Biken journal最新文献

An improved micromethod for infectivity assays and neutralization tests of dengue viruses. 登革病毒感染测定和中和试验的改进微法。

Biken journal Pub Date : 1987-06-01

T Ishimine, M Tadano, T Fukunaga, Y Okuno

引用次数: 0

Adoptive immunotherapy of malignant diseases with IL-2-activated lymphocytes. il -2活化淋巴细胞对恶性疾病的过继免疫治疗。

Biken journal Pub Date : 1987-06-01

Y Kimoto, T Taguchi

引用次数: 0

Serological follow-up study on the antibody levels to Epstein-Barr virus-determined nuclear antigen (EBNA) patients with nasopharyngeal carcinoma (NPC) after radiation therapy. 鼻咽癌患者放射治疗后EBNA抗体水平的血清学随访研究

Biken journal Pub Date : 1987-06-01

M Shimakage, N Ikegami, M Chatani, K Yoshino, T Sato

{"title":"Serological follow-up study on the antibody levels to Epstein-Barr virus-determined nuclear antigen (EBNA) patients with nasopharyngeal carcinoma (NPC) after radiation therapy.","authors":"M Shimakage, N Ikegami, M Chatani, K Yoshino, T Sato","doi":"","DOIUrl":"","url":null,"abstract":"Serological follow-up studies for up to 4 years on the levels of IgG antibody to EBV-determined nuclear antigen (EBNA) were carried out on 36 patients with nasopharyngeal carcinoma (NPC). The serum levels of IgA antibody specific to EBV capsid antigen (VCA) were also measured in some of the patients. The titers of EBNA antibody were measured by enzyme-linked immunosorbent assay (ELISA) and those of IgA antibody to VCA were measured by the indirect immunofluorescence method. The EBNA antibody titers in most sera from the patients before radiation therapy were found to be at least 4 times the mean values in the sera of healthy control adults. Within 2 to 8 months after completion of therapy by 4-MV liniac X-ray irradiation with total doses of 60 to 80 Gy, the titers of EBNA antibody in the sera of 6 patients had returned to normal levels, and low levels of EBNA antibody were maintained for a long time after therapy. These serological data were associated with a good clinical prognosis without recurrence or metastases. But in 6 patients, the patterns of change in the EBNA antibody levels were different: the levels remained high after therapy or first decreased to the normal level and then rose to at least 4 times this level. These 6 patients showed recurrence or metastases. The patterns of change in the EBNA antibody levels were well correlated with those of change in the levels of IgA antibody specific to VCA.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"30 2","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"1987-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13968862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monoclonal antibodies against beta-antigen of Mycobacterium tuberculosis and their interspecies reactivities. 抗结核分枝杆菌β抗原单克隆抗体及其种间反应性。

Biken journal Pub Date : 1987-06-01

T H Paik, M Makino, T Ito

引用次数: 0

Corneal test as a reliable method for detection of the delayed-type hypersensitivity reaction in mice. 角膜试验是检测小鼠迟发性超敏反应的可靠方法。

Biken journal Pub Date : 1987-03-01

I Morisaki, T Shimono, N Kohno, D E Stewart-Tull, S Kotani, H Kitamura

引用次数: 0

Differential ability of tumor-unique and cross-reactive antigen(s) on two murine hepatoma cell lines to induce Lyt-1+2- T cells responsible for in vivo protective immunity. 肿瘤特异性抗原和交叉反应性抗原在两种小鼠肝癌细胞系上诱导负责体内保护性免疫的Lyt-1+2- T细胞的差异能力

Biken journal Pub Date : 1987-03-01

J Shima, T Yoshioka, A Kosugi, M Ogata, H Fujiwara, T Hamaoka, S Ueda, S Kato

{"title":"Differential ability of tumor-unique and cross-reactive antigen(s) on two murine hepatoma cell lines to induce Lyt-1+2- T cells responsible for in vivo protective immunity.","authors":"J Shima, T Yoshioka, A Kosugi, M Ogata, H Fujiwara, T Hamaoka, S Ueda, S Kato","doi":"","DOIUrl":"","url":null,"abstract":"The role of the tumor-unique determinant(s) on two syngeneic murine hepatoma cells in inducing in vivo protective immunity was investigated in comparison with that of the tumor-cross-reactive determinant(s). Induction of vaccinia-reactive helper T cells in C3H/He mice by intraperitoneal (i.p.) inoculation of viable vaccinia virus and then immunization with vaccinia-infected syngeneic MH134 or MH129 tumor cells resulted in the production of potent anti-MH134 or -MH129 antibody as well as the generation of in vivo protective immunity. Neither antibody reacted with other syngeneic plasmacytoma or fibrosarcoma cells, but both cross-reacted appreciably with the other hepatoma cells as well reacted strongly as with the tumor cells used for immunization. The absorptions of anti-MH134 and -MH129 antisera with the respective hepatoma cells abolished their reactivities with both the corresponding hepatoma cells and the other hepatoma cells. In contrast, the absorption of these antisera with the other tumor cells resulted in loss of their cross-reactivities with the other hepatoma cells, but not loss of their specific reactivity to the respective hepatoma cells. Although in these hematoma systems, the above-mentioned immunization protocol resulted in in vivo induction of protective immunity and generation of antibodies, in vivo immunity as observed by Winn assays was mediated by Lyt-1+2- T cells and was specific for each type of hepatoma cells. These results indicate that these two types of hepatoma cells bear two kinds of antigenic determinants, one kind unique to each hepatoma and the other kind cross-reactive with the other hepatoma cells.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"30 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"1987-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13592088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoglobulin M antibody to hepatitis B core antigen (IgM anti-HBc) as a marker of interferon therapy in patients with persistent hepatitis B virus infection. 乙型肝炎核心抗原免疫球蛋白M抗体(IgM抗hbc)作为持续乙型肝炎病毒感染患者干扰素治疗的标志。

Biken journal Pub Date : 1987-03-01

E Nakajima, T Tsuji, K Kachi, K Kagawa, T Okanoue, T Takino, A Yamada, J Imanishi

引用次数: 0

Possible conversion of axonemal microtubules to pellicular microtubules in Trypanosoma gambiense treated with vinblastine, colchicine plus concanavalin A. 长春碱、秋水仙碱加豆豆蛋白A处理冈比亚锥虫轴突微管向细胞微管转化的可能性。

Biken journal Pub Date : 1987-03-01

T Ono, T Nakabayashi

引用次数: 0

Protection of mumps in children with various underlying diseases: application of a live attenuated mumps and trivalent measles-rubella-mumps (MRM) vaccines in these children. 保护患有各种基础疾病的儿童的腮腺炎:在这些儿童中应用减毒腮腺炎活疫苗和三价麻疹-风疹-腮腺炎(MRM)疫苗。

Biken journal Pub Date : 1986-12-01

T Kanesaki, K Baba, N Tsuda, H Yabuuchi, K Yamanishi, M Takahashi

{"title":"Protection of mumps in children with various underlying diseases: application of a live attenuated mumps and trivalent measles-rubella-mumps (MRM) vaccines in these children.","authors":"T Kanesaki, K Baba, N Tsuda, H Yabuuchi, K Yamanishi, M Takahashi","doi":"","DOIUrl":"","url":null,"abstract":"A live attenuated mumps and trivalent measles-rubella-mumps (MRM) vaccines have been applied to 887 and 148 children with various underlying diseases at the vaccine clinic of Osaka University Hospital between 1975 and 1985, respectively. Clinical reactions after mumps vaccination occurred in only 7 children (0.8%) and those after MRM vaccination in 28 children (19%), but their underlying diseases were not deteriorated by either vaccination. Clinical follow up study revealed that 2 of the 430 children immunized with mumps vaccine had contracted the disease during 7 year period and 2 of the 123 children immunized with MRM vaccine had contracted clinical mumps or rubella during 3 year period. The seroconversion rates after mumps vaccination were 70% and 61% by the hemagglutination inhibition (HI) test and neutralization (NT) test, respectively, while 94% by the fluorescent antibody to membrane antigen (FAMA) test. Those after MRM vaccination were 87% for measles, 96% for rubella by the HI test and 89% for mumps by the FAMA test. Serological follow up study revealed that antibodies elicited by mumps vaccination were sustained without substantial decline for at least 7 years. These results suggest that a live attenuated mumps and MRM vaccines are safe and effective in children with various underlying diseases.","PeriodicalId":8767,"journal":{"name":"Biken journal","volume":"29 3-4","pages":"63-71"},"PeriodicalIF":0.0,"publicationDate":"1986-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14433059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induction of gametocytogenesis in Plasmodium falciparum by the culture supernatant of hybridoma cells producing anti-P. falciparum antibody. 产生抗p的杂交瘤细胞培养上清液诱导恶性疟原虫配子细胞发生。恶性疟原虫抗体。

Biken journal Pub Date : 1986-12-01

T Ono, T Nakai, T Nakabayashi

引用次数: 0