{"title":"The impact of the coronavirus disease 2019 pandemic on wellness and healthy lifestyle","authors":"S. Djordjevic, S. Knežević, Nikola Savić","doi":"10.2298/mpns2208211d","DOIUrl":"https://doi.org/10.2298/mpns2208211d","url":null,"abstract":"Introduction. The main goal of wellness is to promote proactive and preventive behavior that improves mental health and lifestyle. This study examined how the lifestyle of respondents was affected by the inability to visit spas and wellness centers during the coronavirus disease 2019 pandemic. Material and Methods. This crosssectional study included a total of 186 participants with an average age of 41.31 ? 10.475 years, 137 female and 49 male. We specifically designed a questionnaire to analyze the impact of the lack of wellness services during the coronavirus disease 2019 pandemic. Results. There was no statistically significant association between gender, age, education, and marital status and visiting wellness destinations. Monthly income, however, showed a statistically significant association with visiting wellness facilities (p = 0.002). There was a significant decrease in the use of wellness centers during the coronavirus disease 2019 pandemic. A small number of the respondents believed the coronavirus disease 2019 pandemic has changed their lifestyle. Conclusion. The lack of wellness services has affected the respondents? inability to relax and get away from daily life, but the coronavirus disease 2019 pandemic has not negatively changed their lifestyle (p = 0.001).","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84154363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Vukovic, D. Antić, V. Otašević, N. Sabljić, Sofija Šarac, B. Mihaljević
{"title":"Primary central nervous system lymphoma - an overview","authors":"V. Vukovic, D. Antić, V. Otašević, N. Sabljić, Sofija Šarac, B. Mihaljević","doi":"10.2298/mpns22s1073v","DOIUrl":"https://doi.org/10.2298/mpns22s1073v","url":null,"abstract":"Introduction. Primary central nervous system lymphoma is a rare entity mostly presenting with non-GCB diffuse large B-cell lymphoma, being confined to the brain, spinal cord, meninges, and eyes. Diagnosis. The diagnosis is frequently established by stereotactic or open the brain biopsy, but in some cases with isolated leptomeningeal involvement, the only way is to identify atypical/monoclonal lymphocytes in cerebrospinal fluid. By workup, we aim to define the extent of disease in the central nervous system and to exclude systemic involvement. Treatment. Treatment is tailored according to the patient?s age, fitness, vital organ function, comorbidities, and available therapy. The backbone of induction treatment is high-dose methotrexate, usually within polychemotherapy. Consolidation phase is a matter of debate between two approaches: 1. high dose chemotherapy with autologous stem cell transplantation, which appears to be the preferable option for young fit patients, and 2. whole brain radiotherapy, preserved for transplant-ineligible ones. Whole brain radiotherapy has been raising concerns because of frequent cognitive impairment, which has been significantly diminished by reducing the irradiation dose. Despite a comprehensive treatment approach, many patients relapse, and since the prognosis of relapsed/refractory disease is devastating, there is a sense of urgency for novel treatment strategies. Several targeted agents and immunomodulatory drugs have been investigated in the settings of both relapsed/refractory and initial therapy, but with limited success. Ibrutinib monotherapy can induce durable remissions in the first line, but in relapse/refractory settings, the results are controversial. Conclusion. Adequate patient selection and new prospective trials should improve survival and preserve the patient?s neurological status.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74180830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Simic-Panic, K. Boskovic, A. Knežević, J. Zvekic-Svorcan, S. Tomasevic-Todorovic, T. Spasojevic
{"title":"Hip osteoarthritis - update on etiopathogenesis, clinical presentation and management","authors":"D. Simic-Panic, K. Boskovic, A. Knežević, J. Zvekic-Svorcan, S. Tomasevic-Todorovic, T. Spasojevic","doi":"10.2298/mpns22s2062s","DOIUrl":"https://doi.org/10.2298/mpns22s2062s","url":null,"abstract":"Osteoarthritis is the most frequent form of arthritis, and the hip is the second most frequently affected joint. The effects of osteoarthritis on the hip joint often lead to marked physical impairment that can contribute to increased disability and dependency in everyday activities. Hip osteoarthritis is a degenerative process with progressive loss of articular cartilage, followed by a reparative process such as reactive bone hypertrophy, which causes osteophyte formation and remodelling. The joint responds with subchondral and synovial inflammation. Patients with hip osteoarthritis report pain in the groin area which can develop slowly and worsen over time. With the progression of the disease, the range of motion of the affected hip is reduced, which affects the walking pattern and may cause a limp. Therapeutic options for hip osteoarthritis should be based on the etiopathogenesis of the disease. The approach to treatment for every patient should be multidisciplinary, multimodal and individualised taking into account personal beliefs and preferences, social and psychological factors and prior medical history. It is important to avoid unnecessary delays in referring patients with advanced hip osteoarthritis for surgical treatment, in order to prevent worse outcomes after total hip arthroplasty. The aim of this article is to offer a concise update on etiopathogenesis, clinical presentation, and management options for hip osteoarthritis.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74146538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The current approach and the treatment of adolescents and young adults with acute lymphoblastic leukemia","authors":"Borivoj Sekulić","doi":"10.2298/mpns22s1015s","DOIUrl":"https://doi.org/10.2298/mpns22s1015s","url":null,"abstract":"Introduction. The treatment outcome of adolescents and young adults with acute lymphoblastic leukemia is much poorer in contrast to pediatric patients. By changing the concept of the treatment for patients who are adolescents and young adults with acute lymphoblastic leukemia, especially with the use of pediatric regimens, significant improvement in survival has been made (current 5-year survival rate goes up to 70%). Contributing factors for different outcomes between children and adolescents and young adults with acute lymphoblastic leukemia. Beside the differences between pediatric and adult protocols, there are several factors which can explain the different outcomes between these groups of patients with acute lymphoblastic leukemia. One of the main factors is different biology of the leukemias and, on the other side, lower accrual rates in clinical trials in adolescents and young adults and their specific psychosocial factors, like poor compliance with the treatment and missed appointments. Current treatment and novel approaches in the treatment of adolescents and young adults with acute lymphoblastic leukemia. Current treatment approach to the adolescent and young adults with acute lymphoblastic leukemia is based on the pediatric protocols with the risk-adapted strategy, which depends primarily on the cytogenetics and postinduction minimal/measurable residual disease. The main goal of the novel treatment, especially with the use of targeted therapy and innovative immunotherapies incorporated in the pediatric protocols, is to achieve a deep and durable leukemia-free survival. To transplant or not to transplant adolescents and young adults with acute lymphoblastic leukemia is still a matter of debate, particularly in the era of pediatric regimens and the new sequence algorithm with the upfront use of novel drugs. Conclusion. Adolescent and young adult patients with acute lymphoblastic leukemia should be treated in specialized centers by an experienced multidisciplinary team with close attention to their particular needs.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85325770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Vidović, D. Šefer, J. Rajić, Tara Gunjak, V. Milošević, S. Jovanović
{"title":"Febrile neutropenia in patients with hematological malignancies - definition, diagnosis and management","authors":"A. Vidović, D. Šefer, J. Rajić, Tara Gunjak, V. Milošević, S. Jovanović","doi":"10.2298/mpns22s1161v","DOIUrl":"https://doi.org/10.2298/mpns22s1161v","url":null,"abstract":"Intensive chemotherapy/radiotherapy in cancer, especially with hematologic malignancies, causes cellular injury and suppression of inflammatory responses, which increase the risks of neutropenia and febrile episodes. Absolute neutrophil count < 1 ? 109/L is considered neutropenia, with absolute neutrophil count < 0.5 ? 109/L or < 1 ? 109/L that is expected to decrease to < 0.5 ? 109/L in the next 48 hours considered severe neutropenia, while absolute neutrophil count < 0.1 ? 109 is referred as profound neutropenia. Febrile episodes are usually defined as oral temperature > 38.3?C or two consecutive readings > 38.0?C lasting more than 1 hour. Although there is the possibility of non-infection-caused febrile neutropenia, most episodes are caused by infections. Febrile neutropenia is a clinical emergency that requires prompt management. Despite advances in therapy in recent years, febrile neutropenia remains a common complication in chemotherapy causing serious clinical results, including death. The administration of empirical antibacterial therapy has been successful in the management of febrile neutropenia since its launching 50 years ago. The wide application of broad-spectrum antibiotics has effectively decreased the mortality of febrile neutropenia patients. Neutropenic patients who remain febrile despite 4-7 days of broad-spectrum antibacterial therapy are at a high risk of invasive fungal infection. Empirical antifungal therapy with Amphotericin B or Caspofungin in persistently febrile neutropenic patients and other high-risk patients has shown to reduce the risk of invasive fungal infection by 50 - 80% and the risk of fungal infection-related mortality by 23- 45%. Lipid formulations which improve the therapeutic ratio of the traditional formulation are available","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86935368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivana Mijatov, A. Kiralj, N. Vuckovic, J. Nikolić, A. Tadić, Saša Mijatov
{"title":"Preoperative determination of tumor thickness in oral squamous cell carcinoma by computed tomography","authors":"Ivana Mijatov, A. Kiralj, N. Vuckovic, J. Nikolić, A. Tadić, Saša Mijatov","doi":"10.2298/mpns2212338m","DOIUrl":"https://doi.org/10.2298/mpns2212338m","url":null,"abstract":"Introduction. Evaluation of the prognostic factors and the survival rate in oral squamous cell carcinoma is extremely important, because patients in the same tumor-node-metastasis stage may have a different survival rate. Numerous studies have been conducted on various clinical and pathological prognostic factors in order to develop a prognostic model for the survival rate of patients with oral cancer. Material and Methods. The study was designed as a prospective study including 65 consecutive patients (n = 65) of both sexes who underwent surgical treatment of oral cancer. The diagnosis of oral cancer was based on the medical history, physical examination, and biopsy. The clinical tumor-node-metastasis staging was determined based on clinical examination. The radiological tumor-node-metastasis staging was done by computed tomography of the head, neck, and chest. The tumor thickness was determined by computed tomography and histopathological analysis of surgical specimens. Results. The histopathological analysis showed a mean tumor thickness of 13.446 mm, while the mean computed tomography tumor thickness was 15.2707 mm. The correlation between computed tomography tumor thickness and histopathological tumor thickness was moderately significant (Spearman?s rho = .581, p = 0.000). Conclusion. This study supports the use of computed tomography in the determination of tumor thickness in patients with oral squamous cell carcinoma. We want to emphasize the importance of preoperative, detailed imaging evaluation of patients in order to avoid multiple surgical procedures, significant morbidity, and unnecessary costs.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"2022 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73936288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypereosinophilic syndrome - diagnostic and treatment approach","authors":"D. Leković","doi":"10.2298/mpns22s1127l","DOIUrl":"https://doi.org/10.2298/mpns22s1127l","url":null,"abstract":"Hypereosinophilic syndrome is defined as a peripheral blood eosinophil count ? 1.5 ? 109/L associated with tissue or organ damage. Eosinophilic disorders represent a group of pathological conditions with heterogeneous pathophysiology, clinical presentation and prognosis. The disease prognosis is based on identifying the subtype and mechanism of eosinophilia. It is important to assess the degree of organ damage based on diagnostics that is directed upon symptoms and signs. After exclusion of secondary causes of eosinophilia, in 2016, the World Health Organization endorsed an assessment towards a molecular classification scheme of disease subtypes named clonal or primary eosinophilias. Diagnostic evaluation of primary eosinophilia relies on a combination of morphologic review of the blood and marrow, standard cytogenetics, fluorescence in situ hybridization, flow immunophenotyping, and a T-cell clonality assessment to detect histopathologic or clonal evidence for an acute or chronic myeloid/lymphoid neoplasm. The goal of the therapy is to reduce eosinophil-mediated organ damage. Depending of cause of eosinophilia therapeutic implications range from a ?watch and wait? to the implementation of allogeneic hematopoietic stem cell transplantation.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74087675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Domić, Ivana Tomasovic, Paula Bernaciak, G. Voronov, R. Igić, R. Škrbić
{"title":"Role of physicians in eliminating risk of cancer caused by combustible tobacco smoke","authors":"A. Domić, Ivana Tomasovic, Paula Bernaciak, G. Voronov, R. Igić, R. Škrbić","doi":"10.2298/mpns2212363d","DOIUrl":"https://doi.org/10.2298/mpns2212363d","url":null,"abstract":"Introduction. Combustible tobacco smoking accounts for nearly 30% of all cancer deaths in the United States of America and about 7 million deaths worldwide each year. Nowadays, e-cigarettes are increasingly used, especially among young people, but nicotine addiction that develops by such smoking easily converts to smoking combustible tobacco. Therefore, public health efforts must be directed to the prevention of initiation of smoking all nicotine-containing products. Role of Physicians. Medical doctors are very influential in smoking-related changes in local society, especially those who work in primary care, and they have an important role in both prevention and cessation of tobacco smoking. Tobacco smoking should be eliminated among medical doctors, yet many of them still smoke. The lowest percentage of smoking among physicians is in Oceania and North America (less than 11%) and the highest in Eurasia (25%). Smoking prevalence among medical students is higher than 35% in Georgia, Greece, Spain, and Italy, but less than 5% in the United States of America and Australia. In Serbia, 23% of physicians smoke. The age of physicians does not affect the number of smokers, but gender has a significant effect; women smoke less than men. Smoking Prevention and Cessation. Education about the effects of combustible tobacco smoking is a critical issue for successful smoking prevention and cessation; the best way is to provide educational programs on smoking at medical schools by introducing a mandatory course on combustible tobacco smoking at the beginning of the first year of study, especially in societies with a large percentage of smokers. Conclusion. In this paper, we showed how smoking can be eliminated among physicians and how they can affect the patients, public health policies, and antismoking campaigns.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84733648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medical terminology in modern Serbia - more than one and a half century long journey (1841-1872-2022)","authors":"A. Jelenković, Rade R. Babić","doi":"10.2298/mpns2212381j","DOIUrl":"https://doi.org/10.2298/mpns2212381j","url":null,"abstract":"Introduction. Linguistic expressions in a certain country, used in new or less developed sciences and professions, are commonly associated with difficulties due to the mother-tongue poverty. This also applies to the medical terminology. In modern Serbia, despite an eight-century-long hospital tradition, an institutional approach to the medical terminology was first established 180 years ago by the Society of Serbian Letters, founded in 1841, lasting until 1885. It was continued 30 years later by the Serbian Medical Society, founded in 1872. Society of Serbian Letters. The work of the Society of Serbian Letters on the Serbian language and terminology was very short, because Vuk Karadzic, among others, pointed out that the Society had to provide accurate and reliable terminology, which was not possible at the time. The work of Dr. Jovan Stejic and his translations of the books Macrobiotics and Anthropology are significant for medical terminology. Serbian Medical Society. Precisely set goals related to medical terminology and the preservation of the Serbian language in medicine were an integral part of the first Constitution of the Serbian Medical Society. However, during the continuous, 150-year-long work of the Society and the beginning of medical terminology standardization, for reasons still not explored, medical terminology has disappeared from its highest legal act, including the current Statute. Conclusion. Not even 180 years since the first short-term and 150 years since the long-term process of institutional approach to medical terminology was enough to develop and standardize medical terminology in modern Serbia. In order not to leave it to the arbitrariness of individuals, medical terminology must be a national strategy, such as, for example, the terminology of 33 professions in the Republic of Croatia called Croatian Professional Nomenclature.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89505756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edin Medjedović, Sabina Šehić-Kršlak, Z. Zvizdic, E. Begić, Alma Suljević, Fahira Imamović
{"title":"Modern concepts of improving procedures and procesess in healthcare facilities - effects of the lean concept","authors":"Edin Medjedović, Sabina Šehić-Kršlak, Z. Zvizdic, E. Begić, Alma Suljević, Fahira Imamović","doi":"10.2298/mpns2212350m","DOIUrl":"https://doi.org/10.2298/mpns2212350m","url":null,"abstract":"Introduction. Lean principles have been successfully adapted to the healthcare environment, enabling hospitals and clinics to streamline their operations and focus on value as perceived by their patients. Many healthcare facilities have implemented lean principles to improve their efficiency. The subject of this paper is the lean concept, the essence of which is implementation of methods that affect the efficiency and quality of providing health services. Our aim was to point out the necessity of applying modern concepts in healthcare. Material and Methods. The primary sources of data were obtained through research on the opinions and possibility of applying the lean concept in hospitals in Bosnia and Herzegovina. We presented the results on the effectiveness of the lean concept in hospitals that apply it. Results. After implementation of the lean concept in an Italian hospital, the results showed a positive impact on the waiting time for admission, faster discharge, and faster flow of information. The results of the research in Bosnia and Herzegovina showed that there were positive attitudes towards the effects that would be achieved by implementing the lean concept. Conclusion. The implementation of the lean concept would reduce medical waste, which would positively affect the quality of health care services.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89577668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}