Current diagnostic pathology最新文献_第4页

Prognostic factors in invasive breast carcinoma: Do new molecular techniques/profiling add significantly to traditional histological factors? 浸润性乳腺癌的预后因素:新的分子技术/谱分析是否显著增加了传统的组织学因素?

Current diagnostic pathology Pub Date : 2007-04-01 DOI: 10.1016/j.cdip.2006.12.002

Mangesh A. Thorat, Sunil Badve

{"title":"Prognostic factors in invasive breast carcinoma: Do new molecular techniques/profiling add significantly to traditional histological factors?","authors":"Mangesh A. Thorat, Sunil Badve","doi":"10.1016/j.cdip.2006.12.002","DOIUrl":"https://doi.org/10.1016/j.cdip.2006.12.002","url":null,"abstract":"<div><p>Greater awareness and use of screening has led to an increase in the proportion of ‘early’ breast cancers. Conventional prognostic factors such as tumour size and nodal status are of limited use with these tumours, because most of them are node negative and small. There is a need for factors that are not only prognostic, but also predict response to therapy, in the selection of appropriate therapy for these low-risk patients, especially to avoid the administration of toxic therapies to patients who are unlikely to gain significant benefit. This has led to the emergence of newer molecular prognostic factors, gene-expression signatures being the latest. Although not many of these newer prognostic factors have proved clinical utility, recent studies report remarkable results with the use of gene-expression signatures as prognostic and predictive factors. These results, though promising, have been compared only with simple parameters such as tumour grade and with broad practice guidelines. Additional studies documenting superiority of gene signatures over existing prognostic algorithms such as the Nottingham prognostic index and Adjuvant! Online are necessary before their widespread routine use. Currently, gene signatures are best used as a part of randomized clinical trials such as MINDACT and TAILORx. In this review, we discuss the biological basis, scientific evidence and clinical application of conventional and molecular prognostic factors, including gene-expression signatures.</p></div>","PeriodicalId":87954,"journal":{"name":"Current diagnostic pathology","volume":"13 2","pages":"Pages 116-125"},"PeriodicalIF":0.0,"publicationDate":"2007-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cdip.2006.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137256961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Guidelines for the handling of benign and malignant surgical breast specimens 乳腺良性和恶性手术标本处理指南

Current diagnostic pathology Pub Date : 2007-04-01 DOI: 10.1016/j.cdip.2006.12.004

E. Provenzano, S.E. Pinder

引用次数: 3

Use and assessment of diagnostic and predictive markers in breast pathology 乳腺病理诊断和预测标志物的使用和评估

Current diagnostic pathology Pub Date : 2007-04-01 DOI: 10.1016/j.cdip.2006.12.001

Rosemary A. Walker

引用次数: 8

Liver tumour pathology 肝肿瘤病理

Current diagnostic pathology Pub Date : 2007-04-01 DOI: 10.1016/j.cdip.2007.02.002

Brian Rous, Susan E. Davies

引用次数: 0

Sentinel lymph node biopsy: Review of the literature and guidelines for pathological handling and reporting 前哨淋巴结活检:病理处理和报告的文献和指南回顾

Current diagnostic pathology Pub Date : 2007-04-01 DOI: 10.1016/j.cdip.2006.12.005

Colin A. Purdie

引用次数: 18

Small round-cell neoplasms of soft tissues: An integrated diagnostic approach 软组织小圆细胞瘤:综合诊断方法

Current diagnostic pathology Pub Date : 2007-04-01 DOI: 10.1016/j.cdip.2007.02.001

Sabrina Rossi , Antonio G. Nascimento , Fabio Canal , Angelo Paolo Dei Tos

引用次数: 20

Technical aspects of predictive and prognostic markers in breast cancer: What UK NEQAS data shows 乳腺癌预测和预后标志物的技术方面:英国NEQAS数据显示

Current diagnostic pathology Pub Date : 2007-04-01 DOI: 10.1016/j.cdip.2006.12.003

Keith Miller , Merdol Ibrahim , Sarah Barnett , Bharat Jasani

引用次数: 14

Renal transplant pathology: An update 肾移植病理学:最新进展

Current diagnostic pathology Pub Date : 2007-02-01 DOI: 10.1016/j.cdip.2006.11.002

Robert B. Colvin, Lynn D. Cornell

引用次数: 4

Pathology of liver transplantation 肝移植病理

Current diagnostic pathology Pub Date : 2007-02-01 DOI: 10.1016/j.cdip.2006.11.006

Beate Haugk , Ahmed El-Refaie , Alastair David Burt

{"title":"Pathology of liver transplantation","authors":"Beate Haugk , Ahmed El-Refaie , Alastair David Burt","doi":"10.1016/j.cdip.2006.11.006","DOIUrl":"https://doi.org/10.1016/j.cdip.2006.11.006","url":null,"abstract":"<div><p>Liver transplantation has been increasingly used over the past four decades as an effective treatment for end-stage liver disease. Although the demand exceeds the supply of cadaveric organs, the donor pool has expanded with the increasing use of split-liver grafts, non-heart-beating donor livers and living-related donors. Histopathologists play a role in the pre-transplant and post-transplant period; their input is crucial in both identifying and monitoring post-transplant complications. The degree of acute cellular rejection is best assessed histologically, and biopsy interpretation informs changes to the immunosuppressive regimen. Chronic rejection is characterised by progressive ductopenia; a number of lesions have been identified that predict the likelihood of progression to chronic rejection. Other post-transplant complications readily assessed on liver core biopsies include vascular and biliary complications, infectious, recurrent and <em>de novo</em> disease. <em>De novo</em> hepatitis with ‘autoimmune’ features is described as is idiopathic chronic hepatitis, but the relationship of these lesions to alloimmune pathways remains uncertain. Although liver transplantation is generally performed in specialist centres, an increasing number of histopathologists working in non-specialist units are being exposed to post-transplant biopsies and need to be aware of the spectrum of changes that can occur.</p></div>","PeriodicalId":87954,"journal":{"name":"Current diagnostic pathology","volume":"13 1","pages":"Pages 75-84"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cdip.2006.11.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137365871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pathology of cholangiocarcinoma 胆管癌的病理

Current diagnostic pathology Pub Date : 2007-02-01 DOI: 10.1016/j.cdip.2006.07.006

Trishe Y.-M. Leong , Pongsak Wannakrairot , Eung Seok Lee , Anthony S.-Y. Leong

{"title":"Pathology of cholangiocarcinoma","authors":"Trishe Y.-M. Leong , Pongsak Wannakrairot , Eung Seok Lee , Anthony S.-Y. Leong","doi":"10.1016/j.cdip.2006.07.006","DOIUrl":"https://doi.org/10.1016/j.cdip.2006.07.006","url":null,"abstract":"<div><p>Cholangiocarcinoma, which is endemic in certain geographic regions, shows a strong association with liver fluke infection and hepatolithiasis, with recurrent inflammation and the high consumption of nitrates, nitrites, dimethylnitrosamines and <em>N</em>-nitropyrolidines as probable mutagenic cofactors. <em>K-ras</em>, <em>p53</em> and <em>bcl-2</em> have been implicated in cholangiocarcinogenesis and several immunohistological markers have been studied, although none is a reliable predictor of outcome. Three macroscopic types of cholangiocarcinoma have been characterized and implicated to be of prognostic relevance, but their behaviour might be a function of their anatomical location rather than a biological characteristic. Periductal-infiltrating tumours present at an advanced stage with infiltration of the portal pedicle. They arise closer to the hepatic hilum than mass-forming tumours, which tend to be peripherally located and show portal invasion and intrahepatic recurrence. The intraductal tumour shows the best prognosis, and long-term survival has been reported. Poor prognostic factors include large tumour size, multifocality, lymphovascular, perineural and serosal invasion, lymph node metastases and involvement of resection margins. Survival following surgical resection, the mainstay of treatment, is generally very poor.</p></div>","PeriodicalId":87954,"journal":{"name":"Current diagnostic pathology","volume":"13 1","pages":"Pages 54-64"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cdip.2006.07.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137365869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5