Dajana Dedic, Aleksandra Kovac, S. Popović-Petrović, Ivana Zelic-Kozomora
{"title":"Effects of depression on the functional well-being of patients with breast cancer","authors":"Dajana Dedic, Aleksandra Kovac, S. Popović-Petrović, Ivana Zelic-Kozomora","doi":"10.2298/mpns2210290d","DOIUrl":"https://doi.org/10.2298/mpns2210290d","url":null,"abstract":"Introduction. The psychological status of patients with breast cancer is often compromised as a result of chronic exposure to negative emotions and psychological distress after the diagnosis of a malignant disease and conditions such as depression and anxiety may have a direct impact on the functional wellbeing of breast cancer patients. The aim of this study was to examine whether depression affects the functional well-being of breast cancer patients. Material and Methods. This crosssectional study was conducted in 2021 and it included 71 breast cancer patients treated at the Department of Physical Medicine and Rehabilitation of the Oncology Institute of Vojvodina at the time of examination. The depression subscale of the Serbian version of the Depression, Anxiety and Stress Scale 21, assessing the degree of depression was used to assess depressive symptoms in the participants. The functional well-being was assessed using the Functional Well-Being subscale of the questionnaire for the Functional Assessment of Cancer Therapy - Breast. Results. A statistically significant correlation was found between depression and functional well-being (r = - 0.438, p < 0.001) of the examined patients. The results of the regression analysis showed that the F model was significant (F (1.69) = 16.366; p < 0.001) and showed 19.2% of the variance. Depression has a significant impact on the functional well-being of breast cancer patients (? = - 438, t = - 4.045, p < 0.001). Conclusion. Through a multidisciplinary approach, it is important to simultaneously functionally train breast cancer patients, but also to implement timely psychological support and rehabilitation.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83537773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Domić, Ivana Tomasovic, Paula Bernaciak, G. Voronov, R. Igić, R. Škrbić
{"title":"Role of physicians in eliminating risk of cancer caused by combustible tobacco smoke","authors":"A. Domić, Ivana Tomasovic, Paula Bernaciak, G. Voronov, R. Igić, R. Škrbić","doi":"10.2298/mpns2212363d","DOIUrl":"https://doi.org/10.2298/mpns2212363d","url":null,"abstract":"Introduction. Combustible tobacco smoking accounts for nearly 30% of all cancer deaths in the United States of America and about 7 million deaths worldwide each year. Nowadays, e-cigarettes are increasingly used, especially among young people, but nicotine addiction that develops by such smoking easily converts to smoking combustible tobacco. Therefore, public health efforts must be directed to the prevention of initiation of smoking all nicotine-containing products. Role of Physicians. Medical doctors are very influential in smoking-related changes in local society, especially those who work in primary care, and they have an important role in both prevention and cessation of tobacco smoking. Tobacco smoking should be eliminated among medical doctors, yet many of them still smoke. The lowest percentage of smoking among physicians is in Oceania and North America (less than 11%) and the highest in Eurasia (25%). Smoking prevalence among medical students is higher than 35% in Georgia, Greece, Spain, and Italy, but less than 5% in the United States of America and Australia. In Serbia, 23% of physicians smoke. The age of physicians does not affect the number of smokers, but gender has a significant effect; women smoke less than men. Smoking Prevention and Cessation. Education about the effects of combustible tobacco smoking is a critical issue for successful smoking prevention and cessation; the best way is to provide educational programs on smoking at medical schools by introducing a mandatory course on combustible tobacco smoking at the beginning of the first year of study, especially in societies with a large percentage of smokers. Conclusion. In this paper, we showed how smoking can be eliminated among physicians and how they can affect the patients, public health policies, and antismoking campaigns.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84733648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The current approach and the treatment of adolescents and young adults with acute lymphoblastic leukemia","authors":"Borivoj Sekulić","doi":"10.2298/mpns22s1015s","DOIUrl":"https://doi.org/10.2298/mpns22s1015s","url":null,"abstract":"Introduction. The treatment outcome of adolescents and young adults with acute lymphoblastic leukemia is much poorer in contrast to pediatric patients. By changing the concept of the treatment for patients who are adolescents and young adults with acute lymphoblastic leukemia, especially with the use of pediatric regimens, significant improvement in survival has been made (current 5-year survival rate goes up to 70%). Contributing factors for different outcomes between children and adolescents and young adults with acute lymphoblastic leukemia. Beside the differences between pediatric and adult protocols, there are several factors which can explain the different outcomes between these groups of patients with acute lymphoblastic leukemia. One of the main factors is different biology of the leukemias and, on the other side, lower accrual rates in clinical trials in adolescents and young adults and their specific psychosocial factors, like poor compliance with the treatment and missed appointments. Current treatment and novel approaches in the treatment of adolescents and young adults with acute lymphoblastic leukemia. Current treatment approach to the adolescent and young adults with acute lymphoblastic leukemia is based on the pediatric protocols with the risk-adapted strategy, which depends primarily on the cytogenetics and postinduction minimal/measurable residual disease. The main goal of the novel treatment, especially with the use of targeted therapy and innovative immunotherapies incorporated in the pediatric protocols, is to achieve a deep and durable leukemia-free survival. To transplant or not to transplant adolescents and young adults with acute lymphoblastic leukemia is still a matter of debate, particularly in the era of pediatric regimens and the new sequence algorithm with the upfront use of novel drugs. Conclusion. Adolescent and young adult patients with acute lymphoblastic leukemia should be treated in specialized centers by an experienced multidisciplinary team with close attention to their particular needs.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85325770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sonja Sedlarevic, Bozidar Dejanovic, Z. Savic, Bojan Vuković, Vanja Calic, M. Lekin
{"title":"Purple urine bag syndrome - a sign of urinary tract infection, or just of urinary catheter bacterial colonization: A case report","authors":"Sonja Sedlarevic, Bozidar Dejanovic, Z. Savic, Bojan Vuković, Vanja Calic, M. Lekin","doi":"10.2298/mpns2210301s","DOIUrl":"https://doi.org/10.2298/mpns2210301s","url":null,"abstract":"Introduction. Purple urine bag syndrome is a condition where the urinary catheter bag turns purple as a result of the interaction between bacteria, urine and components of the urine bag. It appears in a certain group of patients with the following risk factors: urinary tract infection, older age, long-term indwelling urinary catheter, constipation, chronic kidney disease. Case Report. Two patients with purple urine bag syndrome are presented. The first patient, a 66-year-old man, was hospitalized due to decompensation of alcoholic liver cirrhosis. A urinary catheter was placed on admission, and on the fourteenth day of hospitalization, a purple discoloration of the urine in the urinary bag was noticed. Multidrug-resistant Proteus mirabilis and Enterococcus faecalis were isolated by microbiological analysis of urine. The second patient was a 92-year-old man, hospitalized for acute gastrointestinal bleeding in the form of hematochezia, with an indwelling urinary catheter and a history of a prostate cancer surgery. On the third hospital day, a purple content in the urinary catheter bag was detected and Klebsiella pneumoniae and Morganella morganii were confirmed by bacteriological analysis. Both patients were without clinical and laboratory signs of acute infection. In both cases, the urinary catheter was replaced and ceftriaxone was administered empirically. Conclusion. Current guidelines for purple urine bag syndrome recommend catheter replacement and empiric antibiotic therapy. In clinical practice, it is necessary to emphasize that urine sampling for bacteriological analysis is performed only after replacing the catheter, in order to establish the exact etiology of the syndrome and radical use of antibiotics.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85747933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivana Mijatov, A. Kiralj, N. Vuckovic, J. Nikolić, A. Tadić, Saša Mijatov
{"title":"Preoperative determination of tumor thickness in oral squamous cell carcinoma by computed tomography","authors":"Ivana Mijatov, A. Kiralj, N. Vuckovic, J. Nikolić, A. Tadić, Saša Mijatov","doi":"10.2298/mpns2212338m","DOIUrl":"https://doi.org/10.2298/mpns2212338m","url":null,"abstract":"Introduction. Evaluation of the prognostic factors and the survival rate in oral squamous cell carcinoma is extremely important, because patients in the same tumor-node-metastasis stage may have a different survival rate. Numerous studies have been conducted on various clinical and pathological prognostic factors in order to develop a prognostic model for the survival rate of patients with oral cancer. Material and Methods. The study was designed as a prospective study including 65 consecutive patients (n = 65) of both sexes who underwent surgical treatment of oral cancer. The diagnosis of oral cancer was based on the medical history, physical examination, and biopsy. The clinical tumor-node-metastasis staging was determined based on clinical examination. The radiological tumor-node-metastasis staging was done by computed tomography of the head, neck, and chest. The tumor thickness was determined by computed tomography and histopathological analysis of surgical specimens. Results. The histopathological analysis showed a mean tumor thickness of 13.446 mm, while the mean computed tomography tumor thickness was 15.2707 mm. The correlation between computed tomography tumor thickness and histopathological tumor thickness was moderately significant (Spearman?s rho = .581, p = 0.000). Conclusion. This study supports the use of computed tomography in the determination of tumor thickness in patients with oral squamous cell carcinoma. We want to emphasize the importance of preoperative, detailed imaging evaluation of patients in order to avoid multiple surgical procedures, significant morbidity, and unnecessary costs.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"2022 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73936288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medical terminology in modern Serbia - more than one and a half century long journey (1841-1872-2022)","authors":"A. Jelenković, Rade R. Babić","doi":"10.2298/mpns2212381j","DOIUrl":"https://doi.org/10.2298/mpns2212381j","url":null,"abstract":"Introduction. Linguistic expressions in a certain country, used in new or less developed sciences and professions, are commonly associated with difficulties due to the mother-tongue poverty. This also applies to the medical terminology. In modern Serbia, despite an eight-century-long hospital tradition, an institutional approach to the medical terminology was first established 180 years ago by the Society of Serbian Letters, founded in 1841, lasting until 1885. It was continued 30 years later by the Serbian Medical Society, founded in 1872. Society of Serbian Letters. The work of the Society of Serbian Letters on the Serbian language and terminology was very short, because Vuk Karadzic, among others, pointed out that the Society had to provide accurate and reliable terminology, which was not possible at the time. The work of Dr. Jovan Stejic and his translations of the books Macrobiotics and Anthropology are significant for medical terminology. Serbian Medical Society. Precisely set goals related to medical terminology and the preservation of the Serbian language in medicine were an integral part of the first Constitution of the Serbian Medical Society. However, during the continuous, 150-year-long work of the Society and the beginning of medical terminology standardization, for reasons still not explored, medical terminology has disappeared from its highest legal act, including the current Statute. Conclusion. Not even 180 years since the first short-term and 150 years since the long-term process of institutional approach to medical terminology was enough to develop and standardize medical terminology in modern Serbia. In order not to leave it to the arbitrariness of individuals, medical terminology must be a national strategy, such as, for example, the terminology of 33 professions in the Republic of Croatia called Croatian Professional Nomenclature.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89505756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Vidović, D. Šefer, J. Rajić, Tara Gunjak, V. Milošević, S. Jovanović
{"title":"Febrile neutropenia in patients with hematological malignancies - definition, diagnosis and management","authors":"A. Vidović, D. Šefer, J. Rajić, Tara Gunjak, V. Milošević, S. Jovanović","doi":"10.2298/mpns22s1161v","DOIUrl":"https://doi.org/10.2298/mpns22s1161v","url":null,"abstract":"Intensive chemotherapy/radiotherapy in cancer, especially with hematologic malignancies, causes cellular injury and suppression of inflammatory responses, which increase the risks of neutropenia and febrile episodes. Absolute neutrophil count < 1 ? 109/L is considered neutropenia, with absolute neutrophil count < 0.5 ? 109/L or < 1 ? 109/L that is expected to decrease to < 0.5 ? 109/L in the next 48 hours considered severe neutropenia, while absolute neutrophil count < 0.1 ? 109 is referred as profound neutropenia. Febrile episodes are usually defined as oral temperature > 38.3?C or two consecutive readings > 38.0?C lasting more than 1 hour. Although there is the possibility of non-infection-caused febrile neutropenia, most episodes are caused by infections. Febrile neutropenia is a clinical emergency that requires prompt management. Despite advances in therapy in recent years, febrile neutropenia remains a common complication in chemotherapy causing serious clinical results, including death. The administration of empirical antibacterial therapy has been successful in the management of febrile neutropenia since its launching 50 years ago. The wide application of broad-spectrum antibiotics has effectively decreased the mortality of febrile neutropenia patients. Neutropenic patients who remain febrile despite 4-7 days of broad-spectrum antibacterial therapy are at a high risk of invasive fungal infection. Empirical antifungal therapy with Amphotericin B or Caspofungin in persistently febrile neutropenic patients and other high-risk patients has shown to reduce the risk of invasive fungal infection by 50 - 80% and the risk of fungal infection-related mortality by 23- 45%. Lipid formulations which improve the therapeutic ratio of the traditional formulation are available","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86935368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Marjanovic, T. Džopalić, M. Kostic, M. Lazarević, Z. Stojanoski, B. Bonaci-Nikolic
{"title":"From inborn errors of immunity to lymphoma: A hematologist’s point of view","authors":"G. Marjanovic, T. Džopalić, M. Kostic, M. Lazarević, Z. Stojanoski, B. Bonaci-Nikolic","doi":"10.2298/mpns22s1066m","DOIUrl":"https://doi.org/10.2298/mpns22s1066m","url":null,"abstract":"After infections, malignancies, lymphomas especially, are the second most frequent cause of death in patients with inborn errors of immunity. Factors predetermining the appearance and aggressiveness of lymphomas include gene defects, defects of immune surveillance and regulation as well as infections with oncogenic viruses. Aggressive non-Hodgkin lymphomas, mostly diffuse large B-cell and Bukit subtypes are predominant in deoxyribonucleic acid repair defects, while Hodgkin lymphoma becomes equally present in patients with defects of immune regulation. Marginal zone and mucosa-associated lymphoid tissue lymphomas, appear to be frequent in defects of antibody production, especially in patients with common variable immune deficiency. The prevalence of Epstein-Barr virus may vary within entities, but there is no entity without at least a few cases of lymphoma and Epstein-Barr virus co-infection. Standard treatment of lymphomas associated with deoxyribonucleic acid repair defects and severe combined deficiencies, is stem cell transplantation. Lymphomas in inborn errors of immunity with a less severe clinical presentation, should be treated with immunochemotherapy and monoclonal antibodies (Brentuximab, Rituximab) wherever feasible. There is no data about the usefulness of checkpoint inhibitors, bi-specific antibodies and T-cells with chimeric antigen receptor. Allogeneic stem cell transplantation represents a major indication for treatment of relapse/refractory lymphomas in any inborn error of immunity. Potential benefit of therapy with Chimeric antigen receptor Natural-killer cells in lymphomas associated with inborn errors of immunity, remains to be seen in future studies.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"398 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91452218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Zvekic-Svorcan, K. Boskovic, T. Janković, R. Krasnik, Natasa Igic, I. Minaković
{"title":"Diagnosis of osteoporosis and prevention of osteoporotic fractures","authors":"J. Zvekic-Svorcan, K. Boskovic, T. Janković, R. Krasnik, Natasa Igic, I. Minaković","doi":"10.2298/mpns22s2013z","DOIUrl":"https://doi.org/10.2298/mpns22s2013z","url":null,"abstract":"Introduction. Osteoporosis is a metabolic bone disease characterized by reduced bone mineral density and damage to the bone microarchitecture, which leads to bone fragility, thus increasing the risk of osteoporotic fractures. While different diagnostic methods can be employed for detecting bone mineral density decrement in a timely manner, dual energy X-ray absorptiometry remains the gold standard in research and clinical practice. Bone mineral density estimation methods. Osteoporosis can be diagnosed through conventional radiography, quantitative ultrasonography, quantitative computed tomography, and magnetic resonance. Nonetheless, dual energy X-ray absorptiometry is the gold standard in the diagnosis of osteoporosis on which further treatment and monitoring are based. The dual energy X-ray absorptiometry apparatus is equipped with the Fracture Risk Assessment Tool, which estimates the 10- year probability of a major fracture and hip fracture due to osteoporosis. The use and interpretation of osteoporosis diagnostic evaluation modalities is based on the International Society for Clinical Densitometry guidelines for diagnosing osteoporosis in adults and children. According to the International Society for Clinical Densitometry recommendations, the aforementioned quantitative visualization modalities should be used alongside laboratory analyses of bone metabolism markers to supplement diagnostics and monitor treatment efficacy in patients suffering from osteoporosis. Conclusion. Assessment of risk factors and early diagnosis are prerequisites for timely treatment and effective monitoring, which is necessary for arresting the progression of bone mineral density loss and preventing the occurrence of osteoporotic fractures.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"165 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91461571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tatjana Nikolov, A. Savić, T. Janković, Marina Maksimovic-Simovic, K. Boskovic
{"title":"The efficacy of a modality of physical therapy in the treatment of osteoarthritis of the spine - a case report of a patient treated with horizontal therapy","authors":"Tatjana Nikolov, A. Savić, T. Janković, Marina Maksimovic-Simovic, K. Boskovic","doi":"10.2298/mpns22s2053n","DOIUrl":"https://doi.org/10.2298/mpns22s2053n","url":null,"abstract":"Introduction. Horizontal therapy is the only electrotherapy modality for the treatment of osteoarthritis that has a simultaneous bioelectrical and biochemical, effect on deep and superficial joint tissues. The objective of this report was to provide evidence of efficacy of horizontal therapy in a patient suffering from lumbar spine osteoarthritis. Case report. A 70-year-old female patient was admitted to the hospital due to severe low back pain with radiating pain in both legs followed by tingling in left leg. The patient has had this painful condition since 2010. Physical examination revealed a reduction of the range of motion of the lumbar spine followed by spasm of the paraspinal musculature. Deep tendon reflexes of the lower limbs were 2+ bilaterally, except right patellar reflex which was absent. She had hypoesthesia in L4, L5 and S1 dermatome of the left leg and no motor deficits were noted. Radiographic evaluation showed multilevel degenerative changes of the lumbar spine. The patient was prescribed medication, physical and exercise therapy. She underwent horizontal therapy for lumbar spine with a frequency oscillating between 4357 and 12127 hertz. The patient had a total of 15 treatments, 5 per week and each lasted 30 minutes. Conclusion. In a patient with osteoarthritis of the spine, horizontal therapy has proved to be an effective modality of physical therapy leading to pain relief and functional improvement. Additional clinical research is needed for confirming its effectiveness on a larger sample, to define optimal parameters of the application and indication areas.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"169 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89021867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}