Biochimica et biophysica acta. Molecular basis of disease最新文献_第8页

Biological agents as attractive targets for inflammatory bowel disease therapeutics 生物制剂作为炎症性肠病治疗的有吸引力的靶点。

IF 4.2 2区生物学

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-12-30 DOI: 10.1016/j.bbadis.2024.167648

Jia-Chen Xue , Xiao-Ting Hou , Yu-Wei Zhao , Shuo Yuan

引用次数: 0

IL-10 signaling modulates PRKN methylation and influences STAT3 activity to drive regulatory macrophage differentiation IL-10信号调节PRKN甲基化并影响STAT3活性，驱动调节性巨噬细胞分化。

IF 4.2 2区生物学

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-12-27 DOI: 10.1016/j.bbadis.2024.167643

Lihuan Wang , Lingzhi Xu , Shuo Song , Lihua Mo , Le Liu , Hanqing Zhang , Xiaojun Xiao , Aizhi Zhang , Huanping Zhang , Pingchang Yang

{"title":"IL-10 signaling modulates PRKN methylation and influences STAT3 activity to drive regulatory macrophage differentiation","authors":"Lihuan Wang , Lingzhi Xu , Shuo Song , Lihua Mo , Le Liu , Hanqing Zhang , Xiaojun Xiao , Aizhi Zhang , Huanping Zhang , Pingchang Yang","doi":"10.1016/j.bbadis.2024.167643","DOIUrl":"10.1016/j.bbadis.2024.167643","url":null,"abstract":"<div><div>The pathogenesis of many immune disorders is linked to regulatory macrophage dysfunction. The mechanism underlying it is unclear. The objective of this study is to examine the mechanism by which the PRKN ubiquitin protein ligase (PRKN) inhibits the development of regulatory macrophages (Mreg). In this study, dust mite antigens were used as the specific allergens to establish an airway allergy (AA) mouse model. Flow cytometry cell sorting was used to isolate macrophages from the airway tissues. According to the results, the <em>Prkn</em> gene inhibition led to an increase in the number of Mregs in macrophages. Mregs demonstrated the capacity to suppress Th2 polarization, in which IL-10 played a critical role. Pan macrophages isolated from <em>Prkn</em>-deficient mice were more capable of suppressing the activities of other immune cells. PRKN was required for maintaining the hyperubiquitous status of signal transducer and transcriptional activator-3 (STAT3) in macrophages. Exposure to dust mite antigen increased the expression of PRKN in macrophages. IL-10 suppressed PRKN in macrophages by inducing its promoter hypermethylation. PRKN inhibition mitigated the experimental AA. To sum up, PRKN maintains the hyper ubiquitous status of STAT3 and restricts the expression of IL-10 in macrophages, which compromises their immune suppressive functions. Inhibition of PRKN increases Mreg development and mitigates AA. The data suggest that the regulation of Mreg has translation potential to be used in the treatment of immune disorders such as AA.</div></div>","PeriodicalId":8821,"journal":{"name":"Biochimica et biophysica acta. Molecular basis of disease","volume":"1871 3","pages":"Article 167643"},"PeriodicalIF":4.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging insights into the role of microRNAs regulation of ferroptosis in hepatocellular carcinoma 在肝细胞癌中微rna调控铁下垂作用的新见解。

IF 4.2 2区生物学

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-12-27 DOI: 10.1016/j.bbadis.2024.167642

Qi Zhang, Yingdan Zhang, Shiyun Guo, Honggang Wang

引用次数: 0

GBP1 promotes acute rejection after liver transplantation by inducing Kupffer cells pyroptosis GBP1通过诱导库普弗细胞焦亡促进肝移植后急性排斥反应。

IF 4.2 2区生物学

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-12-26 DOI: 10.1016/j.bbadis.2024.167644

Haojiang Duan , Qingyao Chang , Huaxing Ding , Wenhao Shao , Yan Wang , Kairui Lu , Li Zhang , Jun Xu

{"title":"GBP1 promotes acute rejection after liver transplantation by inducing Kupffer cells pyroptosis","authors":"Haojiang Duan , Qingyao Chang , Huaxing Ding , Wenhao Shao , Yan Wang , Kairui Lu , Li Zhang , Jun Xu","doi":"10.1016/j.bbadis.2024.167644","DOIUrl":"10.1016/j.bbadis.2024.167644","url":null,"abstract":"<div><div>Liver transplantation is currently recognized as the most effective treatment for severe liver diseases. Although survival rates after liver transplantation have improved, rejection of the transplanted liver remains a significant cause of morbidity and transplant failure in patients. Our team previously discovered a close association between high GBP1 expression and acute rejection reactions following liver transplantation. Liver biopsies were conducted on patients who experienced acute rejection or successfully achieved immune tolerance post-transplantation. We confirmed that GBP1 was highly expressed in the acute rejection group after transplantation by Immunohistochemistry. This study aims to confirm that GBP1 promotes acute rejection reactions following liver transplantation through inducing pyroptosis in rat transplanted hepatic macrophages (KCs). We knocked down GBP1 in KCs and examined the extent of pyroptosis and the severity of acute rejection in the transplanted liver post-orthotopic liver transplantation in rats and KCs. These data provide new approaches for the study of liver transplant rejection reactions and identify new targets.</div></div>","PeriodicalId":8821,"journal":{"name":"Biochimica et biophysica acta. Molecular basis of disease","volume":"1871 3","pages":"Article 167644"},"PeriodicalIF":4.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation into the molecular mechanisms of biomarkers in psoriasis vulgaris with reduced high-density lipoprotein levels based on bulk transcriptome sequencing data 基于大量转录组测序数据的高密度脂蛋白水平降低的寻常型银屑病生物标志物的分子机制研究

IF 4.2 2区生物学

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-12-26 DOI: 10.1016/j.bbadis.2024.167638

Ying Tu , Xiaoqing Fan , Xiaoli Wang, Jue Qi, Yanjie Chai, Li He

{"title":"Investigation into the molecular mechanisms of biomarkers in psoriasis vulgaris with reduced high-density lipoprotein levels based on bulk transcriptome sequencing data","authors":"Ying Tu , Xiaoqing Fan , Xiaoli Wang, Jue Qi, Yanjie Chai, Li He","doi":"10.1016/j.bbadis.2024.167638","DOIUrl":"10.1016/j.bbadis.2024.167638","url":null,"abstract":"<div><div>It has been found that severe lipid metabolism disorders are often present in patients with Psoriasis, including decreased levels of high-density lipoprotein (HDL). This study initially explored the impact of HDL level variations on psoriasis by collecting. This study collected 12 blood samples and 9 skin samples from psoriasis vulgaris and psoriasis vulgaris with reduced HDL levels and performed bulk RNA sequencing. The genes expressed explicitly in both tissue and blood samples from psoriasis vulgaris patients with low HDL levels were selected to explore their molecular regulation in psoriasis vulgaris further, to elucidate the pathogenesis of psoriasis. A total of 421 specific DEGs in blood and 143 specific DEGs in skin from PN groups were obtained, and these genes were enriched in the terms and pathways related to inflammation and immune system. Also, biomarkers were screened out with same expression pattern in both blood and skin samples. Five intersecting differential genes (METRNL, NDEL1, HLA-DRA, MZB1, MKRN3) were obtained. Their function was further predicted. In conclusion, our research identified five biomarkers in psoriasis that are associated with low HDL levels. Furthermore, our findings revealed that alterations in HDL levels in psoriasis may exacerbate the clinical manifestations of psoriasis through regulation of immune response and lipid metabolism.</div></div>","PeriodicalId":8821,"journal":{"name":"Biochimica et biophysica acta. Molecular basis of disease","volume":"1871 3","pages":"Article 167638"},"PeriodicalIF":4.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of heart and neural crest derivatives-expressed protein factors in pregnancy 心脏和神经嵴衍生物表达蛋白因子在妊娠中的作用。

IF 4.2 2区生物学

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-12-24 DOI: 10.1016/j.bbadis.2024.167639

Chongying Zhu , Qiwei Yang , Qiang Xu , Yanhua Song , Chao Tang

引用次数: 0

Bilirubin nanoparticles modulate Treg/Th17 cells and functional metabolism of gut microbiota to inhibit lung adenocarcinoma 胆红素纳米颗粒调节Treg/Th17细胞和肠道微生物群的功能代谢抑制肺腺癌。

IF 4.2 2区生物学

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-12-23 DOI: 10.1016/j.bbadis.2024.167641

Xiaoling Zhu , Wenxiang Tang , Zili Fan , Shenghua Sun , Xiqing Tan

{"title":"Bilirubin nanoparticles modulate Treg/Th17 cells and functional metabolism of gut microbiota to inhibit lung adenocarcinoma","authors":"Xiaoling Zhu , Wenxiang Tang , Zili Fan , Shenghua Sun , Xiqing Tan","doi":"10.1016/j.bbadis.2024.167641","DOIUrl":"10.1016/j.bbadis.2024.167641","url":null,"abstract":"<div><div>The level of serum bilirubin is associated with the incidence of lung cancer in both smokers and non-smokers, but the specific mechanism is unknown. Bilirubin nanoparticles (BRNPs) were synthesized to explore the effects on Treg/Th17 immunity and gut microbiota in Lewis Lung Carcinoma (LLC) mice, to provide insights for the treatment of lung adenocarcinoma. 10 μg/mL BRNPs promoted apoptosis of A549, NCI-H1299 and LLC cells. BRNPs inhibited lung adenocarcinoma formation in smoking and non-smoking LLC mice. In vivo and in vitro co-culture system proved that BRNPs promoted apoptosis of LLC cells and Treg cell differentiation, and inhibited the cigarette smoke extract (CSE)-induced anti-apoptosis effect and Th17 cell differentiation. In non-smoking LLC mice, <em>Clostridium_sp</em> and <em>Alistipes_inops</em> may be the pathogenic strains for inflammatory infiltration, while <em>Staphylococcus</em>, bile acid, alanine, and glucose metabolism may serve as the therapeutic target in BRNPs group. Fecal supernatant from NPs mice could promote Th17 differentiation and anti-apoptotic effect of LLC cells, while blocking the in vitro pro-apoptotic effect of BRNPs. <em>Helicobacter_rodentium</em>, <em>Streptococcus_salivarius</em> and <em>Bifidobacterium_bifidum</em> and metabolism (lipopolysaccharide and linoleic acid, as well as TCA circulation) may be the potential target for BRNPs+smoke treatment. Fecal supernatant from NPs + smoke mice promoted the CSE-induced Th17 differentiation and the anti-apoptotic effect of LLC cells, but this effect was blocked after the BRNPs intervention. Thus, BRNPs promoted Treg/Th17 cell immunity to inhibit tumor development in both smoking and non-smoking LLC mice through gut microbiota. In addition, BRNPs' therapeutic effect in smoking LLC mice may be related to <em>Helicobacter_rodentium</em>, <em>Streptococcus_salivarius</em> and <em>Bifidobacterium_bifidum</em>.</div></div>","PeriodicalId":8821,"journal":{"name":"Biochimica et biophysica acta. Molecular basis of disease","volume":"1871 3","pages":"Article 167641"},"PeriodicalIF":4.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipidomics-driven drug discovery and delivery strategies in glioblastoma 脂质组学驱动的胶质母细胞瘤药物发现和递送策略。

IF 4.2 2区生物学

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-12-23 DOI: 10.1016/j.bbadis.2024.167637

Xiaohui Weng , Michael Gonzalez , Jeannes Angelia , Somayeh Piroozmand , Saleh Jamehdor , Amir Barzegar Behrooz , Hamid Latifi-Navid , Mazaher Ahmadi , Stevan Pecic

{"title":"Lipidomics-driven drug discovery and delivery strategies in glioblastoma","authors":"Xiaohui Weng , Michael Gonzalez , Jeannes Angelia , Somayeh Piroozmand , Saleh Jamehdor , Amir Barzegar Behrooz , Hamid Latifi-Navid , Mazaher Ahmadi , Stevan Pecic","doi":"10.1016/j.bbadis.2024.167637","DOIUrl":"10.1016/j.bbadis.2024.167637","url":null,"abstract":"<div><div>With few viable treatment options, glioblastoma (GBM) is still one of the most aggressive and deadly types of brain cancer. Recent developments in lipidomics have demonstrated the potential of lipid metabolism as a therapeutic target in GBM. The thorough examination of lipids in biological systems, or lipidomics, is essential to comprehending the changed lipid profiles found in GBM, which are linked to the tumor's ability to grow, survive, and resist treatment. The use of lipidomics in drug delivery and discovery is examined in this study, focusing on how it may be used to find new biomarkers, create multi-target directed ligands, and improve drug delivery systems. We also cover the use of FDA-approved medications, clinical trials that use lipid-targeted medicines, and the integration of lipidomics with other omics technologies. This study emphasizes lipidomics as a possible tool in developing more effective treatment methods for GBM by exploring various lipid-centric techniques.</div></div>","PeriodicalId":8821,"journal":{"name":"Biochimica et biophysica acta. Molecular basis of disease","volume":"1871 3","pages":"Article 167637"},"PeriodicalIF":4.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Ligation of CD180 contributes to endotoxic shock by regulating the accumulation and immunosuppressive activity of myeloid-derived suppressor cells through STAT3.” [Biochim Biophys Acta (BBA) - Mol Basis Dis 2019; 1865(3):535–546.] “CD180结扎通过STAT3调节髓源性抑制细胞的积累和免疫抑制活性，从而导致内毒性休克。”生物化学生物物理学报(BBA) - Mol Basis Dis 2019；1865(3): 535 - 546。]。

IF 4.2 2区生物学

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-12-20 DOI: 10.1016/j.bbadis.2024.167622

Guanjun Dong , Xiaoying Yao , Fenglian Yan , Hui Zhang , Yuzhen Zhu , Yonghong Yang , Hui Shi , Junfeng Zhang , Zhaochen Ning , Cuiling Wang , Panpan Cheng , Yuan Hu , Qun Ma , Jun Dai , Zhihua Li , Chunxia Li , Jiankuo Ming , Xuehui Li , Chuanping Si , Huabao Xiong

引用次数: 0

Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier 轻至中度牛皮癣与十二指肠亚临床炎症和肠屏障紊乱的倾向有关。

IF 4.2 2区生物学

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2024-12-19 DOI: 10.1016/j.bbadis.2024.167634

Patrik Lundquist , Eva Hagforsen , Michael Wagner , Mohammad Alimohammadi , Fabio Rabelo Melo , Gunnar Pejler , Per Artursson , Marie Carlson , Ola Rollman , Maria Lampinen

{"title":"Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier","authors":"Patrik Lundquist , Eva Hagforsen , Michael Wagner , Mohammad Alimohammadi , Fabio Rabelo Melo , Gunnar Pejler , Per Artursson , Marie Carlson , Ola Rollman , Maria Lampinen","doi":"10.1016/j.bbadis.2024.167634","DOIUrl":"10.1016/j.bbadis.2024.167634","url":null,"abstract":"<div><div>Psoriasis is a chronic skin disease occasionally associated with abdominal symptoms and IBD. We aimed to characterize intestinal immune cells and the integrity of the intestinal barrier in psoriasis. Biopsies from the duodenum and colon were analyzed by flow cytometry and immunohistochemistry for the presence and activation status of different immune cell populations. Intestinal permeability was measured using Ussing chambers. Proinflammatory markers were analyzed in fecal and blood samples using ELISA. The intestinal level of inflammatory mediators was assessed using a multiplex proximity extension assay. We found an increased density of intestinal eosinophils, mast cells, macrophages, and CD8<sup>+</sup> T-cells in psoriasis; eosinophils, macrophages, and CD8+ T-cells expressed activation markers. Half of the psoriasis patients showed increased permeability across the duodenum, correlating with increased mucosal IL-17A, IL-13, IL-2, and IL-20, and with gastrointestinal symptoms. Our findings reveal that psoriasis is associated with low-grade intestinal inflammation, which may contribute to abdominal symptoms in these patients and possibly set the stage for the development of intestinal disease.</div></div>","PeriodicalId":8821,"journal":{"name":"Biochimica et biophysica acta. Molecular basis of disease","volume":"1871 3","pages":"Article 167634"},"PeriodicalIF":4.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0