Journal of molecular and genetic medicine : an international journal of biomedical research最新文献

{"title":"Gender and Burnout Syndrome among Health Care Workers in Ethiopia - A Systematic Review and Meta-Analysis","authors":"Tegegne Kt, Tegegne Et, Tessema Mk, Bagajjo Ws","doi":"10.37421/1747-0862.2021.15.502","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.502","url":null,"abstract":"The purpose of this meta-analysis was to assess the association between Gender and Burn out syndrome among health care workers in Ethiopia. Previous findings on the association of gender and burn out syndrome have reported different results. We use data from four studies to do a metaanalysis. We applied the random-effects analytic model and calculated a pooled odds ratio. The odds ratios for all studies revealed no statistically significant association of Burn out syndrome with Male relative to Female (OR = 1.15; 95% CI: 0.48-2.71, Heterogeneity: Tau² = 0.55; Chi² = 12.17, df = 3 (P = 0.007); I² = 75%, Test for overall effect: Z = 0.31 (P = 0.76). The proportion of Burn out syndrome among male and female health professionals is 31.31% (578). 35.43% (302) respectively. The overall proportion of Burn out syndrome among health professionals is 32.73% (880).","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"15 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70061624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-Body MRI and Whole Body [123I]-I-mIBG Scintigraphy: a Comparison in Intermediate and High Risk Neuroblastoma and validation of SIOPEN Scoring System in WB-MRI","authors":"C. Olianti, A. Perrone, M. Allocca, M. DiMaurizio, F. Carra, G. Lacava, A. Tondo","doi":"10.37421/1747-0862.2021.15.505","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.505","url":null,"abstract":"Purpose: To assess the agreement between 123I-metaiodobenzylguanidine or [123I]-I-mIBG and Whole Body Magnetic Resonance Imaging with diffusion-weighted whole-body imaging with background body signal suppression (WB MRI-DWIBS) in High and Intermediate risk Neuroblastoma, a retrospective review was performed on [123I]-I-mIBG and DWIBS paired scans acquired at diagnosis, response-to-therapy, after-surgery, off therapy and after relapse with systemic involvement, and osteo-bone marrow metastatic load was evaluated for each of them. Methods: 80 paired [123I]-I-mIBG and DWIBS scans were acquired for 31 patients between June 2009 and June 2019 within 30 days and without intercurrent therapy. SIOPEN Semi-quantitative Scoring Systems for NB with 12 body sections was applied at whole body MIBG and WB MRI-DWIBS acquired to evaluate the skeletal disease extent. In each case thoracic-abdominal SPECT was used to confirm or exclude doubtful scintigraphic alterations. We evaluated specificity, sensitivity, overall accuracy, positive predictive value (PPV) and negative predictive value (NPV) of WB MRI-DWIBS respect [123I]-I-mIBG scintigraphy considered as gold standard. The inverse theoretical statistic exercise was performed for [123I]-I-mIBG respect DWIBS results. Results: DWIBS and [123I]-I-mIBG images were concordant in 890 out of the 960 analyzed segments, with high agreement between the two techniques (Kendal=0.85 P < 0.0001 and Chi 536.5975 P < 0.0001). Considering [123I]-I-mIBG as gold standard, WB MRI-DWIBS overall accuracy was 93%, sensitivity 78%, specificity 95%, PPV 77% and NPV 96%. Otherwise, on the theoretical statistic exercise, [123I]-I-mIBG overall accuracy was 93%; sensitivity 77%; specificity 97%; VPP 78%; VPN 95%, respect DWIBS. [123I]-I-mIBG and WB MRI-DWIBS SIOPEN scoring resulted superimposable (Rho Spearman=0.88, P < 0.0001). Conclusion: DWIBS and [123I]-I-mIBG images showed a very high concordance: a first validation of SIOPEN Scoring System seems possible on the basis of these data. WB MRI may represent an alternative in weak-avid MIBG tumors and for follow up assessment. A multimodal imaging protocol is proposed for High and Intermediate Risk protocols.","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"15 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70061745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Note for Genetic Aspects","authors":"B. Rita","doi":"10.37421/1747-0862.2021.15.473","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.473","url":null,"abstract":"","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"15 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70041460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated Condensing Osteopathy","authors":"D. André, F. Gouveia, H. Luís, J. Gaspar","doi":"10.37421/1747-0862.2021.15.475","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.475","url":null,"abstract":"A 32-year-old female patient, with no personal history or habitual medication of relief, resorted to the emergency department for pain complaints following trauma to the left hemithorax, with no associated fracture. Imagiologically, the presence of symmetrical radiopaque changes affecting the joint regions at the level of the humerus, femurs and pelvic girdle was verified. Both in the objective examination and analytically, there were no changes. The patient continued to be followed up in Internal Medicine, with the diagnosis of Osteopoikilosis. This benign entity, of autosomal dominant transmission with variable penetrance, is often diagnosed by chance. It afflicts both genders and tends to appear in childhood, persisting throughout the patient's life. As a rule, they have a symmetrical distribution and affect just-articular areas of the bone skeleton.","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"15 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70041519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Note for Special Issue on Molecular and Genetic Aspects of Covid 19","authors":"Shi-Wen Jiang","doi":"10.37421/1747-0862.2021.15.480","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.480","url":null,"abstract":"The Journal of Molecular and Genetic medicine seeks proposals for creating special issues that target specific topics of interest which have high significance to current research in all related fields of medical sciences. Special issues are to create collections of papers on specific topics. The main aim is to build a community of authors and readers to discuss the latest research and develop new ideas and research directions. The Special Issues are led by Guest Editors who are experts in the subject and oversee the editorial process for papers. Papers published in a Special Issue will be collected together on a dedicated page of the journal website.","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"1 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70061774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Note for Medicine Aspects","authors":"B. Rita","doi":"10.37421/1747-0862.2021.15.472","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.472","url":null,"abstract":"","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"15 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70041450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Note on Genetic Code","authors":"Jiang Sw","doi":"10.37421/1747-0862.2021.15.500","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.500","url":null,"abstract":"","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"15 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70061603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose-Derived Stem Cells: A New Player in Radiation Fibrosis Therapy","authors":"A. Ejaz, Rubin Jp","doi":"10.37421/1747-0862.2021.15.492","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.492","url":null,"abstract":"Radiation therapy (RT) is an important component of modern cancer management. RT inherent more benefits as compared to both chemotherapy and surgical intervention due to its cost effectiveness, targeted effects and organ saving properties. Despite the advancement in the field of radiation delivery, radiation induced side effects; mainly to the skin is the limiting factor in delivering high intensity therapeutic doses.","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"15 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70061808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Note for Healthcare Science","authors":"W. Wang","doi":"10.37421/1747-0862.2021.15.487","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.487","url":null,"abstract":"","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"15 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70061900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-operative Atrial Fibrillation at the Start of Atrial Fibrillation Burden","authors":"Mariana Fragão-Marques, F. Teixeira, I. Falcão-Pires, A. Leite-Moreira","doi":"10.37421/1747-0862.2021.15.496","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.496","url":null,"abstract":"Atrial Fibrillation (AF) is the most common persistent arrhythmia with adverse clinical outcomes. AF ectopic firing and re-entry depends on several mechanisms: (1) ion channel dysfunction; (2) Ca2+-handling abnormalities; (3) structural remodelling; (4) autonomic neural dysregulation. The oxidized CAMKII enzyme pathway establishes a connexion between redox imbalance and the electrical and functional cardiomyocyte properties altered in AF patients. Postoperative atrial fibrillation (PoAF) is the most common complication after cardiac surgery and a subtype of AF, associated with increased time spent in the intensive care unit (ICU), in-hospital stay, stroke incidence and 30-day and long-term mortality. Recent studies have implicated oxidative stress in AF pathophysiology including mechanisms such as an imbalance in reactive oxygen species (ROS) production, decreased endothelial nitric oxide synthase (eNOS) activity and nitric oxide unavailability. Indeed, NADPH oxidase enzymes (NOX) are largely responsible for this imbalance, which is supported by the beneficial effect of statins in early atrium electrical remodelling. Epicardial adipose tissue has a direct contact with the myocardium, located between the myocardium and visceral pericardium, and it has been established a clinical relationship between EAT and the development of AF. In this review, we explore pathophysiological mechanisms of AF and POAF, as well as its implications for management.","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"15 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70061932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}