空腹胰岛素对特发性中枢性性早熟女孩维生素D水平的调节作用

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2025-07-03 DOI:10.1016/j.bbadis.2025.167966

Jun Sun , Ya Xiao , Shu-qin Jiang , Hong-ru Zhang , Wen-hui Shi , Jin-bo Li , Ying Yang , Wei Wang

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引用次数: 0

摘要

背景：维生素D缺乏（VDD）是特发性中枢性性早熟（ICPP）的危险因素，但其机制尚不清楚。维生素D （Vit D）与胰岛素的关系提示空腹胰岛素（FINS）可能在Vit D对ICPP发生的影响中起作用。目的探讨FINS在维生素D对女孩ICPP风险的影响中的作用。方法对91例ICPP女童和47例生长正常女童进行回顾性分析。收集了生长参数、第二性征、实验室检查结果和影像学结果等数据。分析了FINS对Vit D对ICPP的调节和中介作用。结果与对照组相比，ICPP女孩的FINS和胰岛素抵抗（HOMA-IR）动态平衡模型评估评分较高，Vit D水平较低。在ICPP女孩中，VDD组的FINS和HOMA-IR值明显高于VDI和VDS组。适度分析显示，FINS影响Vit D对VDD女孩ICPP风险的影响。受试者工作特征（ROC）曲线分析显示，在VDD组中，25(OH)D与FINS联合诊断ICPP的ROC曲线下面积（AUC）为0.910。结论FINS可调节Vit D对VDD女童ICPP的影响，联合评估FINS和Vit D可能有助于VDD女童的早期诊断。

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Moderating role of fasting insulin on the levels of vitamin D in idiopathic central precocious puberty girls

Background

Vitamin D deficiency (VDD) is a risk factor for idiopathic central precocious puberty (ICPP), but the mechanism is unclear. The association between Vitamin D (Vit D) and insulin indicates that fasting insulin (FINS) may play a role in the influence of Vit D on the occurrence of ICPP.

Objective

This study aimed to investigate the role of FINS in the impact of Vit D on ICPP risk in girls.

Methods

A retrospective analysis was conducted on 91 girls with ICPP and 47 girls with normal growth. Data on growth parameters, secondary sex characteristics, laboratory test results, and imaging results were collected. The moderating and mediating effects of FINS on the effect of Vit D on ICPP were analyzed.

Results

Girls with ICPP had higher FINS and homeostasis model assessment of insulin resistance (HOMA-IR) score and lower Vit D levels than those of controls. Among the girls with ICPP, those with VDD had significantly higher FINS and HOMA-IR values than those with Vit D insufficiency (VDI) or sufficiency (VDS). Moderation analysis revealed that FINS influenced the effect of Vit D on ICPP risk in girls with VDD. Receiver operating characteristic (ROC) curve analysis indicated that in the VDD group, the combination of 25(OH)D and FINS had an area under the ROC curve (AUC) of 0.910 for diagnosing ICPP.

Conclusion

FINS can moderate the effect of Vit D on ICPP in girls with VDD, and a combined assessment of FINS and Vit D may aid in the early diagnosis in these girls.

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来源期刊

Biochimica et biophysica acta. Molecular basis of disease 生物-生化与分子生物学

CiteScore

12.30

自引率

0.00%

发文量

218

审稿时长

32 days

期刊介绍： BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. The submission of uninvited reviews to BBA - Molecular Basis of Disease is strongly discouraged, and any such uninvited review should be accompanied by a coverletter outlining the compelling reasons why the review should be considered.