Current diagnostic pathology最新文献

Current diagnostic pathology Pub Date : 2007-12-01 DOI: 10.1016/j.cdip.2007.06.003

Ruliang Xu

{"title":"Neurogenic polyps","authors":"Ruliang Xu","doi":"10.1016/j.cdip.2007.06.003","DOIUrl":"https://doi.org/10.1016/j.cdip.2007.06.003","url":null,"abstract":"<div><p>A neoplastic proliferation of peripheral nerve sheath cells (Schwann cells, fibroblasts and perineurial cells) and ganglion cells in the colorectum may give rise to the mucosal or submucosal polyps. Depending upon the predominant cell types, these neurogenic polyps can be classified as schwannomas, granular cell tumours, neurofibromas, perineuriomas, mixed nerve sheath tumours, ganglioneuromas or paragangliomas. Morphologically, the neoplastic cells repeat or mimic the corresponding nerve sheath cells or neurons in terms of growth pattern, histology and immunoreactivity. They are uncommon, but the polyps can occur in any age group, although the vast majority of patients are adults. The polyps can be either solitary (most peripheral nerve sheath tumours) or multiple, especially if associated with systemic diseases (i.e. syndromes involving the peripheral nerve tissue). They are usually incidental findings or may be accompanied by gastrointestinal symptoms. Almost all colorectal neurogenic polyps are benign, and they rarely undergo malignant transformation unless they are part of a syndromatic manifestation. However, these polyps may cause a diagnostic problem during screening for colorectal cancer. An accurate diagnosis of these entities will help clinicians to make appropriate management decisions.</p></div>","PeriodicalId":87954,"journal":{"name":"Current diagnostic pathology","volume":"13 6","pages":"Pages 438-455"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cdip.2007.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137355394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neck dissections: A practical guide for the reporting histopathologist 颈部解剖:报告组织病理学家的实用指南

Current diagnostic pathology Pub Date : 2007-12-01 DOI: 10.1016/j.cdip.2007.06.007

Julia Woolgar, Asterios Triantafyllou

引用次数: 10

Cutaneous lymphoid infiltrates 皮肤淋巴浸润

Current diagnostic pathology Pub Date : 2007-12-01 DOI: 10.1016/j.cdip.2007.06.008

Eduardo Calonje

引用次数: 0

Non-neoplastic colorectal polyps 非肿瘤性结直肠息肉

Current diagnostic pathology Pub Date : 2007-12-01 DOI: 10.1016/j.cdip.2007.06.009

Jason Daniels, Elizabeth Montgomery

引用次数: 4

Radical prostatectomy specimen processing: A critical appraisal of sampling methods 根治性前列腺切除术标本处理:取样方法的关键评估

Current diagnostic pathology Pub Date : 2007-12-01 DOI: 10.1016/j.cdip.2007.06.005

Ming-Tse Sung , Darrell D. Davidson , Rodolfo Montironi , Antonio Lopez-Beltran , Liang Cheng

引用次数: 6

Serrated colorectal polyps and the serrated neoplastic pathway: Emerging concepts in colorectal carcinogenesis 锯齿状结直肠息肉和锯齿状肿瘤通路:结直肠癌发生中的新概念

Current diagnostic pathology Pub Date : 2007-12-01 DOI: 10.1016/j.cdip.2007.06.006

Rhonda K. Yantiss

{"title":"Serrated colorectal polyps and the serrated neoplastic pathway: Emerging concepts in colorectal carcinogenesis","authors":"Rhonda K. Yantiss","doi":"10.1016/j.cdip.2007.06.006","DOIUrl":"https://doi.org/10.1016/j.cdip.2007.06.006","url":null,"abstract":"<div><p>Several investigators have recently proposed the concept of a ‘serrated neoplastic pathway’ to account for the development of a subset of colonic carcinomas that lack chromosomal instability and loss of heterozygosity. This pathway putatively involves several pathogenetically related polyps, including some hyperplastic polyps, the recently described sessile serrated polyp, serrated adenoma and mixed polyp; and is characterised by early <em>BRAF</em> mutations, DNA hypermethylation and microsatellite instability. Most hyperplastic polyps and sessile serrated polyps harbour mutations in <em>BRAF</em>, one gene involved in the mitogen-activated protein kinase pathway, and abnormal DNA methylation. Presumably, these genetic changes are sufficient to potentiate widespread genomic hypermethylation that ultimately affects the promoter regions of key DNA repair genes, such as <em>hMLH-1</em> and <em>O</em><sup><em>6</em></sup><em>-methylguanine methyltransferase</em>, thereby silencing them from transcription and leading to progressive microsatellite instability. The morphological evolution of non-dysplastic serrated lesions (hyperplastic and sessile serrated polyps) to serrated adenomas, mixed polyps and/or colorectal carcinoma is believed to reflect the accumulation of these genetic events. The purpose of this review is to describe the morphological and molecular features of colorectal serrated polyps and to present the available data supporting the concept of a serrated neoplastic pathway of colorectal carcinogenesis.</p></div>","PeriodicalId":87954,"journal":{"name":"Current diagnostic pathology","volume":"13 6","pages":"Pages 456-466"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cdip.2007.06.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137355389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Pathology of the endoscopically removed malignant colorectal polyp 内镜切除结直肠恶性息肉的病理分析

Current diagnostic pathology Pub Date : 2007-12-01 DOI: 10.1016/j.cdip.2007.06.002

Harry S. Cooper

{"title":"Pathology of the endoscopically removed malignant colorectal polyp","authors":"Harry S. Cooper","doi":"10.1016/j.cdip.2007.06.002","DOIUrl":"https://doi.org/10.1016/j.cdip.2007.06.002","url":null,"abstract":"<div><p>The management of the patient with an endoscopically removed malignant colorectal polyp is predicated on proper handling of the specimen and on the pathologist's histopathological interpretation. The steps of specimen handling are: (1) fixation, (2) gross examination and sectioning, (3) processing, and (4) endoscopic findings and type of removal. The histopathological parameters to be reported on are: (1) the status of the resection margin, (2) the grade of the cancer, and (3) the presence or absence of lymphovascular invasion. Polyps with grade I or II cancer, no lymphovascular invasion and a negative resection margin can be successfully treated by endoscopic polypectomy, whereas those with grade III cancer, lymphovascular invasion, or a positive/close margin require definitive surgical resection subsequent to endoscopic polypectomy. Potentially, new significant parameters for patient management are: (1) depth of invasion, (2) tumour budding, (3) lymphatic vessel density, and (4) cribriform histology. The pathology report must be clear and concise, indicating all relevant important parameters. Finally, the pathologist must differentiate invasive adenocarcinoma from intramucosal adenocarcinoma and ‘pseudoinvasion’.</p></div>","PeriodicalId":87954,"journal":{"name":"Current diagnostic pathology","volume":"13 6","pages":"Pages 423-437"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cdip.2007.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137355395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Non-adenomatous colorectal polyposis syndromes 非腺瘤性结直肠息肉综合征

Current diagnostic pathology Pub Date : 2007-12-01 DOI: 10.1016/j.cdip.2007.06.004

Karel Geboes, Gert De Hertogh, Marie-Astrid Van Caillie, Peter Van Eyken

引用次数: 2

Pathology of the appendix 阑尾病理

Current diagnostic pathology Pub Date : 2007-10-01 DOI: 10.1016/j.cdip.2007.05.014

M.J. Arends

引用次数: 1

The autopsy pathology of sepsis-related death 败血症相关死亡的尸检病理分析

Current diagnostic pathology Pub Date : 2007-10-01 DOI: 10.1016/j.cdip.2007.06.001

Sebastian Lucas

引用次数: 52