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Indoleamine 2,3-dioxygenase--with special reference to the mechanism of interferon action. 吲哚胺2,3-双加氧酶——特别涉及干扰素作用的机制。
Biken journal Pub Date : 1985-06-01
O Hayaishi
{"title":"Indoleamine 2,3-dioxygenase--with special reference to the mechanism of interferon action.","authors":"O Hayaishi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"28 1-2","pages":"39-49"},"PeriodicalIF":0.0,"publicationDate":"1985-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13563705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Address at the 50th anniversary of the Research Institute for Microbial Diseases Osaka University. 在大阪大学微生物病研究所成立50周年纪念仪式上的讲话。
Biken journal Pub Date : 1985-06-01
M Takahashi
{"title":"Address at the 50th anniversary of the Research Institute for Microbial Diseases Osaka University.","authors":"M Takahashi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"28 1-2","pages":"31-5"},"PeriodicalIF":0.0,"publicationDate":"1985-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15025318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of HLA on the cellular immune response to varicella-zoster virus. HLA对水痘-带状疱疹病毒细胞免疫应答的影响。
Biken journal Pub Date : 1985-06-01
Y Chiba, J Miura, T Nakao, A Wakisaka, K Kunikane
{"title":"Effect of HLA on the cellular immune response to varicella-zoster virus.","authors":"Y Chiba,&nbsp;J Miura,&nbsp;T Nakao,&nbsp;A Wakisaka,&nbsp;K Kunikane","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of HLA on varicella-zoster virus (VZV)-specific lymphocyte transformation (LTF) was studied in 100 normal immune adults and 64 children who were immunized with live attenuated varicella vaccine. In the normal adults, a statistically significant association was observed between low responsiveness and the presence of A2 (p less than 0.025), and also between high responsiveness and the presence of Aw24 (p less than 0.05). A similar but clearer association, i.e. low responsiveness with A2 (p less than 0.005) and high responsiveness with Aw24 (p less than 0.025), was observed in the vaccinated children. In these children, Aw31 was also found to be related to low responsiveness (p less than 0.05). These results suggest that the VZV-specific cellular immune response is in some way influenced by HLA.</p>","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"28 1-2","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"1985-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14134932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Demonstration of lysogeny in stable L-forms of Staphylococcus aureus. 稳定的l型金黄色葡萄球菌溶原性的证明。
Biken journal Pub Date : 1984-12-01
N Takemasa, Y Hirachi, Y Kato, M Kurono, Y Toda, S Kotani, T Takahashi, I Tadokoro, K Shinagawa, Y Iida
{"title":"Demonstration of lysogeny in stable L-forms of Staphylococcus aureus.","authors":"N Takemasa,&nbsp;Y Hirachi,&nbsp;Y Kato,&nbsp;M Kurono,&nbsp;Y Toda,&nbsp;S Kotani,&nbsp;T Takahashi,&nbsp;I Tadokoro,&nbsp;K Shinagawa,&nbsp;Y Iida","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"27 4","pages":"177-81"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17304812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation of monoclonal antibodies reactive with Marek's disease tumor-associated surface antigen (MATSA). 马立克病肿瘤相关表面抗原(MATSA)单克隆抗体的分离。
Biken journal Pub Date : 1984-12-01
K Ikuta, S Ueda, S Kato, K Ono, S Osafune, I Yoshida, T Konobe, I Naito, M Naito, K Hirai
{"title":"Isolation of monoclonal antibodies reactive with Marek's disease tumor-associated surface antigen (MATSA).","authors":"K Ikuta,&nbsp;S Ueda,&nbsp;S Kato,&nbsp;K Ono,&nbsp;S Osafune,&nbsp;I Yoshida,&nbsp;T Konobe,&nbsp;I Naito,&nbsp;M Naito,&nbsp;K Hirai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two hybridoma clones producing monoclonal antibodies were obtained from mice immunized with the Marek's disease (MD)-lymphoblastoid cell line MSB1. These monoclonal antibodies reacted with the surface of MD-lymphoblastoid cell lines at higher titers than with avian lymphoid leukosis cell lines or with normal chicken thymus, bursa or peripheral blood lymphocytes. The serological specificity of these monoclonal antibodies seemed to correspond with that of rabbit antiserum reactive with MD tumor-associated surface antigen (MATSA).</p>","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"27 4","pages":"183-8"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17458287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduced resistance to experimental viral and bacterial infections of mice treated with polychlorinated biphenyl. 用多氯联苯治疗小鼠对实验性病毒和细菌感染的抵抗力降低。
Biken journal Pub Date : 1984-12-01
J Imanishi, T Oku, K Oishi, T Kishida, H Nomura, T Mizutani
{"title":"Reduced resistance to experimental viral and bacterial infections of mice treated with polychlorinated biphenyl.","authors":"J Imanishi,&nbsp;T Oku,&nbsp;K Oishi,&nbsp;T Kishida,&nbsp;H Nomura,&nbsp;T Mizutani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>When mice given diet containing 100, 200 or 400 micrograms of polychlorinated biphenyl (PCB) per g, or PCB-free diet for 21 days were inoculated intranasally with influenza virus, the mortality was higher in some groups given PCB than in the control group. When Staphylococcus aureus was inoculated intraperitoneally into mice given a diets with or without PCB, a significant difference was observed in the mortalities in the groups. Subcutaneous injection of S. aureus also caused a larger subcutaneous abscess in the mice given diets containing PCB than in those given control diet. Thus, it is suggested that PCB ingestion reduces host resistance to systemic or local infection with viruses or bacteria.</p>","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"27 4","pages":"195-8"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17503182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidences of HBeAg and anti-HBe in, and clinical course of hepatitis B virus carriers. 乙型肝炎病毒携带者HBeAg和抗hbe的发病率及临床病程。
Biken journal Pub Date : 1984-12-01
H Tsuchie, O Kurimura, I Tamura, K Shimase, E Kaneto, T Kurimura, F Tsuda, M Mayumi
{"title":"Incidences of HBeAg and anti-HBe in, and clinical course of hepatitis B virus carriers.","authors":"H Tsuchie,&nbsp;O Kurimura,&nbsp;I Tamura,&nbsp;K Shimase,&nbsp;E Kaneto,&nbsp;T Kurimura,&nbsp;F Tsuda,&nbsp;M Mayumi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A total of 336 hepatitis B virus (HBV) carriers were followed for more than 3 years with serial measurements of serological markers of HBV to determine the correlation between their clinical course and the HBeAg-anti-HBe system. In all, 139 had hepatitis B e antigen (HBeAg) at the beginning of the study. During the study, 30 of 139 HBeAg-positive carriers became HBeAg negative and subsequently gave a positive reaction for antibody to HBeAg (anti-HBe). The rate of seroconversion was 3.6% per year. Two types of profile of seroconversion were observed, rapid and gradual. No significant differences were observed in the incidences of HBeAg and anti-HBe in HBV carriers with or without liver cirrhosis (LC) and hepatocellular carcinoma (HCC). These findings do not support the report by Chung et al. (1983, J. Med. Virol. 11: 99-104) that a prolonged replicative phase of chronic HBV infection is essential for the occurrence of HCC. Two HBV carriers were diagnosed as having HCC at the time of seroconversion from HBeAg to anti-HBe. This finding supports the reports by Coursaget et al. (1978, J. Clin. Microbiol. 7: 394-395) and Musca et al. (1983, Hepatogastroenterology 30: 3-5) that actively replicating HBV sometimes becomes defective during the course of malignant transformation.</p>","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"27 4","pages":"169-76"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17167202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 1976-1977 rubella epidemic in Fukuoka city in southern Japan: epidemiology and incidences of complications among 80,000 persons who were school children at 28 primary schools and their family members. 1976-1977年日本南部福冈市风疹流行:28所小学8万名学生及其家庭成员的流行病学和并发症发生率。
Biken journal Pub Date : 1984-12-01
K Ueda, F Sasaki, K Tokugawa, K Segawa, H Fujii
{"title":"The 1976-1977 rubella epidemic in Fukuoka city in southern Japan: epidemiology and incidences of complications among 80,000 persons who were school children at 28 primary schools and their family members.","authors":"K Ueda,&nbsp;F Sasaki,&nbsp;K Tokugawa,&nbsp;K Segawa,&nbsp;H Fujii","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>From 1975 to 1977, a nationwide rubella epidemic occurred in Japan. This epidemic provided the last chance for the observation of natural rubella and its epidemiology without the influence of mass-vaccination for rubella and before changes in the epidemic pattern of rubella in the 1980's in Japan. Epidemiological and clinical data were obtained by questionnaires on school children in 28 selected primary schools and their family members (a total of 80,221 persons) in Fukuoka in southern Japan during the 1976-1977 rubella epidemic. At the end of 1975 the rubella epidemic was mainly in the western part of Fukuoka city and then it spread to the eastern part. After a break during the summer of 1976, the epidemic restarted in 1977 mainly in the eastern part with few cases in the western part. Rubella was identified clinically in 14,322 cases (18%) during the 1976 epidemic, the incidences in various age groups being as follows: children of below 6 years of age, 28%; primary school children, 37%; junior and senior high school students, 30%; adults of 18 to 30 years of age, 8%; adults of over 30 years of age, 1%. The incidence in primary school children in 1977 was 18%. Of the 14,322 cases of clinical rubella in 1976, 3 with encephalitis, 9 with purpura and 1,843 with joint complaints (pain and/or swelling of joints) were recorded. Rubella encephalitis was estimated to have occurred in 1 in 4,700 cases with clinical rubella, and purpura in 1 in 1,500 cases.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"27 4","pages":"161-8"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17594094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of interferons on dengue virus multiplication in cultured monocytes/macrophages. 干扰素对培养单核/巨噬细胞中登革病毒增殖的影响。
Biken journal Pub Date : 1984-12-01
H Hotta, S Hotta, M Homma
{"title":"Effect of interferons on dengue virus multiplication in cultured monocytes/macrophages.","authors":"H Hotta,&nbsp;S Hotta,&nbsp;M Homma","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of interferons on dengue virus multiplication in cultured human and mouse monocytes/macrophages were studied. Interferon treatment before, but not after virus inoculation suppressed virus multiplication dose-dependently. Recombinant human leukocyte A interferon was as effective as ordinary human fibroblast interferon in suppressing dengue virus multiplication in cultured human monocytes. Human monocytes, a population of non-proliferating cell lineage, maintained their interferon-mediated antiviral state for a few days after removal of the interferons.</p>","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"27 4","pages":"189-93"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17152713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production, purification and characterization of the plasminogen activator in teratocarcinoma stem cells induced with sodium butyrate. 丁酸钠诱导畸胎癌干细胞纤溶酶原激活物的制备、纯化及特性研究。
Biken journal Pub Date : 1984-12-01
N Ichikawa, T Miyashita, Y Nishimune, A Matsushiro
{"title":"Production, purification and characterization of the plasminogen activator in teratocarcinoma stem cells induced with sodium butyrate.","authors":"N Ichikawa,&nbsp;T Miyashita,&nbsp;Y Nishimune,&nbsp;A Matsushiro","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Suspension cultures of pluripotent teratocarcinoma cells were induced with sodium butyrate to produce plasminogen activator (PA), generally regarded as a marker enzyme of differentiation of the teratocarcinoma. The induction of plasminogen activator was very efficient, resulting in production of sufficient enzyme to allow its purification. The activator was inactivated by rabbit anti-human melanoma plasminogen activator antiserum, indicating that it was a tissue-type activator (t-PA). The enzyme was purified by column chromatograph on phosphocellulose, zinc-chelate agarose, Con-A Sepharose and Sephadex G-150. The preparation at the final step of purification gave a single peak of enzyme activity at pH 7.3 +/- 0.1 on isoelectric focusing, and showed a molecular weight of approximately 77,000 on SDS PAGE.</p>","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"27 4","pages":"143-51"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17503180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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