北京大学学报（医学版）最新文献

{"title":"[Impact of icariin on the differentiation towards dentinogenesis and angiogenesis, and inflammatory regulation of stem cells from human exfoliated deciduous teeth].","authors":"Yu Jin, Liying Dong, Xiaojing Yuan, Rui Song, Zuoying Yuan, Yuming Zhao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effects of icariin (ICA) on the proliferation and migration of stem cells from human exfoliated deciduous teeth (SHED), as well as its impact on dentinogenic and angiogenic differentiation <i>in vitro</i>, and its anti-inflammatory effects.</p><p><strong>Methods: </strong>(1) SHED cells were cultured <i>in vitro</i>, with a blank control group for the culture medium, a blank control group for DMSO, and different concentrations of ICA intervention groups (0.1, 1, 10, 20, 50 μmol/L), and cell viability was detected using the CCK-8 method. (2) Quantitative real-time PCR (RT-qPCR) was used to detect the gene expression levels of dentin sialophosphoprotein (DSPP), dentin matrix protein 1 (DMP1) and vascular endothelial growth factor A (VEGFA) in each group of cells. (3) Western blotting was used to detect the protein levels of DSPP, DMP1. (4) The scratch healing assay was used to test cell migration ability. (5) Lipopolysaccharide (LPS) was used to stimulate SHED cells to construct an <i>in vitro</i> inflammatory model of SHED, and RT-qPCR was used to detect the gene expression levels of tumor necrosis factor-α (<i>TNF-α</i>), interleukin-1β (<i>IL-1β</i>), interleukin-6 (<i>IL-6</i>), and interleukin-8 (<i>IL-8</i>) in each group of cells.</p><p><strong>Results: </strong>(1) In the 1, 10 μmol/L ICA intervention group, the proliferation ability of SHED cells was significantly enhanced; in the 0.1 μmol/L ICA intervention group, there was no significant change in the proliferation ability of SHED cells, and in the 20, 50 μmol/L ICA intervention group, the proliferation ability of SHED cells was significantly reduced. (2) In the 0.1, 1, 10 μmol/L ICA intervention group, the cell wound healing speed was faster. (3) In the 0.1, 1, 10 μmol/L ICA intervention group, the gene expression levels of <i>DSPP</i> and <i>DMP1</i> were higher, and the protein expression levels of DSPP and DMP1 were higher in the 0.1 μmol/L ICA intervention group. (4) In the 1, 10 μmol/L ICA intervention group, the gene expression level of <i>VEGFA</i> was higher, and it had stronger tubular formation ability. (5) The expression of pro-inflammatory cytokines <i>IL-1β</i>, <i>IL-6</i>, <i>TNF-α</i> and <i>IL-8</i> in the SHED cells in the 0.1, 1, 10 μmol/L ICA intervention group was significantly reduced.</p><p><strong>Conclusion: </strong>Suitable concentrations of ICA can promote the proliferation, migration and odontoblast-like differentiation of SHED cells, enhance their angiogenic ability, and have a certain anti-inflammatory effect.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"58 5","pages":"906-911"},"PeriodicalIF":0.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of inferior alveolar nerve transection on mandibular condyles in rats and the repair effect of calcitonin gene-related peptide].","authors":"Meizi Zhang, Kaiyuan Cheng, Jian Li, Zhongning Liu, Ting Jiang","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To explore the impact of inferior alveolar nerve injury on mandibular condylar cartilage and condylar subchondral bone. And to further investigate the potential roles and molecular mechanisms of calcitonin gene-related peptide (CGRP) in condylar cartilage and subchondral bone.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Sixty male 4-week-old Sprague-Dawley (SD) rats were randomly divided into three groups: a sham operation control group (only the right inferior alveolar nerve exposed and no other treatment was done), an inferior alveolar nerve transection (IANT) group (the right inferior alveolar nerve was transected more than 3 mm at the level of right mandibular oblique ridge), and a CGRP group (injection of 100 nmol/L CGRP into the right temporomandibular joint area after nerve transection, with 200 μL injections every three days for four weeks). Samples were collected at 1-, 2-, 4-, 6-, and 8-weeks post-surgery for analysis using a stereomicroscope, micro-CT, and histological staining to observe changes in the condylar cartilage and subchondral bone. Transcriptome sequencing and Western blot experiments were conducted on chondrocyte treated with CGRP (100 nmol/L) to analyze differences in gene and protein expression, as well as related biological processes and pathways. SPSS was used to analyze the differences between groups of the samples.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Compared with the sham operation group, alterations in the right condylar cartilage and subchondral bone were observable in the IANT group during the early phase of inferior alveolar nerve transection, specifically within the first week. For condylar cartilage, it could be observed that its overall thickness decreased, the surface fiber layer was incomplete, the pro-liferation layer cells decreased, and the hypertrophic cells increased relatively. For the subchondral bone of condyle, it could be seen that the head was narrowed, and the bone quality was worse than that of the sham group. In the CGRP group, the morphology of the condylar process, the thickness of the condylar cartilage layer, and the quality of the condylar subchondral bone were significantly better than those in the IANT group. &lt;i&gt;In vitro&lt;/i&gt; cultured rat chondrocytes treated with CGRP were subjected to transcriptomic sequencing analysis, which suggested that CGRP might upregulate cartilage cell synthesis metabolism and cartilage-protective genes such as &lt;i&gt;Col2a1&lt;/i&gt; and &lt;i&gt;Prg4&lt;/i&gt; through pathways like phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt). After 7 days of CGRP induction, Western blot experiments revealed that CGRP had increased the expression of COL2A1 and SOX9 proteins.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Damage to the inferior alveolar nerve can cause degenerative changes in the condylar cartilage and subchondral bone. Injection of CGRP into the joint area can repair these damages to a certain extent. It is inferred that the injury of inferior alveolar nerve may le","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"58 5","pages":"895-905"},"PeriodicalIF":0.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics and risk factors of patients with rheumatoid arthritis complicated with urinary tract infection].","authors":"Kangkai Luo, Chunyan Pang, Fuai Lu, Yongfu Wang","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To explore the clinical characteristics of urinary tract infection (UTI) in patients with rheumatoid arthritis (RA), to evaluate the effects of different treatment regimens on the risk of UTI, and to identify independent risk factors for UTI complicated with RA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective cohort study was conducted. RA patients hospitalized in the Department of Rheumatology and Immunology, The First Affiliated Hospital of Baotou Medical College from September 2020 to September 2023 were enrolled. General clinical data, laboratory indicators and medication information of the patients were collected. Patients were divided into two groups according to the presence or absence of UTI for comparative analysis. Patients were grouped based on different treatment regimens received, and the proportions of UTI occurrence were compared among each group. The results of urine culture and drug susceptibility test in the RA patients with UTI were analyzed. Univariate and multivariate Logistic regression analyses were further performed to screen relevant factors for UTI in the RA patients, and the diagnostic value of combined indicators was assessed using receiver operating characteristic (ROC) curve.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 196 RA patients were included, among whom 99 cases were complicated with UTI and 97 cases without UTI. Compared with the non-UTI group, the UTI group had higher proportions of female patients, patients aged ≥65 years, patients with RA disease duration ≥10 years, patients hospitalized for infection within the past two years, and patients with comorbidities (diabetes mellitus, hypertension, etc.). Peripheral blood leukocyte count, percentage of neutrophils, serum procalcitonin, erythrocyte sedimentation rate (ESR) and C-reactive protein level were elevated (&lt;i&gt;P&lt;/i&gt; &lt; 0.05), while hemoglobin, percentage of lymphocytes and plasma albumin level were decreased (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). The RA patients were divided into four groups according to different treatment regimens: ①glucocorticoids (GCs) monotherapy group; ②conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) monotherapy group; ③csDMARDs combined with GCs group; ④ csDMARDs combined with biological DMARDs (bDMARDs)/ targeted synthetic DMARDs (tsDMARDs) group. The overall difference in UTI proportion among the four groups was statistically significant (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). After Bonferroni correction, the UTI proportion in group ① and group ③ was higher than that in group ② and group ④ (adjusted &lt;i&gt;P&lt;/i&gt; &lt; 0.05). GSs use was associated with increased UTI risk, and the risk of UTI showed an upward trend with the increase of daily dose. Multivariate Logistic regression analysis demonstrated that RA disease duration ≥10 years, previous hospitalization due to infection within the past two years, comorbid diabetes mellitus, and elevated disease activity score in 28 joints based on ESR (DAS28-ESR) were independent ris","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"58 5","pages":"1038-1047"},"PeriodicalIF":0.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characterization and prognosis of connective tissue disease-associated hemophago-cytic syndrome in adults].","authors":"Xujing Yuan, Zhijun Luo, You Song, Weiwei Wang, Wenxun Lin, Jiajia Wu, Rong DU","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical characteristics and outcomes of macrophage activation syndrome (MAS) associated with connective tissue diseases in adults.</p><p><strong>Methods: </strong>We retrospectively reviewed patients aged ≥16 years with MAS who were hospitalized in the Department of Rheumatology and Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, between 2012 and 2022. The distribution of underlying rheumatic diseases was summarized, and demographic, clinical, and laboratory characteristics were compared across disease groups. The patients were further classified according to in-hospital outcome as those who died during hospitalization or were discharged alive. Univariate and multivariable Logistic regression analyses were performed to identify factors associated with in-hospital mortality. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive performance of individual variables and the combined model for in-hospital mortality.</p><p><strong>Results: </strong>A total of 109 patients with MAS were included. The mean age at MAS onset was (36.39± 13.65) years, and 82 patients (75.2%) were female. Fever and hyperferritinemia were among the most common clinical and laboratory findings. Systemic lupus erythematosus (SLE)-associated MAS and adult-onset Still's disease (AOSD)-associated MAS were the two most common subtypes, accounting for 48.6% (53/109) and 25.7% (28/109) of cases, respectively. Patients with AOSD-associated MAS had a longer duration of fever than those with SLE-associated MAS. Compared with patients with AOSD-associated MAS, those with SLE-associated MAS had significantly lower white blood cell and platelet counts, ferritin levels, percentages of CD4⁺ T lymphocytes, and C-reactive protein-to-albumin ratio (CAR), but higher triglyceride levels and percentages of B lymphocytes. Thirteen patients (11.9%) died during hospitalization. Multivariable Logistic regression analysis identified total protein, albumin, globulin, and D-dimer as independent factors associated with in-hospital mortality. ROC curve analysis showed that the model combining total protein and D-dimer yielded an area under the curve (AUC) of 0.872 for predicting in-hospital mortality, compared with 0.820 for total protein alone and 0.659 for D-dimer alone.</p><p><strong>Conclusion: </strong>Patients with SLE-associated MAS and AOSD-associated MAS differed in several clinical and laboratory features, suggesting clinical heterogeneity of MAS across different underlying rheumatic diseases. Assessment and management of MAS should therefore take the underlying disease into account. In-hospital mortality remained substantial in this cohort, and the combination of total protein and D-dimer showed potential value for risk stratification of in-hospital mortality.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"58 5","pages":"1024-1030"},"PeriodicalIF":0.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Short-term clinical outcomes of complete dentures fabricated by conventional and CAD/CAM milling techniques: A self-controlled study with randomized wearing sequence].","authors":"Hui Cao, Kaiqi Qin, Xu Zhang, Hu Chen, Yuchun Sun, Xuemei Bao, Yongsheng Zhou","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To preliminarily compare the short-term clinical outcomes of conventional and computer-aided design/computer-aided manufacturing (CAD/CAM) monolithic milled complete dentures and to provide clinical evidence for selecting a digital complete-denture fabrication technique.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Seven edentulous patients were enrolled in a self-controlled study with a randomized wearing sequence. Each participant received one conventionally fabricated complete denture and one CAD/CAM monolithic milled complete denture. The fabrication technique was not actively disclosed before subjective assessment. A 2-week washout period, during which the participants wore their previous dentures, separated the two wearing periods. Subjective visual analogue scale (VAS) scores for overall satisfaction, mandibular denture retention, masticatory function, mucosal comfort, speech, and esthetics, together with pressure-point count, objective mandibular retention force, and objective masticatory efficiency, were assessed at insertion, 1 week, and 1 month. Within-patient comparisons between the two techniques were performed at each time point. Overall satisfaction, pressure-point count, objective retention force, and objective masticatory efficiency were additionally analyzed using a 2×3 fully within-subject repeated-measures analysis of variance (ANOVA), followed by Bonferroni-adjusted post hoc comparisons.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Significant between-process differences in satisfaction, aesthetics, retention VAS, mastication VAS, and pressure point counts were found over three time points (all &lt;i&gt;P&lt;/i&gt; &lt; 0.05), favoring CAD/CAM milling. No significant between-group difference in phonation. CAD/CAM milling yielded higher mandibular retention force at insertion, 1 week, and 1 month (&lt;i&gt;P&lt;/i&gt; &lt; 0.001, &lt;i&gt;P&lt;/i&gt;=0.004, and &lt;i&gt;P&lt;/i&gt; &lt; 0.001, respectively). Objective masticatory efficiency was 38.53%±3.75% &lt;i&gt;versus&lt;/i&gt; 42.73%±3.67% at insertion (&lt;i&gt;P&lt;/i&gt;=0.057), 45.09% ±3.89% &lt;i&gt;versus&lt;/i&gt; 52.93%±2.60% at 1 week (&lt;i&gt;P&lt;/i&gt;=0.001), and 52.22%±3.88% &lt;i&gt;versus&lt;/i&gt; 56.69%±3.28% at 1 month (&lt;i&gt;P&lt;/i&gt;=0.031) for the conventional and CAD/CAM groups, respectively. Repeated-measures ANOVA revealed significant technique and time effects for all four variables. A significant technique×time interaction was identified only for pressure-point count [&lt;i&gt;F&lt;/i&gt;(2, 12)=5.550, &lt;i&gt;P&lt;/i&gt;=0.020]; the interaction for objective mandibular retention force was not significant after Greenhouse-Geisser correction [&lt;i&gt;F&lt;/i&gt;(1.090, 6.540)=2.547, &lt;i&gt;P&lt;/i&gt;=0.162].&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In this small, short-term, within-patient study with a randomized wearing sequence, CAD/CAM monolithic milled complete dentures showed advantages in several patient-reported outcomes, objective mandibular retention force, and objective masticatory efficiency at 1 week and 1 month. These advantages did not extend to all outcomes or time points, and the between-techn","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"58 5","pages":"940-949"},"PeriodicalIF":0.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between different types of first-degree relatives' stroke history and the incidence risk of stroke: A prospective cohort study].","authors":"Huairong Wang, Yiqun Wu, Kun Wang, Ruotong Yang, Huan Yu, Liuyan Zheng, Jingxian Wu, Haiying Gong, Xueying Qin, Tao Wu, Dafang Chen, Yonghua Hu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To assess the association between different types of first-degree relatives' stroke history and the incidence risk of stroke, and to explore the familial aggregation and intergenerational transmission of stroke risk.</p><p><strong>Methods: </strong>A prospective cohort study design was adopted, based on the data of the Fangshan Family-based Ischemic Stroke Study in China(FISSIC). The Cox proportional hazards model was used to analyze the association between different types of first-degree relatives' stroke history (paternal stroke history, maternal stroke history, parental history of stroke, and sibling stroke history) and the incidence risk of stroke. The hazard ratio (<i>HR</i>) and its 95% confidence interval (<i>CI</i>) were estimated. Stroke was classified as early-onset and late-onset, and the association between different types of first-degree relatives ' stroke history and the risk of early-onset and late-onset stroke was further analyzed.</p><p><strong>Results: </strong>A total of 3 631 subjects were included in the study, with 1 650 males (45.4%) and a mean age of (56.7±8.4) years. The median follow-up duration was 6.98 years, during which 1 337 new cases of stroke occurred. The risk of stroke occurrence was higher in those with a first-degree relative history of stroke (<i>HR</i>=1.24, 95%<i>CI</i>: 1.08-1.43, <i>P</i>=0.002). For different types of first-degree relatives ' stroke history, the association between maternal and sibling history of stroke and the incidence risk of stroke was statistically significant (maternal history of stroke: <i>HR</i>=1.15, 95%<i>CI</i>: 1.00-1.32, <i>P</i>=0.049; sibling history of stroke: <i>HR</i>=1.17, 95%<i>CI</i>: 1.03-1.33, <i>P</i>=0.013). No association was observed between a paternal history of stroke or a parental history of stroke and the risk of stroke (both <i>P</i>>0.05). Compared with those without a family history, the <i>HRs</i> for early-onset and late-onset stroke in those with a maternal history of stroke were 1.40 (95%<i>CI</i>: 1.10-1.77, <i>P</i>=0.005) and 1.19 (95%<i>CI</i>: 1.01-1.41, <i>P</i>=0.043), respectively. Compared with those without a family history, the <i>HRs</i> for early-onset and late-onset stroke in those with a sibling history of stroke were 1.28 (95%<i>CI</i>: 1.02-1.61, <i>P</i>=0.034) and 1.17 (95%<i>CI</i>: 1.00-1.37, <i>P</i>=0.045), respectively.</p><p><strong>Conclusion: </strong>Stroke exhibits familial aggregation, and the history of stroke in first-degree relatives is associated with the incidence risk of stroke. In particular, the maternal and sibling stroke history demonstrate a stronger association with the incidence risk of stroke. This finding suggests that during the intergenerational transmission of stroke risk, the genetics and family environment reflected by the maternal and sibling stroke history may play an important role.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"58 5","pages":"1000-1006"},"PeriodicalIF":0.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prognostic value of angio-based microvascular resistance on left ventricular systolic function in patients with acute ST-segment elevation myocardial infarction].","authors":"Defu Liu, Jisheng Zhou, Jiangli Han","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between angio-based microvascular resistance (AMR) and impaired left ventricular systolic function in patients with acute ST-elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI), and to assess its predictive value for left ventricular systolic function.</p><p><strong>Methods: </strong>A study was conducted, enrolling consecutive STEMI patients who underwent primary PCI at the Department of Cardiology, Peking University Third Hospital from May 2023 to June 2024. Quantitative flow ratio (QFR) and AMR were calculated from coronary angiography images immediately after PCI, and myocardial biomarker or left ventricular ejection fraction (LVEF) assessed by echocardiography at half-year follow-up were collected. The correlation between AMR, QFR, myocardial biomarkers, and LVEF after half a year was analyzed. The STEMI patients were divided into normal or reduced left ventricular systolic function with LVEF 0.5 as the boundary. The accuracy of AMR in diagnosing reduced left ventricular systolic function was analyzed by receiver operating characteristic curve (ROC).</p><p><strong>Results: </strong>A total of 194 patients were enrolled, with an average age of (63.3±13.6) years, and the average AMR value was (246.99±57.18) mmHg·s/m. Age, peak creatine kinase (CK), troponin T (TnT), N-terminal pro-brain natriuretic peptide (NT-proBNP), and AMR were identified as independent predictive factors for LVEF at half-year follow-up (<i>β</i>=-0.160, <i>t</i>=-2.533, <i>P</i>=0.012; <i>β</i>=-0.271, <i>t</i>=-3.068, <i>P</i>=0.002; <i>β</i>=-0.191, <i>t</i>=-2.157, <i>P</i>=0.032; <i>β</i>=-0.280, <i>t</i>=-4.515, <i>P</i> < 0.001; <i>β</i>=-0.162, <i>t</i>=-2.711, <i>P</i>=0.007). ROC curve analysis showed that AMR had a certain value in predicting reduced left ventricular systolic function [area under curve (95% confidence interval) was 0.631 (0.543-0.718), <i>P</i>=0.006], and the optimal cut-off value for predicting an LVEF < 0.5 was 250.5 mmHg·s/m.</p><p><strong>Conclusion: </strong>AMR is an independent predictor of LVEF at half-year post-procedure and has significant predictive value for reduced left ventricular systolic function, potentially playing an important role in predicting the prognosis of STEMI patients.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"58 5","pages":"987-991"},"PeriodicalIF":0.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Risk factors of carotid atherosclerosis in patients with rheumatoid arthritis].","authors":"Jiajun Liu, Qing Peng, Yan Liu, Tianzuo Lan, Li Long","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To analyze the characteristics of lipid profile and the risk factors of carotid atherosclerosis (CAS) in patients with rheumatoid arthritis (RA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Subjects with 216 RA and 214 healthy controls, both without known cardiovascular disease (CVD), were included. CAS plaques were determined by color Doppler ultrasound. Lipid levels were compared between RA patients and healthy controls, and independent risk factors for CAS plaques in the RA patients were analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;(1) The total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels were lower (&lt;i&gt;P&lt;/i&gt; &lt; 0.001, &lt;i&gt;P&lt;/i&gt;=0.001, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), TC/HDL-C and LDL-C/HDL-C were higher (&lt;i&gt;P&lt;/i&gt;=0.003, &lt;i&gt;P&lt;/i&gt;=0.009) in the RA group than in the healthy controls. (2) In RA group, TC and HDL-C were negatively correlated with high-sensitivity C-reactive protein (hs-CRP) (&lt;i&gt;r&lt;/i&gt;=-0.237, &lt;i&gt;P&lt;/i&gt;=0.002; &lt;i&gt;r&lt;/i&gt;=-0.351, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), neutrophil-to-lymphocyte ratio (NLR) (&lt;i&gt;r&lt;/i&gt;=-0.210, &lt;i&gt;P&lt;/i&gt;=0.006; &lt;i&gt;r&lt;/i&gt;=-0.182, &lt;i&gt;P&lt;/i&gt;=0.018); LDL-C was negatively correlated with NLR (&lt;i&gt;r&lt;/i&gt;=-0.200, &lt;i&gt;P&lt;/i&gt;=0.009), triglyceride (TG) was negatively correlated with erythrocyte sedimentation rate (&lt;i&gt;r&lt;/i&gt;=-0.184, &lt;i&gt;P&lt;/i&gt;=0.016), TC/HDL-C was positively correlated with hs-CRP and NLR (&lt;i&gt;r&lt;/i&gt;=0.286, &lt;i&gt;P&lt;/i&gt; &lt; 0.001; &lt;i&gt;r&lt;/i&gt;=0.159, &lt;i&gt;P&lt;/i&gt;=0.039), LDL-C/HDL-C was positively correlated with hs-CRP (&lt;i&gt;r&lt;/i&gt;=0.161, &lt;i&gt;P&lt;/i&gt;=0.040). In patients with RA, HDL-C levels were higher, and TG and TC/HDL-C levels were lower in the group treated regularly with conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) than without csDMARDs (&lt;i&gt;P&lt;/i&gt;=0.035, &lt;i&gt;P&lt;/i&gt;=0.003, &lt;i&gt;P&lt;/i&gt;=0.006). (3) The prevalence of CAS plaques in RA patients was 37.5%. Age, disease duration, prevalence of hypertension, prevalence of diabetes, LDL-C/HDL-C, homocysteine (Hcy) and hs-CRP levels were higher in the RA with plaque group than in the RA without plaque group (all &lt;i&gt;P&lt;/i&gt; &lt; 0.05). (4) Logistic regression showed that age (&lt;i&gt;OR&lt;/i&gt;=1.085, 95%&lt;i&gt;CI&lt;/i&gt;: 1.045-1.128), disease duration (&lt;i&gt;OR&lt;/i&gt;=1.008, 95%&lt;i&gt;CI&lt;/i&gt;: 1.003-1.014), diabetes (&lt;i&gt;OR&lt;/i&gt;=4.326, 95%&lt;i&gt;CI&lt;/i&gt;: 1.606-11.655), and hs-CRP (&lt;i&gt;OR&lt;/i&gt;=1.022, 95%&lt;i&gt;CI&lt;/i&gt; : 1.006-1.038) were independent risk factors for the presence of CAS plaques in the RA patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Patients with RA are more likely to exhibit lipid metabolic abnormalities which are mainly manifested as low cholesterol levels (TC, LDL-C, HDL-C) and high lipid ratios (TC/HDL-C, LDL-C/HDL-C). Such disordered lipid profileis are associated with gender, inflammatory and drug therapy. Age, disease duration, inflammatory status, and diabetes are independent risk factors for CAS plaques in RA patients. Effective control of inflammatory status are important goals of RA management and may also be essential to delay the p","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"58 5","pages":"1031-1037"},"PeriodicalIF":0.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Bioactivity of multi-matrix bioceramic root canal sealer: An <i>in vitro</i> study].","authors":"Weijia Lyu, Wei Bai, Xiaoyan Wang, Yuhong Leung","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate <i>in vitro</i> bioactivity of the bioceramic root canal sealer Bioseal.</p><p><strong>Methods: </strong>An <i>in vitro</i> mineralization model consisting of root canal sealer specimens and simulated body fluid (SBF) was constructed. Bioceramic-based root canal sealers Bioseal, iRoot SP, and silicone root canal sealer GuttaFlow2 were each prepared into cylindrical specimens with a diameter of 10 mm and a height of 2 mm. All the root canal sealer specimens were then immersed in SBF and maintained at 37 ℃ in a water bath for 4 weeks. Scanning electron microscopy (SEM) and X-ray energy dispersive spectroscopy (EDS) were used to observe the morphology of the root canal sealer specimens after immersion. The surface composition was analyzed by X-ray diffraction (XRD). Calcium ion concentration in the extraction solution was measured using inductively coupled plasma optical emission spectrometry (ICP-OES) and pH value was monitored for 1, 2, 7, 14, 21, and 28 days. Statistical analysis was performed using one-way ANOVA test. The level of significance was set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>After 4 weeks of immersion in SBF, spherical particles were observed on the surfaces of both Bioseal and iRoot SP under SEM. XRD analysis confirmed that the calcium-to-phosphorus ratios were 1.64 and 1.56, respectively, indicating the formation of hydroxyapatite. The calcium ion concentration in bioceramic-based root canal sealers Bioseal and iRoot SP extraction solutions peaked at (110.4±2.8) mg/L and (125.4±3.8) mg/L after 7 days, respectively (<i>P</i> < 0.05), then stabilized (<i>P</i>>0.05). After 2 days, the pH value peaked at 7.99±0.11 and 8.23±0.10, respectively (<i>P</i> < 0.05). The calcium ion concentration and pH value of Bioseal extraction solution were lower than those of iRoot SP at all time points (<i>P</i> < 0.05). No hydroxyapatite formation was observed on the sample surface of silicone root canal sealer GuttaFlow2, and during the evaluation period of 28 days, there were no significant changes in calcium ion concentration or pH value (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The bioceramic root canal sealer Bioseal and iRoot SP demonstrated bioactivity by promoting calcium ion deposition and forming hydroxyapatite in physiological solutions.</p>","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"58 5","pages":"921-926"},"PeriodicalIF":0.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of sample-efficient neural network in predicting postoperative facial profiles in skeletal class Ⅱ orthognathic patients].","authors":"Yuxin Li, Jiachen Dong, Xiaojing Liu, Chuanchuan Yang, Jiakun Fang, Ling Wu","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Soft tissue prediction is of great importance for the surgical design and patients ' satisfaction in orthognathic surgery. Previous studies either rely on elastic mechanical models, such as finite element which involves time-consuming computations, or using artificial intelligence method which require insatiable large patient data. Therefore, in this study, we proposed a more efficient and lightweight method for facial morphology prediction and validated its accuracy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 85 skeletal class Ⅱ patients who underwent double jaw surgery performed by the same senior surgeon were included in the study. Three-dimensional (3D) facial images were acquired before and 6 months after surgery. Among them, 72 data sets were utilized to train the neural network. The Basel face model (BFM), a 3D morphable face model, was employed to parameterically reduce the dimensionality of the three-dimensional facial data. An artificial neural network (ANN) was trained to learn the mapping relationship between the preoperative and postoperative latent codes. The predicted postoperative latent code was subsequently decoded through BFM to reconstruct the three-dimensional facial morphology and gene-rate the predicted postoperative facial appearance. Thirteen patients excluded from the training set were used as the test set. The postoperative facial soft tissue morphology obtained from each patient was considered as the ground truth. The postoperative facial predictions generated by proposed neural network model were defined as the experimental group, while predictions generated by the orthognathic surgical planning software ProPlan CMF were used as the control group. The prediction accuracy was quantitatively evaluated by calculating the root mean square error (RMSE), mean absolute error (MAE), and the percentage of points with prediction errors within ±1 mm and ±2 mm, namely the inlier overlap percen-tages [IO&lt;sub&gt;(±1 mm)&lt;/sub&gt;% and IO&lt;sub&gt;(±2 mm)&lt;/sub&gt;%].&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The experimental group exhibited a mean RMSE of (0.96±0.15) mm and MAE of (0.84±0.12) mm for the entire face. The IO&lt;sub&gt;(±1 mm)&lt;/sub&gt;% and IO&lt;sub&gt;(±2 mm)&lt;/sub&gt;% were (72.17±9.87)% and (96.85±2.60)%, respectively. The errors in the chin and lower lip regions were relatively larger than in other facial regions, with RMSE values of (1.35±0.42) mm and (1.47±0.46) mm, and all results were under 2 mm (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). For the control group, the RMSE was (1.69±0.47) mm, MAE was (1.37±0.39) mm, IO&lt;sub&gt;(±1 mm)&lt;/sub&gt;% and IO&lt;sub&gt;(±2 mm)&lt;/sub&gt;% were (51.31±14.39)% and (79.69±13.71)%, respectively. The experimental group demonstrated smaller RMSE and MAE for the entire face compared with the control group (&lt;i&gt;P&lt;/i&gt; &lt; 0.001), and higher IO&lt;sub&gt;(±1 mm)&lt;/sub&gt;% and IO&lt;sub&gt;(±2 mm)&lt;/sub&gt;% (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). In each region, there was no statistically significant difference in the RMSE between the experimental and control groups in the upp","PeriodicalId":8790,"journal":{"name":"北京大学学报（医学版）","volume":"58 5","pages":"950-958"},"PeriodicalIF":0.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}