Biochemistry and Molecular Biology Education最新文献_第6页

An interdisciplinary course on computer-aided drug discovery to broaden student participation in original scientific research 关于计算机辅助药物发现的跨学科课程，以扩大学生对原创科学研究的参与。

IF 1.4 4区教育学

Biochemistry and Molecular Biology Education Pub Date : 2024-02-03 DOI: 10.1002/bmb.21811

Christopher Stratton, Avery Christensen, Chelsey Jordan, Brian A. Salvatore, Elahe Mahdavian

{"title":"An interdisciplinary course on computer-aided drug discovery to broaden student participation in original scientific research","authors":"Christopher Stratton, Avery Christensen, Chelsey Jordan, Brian A. Salvatore, Elahe Mahdavian","doi":"10.1002/bmb.21811","DOIUrl":"10.1002/bmb.21811","url":null,"abstract":"We present a new highly interdisciplinary project-based course in computer aided drug discovery (CADD). This course was developed in response to a call for alternative pedagogical approaches during the COVID-19 pandemic, which caused the cancellation of a face-to-face summer research program sponsored by the Louisiana Biomedical Research Network (LBRN). The course integrates guided research and educational experiences for chemistry, biology, and computer science students. We implement research-based methods with publicly available tools in bioinformatics and molecular modeling to identify and prioritize promising antiviral drug candidates for COVID-19. The purpose of this course is three-fold: I. Implement an active learning and inclusive pedagogy that fosters student engagement and research mindset; II. Develop student interdisciplinary research skills that are highly beneficial in a broader scientific context; III. Demonstrate that pedagogical shifts (initially incurred during the COVID-19 pandemic) can furnish longer-term instructional benefits. The course, which has now been successfully taught a total of five times, incorporates four modules, including lectures/discussions, live demos, inquiry-based assignments, and science communication.","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":"52 3","pages":"276-290"},"PeriodicalIF":1.4,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmb.21811","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the effectiveness of an introductory general chemistry course in dentistry students enrolled in a biochemistry course 评估普通化学入门课程对参加生物化学课程的牙科学生的效果。

IF 1.4 4区教育学

Biochemistry and Molecular Biology Education Pub Date : 2024-02-03 DOI: 10.1002/bmb.21816

Gloria Gutiérrez-Venegas, Marisol Rosas-Martínez, Itzel Juárez-Ramos, Jesús Iván Jiménez-Rivera

引用次数: 0

The implementation of an active inquiry learning centered “7E” teaching mode in the cell biology course enhances the learning effects of postgraduate students 在细胞生物学课程中实施以主动探究学习为中心的 "7E "教学模式，提高了研究生的学习效果。

IF 1.4 4区教育学

Biochemistry and Molecular Biology Education Pub Date : 2024-02-03 DOI: 10.1002/bmb.21818

Jingjing Han, Lina Zhang, Liucai Yang, Yougen Luo, Ruiqin Yao, Xuebin Qu

{"title":"The implementation of an active inquiry learning centered “7E” teaching mode in the cell biology course enhances the learning effects of postgraduate students","authors":"Jingjing Han, Lina Zhang, Liucai Yang, Yougen Luo, Ruiqin Yao, Xuebin Qu","doi":"10.1002/bmb.21818","DOIUrl":"10.1002/bmb.21818","url":null,"abstract":"The primary objective of science postgraduate education is to foster students' capacity for creative thinking and problem-solving, particularly in the context of scientific research quality. In order to achieve this goal, the “7E” teaching mood has been implemented in the cell biology course for postgraduate students to promote student-centered active inquiry learning instead of breaking away from traditional indoctrination-based teaching methods. This study demonstrates that the implementation of the “7E” teaching mode, through content programming, process design, and effect evaluation, effectively meets the needs of the majority of students, fosters their interest in learning, enhances their performance in comprehensive questioning, and enhances their innovative abilities in scientific research. Consequently, this research offers a theoretical framework and practical foundation for the development of the “7E” teaching mode in postgraduate courses, aiming to cultivate highly skilled scientific professionals.","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":"52 3","pages":"323-331"},"PeriodicalIF":1.4,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomedical students' satisfaction with and engagement in laboratory e-learning support are related to their self-regulation 生物医学专业学生对实验室电子学习支持的满意度和参与度与其自我调节有关。

IF 1.4 4区教育学

Biochemistry and Molecular Biology Education Pub Date : 2024-01-25 DOI: 10.1002/bmb.21810

C. B. Moelans, J. J. Geerling, R. D. Radersma, M. J. Moons, P. J. van Diest, M. F. van der Schaaf

{"title":"Biomedical students' satisfaction with and engagement in laboratory e-learning support are related to their self-regulation","authors":"C. B. Moelans, J. J. Geerling, R. D. Radersma, M. J. Moons, P. J. van Diest, M. F. van der Schaaf","doi":"10.1002/bmb.21810","DOIUrl":"10.1002/bmb.21810","url":null,"abstract":"Laboratory e-learning support tools can assist students' learning while preparing for laboratory classes. To successfully work in such virtual experimental environments (VEEs) outside class, students require self-regulated learning (SRL) skills. A deeper understanding of the continuous reciprocal interactions between SRL, satisfaction, and online engagement is needed to develop more effective online learning experiences. This study therefore aimed to explore the interconnection between students' satisfaction with, effort/importance and engagement in an exemplary VEE, and to relate this to their perceived SRL and learning outcomes. Based on surveys in 79 university students, SRL was related to VEE engagement, effort/importance, and satisfaction. VEE engagement and satisfaction were not related to learning outcomes, while SRL and effort were. Students with different SRL also tended to interact differently with the VEE and experienced differing degrees of procedural and feedback support by the e-environment. We conclude that, for optimal learning experience and outcomes, students' effort regulation and SRL need to be supported while interacting with the VEE, preferably by interventions that integrate personalized and adaptive features. This study has implications for designing and optimizing VEEs and indicates that future research should focus on VEEs taking students' SRL and effort regulation into account to support individual learners effectively.","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":"52 3","pages":"262-275"},"PeriodicalIF":1.4,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bmb.21810","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139544868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blended learning in biochemistry: The development of pre-class and post-class learning aids for electron transport chain and oxidative phosphorylation 生物化学混合学习：为电子传递链和氧化磷酸化开发课前和课后学习辅助工具。

IF 1.4 4区教育学

Biochemistry and Molecular Biology Education Pub Date : 2024-01-16 DOI: 10.1002/bmb.21809

Rebecca K. Y. Lee, Bernard Y. N. Ng, Daisy M. H. Chen

{"title":"Blended learning in biochemistry: The development of pre-class and post-class learning aids for electron transport chain and oxidative phosphorylation","authors":"Rebecca K. Y. Lee, Bernard Y. N. Ng, Daisy M. H. Chen","doi":"10.1002/bmb.21809","DOIUrl":"10.1002/bmb.21809","url":null,"abstract":"Electron transport chain and oxidative phosphorylation are always a challenging topic for students studying metabolism. We had adopted blended learning in metabolism teaching and evaluated the learning experiences of students. In this project, a pre-class learning aid the Story Mode and a post-class learning aid the Revision Mode in the Powerland was developed that facilitated students learning electron transport chain and oxidative phosphorylation. In the Story Mode, pathways were presented by short animations and simplified diagram that allowed students to understand basic concepts and recall simple facts of the topic. Students were asked to watch the animations before class to acquire lower level of cognitive learning first, and this facilitated students in understanding more complicated concepts later on during class. Another challenge that students faced was that they were especially weak at integrating metabolic pathways and understand the relationships between these pathways. A metro map was designed in the Revision Mode that aided students in knowledge integration, and the functions of biomolecules were summarized in flashcards that helped students in revising the concepts. This interactive self-learning tool was packaged as a courseware using the Articulate Storyline.","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":"52 2","pages":"220-227"},"PeriodicalIF":1.4,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139471766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of early scientific research skills training for medical undergraduates in China 中国医学本科生早期科研能力培训评估

IF 1.4 4区教育学

Biochemistry and Molecular Biology Education Pub Date : 2024-01-13 DOI: 10.1002/bmb.21806

Xueer Liu, Huiyu Chen, Xiaoying Liu, Teng Teng, Xuemei Li, Dan Zhu, Xinyu Zhou

{"title":"Assessment of early scientific research skills training for medical undergraduates in China","authors":"Xueer Liu, Huiyu Chen, Xiaoying Liu, Teng Teng, Xuemei Li, Dan Zhu, Xinyu Zhou","doi":"10.1002/bmb.21806","DOIUrl":"10.1002/bmb.21806","url":null,"abstract":"The medical field is facing a physician-scientist shortage, threatening future medical research and development. Medical institutions can contribute to developing physician-scientists by stimulating students' involvement in research. In this study, a medical undergraduate teaching module to develop research skills and encourage interest in research was held in Chongqing, China. Undergraduate medical students at Chongqing Medical University completed research skills training. Before and after the training, an online, anonymous, self-reported questionnaire was administered. The self-reported questionnaire investigated students' demographic characteristics, students' perception of attitudes toward conducting research, research skills (e.g., identifying and utilizing information, critical appraisal of literature, paper writing, and understanding of research), and feedback on scientific research training. The module was implemented with 25 students from July 2019 to October 2019, and 96.0% (N = 24) of participants responded to the questionnaire both prior to and after the training. In the evaluation of research skills, results showed that use of appropriate tools for research (Z = −3.340, p < 0.01), students' ability to undertake a focused literature search (Z = −3.40, p < 0.01), identifying and utilizing information (Z = −3.34, p < 0.01), and paper-writing skills (Z = −3.49, p < 0.01) were significantly improved after the undergraduates participated in the scientific research training. A qualitative analysis of the feedback showed that students found that the training helped to enhance their knowledge, improve their study scores, and motivate them to conduct research in the future. Early scientific research ability training strengthened the research skills of medical undergraduates and motivated them to pursue research.","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":"52 2","pages":"210-219"},"PeriodicalIF":1.4,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139458610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-focused laboratory experiments based on Quorum Sensing and Quorum Quenching for acquiring Microbial Physiology concepts 以 "法定人数感应 "和 "法定人数淬灭 "为基础的多重点实验室实验，以获取微生物生理学概念。

IF 1.4 4区教育学

Biochemistry and Molecular Biology Education Pub Date : 2024-01-13 DOI: 10.1002/bmb.21815

Mariela Analía Torres, Alejandra Leonor Valdez, Carolina de Lourdes Olea, María Fernanda Figueroa, Carlos Gabriel Nieto-Peñalver

{"title":"Multi-focused laboratory experiments based on Quorum Sensing and Quorum Quenching for acquiring Microbial Physiology concepts","authors":"Mariela Analía Torres, Alejandra Leonor Valdez, Carolina de Lourdes Olea, María Fernanda Figueroa, Carlos Gabriel Nieto-Peñalver","doi":"10.1002/bmb.21815","DOIUrl":"10.1002/bmb.21815","url":null,"abstract":"After a time away from the classrooms and laboratories due to the global pandemic, the return to teaching activities during the semester represented a challenge to both teachers and students. Our particular situation in a Microbial Physiology course was the necessity of imparting in shorter time, laboratory practices that usually take longer. This article describes a 2-week-long laboratory exercise that covers several concepts in an interrelated way: conjugation as a gene transfer mechanism, regulation of microbial physiology, production of secondary metabolites, degradation of macromolecules, and biofilm formation. Utilizing a Quorum Quenching (QQ) strategy, the Quorum Sensing (QS) system of Pseudomonas aeruginosa is first attenuated. Then, phenotypes regulated by QS are evidenced. QS is a regulatory mechanism of microbial physiology that relies on signal molecules. QS is related in P. aeruginosa to several virulence factors, some of which are exploited in the laboratory practices presented in this work. QQ is a phenomenon by which QS is interrupted or attenuated. We utilized a QQ approach based on the enzymatic degradation of the P. aeruginosa QS signals to evidence QS-regulated traits that are relevant to our Microbial Physiology course. Results obtained with the same test performed by a random group of students before and after the activities show the positive effectiveness of the approach presented in this work.","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":"52 3","pages":"359-368"},"PeriodicalIF":1.4,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Teaching biologics design using molecular modeling and simulations 利用分子建模和模拟教授生物制剂设计。

IF 1.4 4区教育学

Biochemistry and Molecular Biology Education Pub Date : 2024-01-10 DOI: 10.1002/bmb.21813

Andrew Phillips, Anusha Srinivas, Ilina Prentoska, Margaret O'Dea, Matthew Kustrup, Sarah Hurley, Savannah Bruno, Vy Nguyen, Pin-Kuang Lai

{"title":"Teaching biologics design using molecular modeling and simulations","authors":"Andrew Phillips, Anusha Srinivas, Ilina Prentoska, Margaret O'Dea, Matthew Kustrup, Sarah Hurley, Savannah Bruno, Vy Nguyen, Pin-Kuang Lai","doi":"10.1002/bmb.21813","DOIUrl":"10.1002/bmb.21813","url":null,"abstract":"Teaching chemistry and biology students about biologics design remains challenging despite its increasing importance in pharmaceutical development. Monoclonal antibodies, commonly called mAbs, are the most popular biologics. They have been developed into drugs to treat various diseases in the past decades. Multiple challenges exist for designing proper formulations to stabilize mAbs, such as preventing aggregation and mitigating viscosity. Molecular modeling and simulations can improve pharmaceutical products by examining the interactions between mAbs and other compounds, such as excipients. To introduce students to biopharmaceuticals, eight students at the Stevens Institute of Technology participated in a semester-long course to learn the challenges of pharmaceutical development and different computational skills to study biologics design. The students started with a limited background in this field. Throughout one semester, they were introduced to various literature and software tools for modeling antibodies and studying their interactions with excipients. This paper aims to develop a course structure to be replicated at other universities and institutions to teach biopharmaceutical development to students.","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":"52 3","pages":"299-310"},"PeriodicalIF":1.4,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139401635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Writing a literature review as a class project in an upper-level undergraduate biochemistry course 将撰写文献综述作为高年级本科生物化学课程的课堂项目。

IF 1.4 4区教育学

Biochemistry and Molecular Biology Education Pub Date : 2024-01-09 DOI: 10.1002/bmb.21814

Sanchita Hati, Sudeep Bhattacharyya

引用次数: 0

A comprehensive stem cell laboratory module with blended learning for medical students at Tongji University 为同济大学医科学生提供混合式学习的综合干细胞实验模块。

IF 1.4 4区教育学

Biochemistry and Molecular Biology Education Pub Date : 2024-01-08 DOI: 10.1002/bmb.21812

Jie Xu, Zhihua Shao, Song Jia, Jihong Sha, Jiao Li, Furong Gao, Xiujuan Shi, Juan Wang, Caixia Jin, Mei Jiang, Haibin Tian, Jinfeng Cao, Hu Pu, Lei Xu, Lixia Lu

{"title":"A comprehensive stem cell laboratory module with blended learning for medical students at Tongji University","authors":"Jie Xu, Zhihua Shao, Song Jia, Jihong Sha, Jiao Li, Furong Gao, Xiujuan Shi, Juan Wang, Caixia Jin, Mei Jiang, Haibin Tian, Jinfeng Cao, Hu Pu, Lei Xu, Lixia Lu","doi":"10.1002/bmb.21812","DOIUrl":"10.1002/bmb.21812","url":null,"abstract":"The laboratory practice “Primary culture and directional differentiation of rat bone marrow mesenchymal stem cells (BMSCs)” is part of a required course for sophomore medical students at Tongji university, which has been conducted since 2012. Blended learning has been widely applied in medical courses. Based on a student-centered teaching philosophy, we reconstructed a comprehensive stem cell laboratory module with blended learning in 2021, aiming to facilitate students in enhancing their understanding of the multi-lineage differentiation potential of stem cells and improve their experimental skills, self-directed learning ability, and innovative thinking. First, we constructed in-depth online study resources, including videos demonstrating laboratory procedures, a PowerPoint slide deck, and published literature on student self-learning before class. In class, students performed a primary culture of BMSCs, freely chose among adipogenic, osteogenic, or chondrogenic differentiation, and used cytochemical or immunofluorescence staining for identification. After class, the extracurricular part involved performing quantitative polymerase chain reaction to examine the expression of multi-lineage differentiation marker genes, which was designed as an elective. After 2 years of practice, positive feedback was obtained from both students and faculty members who achieved, the learning goal as expected. The reconstructed stem cell laboratory module provides comprehensive practice opportunities for students. Students have a better understanding of BMSC at the molecular, cellular, and functional levels and have improved their experimental skills, which forms a basis for scientific research for medical students. Introducing blended learning into other medical laboratory practices thus seems valuable.","PeriodicalId":8830,"journal":{"name":"Biochemistry and Molecular Biology Education","volume":"52 3","pages":"291-298"},"PeriodicalIF":1.4,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0