A. Krsman, Branislava Baturan, S. Bulatović, D. Petrovic, Ksenija Antic-Trifunovic, D. Stajic
{"title":"Uterocutaneous fistula after cesarean section − a rare diagnosis not to be missed - a case report","authors":"A. Krsman, Branislava Baturan, S. Bulatović, D. Petrovic, Ksenija Antic-Trifunovic, D. Stajic","doi":"10.2298/mpns2212374k","DOIUrl":"https://doi.org/10.2298/mpns2212374k","url":null,"abstract":"Introduction. Uterocutaneous fistula is a rare complication of cesarean section which is challenging to diagnose and treat. The aim of this paper is to present a case of uterocutaneous fistula in order to contribute to the literature and help in the therapy and diagnosis of this rare complication. Case Report. A 29-year-old patient was referred to our clinic two months after her second cesarean section. The immediate postpartum course was complicated by endometritis treated with antibiotic therapy. At the time of admission, she was afebrile, without complaints other than a 2 cm long wound dehiscence on the anterior abdominal wall. The uterocutaneous fistula was confirmed by injecting methylene blue through the dehiscence on the anterior abdominal wall, which then spread into the vagina through the cervix. After laboratory tests, ultrasound and clinical examination, the patient underwent surgery. A total excision of the fistula was performed by laparotomy. Histopathological findings confirmed the diagnosis of uterocutaneous fistula. The postoperative recovery was uneventful. At the follow-up examination, three months after surgery, the patient had no complaints; the menstrual cycles were normal, as well as the transvaginal ultrasound findings. Conclusion. Uterocutaneous fistula is a rare complication following cesarean section. Timely identification of the fistula, its complete resection, and adequate antibiotic therapy in case of infection are necessary.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82981158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Golubović, S. Slavković, Z. Gajic, Aleksandra Becagul
{"title":"The audio recorded cognitive screen for brief screening of cognitive impairment in patients with psychosis: A pilot study","authors":"B. Golubović, S. Slavković, Z. Gajic, Aleksandra Becagul","doi":"10.2298/mpns2202026g","DOIUrl":"https://doi.org/10.2298/mpns2202026g","url":null,"abstract":"Introduction. Disorders of cognitive functioning in patients with psychosis can manifest in different domains. The disorders vary depending on the severity, from mild to severe, and on the severity of symptoms within the underlying disease. The aim of this study was to examine the possibility of using the Audio Recorded Cognitive Screen in patients with schizophrenia. Material and Methods. The study included a total of 61 subjects divided into two groups: 31 subjects with schizophrenia and 30 healthy controls. All subjects completed the Audio Recorded Cognitive Screen to assess the cognitive status in five domains of cognitive functioning. Results. The Audio Recorded Cognitive Screen showed a good reliability index (? = 0.85). Multivariate analysis of variance confirmed the differences between the two groups in all examined cognitive domains (F (6.53) = 26.719, p < .001). The partial eta squared results were as follows: object naming 0.159; immediate recall 0.531; delayed recall 0.585; visuospatial functions 0.334; attention 0.644; and verbal fluency 0.590. These results indicated significant differences between the two groups. Conclusion. The Audio Recorded Cognitive Screen is a feasible tool for the detection of neurocognitive impairment in individuals with schizophrenia. However, it is necessary to conduct further research in larger samples and use additional assessment instruments in this population.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"546 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91252979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Vujic, Željko Zečević, Marija K Simic, B. Gobeljic, E. Lazic, G. Samardžija, O. Šerbić
{"title":"Pediatric hematopoietic stem cell transplantation in Serbia - 25 years of experience","authors":"D. Vujic, Željko Zečević, Marija K Simic, B. Gobeljic, E. Lazic, G. Samardžija, O. Šerbić","doi":"10.2298/mpns22s1050v","DOIUrl":"https://doi.org/10.2298/mpns22s1050v","url":null,"abstract":"The first allogeneic identical sibling donor hematopoietic stem cell transplantation at the Institute for Mother and Child Health Care of Serbia ?Dr. Vukan Cupic? (Institute) was performed in the seventies of the last century. Almost twenty years later, the first allogeneic transplant from sibling haploidentical donor was performed in an infant suffering from severe combined immunodeficiency. After several years of efforts, the bone marrow transplant unit was opened in April 1997 at the Institute. Over the 25 years, the transplant team performed 360 hematopoietic stem cell transplantations, 175 autologous and 185 allogeneic (103 from identical sibling donor, 43 from haploidentical sibling donor, 36 from matched unrelated donor, 2 from identical sibling cord blood and 1 from unrelated identical cord blood).","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84196648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of patients with acute lymphoblastic leukemia who are not suitable for high-dose chemotherapy and hematopoietic stem cell transplantation","authors":"N. Govedarović","doi":"10.2298/mpns22s1019g","DOIUrl":"https://doi.org/10.2298/mpns22s1019g","url":null,"abstract":"Introduction. Acute lymphoblastic leukemia is a malignant disease characterized by the proliferation of precursor B-cells, Tcells or less often, precursors of NK-cells. B-cell acute lymphoblastic leukemia is more common in patients >60 years of age compared to patients <60 years of age (89% vs. 66%), and cytogenetic abnormalities such as t(9;22) (Ph+) are more common in older than younger patients (36% against 19%). Elderly patients often have a poor status and comorbidities, so poor disease outcome is more common. Clinical and biological features. B cell acute lymphoblastic leukemia is more common in patients >60 years of age compared to patients <60 years of age (89% vs 66%) and cytogenetic abnormalities such as t(9;22) are more common in older vs. younger (36% vs. 19%). Therapy. The elderly and patients with comorbidities require less intensive therapy, based on corticosteroids, vincristine and asparaginase, while avoiding anthracyclines and alkylating agents, due to the high mortality associated with treatment. For ?unfit? patients with Ph-positive acute lymphoblastic leukemia, tyrosine kinase inhibitors with reduced-intensity chemotherapy or corticosteroids alone are recommended. For t(9;22) negative patients, low-dose corticosteroid chemotherapy with or without immunotherapy is recommended. For patients with T-cell acute lymphoblastic leukemia, chemotherapy with venetoclax may be an option. Conclusion. The introduction of targeted therapy has changed treatment options in acute lymphoblastic leukemia. For elderly patients, targeted therapy is a necessary modality since standard chemotherapy leads to a poor outcome due to its toxicity and ineffectiveness.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"294 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90384252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Vukovic, D. Antić, V. Otašević, N. Sabljić, Sofija Šarac, B. Mihaljević
{"title":"Primary central nervous system lymphoma - an overview","authors":"V. Vukovic, D. Antić, V. Otašević, N. Sabljić, Sofija Šarac, B. Mihaljević","doi":"10.2298/mpns22s1073v","DOIUrl":"https://doi.org/10.2298/mpns22s1073v","url":null,"abstract":"Introduction. Primary central nervous system lymphoma is a rare entity mostly presenting with non-GCB diffuse large B-cell lymphoma, being confined to the brain, spinal cord, meninges, and eyes. Diagnosis. The diagnosis is frequently established by stereotactic or open the brain biopsy, but in some cases with isolated leptomeningeal involvement, the only way is to identify atypical/monoclonal lymphocytes in cerebrospinal fluid. By workup, we aim to define the extent of disease in the central nervous system and to exclude systemic involvement. Treatment. Treatment is tailored according to the patient?s age, fitness, vital organ function, comorbidities, and available therapy. The backbone of induction treatment is high-dose methotrexate, usually within polychemotherapy. Consolidation phase is a matter of debate between two approaches: 1. high dose chemotherapy with autologous stem cell transplantation, which appears to be the preferable option for young fit patients, and 2. whole brain radiotherapy, preserved for transplant-ineligible ones. Whole brain radiotherapy has been raising concerns because of frequent cognitive impairment, which has been significantly diminished by reducing the irradiation dose. Despite a comprehensive treatment approach, many patients relapse, and since the prognosis of relapsed/refractory disease is devastating, there is a sense of urgency for novel treatment strategies. Several targeted agents and immunomodulatory drugs have been investigated in the settings of both relapsed/refractory and initial therapy, but with limited success. Ibrutinib monotherapy can induce durable remissions in the first line, but in relapse/refractory settings, the results are controversial. Conclusion. Adequate patient selection and new prospective trials should improve survival and preserve the patient?s neurological status.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74180830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypereosinophilic syndrome - diagnostic and treatment approach","authors":"D. Leković","doi":"10.2298/mpns22s1127l","DOIUrl":"https://doi.org/10.2298/mpns22s1127l","url":null,"abstract":"Hypereosinophilic syndrome is defined as a peripheral blood eosinophil count ? 1.5 ? 109/L associated with tissue or organ damage. Eosinophilic disorders represent a group of pathological conditions with heterogeneous pathophysiology, clinical presentation and prognosis. The disease prognosis is based on identifying the subtype and mechanism of eosinophilia. It is important to assess the degree of organ damage based on diagnostics that is directed upon symptoms and signs. After exclusion of secondary causes of eosinophilia, in 2016, the World Health Organization endorsed an assessment towards a molecular classification scheme of disease subtypes named clonal or primary eosinophilias. Diagnostic evaluation of primary eosinophilia relies on a combination of morphologic review of the blood and marrow, standard cytogenetics, fluorescence in situ hybridization, flow immunophenotyping, and a T-cell clonality assessment to detect histopathologic or clonal evidence for an acute or chronic myeloid/lymphoid neoplasm. The goal of the therapy is to reduce eosinophil-mediated organ damage. Depending of cause of eosinophilia therapeutic implications range from a ?watch and wait? to the implementation of allogeneic hematopoietic stem cell transplantation.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74087675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Simic-Panic, K. Boskovic, A. Knežević, J. Zvekic-Svorcan, S. Tomasevic-Todorovic, T. Spasojevic
{"title":"Hip osteoarthritis - update on etiopathogenesis, clinical presentation and management","authors":"D. Simic-Panic, K. Boskovic, A. Knežević, J. Zvekic-Svorcan, S. Tomasevic-Todorovic, T. Spasojevic","doi":"10.2298/mpns22s2062s","DOIUrl":"https://doi.org/10.2298/mpns22s2062s","url":null,"abstract":"Osteoarthritis is the most frequent form of arthritis, and the hip is the second most frequently affected joint. The effects of osteoarthritis on the hip joint often lead to marked physical impairment that can contribute to increased disability and dependency in everyday activities. Hip osteoarthritis is a degenerative process with progressive loss of articular cartilage, followed by a reparative process such as reactive bone hypertrophy, which causes osteophyte formation and remodelling. The joint responds with subchondral and synovial inflammation. Patients with hip osteoarthritis report pain in the groin area which can develop slowly and worsen over time. With the progression of the disease, the range of motion of the affected hip is reduced, which affects the walking pattern and may cause a limp. Therapeutic options for hip osteoarthritis should be based on the etiopathogenesis of the disease. The approach to treatment for every patient should be multidisciplinary, multimodal and individualised taking into account personal beliefs and preferences, social and psychological factors and prior medical history. It is important to avoid unnecessary delays in referring patients with advanced hip osteoarthritis for surgical treatment, in order to prevent worse outcomes after total hip arthroplasty. The aim of this article is to offer a concise update on etiopathogenesis, clinical presentation, and management options for hip osteoarthritis.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74146538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edin Medjedović, Sabina Šehić-Kršlak, Z. Zvizdic, E. Begić, Alma Suljević, Fahira Imamović
{"title":"Modern concepts of improving procedures and procesess in healthcare facilities - effects of the lean concept","authors":"Edin Medjedović, Sabina Šehić-Kršlak, Z. Zvizdic, E. Begić, Alma Suljević, Fahira Imamović","doi":"10.2298/mpns2212350m","DOIUrl":"https://doi.org/10.2298/mpns2212350m","url":null,"abstract":"Introduction. Lean principles have been successfully adapted to the healthcare environment, enabling hospitals and clinics to streamline their operations and focus on value as perceived by their patients. Many healthcare facilities have implemented lean principles to improve their efficiency. The subject of this paper is the lean concept, the essence of which is implementation of methods that affect the efficiency and quality of providing health services. Our aim was to point out the necessity of applying modern concepts in healthcare. Material and Methods. The primary sources of data were obtained through research on the opinions and possibility of applying the lean concept in hospitals in Bosnia and Herzegovina. We presented the results on the effectiveness of the lean concept in hospitals that apply it. Results. After implementation of the lean concept in an Italian hospital, the results showed a positive impact on the waiting time for admission, faster discharge, and faster flow of information. The results of the research in Bosnia and Herzegovina showed that there were positive attitudes towards the effects that would be achieved by implementing the lean concept. Conclusion. The implementation of the lean concept would reduce medical waste, which would positively affect the quality of health care services.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89577668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nataša Puškar, Milica Puskar, P. Vucinic, Stojan Ivić, D. Petrović
{"title":"Determination of dentoalveolar parameters in patients with progenia","authors":"Nataša Puškar, Milica Puskar, P. Vucinic, Stojan Ivić, D. Petrović","doi":"10.2298/mpns2210279p","DOIUrl":"https://doi.org/10.2298/mpns2210279p","url":null,"abstract":"Introduction. Class III malocclusions are characterized by a more prominent lower jaw compared to the upper jaw and a Class III skeletal and dentoalveolar relationship according to Angle. In the scientific literature, there is a small amount of data on the morphological characteristics of malocclusion in different populations, so there is a justified need to examine the morphological characteristics of Class III malocclusion in the population of Vojvodina. The aim of this study was to determine the morphological characteristics of Class III malocclusions, to compare them with the average values found in the scientific literature, and to determine the correlation between the examined parameters of the upper and lower jaw. Material and Methods. This retrospective study included subjects with Class III dentoalveolar malocclusion treated at the Dentistry Clinic of Vojvodina in Novi Sad. The method of random selection was used to select 50 study models. The data were statistically processed with a significance level of p < 0.05. Results. The obtained results indicate that the sum of crown width of the mandibular incisors, the length of the mandibular dental arch, and the mandibular apical base in subjects with Class III malocclusion are higher than the average values in the general population. The values of the posterior width of the maxillary dental arch in the examined group are lower compared to the average values in the general population. Conclusion. Subjects with Class III malocclusion present with a greater mandibular dental arch in regard to the maxillary dental arch.","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81007922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of the coronavirus disease 2019 pandemic on wellness and healthy lifestyle","authors":"S. Djordjevic, S. Knežević, Nikola Savić","doi":"10.2298/mpns2208211d","DOIUrl":"https://doi.org/10.2298/mpns2208211d","url":null,"abstract":"Introduction. The main goal of wellness is to promote proactive and preventive behavior that improves mental health and lifestyle. This study examined how the lifestyle of respondents was affected by the inability to visit spas and wellness centers during the coronavirus disease 2019 pandemic. Material and Methods. This crosssectional study included a total of 186 participants with an average age of 41.31 ? 10.475 years, 137 female and 49 male. We specifically designed a questionnaire to analyze the impact of the lack of wellness services during the coronavirus disease 2019 pandemic. Results. There was no statistically significant association between gender, age, education, and marital status and visiting wellness destinations. Monthly income, however, showed a statistically significant association with visiting wellness facilities (p = 0.002). There was a significant decrease in the use of wellness centers during the coronavirus disease 2019 pandemic. A small number of the respondents believed the coronavirus disease 2019 pandemic has changed their lifestyle. Conclusion. The lack of wellness services has affected the respondents? inability to relax and get away from daily life, but the coronavirus disease 2019 pandemic has not negatively changed their lifestyle (p = 0.001).","PeriodicalId":87940,"journal":{"name":"Calcutta medical review","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84154363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}