Journal of molecular and genetic medicine : an international journal of biomedical research最新文献_第3页

Cell Systems Biology of Translation Factors and Proteasome-Targeted Protein Complexes Associated with AGC Kinase Sch 9 与AGC激酶相关的翻译因子和蛋白酶体靶向蛋白复合物的细胞系统生物学

Journal of molecular and genetic medicine : an international journal of biomedical research Pub Date : 2021-01-01 DOI: 10.37421/1747-0862.2021.15.470

A. Sobko

{"title":"Cell Systems Biology of Translation Factors and Proteasome-Targeted Protein Complexes Associated with AGC Kinase Sch 9","authors":"A. Sobko","doi":"10.37421/1747-0862.2021.15.470","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.470","url":null,"abstract":"Sch-9 appears to be the Saccharomyces cerevisiae homolog of protein kinase B and S6 kinase and is involved in the control of numerous nutrient-sensitive processes, including regulation of cell size, cell cycle progression, and stress resistance. Sch-9 has also been implicated in the regulation of replicative and chronological life span. The availability of data from global studies of protein-protein interactions now makes it possible to predict and validate functional connections between Sch-9, its putative substrates, and other proteins. Sch-9 appears to be involved in control of biosynthetic and catabolic pathways. Thus, the analysis of Sch-9-associated proteins indicates that this kinase may be involved in regulation of protein synthesis. Sch-9 forms a complex with, and, presumably, phosphorylates starvation- and stress-induced protein kinase GCN2, which, in turn, phosphorylates translation initiation factor eIF2-alpha. Sch-9 also interacts with translation factors Arc1, Pab1 and prion-like protein Sup-35. Thus, Sch-9 may be part of the mechanism that relays availability of nutrients to utilization of glucose and to the rates of protein synthesis. One of the interesting outcomes of the proteome-wide analysis of protein-protein interactions in yeast is the finding that Sch-9 associates with Shp1, Cdc48, and Ufd1, which form a complex responsible for the recognition and targeting of ubiquitinated proteins to the proteasome for degradation. It is unknown and remains to be elucidated, whether mammalian paralogues of Sch-9 are also associated with the proteins involved in translation/protein synthesis and proteasomal degradation.","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"15 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70041369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Molecular Linking of HIPEC (Hyperthermic Intraperitoneal Chemotherapy) and Tregs (Regulatory T- cells) in Advanced Epithelial Ovarian Cancer - A Review HIPEC(高温腹腔化疗)和Tregs(调节性T细胞)在晚期上皮性卵巢癌中的分子联系综述

Journal of molecular and genetic medicine : an international journal of biomedical research Pub Date : 2021-01-01 DOI: 10.37421/1747-0862.2021.15.471

Ray, Deo Svs, K. Luthra, S. Mathur, An, Ashok Sharma

{"title":"Molecular Linking of HIPEC (Hyperthermic Intraperitoneal Chemotherapy) and Tregs (Regulatory T- cells) in Advanced Epithelial Ovarian Cancer - A Review","authors":"Ray, Deo Svs, K. Luthra, S. Mathur, An, Ashok Sharma","doi":"10.37421/1747-0862.2021.15.471","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.471","url":null,"abstract":"The mainstay in the management of advanced epithelial ovarian cancer is platinum-based chemotherapy and complete cytoreductive surgery. Despite this, about two-thirds of patients have disease recurrence mostly within the peritoneal cavity. HIPEC (Hyperthermic Intraperitoneal Chemotherapy) is a modality that delivers cell-cycle non-specific chemotherapeutic agents along with heat 41°C to 43°C into the peritoneal cavity. HIPEC is done intra-operatively after achieving complete cytoreduction (which means after removal of all the tumor deposits more than 2.5 mm). Ovarian cancer is associated with the frequent finding of tumor-infiltrating lymphocytes in their tissue microenvironment. Especially studies have shown that ovarian cancer evades immune surveillance by higher expression of FOXP3 T cells. HIPEC has been used in the treatment of primary and recurrent tumors. In this review, we discuss how the significance of HIPEC on genetics and immunology of these patients with cancer have provided unique insights into the molecular and cellular basis of Treg cells. Studies of HIPEC and its association with Tregs cells should make it possible to increase the paucity of immuno- therapeutic modalities of most human cancer at an unprecedented level of molecular and cellular precision. The predictive, preventive, and therapeutic implications of these studies of HIPEC in relation to immunity in EOC may extend to patients with other peritoneal carcinomatosis.","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"543 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70041384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Note for Gene Therapeutics 《基因治疗》编辑说明

Journal of molecular and genetic medicine : an international journal of biomedical research Pub Date : 2021-01-01 DOI: 10.37421/1747-0862.2021.15.478

B. Rita

引用次数: 0

Editorial Note for Medicinal Biotechnology 《医药生物技术》编辑说明

Journal of molecular and genetic medicine : an international journal of biomedical research Pub Date : 2021-01-01 DOI: 10.37421/1747-0862.2021.15.479

B. Rita

引用次数: 0

Editorial Note on Molecular Genetics and Genomic Medicine 《分子遗传学与基因组医学》社论注释

Journal of molecular and genetic medicine : an international journal of biomedical research Pub Date : 2021-01-01 DOI: 10.37421/1747-0862.2021.15.499

B. Rita

引用次数: 0

Biosynthetic Gene Clusters in Organism: The Sole Source of New Drug Discovery 生物合成基因簇:新药发现的唯一来源

Journal of molecular and genetic medicine : an international journal of biomedical research Pub Date : 2021-01-01 DOI: 10.37421/1747-0862.2021.15.501

P. Chakraborty, A. Chakraborty

引用次数: 1

Editorial Note for Integrative Medicine 《中西医结合》编辑说明

Journal of molecular and genetic medicine : an international journal of biomedical research Pub Date : 2021-01-01 DOI: 10.37421/1747-0862.2021.15.485

R. Badigeru

引用次数: 0

Editorial Note on COVID-19: Coronavirus Vaccines 关于COVID-19:冠状病毒疫苗的社论说明

Journal of molecular and genetic medicine : an international journal of biomedical research Pub Date : 2021-01-01 DOI: 10.37421/1747-0862.2021.15.494

Jiang Sw

引用次数: 0

Percutaneous Electrolysis in Patients with Musculoskeletal Disorders: A Systematic Review 经皮电解法治疗肌肉骨骼疾病:系统综述

Journal of molecular and genetic medicine : an international journal of biomedical research Pub Date : 2021-01-01 DOI: 10.37421/1747-0862.2021.15.476

S. Varela-Rodríguez, Caceres-Pajuelo Je, S. Jl

{"title":"Percutaneous Electrolysis in Patients with Musculoskeletal Disorders: A Systematic Review","authors":"S. Varela-Rodríguez, Caceres-Pajuelo Je, S. Jl","doi":"10.37421/1747-0862.2021.15.476","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.476","url":null,"abstract":"Background: Musculoskeletal disorders are a leading cause of disability and loss of quality of life with a great economic impact. Percutaneous electrolysis is a minimally invasive technique with emerging evidence related to these pathologies. Objective: To examine the effectiveness of percutaneous electrolysis for musculoskeletal pain. Methods: A randomized clinical trials concerning percutaneous electrolysis were searched in the following electronic databases: PubMed, PEDro, CINAHL, MEDLINE, Scopus, Web of Science, Cochrane Library and ScienceDirect. Methodological quality was evaluated according to PEDro score. Risk of bias assessment was conducted using the Cochrane RoB 2 tool. These procedures were carried out by two independent researchers, with the participation of a third reviewer in case of disagreement. Results: Electronic databases searches identified a total of 175 results. After the study selection procedure, 7 studies published from 2015 to 2018 were finally included in the present review. These articles involved a total of 407 patients with different musculoskeletal disorders. Clinical outcomes were evaluated for pain and disability, usually reporting greater improvements in the group with percutaneous electrolysis. The mean score of PEDro scale was 7 points and overall risk of bias was generally reported as high. Conclusion: Percutaneous electrolysis appears to be an effective therapy for the improvement of pain and disability in patients with musculoskeletal disorders. However, the heterogeneity and the high risk of bias of the included studies should be taken into account. Further research is warranted to standardise percutaneous electrolysis application and generate protocols that would improve clinical outcomes.","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"15 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70041844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Polymorphism of Glutathione Sand#8209;Transferase M1 and T1 Genes and Susceptibility to Childhood Asthma: A Study from North India 谷胱甘肽沙#8209;转移酶M1和T1基因多态性与儿童哮喘易感性:一项来自印度北部的研究

Journal of molecular and genetic medicine : an international journal of biomedical research Pub Date : 2021-01-01 DOI: 10.37421/1747-0862.2021.15.477

Srivastava Dsl, K. Mittal, P. Jindal, A. Kumar

{"title":"Polymorphism of Glutathione Sand#8209;Transferase M1 and T1 Genes and Susceptibility to Childhood Asthma: A Study from North India","authors":"Srivastava Dsl, K. Mittal, P. Jindal, A. Kumar","doi":"10.37421/1747-0862.2021.15.477","DOIUrl":"https://doi.org/10.37421/1747-0862.2021.15.477","url":null,"abstract":"Objectives: Glutathione S-transferases (GSTs) enzymes play an important role in the xenobiotic biotransformation of endogenous or exogenous toxicants and thought to protect the airways from oxidative stress, inflammation, and genotoxicity. Polymorphisms in the GST genes may lead to an increased imbalance in antioxidant systems and may influence the pathogenesis of asthma. We examined the association of the GST gene polymorphism to ascertain whether high-risk genotypes of GSTM1/GSTT1 could influence the susceptibility to childhood asthma in the N orth Indian population. Methods: The study constituted of 100 childhood asthmatic cases and 180 age-matched controls. The GSTT1 and GSTM1 null genotypes were identified by multiplex PCR in peripheral blood DNA samples. Statistical analysis was done by using SPSS 20.0 soft ware. Results: No association was seen either the null genotype of the GSTM1 or GSTTT1 (P > 0.05); however, in atopy patients significant association were observed with null genotype of GSTT1 (OR=2.67; P<0.05) for risk of child hood asthma. In combined analysis of GSTM1/GSTT1, presence of null genotypes of GSTM1 G P<0.05) compared to positive genotypes of GSTM1 and GSTT1. When compared among gender, GSTT1 null genotype was found to be statistically significant in male (OR=2.71; P<0.005) as compared to female childhood asthmatic patients. Conclusion: In conclusion, null genotype of GSTT1 exhibits significant association for the risk of childhood asthma, especially in disease predisposition and initiation.","PeriodicalId":88269,"journal":{"name":"Journal of molecular and genetic medicine : an international journal of biomedical research","volume":"15 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70041858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0