Current diagnostic pathology最新文献_第10页

Gastrointestinal stromal tumours: An update 胃肠道间质瘤:最新进展

Current diagnostic pathology Pub Date : 2005-12-01 DOI: 10.1016/j.cdip.2005.08.003

Muna Sabah, Mary Leader, Elaine Kay

{"title":"Gastrointestinal stromal tumours: An update","authors":"Muna Sabah, Mary Leader, Elaine Kay","doi":"10.1016/j.cdip.2005.08.003","DOIUrl":"https://doi.org/10.1016/j.cdip.2005.08.003","url":null,"abstract":"<div><p>Gastrointestinal stromal tumours (GISTs) comprise the largest subset of mesenchymal tumours of the digestive tract. These tumours have been the subject of considerable debate in the literature regarding their histogenesis, criteria for diagnosis, prognostic features and biological behaviour.</p><p>The majority of GISTs express CD117 immunostaining and show various degrees of differentiation towards the phenotype of interstitial cell of Cajal.</p><p>Clinically and histologically, GISTs represent a spectrum that includes benign and malignant variants. The prediction of clinical behaviour is best achieved by evaluation of multiple parameters including clinical, morphological and cytogenetic features.</p><p>The recognition of the central role played by activating mutations of <em>c-kit</em> and platelet derived growth factor receptor alpha in the pathogenesis of GISTs and the introduction of STI-571, a receptor tyrosine kinase inhibitor that has proved extremely effective in the treatment of GISTs, have not only have focused attention on these tumours but also made it necessary to accurately define these tumours and separate them from other mesenchymal lesions. This review discusses the definition, histogenesis, epidemiology, clinical presentation, morphological and immunohistochemical features and the differential diagnosis of GISTs and addresses predictors of malignancy and management of GISTs.</p></div>","PeriodicalId":87954,"journal":{"name":"Current diagnostic pathology","volume":"11 6","pages":"Pages 400-410"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cdip.2005.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137004795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The histopathological differential diagnosis of mesenchymal tumours of the skin 皮肤间充质肿瘤的组织病理学鉴别诊断

Current diagnostic pathology Pub Date : 2005-12-01 DOI: 10.1016/j.cdip.2005.08.002

J.F. Graadt van Roggen , T.K. Lim , P.C.W. Hogendoorn

引用次数: 6

Central high-grade osteosarcoma of bone: Diagnostic and genetic considerations 中枢性高级别骨肉瘤:诊断和遗传学考虑

Current diagnostic pathology Pub Date : 2005-12-01 DOI: 10.1016/j.cdip.2005.08.005

Anne-Marie Cleton-Jansen , Horst Buerger , Pancras C.W. Hogendoorn

引用次数: 19

Recent advances in the pathology of fibroepithelial tumours of the breast 乳腺纤维上皮肿瘤病理的最新进展

Current diagnostic pathology Pub Date : 2005-12-01 DOI: 10.1016/j.cdip.2005.08.007

Gary M.K. Tse , Puay Hoon Tan

{"title":"Recent advances in the pathology of fibroepithelial tumours of the breast","authors":"Gary M.K. Tse , Puay Hoon Tan","doi":"10.1016/j.cdip.2005.08.007","DOIUrl":"https://doi.org/10.1016/j.cdip.2005.08.007","url":null,"abstract":"<div><p>Fibroepithelial lesions of the breast are biphasic lesions with epithelial and stromal components, as exemplified by fibroadenoma and phyllodes tumour. Fibroadenomas are benign, but a subset of complex fibroadenoma is associated with slightly increased long-term cancer risk. Phyllodes tumour is characterised by a leaf-like pattern arising from stromal expansion. It shows a variable degree of malignancy, with a potential for recurrence or metastasis. Conventionally, histological parameters of stromal cellularity, nuclear pleomorphism, overgrowth, mitotic activity and margin configuration are used for grading, but no definitive criteria have been identified to predict the behaviour. Other markers that have been investigated so far include p53, hormonal receptors, proliferation markers, angiogenesis, c-kit (CD117) and CD10 (CALLA), all without clear-cut advantage over histological criteria. There is also emerging histological and molecular evidence that fibroadenoma and phyllodes tumour may be related and epithelial–stromal interaction may play a role in the pathogenesis of these fibroepithelial lesions.</p></div>","PeriodicalId":87954,"journal":{"name":"Current diagnostic pathology","volume":"11 6","pages":"Pages 426-434"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cdip.2005.08.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137005335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Cervical pathology 宫颈病理

Current diagnostic pathology Pub Date : 2005-12-01 DOI: 10.1016/j.cdip.2005.08.004

引用次数: 0

Accurate determination of breast cancer size: The role of histopathology and imaging 准确确定乳腺癌的大小:组织病理学和影像学的作用

Current diagnostic pathology Pub Date : 2005-12-01 DOI: 10.1016/j.cdip.2005.08.008

Bobbi Pritt, Donald L. Weaver

引用次数: 11

The molecular pathology of new anti-cancer agents 新型抗癌药物的分子病理学

Current diagnostic pathology Pub Date : 2005-10-01 DOI: 10.1016/j.cdip.2005.05.004

Simon S. Cross

{"title":"The molecular pathology of new anti-cancer agents","authors":"Simon S. Cross","doi":"10.1016/j.cdip.2005.05.004","DOIUrl":"https://doi.org/10.1016/j.cdip.2005.05.004","url":null,"abstract":"<div><p>Conventional anti-cancer drugs usually act against dividing cells and work on the premise that cancer cells divide more quickly than normal cells in the body, so that repeated doses will put the cancer cells at a selective disadvantage. In many tumours, however, it is not the rate of proliferation that causes tumour growth but the lack of tumour cell death by apoptosis, so these drugs will not be effective against such tumours. These agents also cause many side-effects because of their effect on normal rapidly dividing cells in the body, such as the bone marrow and the epithelial lining of the gut, and it is these side-effects which often limit the dose. There are now a whole range of new anti-cancer agents that target cancer cells more specifically because they are directed against unique protein targets in these cells. These targets often include specific growth factor receptors that are overexpressed in particular types of cancer. These new agents are often monoclonal antibodies directed against these proteins or small molecule inhibitors of their enzymatic intracytoplasmic domains. Examples include cetuximab, trastuzumab, bevacizumab, imatinib mesylate and gefitinib. This article reviews the molecular pathology of these agents and describes the role of histopathology testing in selecting these therapies for individual patients.</p></div>","PeriodicalId":87954,"journal":{"name":"Current diagnostic pathology","volume":"11 5","pages":"Pages 329-339"},"PeriodicalIF":0.0,"publicationDate":"2005-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cdip.2005.05.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137350196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Learning histopathology: A trainee's viewpoint 学习组织病理学:一个学员的观点

Current diagnostic pathology Pub Date : 2005-10-01 DOI: 10.1016/j.cdip.2005.05.011

Katherine S. Syred

引用次数: 3

The ophthalmic pathology cut-up–Part 2 眼科病理切片-第二部分

Current diagnostic pathology Pub Date : 2005-10-01 DOI: 10.1016/j.cdip.2005.05.005

Alison L. Ford , Hardeep S. Mudhar , Robin Farr , M. Andrew Parsons

引用次数: 6

Teaching pathology to medical undergraduates 给医科本科生讲授病理学

Current diagnostic pathology Pub Date : 2005-10-01 DOI: 10.1016/j.cdip.2005.05.009

Julian L. Burton

引用次数: 25