北京大学学报（医学版）最新文献

{"title":"[Challenges and prospects of the application of the amendments to the <i>International Health Regulations</i> (<i>2005</i>) in China].","authors":"L Chen, M Ren","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With the increasingly complex global health and safety situation, in order to establish a strong global health and safety governance system, promote international cooperation and ensure public health and safety, the member countries of the World Health Organization initiated the revision of the <i>International Health Regulations</i> (<i>2005</i>). After the amendment of the <i>International Health Regulations</i> (<i>2005</i>) was adopted on 1 June 2024, China, as one of the contracting parties, urgently needs to promote the domestic rule of law and the foreign-related rule of law as a whole, realise the effective connection between domestic law and this regulation, and promote the transformation and application of international law. Compared with the original regulations, the Amendment has adjusted and improved relevant health measures, strengthened the construction of the public health service system, and further clarified the responsibilities and obligations of both the World Health Organization and the Parties, which has led to the application of the amendment to the <i>International Health Regulations</i> (<i>2005</i>) in China. Therefore, it is necessary to improve the domestic health law and regulation system, strengthen domestic core capacity building, deepen international cooperation and promote global governance, and strive to promote the solution of these problems.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 3","pages":"411-416"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Epidemiological characteristics of febrile seizure among children under 6 years old in Ningbo City from 2015 to 2021].","authors":"G Liu, L Zhang, H Zhao, S Deng, J Yang, N Li, R Ma, Y He, G Xu, Z Liu, S Zhan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To describe the epidemiological characteristics and changes of febrile seizure (FS) among children under 6 years old in Ningbo City, Zhejiang Province from 2015 to 2021.</p><p><strong>Methods: </strong>Based on the Ningbo Regional Health Information Platform, a dynamic cohort was established using vaccination registration information, and the cases of FS were identified by the diagnostic results of Chinese terms or International Classification of Diseases 10th revision (ICD-10) R56.0 code in the electronic medical records. The first visit of FS during the observation period was defined as a new case, and a recurrence case was defined as the case with a visit interval of more than 7 days. The 95% confidence interval (<i>CI</i>) of FS incidence density was calculated by the Poisson distribution.</p><p><strong>Results: </strong>From January 2015 to June 2020, there were 1.3 million children under 6 years old in Ningbo, with male accounting for 52.87%. The median follow-up time was 2.83 (1.55-4.00) years. During the follow-up period, 12 776 new onset cases had FS, with more males than females, with an overall incidence density of 4.34 (95%<i>CI</i> 4.27-4.40)/1 000 person-years and a recurrence rate of 21.63%. There was a higher incidence density in children who were male, born in Ningbo and of non-mobility. The incidence density of FS was higher in urban areas than in rural and rural-urban fringe areas, and the incidence density was different among districts and counties. The peak density was found in children aged 18-23 months [8.42 (95%<i>CI</i> 8.11-8.74)/1 000 person-years]. From 2015 to 2019, the incidence density increased with calendar year (<i>P</i>_trend < 0.001), and the highest was 5.62 (95%<i>CI</i> 5.43-5.81) /1 000 person-years. The incidence density of FS decreased significantly during the period between 2020 and 2021. The incidence density was higher in winter.</p><p><strong>Conclusion: </strong>From 2015 to 2019, the overall incidence density of FS in children under 6 years old in Ningbo City presented an increasing trend. More attention should be paid to the health education, the improvement of the health maintenance model, the enhancement of the cognition of FS, the identification and treatment of FS among high-risk population and regions so as to prevent its recurrence and reduce the disease burden during the corona virus disease 2019 (COVID-19) epide-mic.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 3","pages":"584-591"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Fitness of onlays fabricated with direct and indirect CAD/CAM technology <i>in vitro</i>].","authors":"K Qian, Y Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the fitness of zirconia and lithium disilicate glass-ceramic onlays fabricated with direct and indirect computer-aided design and computer-aided manufacturing (CAD/CAM) technology <i>in vitro</i>.</p><p><strong>Methods: </strong>In the study, 48 standardised typodont left mandibular first molars received standardised onlay preparation. Then, all the specimens were randomly divided into 4 groups. There were 12 specimens in each group. The preparation quality was checked under the stereomicroscope. All the specimens were fixed in typodonts. Subsequently, the typodonts were fixed in the dental simulators to simulate the oral conditions. In groups A and B, the digital impressions were obtained by using the intraoral scanner. In groups C and D, conventional impressions of polyether impression material were obtained according to the instructions of the manufacturer using individual trays. The stone casts were made with type Ⅳ gypsum later. Then, all casts were digitized with the model scanner. Based on the data obtained from the scan, onlay restorations of all the groups were designed using the corresponding software, the simulated cement thickness was set to 50 μm. Then, the final onlays restorations of all the groups were machined with the milling machines in lab. The fabrication materials were different in groups. The specimens of groups A and C were fabricated with zirconia. While, the specimens of groups B and D were fabricated with lithium disilicate glass-ceramic. The marginal gap and internal gap of all restorations were analyzed by 3D replica technique, for each measurement, the specimen was digitised using the model scanner.</p><p><strong>Results: </strong>The marginal gap of the onlays fabricated with indirect digital impressions were smaller than that with direct digital impressions (<i>P</i> < 0.05). At the same time, the internal gap of the onlays fabricated with indirect digital impressions were smaller than that with direct digi-tal impressions (<i>P</i> < 0.05). The marginal gap was larger in distal gingival than that in the other regions in all the groups (<i>P</i> < 0.05). Different fabrication materials, zirconia or lithium disilicate reinforced glass-ceramic, had no effect on onlay marginal and internal fit (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The marginal and internal adaptation of the onlays fabricated with indirect digital impressions was better than with direct digital impressions. Zirconia and lithium disilicate reinforced glass-ceramic had no effect on the onlay adaptation.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 3","pages":"604-609"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prospective association between physical activity and mortality in patients with chronic obstructive pulmonary disease].","authors":"S Zhang, Y Lan, D Sun, P Pei, H DU, J Chen, Z Chen, J Lv, L Li, C Yu","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To explore the prospective association between physical activity level and mortality risk in Chinese adults with chronic obstructive pulmonary disease (COPD).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Based on the China Kadoorie Biobank (CKB) who had COPD at the baseline survey, this study employed the Cox proportional hazards regression model to estimate the prospective associations between the overall physical activity, different intensities (low-level, moderate-to-vigorous-level), and types (occupational, non-occupational) of physical activity level and the risks of all-cause and cause-specific mortality, such as vascular diseases, cancer, and respiratory diseases. Based on the quintiles of physical activity level, participants were divided into five groups (Q1-Q5), with the lowest quintile group (Q1) as the reference group. Hazard ratio (&lt;i&gt;HR&lt;/i&gt;) and 95% confidence interval (95%&lt;i&gt;CI&lt;/i&gt;) were calculated for the remaining. In our study, we also performed sensitivity and subgroup analyses, including age, gender, self-rated health status, severity of COPD, &lt;i&gt;etc&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among 33 588 COPD patients at the baseline survey, 8 314 (22.2%) deaths were documented during an average follow-up of (11.1±3.1) years. Negative linear associations between the overall physical activity level and mortality risk from all-cause, vascular, and respiratory diseases were observed (&lt;i&gt;P&lt;/i&gt; trend for linear correlation being &lt; 0.001, 0.002, &lt; 0.001). Compared with the lowest quintile group of total physical activity (Q1), the hazard ratios (&lt;i&gt;HR&lt;/i&gt;) and 95% confidence intervals (&lt;i&gt;CI&lt;/i&gt;) for all-cause mortality, vascular disease mortality, and respiratory disease mortality in the highest quintile group (Q5) were 0.77 (0.70, 0.85), 0.77 (0.65, 0.91), and 0.58 (0.48, 0.71), respectively. The low-level and moderate-to-vigorous-level physical activity were negatively associated with all-cause mortality in the COPD patients (&lt;i&gt;P&lt;/i&gt; trend for linear correlation: 0.002, &lt; 0.001, respectively). Compared with the lowest quintile group of low-intensity and moderate-to-vigorous intensity physical activity (Q1), the &lt;i&gt;HRs&lt;/i&gt; (95%&lt;i&gt;CI&lt;/i&gt;) for all-cause mortality in the highest quintile group (Q5) were 0.89 (0.82, 0.97) and 0.79 (0.72, 0.87), respectively. The occupational and non-occupational physical activity were also found to have a linear inverse association with all-cause mortality risk among the COPD patients (&lt;i&gt;P&lt;/i&gt; trend &lt; 0.001 and 0.015, respectively). Compared with the lowest quintile group of occupational and non-occupational physical activity (Q1), the &lt;i&gt;HR&lt;/i&gt; (95%&lt;i&gt;CI&lt;/i&gt;) for all-cause mortality in the highest quintile group (Q5) were 0.69 (0.61, 0.78) and 0.91 (0.84, 0.98), respectively. The associations between overall physical activity and all-cause mortality risk were stronger for patients aged 60 and above, female, and who reported poor health status (&lt;i&gt;P&lt;/i&gt; for interaction: 0.028, 0.012, 0.","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 3","pages":"537-544"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association of triglyceride-glucose index and cardiovascular disease in a community-based Chinese cohort].","authors":"M Lu, Q Liu, T Zhou, X Liu, Y Sun, P Shen, H Lin, X Tang, P Gao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between the triglyceride-glucose (TyG) index and the incidence and mortality of cardiovascular disease (CVD) in a large population-based cohort.</p><p><strong>Methods: </strong>Participants aged 40-79 years without a history of CVD at baseline were drawn from the CHinese Electronic health Records Research in Yinzhou (CHERRY) study between January 1, 2010, and May 31, 2020. The TyG index was calculated using baseline triglyceride and fasting blood glucose. Cox proportional hazards models were used to assess the association between the TyG index and the composite outcome of CVD (incidence and mortality), adjusting for age, gender, education, region, smoking status, body mass index, systolic blood pressure, and total cholesterol. Hazard ratios (<i>HR</i>) and 95% confidence intervals (<i>CI</i>) were calculated. Nonlinear associations between the TyG index and CVD were further evaluated using restricted cubic splines, and subgroup analyses by gender and age were conducted to explore potential differences.</p><p><strong>Results: </strong>A total of 226 406 individuals were included, with a mean age of (55.0±9.7) years at baseline, 46.8% of whom were men, and a median TyG index of 8.68. Over a median follow-up of 7.99 years, 9 815 (4.34%) participants experienced CVD incidence or mortality. After adjusting for age, gender, education, region, smoking status, body mass index, systolic blood pressure and total cholesterol, the risk of CVD increased with higher TyG index levels (<i>P</i> < 0.001). The risk in the highest TyG quartile (TyG>9.10) was 42% higher than in the lowest quartile (TyG≤8.32) (<i>HR</i>=1.42, 95%<i>CI</i>: 1.34-1.51). Individuals under 60 years had a higher HR for CVD compared with those aged 60 years and above (<i>HR</i>: 1.71 <i>vs.</i> 1.27, <i>P</i> < 0.05). Restricted cubic spline analysis revealed a reverse L-shaped association between the TyG index and CVD risk in the overall population (<i>P</i> < 0.001 for nonlinear trend), with risk increasing after the TyG index exceeded 8.67. However, the threshold varied by gender, with a lower threshold in women (8.51) than in men (8.67).</p><p><strong>Conclusion: </strong>A significant nonlinear relationship was revealed between the TyG index and CVD risk, with a threshold effect. The risk of CVD increased once the TyG index surpassed a certain threshold, with a lower threshold in women than in men. These findings suggest that cardiovascular risk prediction and interventions based on the TyG index should be gender-stratified, and early intervention for individuals under 60 years old might have important public health implications.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 3","pages":"430-435"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Healthcare institution resilience and the influencing factors during infectious disease outbreaks].","authors":"Y Fu, J Zhang, B Han, Q Wang, Z Zhu, Z Nie, Y Tan, Q Liu, X Li, J Guo, R Jiang, L Yang","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To analyze the association between healthcare workers mental health, institutional supplies and facilities, inter-organizational coordination during infectious disease outbreaks, and the healthcare institution resilience.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;An online questionnaire survey was conducted among the healthcare workforce from 146 institutions in Beijing from January 13, 2023 to February 9, 2023, and a total of 1 434 eligible respondents were included. The sample comprised 408 responses from tertiary hospitals, 117 from secondary hospitals, and 909 from primary care institutions. The resilience indicator for healthcare institutions was defined as the degree to which medical services met patient demands, with influencing factors including physical factors, such as material shortages and facility space adaptation or expansion, organizational factors such as information sharing and patient referral, and psychological factors were evaluated using job satisfaction (extrinsic satisfaction, intrinsic satisfaction), burnout (emotional exhaustion, depersonalization, reduced personal accomplishment), and depression status. Ordered multiclassification Logistic regression was used to examine the impact of various factors on the degree to which healthcare services met patient needs; additionally, demographic factors that might influence institutional resilience were controlled.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;During the emergency response phase, 93% of hospitals maintained the capacity to meet patient needs, though tertiary hospitals demonstrated significantly higher rates of service inadequacy (21.05%). Material shortages were reported across all institutions, with tertiary hospitals experiencing more frequent multi-item shortages. Inter-institutional collaboration patterns revealed substantial variation: 87.50% of primary care facilities, 42.86% of secondary hospitals, and 31.58% of tertiary hospitals. Healthcare workers across all levels reported mild depressive symptoms and moderate-to-severe burnout levels. Regression analysis showed high satisfaction (overall satisfaction &lt;i&gt;β&lt;/i&gt;=0.04, extrinsic satisfaction &lt;i&gt;β&lt;/i&gt;=0.06, and intrinsic satisfaction &lt;i&gt;β&lt;/i&gt;=0.08), low degree of job burnout (emotional exhaustion &lt;i&gt;β&lt;/i&gt;=-0.04, depersonalization &lt;i&gt;β&lt;/i&gt;=-0.07 and reduced personal accomplishment &lt;i&gt;β&lt;/i&gt;=0.01), low degree of depression (&lt;i&gt;β&lt;/i&gt;=-0.06) were significantly associated with higher healthcare institution resilience. In addition, material shortages were significantly associated with lower resilience, and renovation and expansion of treatment spaces, and information sharing, were all associated with higher resilience. Demographic factors (age, gender, marital status, educational background, etc.) had no significant impact on resilience.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Mental health status significantly influences healthcare institution resilience. As human resources constitute the core asset of healthca","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 3","pages":"529-536"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Perinatal outcomes of single intrauterine fetal demise in monochorionic diamniotic twins].","authors":"W Bian, W Zhou, T Wu, P Zhu, Y Chen, P Yuan, X Wang, Y Wang, Y Wei, Y Zhao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To compare the pregnancy outcomes of surviving fetuses in monochorionic diamniotic (MCDA) twin pregnancies after selective feticide or spontaneous single intrauterine fetal demise (sIUFD), and to explore the influencing factors of prognosis.</p><p><strong>Methods: </strong>A total of 219 cases of intra-uterine death of one fetus in MCDA twin pregnancies admitted to Peking University Third Hospital from September 2010 to August 2021 were collected. According to the mode of fetal death, they were divided into the spontaneous sIUFD group (120 cases) and the selective feticide group (99 cases). Data on the maternal conditions during pregnancy, the situation of the intrauterine-dead fetus, and pregnancy outcomes were collected for retrospective case-analysis.</p><p><strong>Results: </strong>The live-birth rates of surviving fetuses in the spontaneous sIUFD group and the selective feticide group were 85.0% and 81.8% respectively, and the total perinatal survival rates of surviving fetuses were 73.3% and 81.8% respectively, and there were no statistically significant differences. Compared with the spontaneous sIUFD group, the selective feticide group had a greater gestational week at delivery, and lower rate of preterm birth before 37 weeks, neonatal asphyxia, and early neonatal mortality. Using the gestational week at delivery as the outcome variable, Cox regression analysis showed that the mode of fetal death was not a risk factor affecting the gestational week at delivery of the surviving fetus, while gestational hypertension and the gestational week of fetal death were independent risk factors affecting the gestational week at delivery of the surviving fetus. Using preterm birth before 37 weeks, intrauterine death of the surviving fetus, and abnormal neonatal cranial ultrasound as outcome variables respectively, unconditional logistic regression analysis showed that the mode of fetal death, the gestational week of fetal death, the position of the dead fetus, and fetal complications were independent risk factors affecting the outcomes of the above-mentioned surviving fetuses. According to the results of the univariate analysis, the above risk factors were included in the multivariate regression analysis, and the results were the same as those of the univariate analysis.</p><p><strong>Conclusion: </strong>For MCDA twin pregnancy patients with severe twin-related complications, the prognosis of surviving fetuses after selective feticide is better. The proactive intrauterine intervention and treatment are of great significance for improving the prognosis of surviving fetuses.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 3","pages":"592-598"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Spousal correlations of blood lipid based on a family design].","authors":"Y Li, H Guo, H Peng, T Hou, H Zhang, Y Tan, Y Zheng, M Wang, Y Wu, X Qin, J Li, Y Ye, T Wu, D Chen, Y Hu, L Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the spousal correlations of total cholesterol (TC), total triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), and to investigate the reasons behind these spousal correlations.</p><p><strong>Methods: </strong>Participants and data were from the baseline survey of family-based cohort studies in Fangshan, Beijing and Tulou, Fujian. The origin of spousal correlations were explored from perspectives of convergence, assortative mating, social homogamy. Pearson ' s correlation and generalized linear models (GLM) were used to estimate the spousal correlation. Convergence was assessed by Pearson ' s correlation between the phenotypic differences between couples and the duration of marriage, with GLM used for further validation. Pearson ' s correlation of genetic risk scores (GRS) and couple-specific Mendelian randomization (MR) were calculated to assess the genetic correlation and possible causal relationships between spouses. Two-independent-sample <i>t</i>-tests were used to compare GRS consistency across subgroups divided by education attainment, couple-specific MR and <i>Q</i> statistics used to test assortative mating in subgroups and intergroup differences.</p><p><strong>Results: </strong>In the study, 342 couples (287 couples from Fangshan and 55 couples from Fujian) were included, with the average age of (64.91±8.76) years. Spousal correlations of TC, TG, HDL-C, and LDL-C showed statistically significant associations both before and after adjusting for covariates, with effect sizes of 0.229 (95%<i>CI</i>: 0.125-0.327), 0.257 (95%<i>CI</i>: 0.155-0.354), 0.179 (95%<i>CI</i>: 0.074-0.280), and 0.181 (95%<i>CI</i>: 0.076-0.282). For convergence, for each additional year of marriage, ΔTC increased by 0.016 mmol/L (95%<i>CI</i>: 0.001-0.033 mmol/L), and ΔLDL-C increased by 0.017 mmol/L (95%<i>CI</i>: 0.002-0.031 mmol/L). For assortative mating, GRS correlations and results of couple specific MR didn ' t show any statistical significance. For social homogamy, no differences in GRS or assortative mating were found between subgroups stratified by education attainment.</p><p><strong>Conclusion: </strong>The blood lipid in participants exhibit spousal phenotypic correlations, however, no effects of convergence, assortative mating or social homogamy were observed. More independent studies with larger sample sizes are warranted to further validate these findings in the future.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 3","pages":"423-429"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Three-party game and simulation analysis of health-related information quality regulation in public health emergencies].","authors":"Y Wang, R Yuan, S Li, C Chang","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To construct a tripartite game model involving the government, the public, and the pharmaceutical industry alliance during public health emergencies, revealing the dynamic mechanisms of health-related information quality regulation and exploring effective strategies to optimize the information dissemination environment through reward-punishment mechanisms.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Based on evolutionary game theory, a tripartite evolutionary game model was established, integrating strategy spaces, payoff functions, and parameter definitions for each stakeholder. The pharmaceutical industry alliance ' s strategies included publishing high- or low-quality information (&lt;i&gt;α&lt;/i&gt;), the public ' s strategies encompassed rational analysis or passive response (&lt;i&gt;β&lt;/i&gt;), and the government's strategies involved regulatory enforcement or inaction (&lt;i&gt;γ&lt;/i&gt;). Key parameters, such as economic benefits (&lt;i&gt;I&lt;sub&gt;yy&lt;/sub&gt;&lt;/i&gt;), regulatory costs (&lt;i&gt;C&lt;sub&gt;zf&lt;/sub&gt;&lt;/i&gt;), penalties (&lt;i&gt;F&lt;sub&gt;yy&lt;/sub&gt;&lt;/i&gt;), and incentives (&lt;i&gt;P&lt;sub&gt;yy&lt;/sub&gt;&lt;/i&gt;), were quantified to reflect real-world scenarios. Replicator dynamic equations and Jacobian matrices were derived to analyze the stability of equilibrium points, while MATLAB 2016a simulations were conducted to validate the model under varying initial conditions (&lt;i&gt;e.g&lt;/i&gt;., &lt;i&gt;I&lt;sub&gt;yy&lt;/sub&gt;&lt;/i&gt;=100, 150, 200; &lt;i&gt;P&lt;sub&gt;yy&lt;/sub&gt;&lt;/i&gt;=0, 20, 35; &lt;i&gt;F&lt;sub&gt;yy&lt;/sub&gt;&lt;/i&gt;=0, 10, 20). Sensitivity analyses examined the impact of critical parameters on system evolution, by 50 iterative simulations to observe convergence patterns.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study revealed three key findings: (1) Public rational discernment (&lt;i&gt;β&lt;/i&gt;) significantly influenced the pharmaceutical industry ' s strategy. Simulations demonstrated that increasing &lt;i&gt;I&lt;sub&gt;qz&lt;/sub&gt;&lt;/i&gt;(benefits of information acquisition) reduced &lt;i&gt;C&lt;sub&gt;qz&lt;/sub&gt;&lt;/i&gt; (cognitive costs), elevating &lt;i&gt;β&lt;/i&gt; from 0.4 to 0.8 and driving &lt;i&gt;α&lt;/i&gt; (high-quality information probability) to stabilize at 1. (2) Government regulatory intensity (&lt;i&gt;γ&lt;/i&gt;) correlated positively with the social hazards of low-quality information. When &lt;i&gt;F&lt;sub&gt;yy&lt;/sub&gt;&lt;/i&gt;+ &lt;i&gt;P&lt;sub&gt;yy&lt;/sub&gt;&lt;/i&gt;&gt;&lt;i&gt;I&lt;sub&gt;yy&lt;/sub&gt;&lt;/i&gt;, speculative behaviors decreased, achieving equilibrium at α=1. (3) Dual stable equilibria emerged: a high-quality equilibrium (&lt;i&gt;α&lt;/i&gt;=1, &lt;i&gt;β&lt;/i&gt;=1, &lt;i&gt;γ&lt;/i&gt;=0) with lower regulatory costs and a low-quality equilibrium (&lt;i&gt;α&lt;/i&gt;=0, &lt;i&gt;β&lt;/i&gt;=0, &lt;i&gt;γ&lt;/i&gt;=1) associated with higher social risks. Phase diagrams illustrated path dependency, where initial α &lt; 0.5 led to the low-quality equilibrium unless dynamic penalties (&lt;i&gt;F&lt;sub&gt;yy&lt;/sub&gt;&lt;/i&gt;&gt;20) and incentives (&lt;i&gt;P&lt;sub&gt;yy&lt;/sub&gt;&lt;/i&gt;&gt;30) were enforced.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;A \"carrot-stick\" collaborative governance framework is proposed, emphasizing categorized regulation, AI-enabled auditing, and dynamic penalty systems. Future research should integrate emotional utility functions t","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 3","pages":"514-521"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between DNA methylation clock and obesity-related indicators: A longitudinal twin study].","authors":"S Liu, W Cao, J Lv, C Yu, T Huang, D Sun, C Liao, Y Pang, R Hu, R Gao, M Yu, J Zhou, X Wu, Y Liu, W Gao, L Li","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To explore the relationship between obesity indicators and DNA methylation clocks acceleration, and to analyze their temporal sequence.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Data were obtained from two surveys conducted in 2013 and 2017-2018 by the Chinese National Twin Registry. Peripheral blood DNA methylation data were measured using the Illumina Infinium Human Methylation 450K BeadChip and EPIC BeadChip. DNA methylation clocks/acceleration metrics (GrimAA, PCGrimAA and DunedinPACE) were calculated using the DNA methylation online tool (https://dnamage.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Genetics: &lt;/strong&gt;ucla.edu/) or R code provided by researchers. Obesity indicators included weight, body mass index (BMI), waist circumference, waist-hip ratio, and waist-height ratio. A total of 1 070 twin individuals were included in the cross-sectional analysis, comprising 378 monozygotic (MZ) twin pairs and 155 dizygotic (DZ) twin pairs for within-pair analysis. Mixed-effects models were used to examine the associations between obesity indicators and DNA methylation clocks, as well as their acceleration measures. The longitudinal analysis included 314 twin individuals, comprising 95 MZ twin pairs and 62 DZ twin pairs for within-pair analysis. Cross-lagged panel models were applied to further explore the temporal relationships between obesity and DNA methylation clock indicators. All analyses were conducted both in the full twin sample and separately within MZ and DZ twin pairs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In the cross-sectional analysis population, monozygotic twins accounted for 71.0%, males for 68.0%, and the mean chronological age was (49.9±12.1) years. In the longitudinal analysis population, monozygotic twins accounted for 60.5%, males for 60.8%, with a mean baseline chronological age of (50.4±10.2) years and a mean follow-up duration of (4.6±0.6) years. Except for the waist-to-hip ratio, which was significantly higher at follow-up compared with baseline, no statistically significant differences were observed in the means of other obesity indicators between baseline and follow-up. Correlation analysis revealed that weight, BMI, waist circumfe-rence, waist-hip ratio (WHR), and waist-height ratio (WHtR) were positively correlated with DunedinPACE in all the twins, with WHtR showing the strongest association (&lt;i&gt;β&lt;/i&gt;=0.21, 95%&lt;i&gt;CI&lt;/i&gt;: 0.11 to 0.31). Weight and BMI were negatively associated with GrimAA (&lt;i&gt;β&lt;/i&gt;=-0.03, 95%&lt;i&gt;CI&lt;/i&gt;: -0.05 to -0.01; &lt;i&gt;β&lt;/i&gt;=-0.07, 95%&lt;i&gt;CI&lt;/i&gt;: -0.12 to -0.02), while weight was negatively associated with PCGrim- AA (&lt;i&gt;β&lt;/i&gt;=-0.02, 95%&lt;i&gt;CI&lt;/i&gt;: -0.03 to 0.00). However, within-twin-pair analyses showed no statistically significant correlations. Cross-lagged panel model analysis indicated that higher baseline weight might lead to increased GrimAA at follow-up, while elevated baseline weight, BMI, and waist circumference might increase PCGrimAA. Higher baseline WHR was associated with increased DunedinPACE at f","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 3","pages":"456-464"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}