北京大学学报（医学版）最新文献

{"title":"[Early efficacy of local tranexamic acid in reducing postoperative swelling in hallux valgus surgery].","authors":"Ning Sun, Xuewen Wang, Yong Wu, Shuang Ren, Heng Li, Hui DU, Xiaofeng Gong","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the early efficacy of local application of tranexamic acid on the osteotomy surface during hallux valgus surgery in reducing postoperative occult blood loss and thus postoperative swelling.</p><p><strong>Methods: </strong>The data of 40 cases with hallux valgus osteotomy admitted to the Department of Foot and Ankle Surgery of Jishuitan Hospital from July 11, 2022 to October 8, 2022, including 5 males and 35 females were retrospectively analyzed. According to the inclusion and exclusion criteria, 32 cases were finally divided into 16 cases in the observation group (application of tranexamic acid) and 16 cases in the control group (no application of tranexamic acid). The observation group was paired with the control group one by one in accordance with the operation style, and the change in the anterior and posterior diameter of the first metatarsal head, the change in the circumferential diameter of the foot, the length of the first metatarsal midline and the length of the plumbline of the foot measured by postoperative CT were compared between the two groups before and after surgery, in order to evaluate the degree of swelling around the incision after the surgery. The first metatarsal midline and plumb line were measured by reference to the two auxiliary lines that intersect the soft tissue border in the sesamoid bone position to measure the rotation angle of the first metatarsal. A total of three clinicians completed the measurements of these two line segments and interobserver comparisons were performed.</p><p><strong>Results: </strong>By interobserver comparison, the consistency of the length of the midline of the first metatarsal and the plumbline measured by CT was high and could be considered a reliable measurement. After the paired <i>t</i>-test, there was no statistical difference in the amount of changes in the anteroposterior diameter of the first metatarsal before and after surgery between the observation and control groups (<i>P</i>>0.05), and the amount of changes in the circumferential diameter of the foot before and after surgery was smaller in the observation group than in the control group, which was statistically significant (<i>P</i> < 0.05); the length of the midline of the first metatarsal and the plumbline of the foot measured by CT after surgery was smaller in the observation group than in the control group, which was statistically significant (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Local application of tranexamic acid on the osteotomy surface during hallux valgus osteotomy can relieve postoperative swelling to some extent, which may be related to the fact that tranexamic acid reduces occult blood loss in the postoperative period.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 1","pages":"172-177"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Durability of the anti-demineralization effects of fluoride varnish on dental root surfaces: An <i>in vitro</i> study].","authors":"Hongyan Tian, Xue Cai, Xiaoyan Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To study the durability of the anti-demineralization effects of fluoride varnish after being applied to dental root surfaces.</p><p><strong>Methods: </strong>Coronal and radicular dentin samples were prepared from extracted human teeth. Duraphat^® (DP) was applied to the dentine surfaces to form a protective film. The film-dentin interfaces were observed by scanning electron microscopy (SEM) and the fluoride element was analyzed with energy dispersive spectrometer (EDS). Thus, the differences between applying DP on crowns and roots were compared. Radicular dentin samples were prepared and randomly divi-ded into four groups: (1) Blank: DP was not applied, and demineralized in acetic acid (pH 4.5) for 4 days; (2) Blank+aging: DP was not applied, the samples were put into deionized water for 14 days at room temperature, and then demineralized in acetic acid (pH 4.5) for 4 days; (3) DP: DP was applied and demineralized in acetic acid (pH 4.5) for 4 days; (4) DP+aging: DP was applied, the samples were put into deionized water for 14 days at room temperature, and then demineralized in acetic acid (pH 4.5) for 4 days. Finally, SEM observation and EDS analysis of fluoride content were performed on film-dentin interfaces to evaluate the degree of demineralization, the morphology of DP film, and the penetration of fluorine.</p><p><strong>Results: </strong>The immediate penetration depth of fluoride element from DP was deeper in the coronal dentin than that in radicular dentin. The samples in the blank and blank+aging groups demine-ralized significantly after acid etching. The DP group did not undergo demineralization, and the fluorine element penetrated to (76.00±8.94) μm below the interfaces. The structure of the protective film in the DP+aging group was damaged, but the underneath dentin did not undergo demineralization. The fluorine element still remained at a depth of (5.00±3.53) μm below the interfaces.</p><p><strong>Conclusion: </strong>DP has an anti-demineralization effect on the root surface, and this effect can still be exerted for a period of time after losing the structure of protective film. It has the ability to prevent root caries and a certain durability.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 1","pages":"73-77"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[LIM and calponin homology domains 1 may function as promising biological markers to aid in the prognostic prediction of oral squamous cell carcinoma].","authors":"Li Xu, Wen Shi, Yuehua Li, Yajun Shen, Shang Xie, Xiaofeng Shan, Zhigang Cai","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the function of LIM and calponin homology domains 1 (LIMCH1) in the development and progression of oral squamous cell carcinoma (OSCC), along with their potential clinical applications.</p><p><strong>Methods: </strong>By utilizing transcriptome sequencing data from two groups of oral squamous cell carcinoma patients, along with bioinformatics analytical techniques such as Gene Ontology (GO) and gene co-expression networks, we identified genes that might play a pivotal role in the pathogenesis of oral squamous cell carcinoma. We employed real-time quantitative PCR and Western blotting to validate the expression patterns of these genes across twelve patient tissue samples. Furthermore, we conducted CCK-8 assays, flow cytometry analyses, and scratch wound healing assays to assess the impact of key genes on the biological behaviors of both the Cal27 oral squamous cell carcinoma cell line and the potentially malignant DOK oral lesion cell line. Additionally, we examined correlations between these key genes and clinical disease parameters in 214 oral squamous cell carcinoma patients using The Cancer Genome Atlas (TCGA) data; gene set enrichment analysis (GSEA) analysis results were also incorporated to enhance our findings from real-time quantitative PCR and Western blotting regarding potential mechanisms underlying the action of these key genes.</p><p><strong>Results: </strong>The integrated analysis of sequencing data and bioinformatics revealed that <i>LIMCH1</i> exhibited significantly reduced mRNA (<i>P</i> < 0.001) and protein levels (<i>P</i> < 0.01) in the oral squamous cell carcinoma tissues compared with normal control tissues. In the Cal27 cells, the low LIMCH1 level group demonstrated a larger wound healing area within 24 hours than the control group (<i>P</i> < 0.01), enhanced proliferation capacity over 72 hours relative to the control group (<i>P</i> < 0.01), and an increased apoptosis rate within 24 hours compared with the high expression group (<i>P</i> < 0.05). However, no significant differences were observed between the low and high level groups in DOK cells. Furthermore, it was determined that low LIMCH1 level correlated with poor prognosis in the patients (<i>P</i>=0.013) and a higher lymph node metastasis rate (<i>P</i> < 0.05). Investigations into the potential mechanisms of action indicated that <i>LIMCH1</i> did not influence the onset or progression of oral squamous cell carcinoma via the epithelial-mesenchymal transition pathway.</p><p><strong>Conclusion: </strong>LIMCH1 level may function as a promising biomarker to aid in the prognostic assessment of oral squamous cell carcinoma; however, its precise mechanistic role requires further investigation.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 1","pages":"19-25"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Characteristics of occlusal force and contact in 20 individual normal occlusion children with mixed dentition].","authors":"Xiaoran Wu, Yifan Jin, Ruisi Xiao, Peiwen Liao, Yuanyuan Wang","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To measure and analyze the occlusal force and contact in children with mixed dentition, and to preliminarily provide baseline data on the occlusion of individual normal occlusion children with mixed dentition.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A cross-sectional study was conducted, including 20 children with mixed dentition and individual normal occlusion, consisting of 12 boys and 8 girls, aged 6.5-9.8 years. The Dental Prescale Ⅱ occlusal analysis system was used to measure the occlusal force and contact at the intercuspal position, including the maximum occlusal force (N) and the occlusal contact area (mm&lt;sup&gt;2&lt;/sup&gt;) of the entire dentition, and the left and right sides, average occlusal pressure (MPa), maximum occlusal pressure (MPa), and to determine the position of the center of occlusal force. The gender differences in maximum occlusal force, average occlusal pressure, and occlusal contact area were analyzed, the bilateral symmetry of occlusion in children with mixed dentition and individual normal occlusion was compared, and the correlation between occlusal data and age, height, weight, and body mass index (BMI) was analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;(1) The average maximum occlusal force of the entire dentition in the 20 children with mixed dentition at the intercuspal position was (869.18±106.64) N, the average occlusal contact area was (25.19±2.89) mm&lt;sup&gt;2&lt;/sup&gt;, the average occlusal pressure was (34.37±5.98) MPa, and the maximum occlusal pressure &lt;i&gt;M&lt;/i&gt;(&lt;i&gt;P&lt;/i&gt;&lt;sub&gt;25&lt;/sub&gt;, &lt;i&gt;P&lt;/i&gt;&lt;sub&gt;75&lt;/sub&gt;) was 120 (120, 120) MPa; (2) There was no statistically significant difference in the maximum occlusal force, average occlusal pressure, maximum occlusal pressure, and occlusal contact area between the left and right sides (&lt;i&gt;P&lt;/i&gt;&gt;0.05); (3) At the intercuspal position, the average occlusal contact area for 12 boys and 8 girls was (26.71±3.91) mm&lt;sup&gt;2&lt;/sup&gt; and (21.62±3.08) mm&lt;sup&gt;2&lt;/sup&gt; respectively, and the average maximum occlusal force was (911.92±145.05) N and (769.47±116.45) N respectively, with statistically significant differences (&lt;i&gt;P&lt;/i&gt; &lt; 0.05), while there was no statistically significant difference in the average occlusal pressure between boys and girls (&lt;i&gt;P&lt;/i&gt;&gt;0.05); (4) The maximum occlusal force at the intercuspal position was weakly correlated with age (&lt;i&gt;r&lt;/i&gt;=0.219, &lt;i&gt;P&lt;/i&gt;=0.046), and strongly positively correlated with the occlusal contact area (&lt;i&gt;r&lt;/i&gt;=0.949, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), while the average occlusal pressure, maximum occlusal pressure, and occlusal contact area were not correlated with age, height, weight, or BMI; (5) The center of occlusal force in the 20 children with mixed dentition and individual normal occlusion was located in the molar region, with 7 children having the maximum occlusal pressure point only in the first permanent molar region, 10 children having it in both the deciduous molar region and the first permanent molar region, and 3 children having it","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 1","pages":"154-160"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between weight-adjusted waist index and pain: A cross-sectional study].","authors":"Huili Liu, Bei Wen, Xue Bai, Ming'an Chen, Min Li","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the relationship between the weight-adjusted waist index (WWI) and acute, subacute pain or chronic pain among American adults.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;There was a cross-sectional study. Data from the 1999-2004 National Health and Nutrition Examination Survey (NHANES) concerning waist circumference, weight, pain status and covariates (age, gender, race, marital status, education level and income, physical activity, alcohol consumption, smoking status, and diabetes) were extracted for analysis. Multinomial Logistic regression was conducted across the three models to investigate the associations between WWI and acute, subacute and chronic pain. Model 1 did not involve any adjustments. Model 2 involved adjustments for age, gender, race, marital status, education level, and income. Model 3 was further adjusted for physical activity, alcohol consumption, smoking, and diabetes status.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;This study involved 12 694 participants with an average age of (50.6±18.7) years. Among all the participants, 9 614 people (75.74%) had no pain, 870 people (6.85%) experienced acute pain, 354 people (2.79%) suffered from subacute pain, and 1 856 people (14.62%) experienced chronic pain. The WWI of all the participants was (10.95±0.85) cm/$sqrt{mathrm{kg}}$, divided into four groups based on quartiles: Group Q1 (7.90-10.36) cm/$sqrt{mathrm{kg}}$, group Q2 (10.37-10.94) cm/$sqrt{mathrm{kg}}$, group Q3 (10.95-11.53) cm/$sqrt{mathrm{kg}}$ and group Q4 (11.54-15.20) cm/$sqrt{mathrm{kg}}$. With the increase of WWI, the analysis revealed a significant statistical difference in the participants' acute and chronic pain status (all &lt;i&gt;P&lt;/i&gt; &lt; 0.001). In Model 1, the prevalence of acute pain was lower in group Q2 and group Q4 compared with group Q1 (group Q2: &lt;i&gt;OR&lt;/i&gt;=0.765, 95%&lt;i&gt;CI&lt;/i&gt;: 0.615-0.953, &lt;i&gt;P&lt;/i&gt;=0.017; group Q4: &lt;i&gt;OR&lt;/i&gt;= 0.648, 95%&lt;i&gt;CI&lt;/i&gt;: 0.503-0.835, &lt;i&gt;P&lt;/i&gt; &lt; 0.001). Compared with group Q1, the prevalence of chronic pain increased in group Q2, group Q3, and group Q4 (group Q2: &lt;i&gt;OR&lt;/i&gt; =1.365, 95%&lt;i&gt;CI&lt;/i&gt;: 1.149-1.622, &lt;i&gt;P&lt;/i&gt; &lt; 0.001; group Q3&lt;i&gt;: OR&lt;/i&gt;=1.291, 95%&lt;i&gt;CI&lt;/i&gt;: 1.082-1.541, &lt;i&gt;P&lt;/i&gt;=0.005; group Q4: &lt;i&gt;OR&lt;/i&gt;=1.874, 95%&lt;i&gt;CI&lt;/i&gt;: 1.579-2.224, &lt;i&gt;P&lt;/i&gt; &lt; 0.001). In Model 2, compared with group Q1, an increase in chronic pain prevalence was still associated with an increase in WWI in other three groups (group Q2: &lt;i&gt;OR&lt;/i&gt;=1.359, 95%&lt;i&gt;CI&lt;/i&gt;: 1.137-1.624, &lt;i&gt;P&lt;/i&gt;=0.001; group Q3: &lt;i&gt;OR&lt;/i&gt;=1.260, 95%&lt;i&gt;CI:&lt;/i&gt; 1.039-1.528, &lt;i&gt;P&lt;/i&gt;=0.019; group Q4: &lt;i&gt;OR&lt;/i&gt;=1.735, 95%&lt;i&gt;CI&lt;/i&gt;: 1.413-2.132, &lt;i&gt;P&lt;/i&gt; &lt; 0.001). In Model 3, group Q4 had a 49.2% increased prevalence of chronic pain compared to group Q1 (&lt;i&gt;OR&lt;/i&gt; = 1.492, 95%&lt;i&gt;CI&lt;/i&gt;: 1.208-1.842, &lt;i&gt;P&lt;/i&gt; &lt; 0.001). However, in Models 2 and 3, no significant relationship was observed between acute pain and WWI (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). And none of the three models identified a significant association between subacu","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 1","pages":"178-184"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical application of multidisciplinary team in the diagnosis and treatment of chronic refractory wounds].","authors":"Liwei Wang, Bingchuan Liu, Yinyin Qu, Changyi Wu, Yun Tian","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To explore the application effectiveness of multidisciplinary team (MDT) in the diagnosis and treatment of chronic refractory wounds, and to provide new ideas for optimizing the clinical diagnosis and treatment of such diseases.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis was performed on the clinical data of patients with chronic refractory wounds who underwent surgery at Peking University Third Hospital from January 2015 to October 2023, and a total of 456 patients, including 290 males and 166 females, with an average age of (49.4±16.9) years. According to whether preoperative MDT discussion was conducted, the patients were divided into MDT discussion group and non-MDT discussion group. The overall implementation process of MDT included: Starting and recording with the medical office, collecting data and discussing the initial MDT, informing the patient of the treatment plan and strictly implementing it, and the change of the condition needs to be discussed again by MDT. The general clinical data, anesthesia risk grade, complications (hypertension, diabetes, coronary heart disease), and the etiology and location of chronic refractory wounds between the two groups were compared. The main observational measurements and outcome indicators of treatment effectiveness included the number of surgeries required to achieve wound healing after admission, the recurrence rate after wound healing, the incidence of perioperative complications (pulmonary infection, severe cardiovascular event, vein thrombus embo-lism, cerebral stroke and delirium, &lt;i&gt;etc&lt;/i&gt;.), and patient satisfaction score.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There were 189 patients in the MDT discussion group and 267 patients in the non-MDT discussion group. There was no significant statistical difference in the clinical data, such as age, gender, body mass index, American Society of Anesthesiologists, comorbidities, etiology, and location of chronic refractory wounds between the two groups (&lt;i&gt;P&lt;/i&gt;&gt;0.05). The average number of surgeries required for wound healing in MDT discussion group and non-MDT discussion group was 2.1±1.1 and 2.8±1.6, respectively, with a statistically significant difference (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). This difference was also significant in chronic refractory wounds caused by three etiologies: Diabetic ulcer, infection after trauma or surgery, and non-union after radiotherapy (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The recurrence rate of the patients in the non-MDT discussion group after wound healing was 18.0%, slightly higher than that in the MDT discussion group of 14.3% (&lt;i&gt;P&lt;/i&gt;&gt;0.05). In terms of perioperative complications, the non-MDT discussion group also had a higher incidence (3.7% &lt;i&gt;vs&lt;/i&gt;. 2.6%), but the difference was not statistically significant (&lt;i&gt;P&lt;/i&gt;&gt;0.05). In terms of patient satisfaction, the MDT discussion group scored significantly higher (96.5 &lt;i&gt;vs&lt;/i&gt;. 91.1, &lt;i&gt;P&lt;/i&gt;=0.028).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The MDT mode can","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 1","pages":"185-191"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical efficacy of clear aligner treatment for pathologically migrated teeth in the anterior region of patients with severe periodontitis].","authors":"Jingqian Li, Zilu Zhu, Jian Jiao, Jie Shi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of clear aligner therapy in patients with severe periodontitis accompanied by pathological tooth displacement in the anterior region.</p><p><strong>Methods: </strong>This retrospective study analyzed patients diagnosed with severe periodontitis and pathological displacement in the anterior region, who visited both the Periodontics and Orthodontics Departments at Peking University School and Hospital of Stomatology between 2019 and 2022. A total of 26 eligible cases were included in this study. All the patients underwent regular periodontal maintenance throughout the treatment process, and clear aligners were used for orthodontic treatment. Intraoral scans were analyzed by dedicated software to measure and compare occlusal distribution and proximal contact scores before and after orthodontic treatment. Periodontal clinical indicators were assessed at three key time points: before periodontal treatment (T0), before orthodontic treatment (T1), and after orthodontic treatment (T2). All the cases were treated with clear aligner.</p><p><strong>Results: </strong>A total of 217 pathologically displaced anterior teeth from 26 patients were analyzed. Among these, 105 teeth exhibited periodontal pockets [probing depth (PD) ≥5 mm] before periodontal treatment. After clear aligner therapy, the occlusal score improved significantly from 10.35±8.61 to 23.62±9.73 (<i>P</i> < 0.001), and the proximal contact score increased from 13.62±4.73 to 31.62±10.37 (<i>P</i> < 0.001). The median PD decreased significantly from 3.33 mm [interquartile range (IQR)=0.92] at T0 to 2.50 mm (IQR=0.67, <i>P</i> < 0.001) at T1 and remained stable at 2.50 mm (IQR=0.50) after treatment (T2). A significant reduction in PD was observed between T0 and T2 (<i>P</i> < 0.001), but no significant difference was found between T1 and T2 (<i>P</i>=0.948).</p><p><strong>Conclusion: </strong>Clear aligner therapy demonstrates favorable clinical efficacy in patients with severe periodontitis and pathological anterior tooth displacement. It effectively improves occlusal distribution and proximal contact while maintaining periodontal health in these patients. However, further large-scale prospective controlled studies are needed to verify its long-term clinical outcomes.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 1","pages":"51-56"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Establishment and evaluation of a similarity measurement model for orthognathic patients based on the 3D craniofacial features].","authors":"Ling Wu, Jiakun Fang, Xiaojing Liu, Zili Li, Yang Li, Xiaoxia Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To establish a similarity measurement model for patients with dentofacial deformity based on 3D craniofacial features and to validate the similarity results with quantifying subjective expert scoring.</p><p><strong>Methods: </strong>In the study, 52 cases of patients with skeletal Class Ⅲ malocclusions who underwent bimaxillary surgery and preoperative orthodontic treatment at Peking University School and Hospital of Stomatology from January 2020 to December 2022, including 26 males and 26 females, were selected and divided into 2 groups by sex. One patient in each group was randomly selected as a reference sample, and the others were set as test samples. Three senior surgeons rated the similarity scores between the test samples and the reference sample. Similarity scores ranged from 1 to 10, where 1 was completely different, and 10 was exactly the same. Scores larger than 7.5 was considered as clinically similar. Preoperative cone beam computed tomography (CBCT) and 3D facial images of the patients were collected. The three-dimensional hard and soft tissue features, including distances, angles and 3D point cloud features were extracted. The similarity measurement model was then established to fit with the experts' similarity scoring by feature selection algorithm and linear regression model. To verify the reliability of the model, 14 new patients were selected and input to similarity measurement model for finding similar cases. The similarity scoring of these similar cases were rated by experts, and used to evaluate the reliability of the model.</p><p><strong>Results: </strong>The similarity metric models indicated that the features of the middle and lower craniofacial features were the main features to influence the craniofacial similarity. The main features that were related to the expert' s similarity scoring included distance of anterior nasal spine-menton (ANS-Me), distance of right upper canion point-Frankfurt horizontal plane (U3RH), distance of left superior point of the condyle-left gonion (CoL-GoL), distance of left gonion-menton (CoL-Me), distance of pogonion-midsagittal plane (Pog-MSP), distance of right alar base-left alar base (AlR-AlL), angle of pronasale-soft tissue pogonion-labrale inferius (Pn-Pog' -Li), distance of trichion-right tragus (Tri-TraR), distance of left exocanthion-left alar base (ExL-AlL), lower 1/3 of skeletal face, middle and lower 2/3 of skeletal face and upper lip region of soft tissue. Fourteen new patients were chosen to evaluate the model. The similar cases selected by the model had an average experts' similarity scoring of 7.627± 0.711, which was not significantly different with 7.5.</p><p><strong>Conclusion: </strong>The similarity measurement model established by this model could find the similar cases which highly matched experts' subjective similarity scoring. The study could be further used for similar cases retrieval in skeletal Ⅲ malocclusion patients.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 1","pages":"128-135"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of dual chamber round tissue expander in immediate breast reconstruction].","authors":"Jianxun Ma, Xi Bu, Bi Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the application value of dual chamber round tissue expander in immediate breast reconstruction.</p><p><strong>Methods: </strong>Sixteen patients, who had been provided immediate tissue expander/implant two-stage breast reconstruction using dual chamber round tissue expander in our hospital from March 2022 to October 2023, were involved in this study, and the relevant information was analyzed retrospectively. The overall design of the expander is a round shape, consisting of two equally divided semi-circular chambers. The two expansion chambers are connected by a silicone pad below and are respectively connected to their own water injection tubes. Both chambers are designed to expand unidirectionally towards the surface. The expansion principle, insertion process, and type of expander selection were investigated. The expansion effect and incidence of complications were summarized. The aesthetic effect of reconstructed breasts was evaluated from three aspects after stage Ⅱ surgery: the position of infra mammary fold, the breast protrusion, and the breast volume.</p><p><strong>Results: </strong>Among sixteen patients in this study, three patients were selected with the type of 400 mL expander and thirteen patients were given the type of 600 mL expander. The median time of tissue expansion was 4.0 (2.0, 5.0) months, with an average volume of expansion of (538.8±111.7) mL. The average expansion ratio of upper/lower chamber was 45.4%±8.4%. The position of the infra mammary fold needed not to be adjusted during the prosthesis exchange process. All the patients were applied anatomical prostheses, and the median volume of the prosthesis was 395 (345, 410) mL. One patient developed seroma during expansion period, who got improved after local aspiration. The average follow-up time was (9.0±3.6) months. 81.3% (13/16) of the patients achieved an aesthetic evaluation of \"Good\" in breast reconstruction, and 75.0% (12/16) of the patients got a grade Ⅰ or grade Ⅱ capsule contracture of the prosthesis.</p><p><strong>Conclusion: </strong>The application of dual chamber round tissue expander could effectively dilate the lower pole of the breast, personalize the expansion ratio of the upper and lower poles of the breast, and avoid the displacement of the expander during the expansion period. Therefore, it could provide a good foundation for subsequent prosthesis exchange.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 1","pages":"166-171"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[One-stage mandibular reconstruction combining iliac flap with immediate implant-based denture].","authors":"Yifan Kang, Yanjun Ge, Xiaoming Lv, Shang Xie, Xiaofeng Shan, Zhigang Cai","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical outcomes and define the indications for a one-stage mandibular reconstruction technique that combines iliac bone flaps with immediate implant-based dentures, and to assess both the accuracy of surgical planning and the long-term success of the procedure.</p><p><strong>Methods: </strong>A total of ten patients underwent the procedure at Peking University Hospital of Stomatology between June 2020 and August 2023. The preoperative biopsy pathology of all the patients confirmed a benign tumor. In this technique, iliac bone flaps were used for mandibular reconstruction, and immediate implant-based dentures were placed during the same surgical session. Various outcome measures were evaluated, including the accuracy of the surgical reconstruction, implant placement deviations (entry point, apical point, depth, and angle), and long-term outcomes, such as cervical bone resorption, implant survival, and the cumulative survival rate.</p><p><strong>Results: </strong>Thirty-eight implants were successfully inserted into the iliac flaps of the ten patients. The median follow-up duration was 23.5 months, and no significant complications occurred during the follow-up period, such as infections, titanium plate exposure, implant loosening, or damage to the implants and dentures. The accuracy of preoperative virtual surgical planning (VSP) was highly reliable. The repeatability of the VSP model compared to the postoperative reconstructed mandible was as follows: 67.82% ±10.16% within 1 mm, 82.14% ±6.58% within 2 mm, and 90.61% ±4.62% within 3 mm. The average maximum deviation from the plan was (6.10±0.89) mm, with an average overall deviation of (1.14±0.31) mm. For the implants, deviations in critical parameters were as follows: entry point deviation was (2.02±0.58) mm, apical point deviation was (2.25± 0.66) mm, depth deviation was (1.26±0.51) mm, and angular deviation was 1.84°±1.10°. The implant survival rate remained 100% during the follow-up, with a cumulative survival rate of 97.37% from 1 to 4 years. Average cervical bone resorption was 0.94 mm.</p><p><strong>Conclusion: </strong>The combination of iliac bone flaps with immediate implant-based dentures for one-stage mandibular reconstruction demonstrated pro-mising clinical outcomes, including high implant survival and minimal complications. This technique proved to be safe and reliable for mandibular reconstruction. However, further studies with larger sample sizes and longer follow-up periods are necessary to confirm the long-term efficacy and optimal indications for this procedure.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"57 1","pages":"78-84"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}