,324 children. Among them, 2655 were diagnosed with ADHD, while the remaining 8669 were recruited as healthy controls. All eight trials reported significantly lower serum concentrations of 25(OH)D in patients diagnosed with ADHD compared to healthy controls. The pooled data showed that there was a significant difference between the ADHD group and the control group (SMD = - 0.73, 95% CI [- 1.00, - 0.46]). The systematic review and meta-analysis of observational studies demonstrated an inverse association between serum 25(OH)D and young patients with ADHD. Large cohort studies are required to investigate whether vitamin D-deficient infants are more likely to develop ADHD in the future. Also, whether children with ADHD should be supplemented with higher doses of vitamin D3 remains to be confirmed through long-term controlled clinical trials.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 3","pages":"221-232"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-018-0276-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36667286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patients in medical treatment for attention deficit/hyperactivity disorder (ADHD): Are they at risk in drug screening?","authors":"Christina Mohr Jensen, Torben Breindahl","doi":"10.1007/s12402-018-0282-9","DOIUrl":"https://doi.org/10.1007/s12402-018-0282-9","url":null,"abstract":"<p><p>The use of medicines to treat attention deficit/hyperactivity disorder (ADHD) has increased worldwide, including the use of amphetamine-based medicines or prodrugs that metabolise to amphetamine in vivo. At the same time, drugs-of-abuse testing by non-specific, point-of-care immunoassay methods ('quick tests') has increased. This article discusses the risk of 'false positive' results or post-analytical misinterpretations of results when immunoassays are used to analyse biological samples from ADHD patients. A rapid evidence review was conducted to identify studies that have focused on the risk of 'false positive' test results in immunoassay testing of patients treated with atomoxetine, bupropion, clonidine, guanfacine, methylphenidate, and modafinil. There is only evidence to suggest that bupropion should cause 'false positive' immunoassay results. However, there is a lack of systematic, updated evaluations and validations of cross-reactivity patterns for immunoassays in the literature. Advanced laboratory methods can distinguish the use of medicines from illicit amphetamine by stereospecific analysis of dextro- and levoamphetamine; however, these analytical services are not commonly available for routine drug testing. The present situation calls for more awareness, proper education and information on these critical ethical issues in drug testing, both for clinicians, other healthcare professionals involved in drug testing and for patients in medical treatment for ADHD. The pitfalls of immunoassays due to cross-reactivity and insufficient specificity/sensitivity can have serious negative consequences for patients safety with regard to incorrect laboratory drug-testing results. Consequently, confirmatory laboratory analysis should always be performed for 'presumptive' positive immunoassay screening results.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 3","pages":"333-340"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-018-0282-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36814113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kirsten D Leaberry, Paul J Rosen, Kelly E Slaughter, Joseph Reese, Nicholas D Fogleman
{"title":"Temperamental negative affect, emotion-specific regulation, and concurrent internalizing and externalizing pathology among children with ADHD.","authors":"Kirsten D Leaberry, Paul J Rosen, Kelly E Slaughter, Joseph Reese, Nicholas D Fogleman","doi":"10.1007/s12402-019-00294-8","DOIUrl":"https://doi.org/10.1007/s12402-019-00294-8","url":null,"abstract":"<p><p>Children with attention-deficit/hyperactivity disorder (ADHD) experience high rates of temperamental negative affect and comorbid internalizing and externalizing pathology. The current study explored the role of emotion-specific regulation in accounting for the link between temperamental negative affect and psychopathology among children with ADHD. Forty parents of children ages 8-11 (N =29 males, N =11 females) completed measures of child temperament, emotion-specific dysregulation (i.e., anger dysregulation, sadness dysregulation), and psychopathology. Children completed a measure of emotion-specific dysregulation. Results revealed that anger dysregulation fully statistically accounted for the relationship between temperamental negative affect and concurrent externalizing problems. Sadness dysregulation did not account for the relationship between temperamental negative affect and internalizing problems. These novel findings implicate the robust role of anger dysregulation in explaining the link between temperamental negative affect and concurrent externalizing pathology. The results of this study have significant implications for the treatment of emotionally driven externalizing behavior among children with ADHD.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 3","pages":"311-324"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-019-00294-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37085299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tamsin Newlove-Delgado, William Hamilton, Tamsin J Ford, Ken Stein, Obioha C Ukoumunne
{"title":"Prescribing for young people with attention deficit hyperactivity disorder in UK primary care: analysis of data from the Clinical Practice Research Datalink.","authors":"Tamsin Newlove-Delgado, William Hamilton, Tamsin J Ford, Ken Stein, Obioha C Ukoumunne","doi":"10.1007/s12402-019-00288-6","DOIUrl":"https://doi.org/10.1007/s12402-019-00288-6","url":null,"abstract":"<p><p>Guidance on management of attention deficit hyperactivity disorder (ADHD) in the UK was issued by the National Institute for Clinical Excellence in 2008. No UK study has examined all psychotropic prescribing in young people with ADHD since the introduction of the guidance; this is especially relevant due to the high prevalence of psychiatric comorbidity in this population. The aim of this study was to describe primary care prescribing of ADHD and other psychotropic medications for young people with ADHD. The analysis of records of patients with an ADHD diagnosis in the UK Clinical Practice Research Datalink from 2005 to 2013 was performed. Estimation of the prevalence of prescribing of ADHD and other psychotropic medications over 8-year follow-up for cases aged 10-20 years in 2005 was carried out. Of 9390 ADHD cases, 61.6% [95% confidence interval (CI) 60.6-62.5%] had a prescription at some point for ADHD medication. Prescribing of other psychotropic medications was higher in girls than in boys (36.4% vs. 22.7%; p < 0.001). ADHD prescribing prevalence declined steeply between the ages of 16 and 18 from 37.8% (95% CI 36.6-38.9) to 23.7% (95% CI 22.7-24.6%). There was a parallel increase in prescribing of other psychotropics from 3.8% (95% CI 3.4-4.3%) to 6.6% (95% CI 6.0-7.3%). There is scope to optimise the management of ADHD and psychiatric comorbidities in young people, and there is a need for sustainable models of ADHD care for young adults, supported by appropriate training and specialist services.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 3","pages":"255-262"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-019-00288-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36938885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}