脑卒中多肽药物的临床研究进展。

Yan Huo, Zhe Zhang, Suzhen Dong, Yijie Du, Mingliang Ma
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引用次数: 0

摘要

中风仍然是全球死亡和残疾的主要原因,目前可用的治疗方案有限。幸运的是,肽药物已经成为治疗中枢神经系统疾病(包括中风)的有希望的候选药物。它们具有高特异性、低毒性和有效穿透血脑屏障的特点,显示出显著的治疗潜力。本文系统地介绍了几种有前景的多肽药物,分析了它们的作用机制、临床试验的治疗效果和潜在的应用前景。它还解决了用于中风治疗的肽药物开发中的关键挑战,例如优化剂量策略,增强稳定性和改进给药系统。对当前临床证据的分析表明,基于肽的治疗方法代表了卒中治疗的一个有前景的前沿,可能为患者提供新的治疗选择。这篇综述不仅强调了肽药物的发展现状,也为未来推进脑卒中治疗的方向提供了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in clinical studies of peptide drugs in stroke disease.

Stroke remains a leading cause of death and disability globally, with limited treatment options currently available. Fortunately, peptide drugs have emerged as promising candidates for treating central nervous system disorders, including stroke. They offer high specificity, low toxicity, and efficient blood-brain barrier penetration, demonstrating significant therapeutic potential. This review systematically introduces several promising peptide drugs, analyzing their mechanisms, therapeutic efficacy in clinical trials, and potential applications. It also addresses critical challenges in peptide drug development for stroke therapy, such as optimizing dosing strategies, enhancing stability, and improving delivery systems. The analysis of current clinical evidence suggests that peptide-based therapeutics represent a promising frontier in stroke treatment, potentially offering new therapeutic options for patients. This comprehensive review not only highlights the current status of peptide drug development but also provides insights into future directions for advancing stroke therapy.

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