Bezmialem Science最新文献

{"title":"Relationship Between Toilet Type and Hemorrhoids","authors":"N. Uzun, Emine Yıldırım","doi":"10.14235/bas.galenos.2022.60352","DOIUrl":"https://doi.org/10.14235/bas.galenos.2022.60352","url":null,"abstract":"ABSTRACT","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49060863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Dehydroepiandrosterone-Sulphate be a New Diagnostic Parameter in Idiopathic Hypogonadotropic Hypogonadism?","authors":"K. Çadırcı, H. Keskin, Muharrem Bayrak, A. Çarlıoğlu, Şenay CEYLAN ARIKAN","doi":"10.14235/bas.galenos.2021.6094","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.6094","url":null,"abstract":"Objective: Dehydroepiandrosterone (DHEA) and its sulfate derivative DHEA-sulfate (DHEA-s) are major androgen hormones which are synthesis from the adrenal origin. The purpose of this study was to investigate DHEA-s levels in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and to determine whether DHEA-s level are a useful marker for diagnosis of IHH. Methods: A total of 91 subjects, 31 males with IHH (mean age 19.7±2.6 years) and 60 healthy males (mean age 20.7±2.6 years), were enrolled in this study. The patients with IHH were selected from the subjects who had not yet started treatment for hypogonadism and who had no additional disease, while the healthy control group consisted entirely from individuals admitted to the same hospital outpatient clinic for routine check-ups. Both groups’ blood sampling, anthropometric measures, and physical examination were undertaken Results: Mean DHEA-s level was 133.4±56.5 µg/dL in the IHH group and 433.3±160.3 µg/dL in the control group (p=0.000). The low DHEA-s level in patients with IHH was independent of age, cortisol, and adrenocorticotropic hormone (ACTH) at multivariate logistic regression analysis. The ROC analysis showed that DHEA-s ≤38.2 µg/dL supports a diagnosis of IHH with 100% specificity and 100% sensitivity. DHEA-s was as predictive as total testosterone which is used in the diagnosis of patients with IHH. Conclusion: DHEA-s level was significantly lower in the males with IHH compared to controls. Therefore, DHEA-s may be a potential predictive marker for diagnosis of IHH.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48952796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Patients’ Knowledge of Exercise in Cancer: A Cross-sectional Study","authors":"Ahsen Oğul, Sabriye Ercan","doi":"10.14235/bas.galenos.2021.6532","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.6532","url":null,"abstract":"ÖZ Objective: Exercise is effective in reducing the risk of cancer, and treatment side effects. However, our empirical observations indicate that patients diagnosed with cancer have poor knowledge of exercise in cancer. This study aimed to evaluate cancer patients’ knowledge of exercise in cancer. Methods: After a review of the literature, the researchers developed a questionnaire aimed at evaluating knowledge of exercise in cancer. The study included patients with a history of cancer aged ≥18 years. The participants were asked to respond to each item in the electronic survey by selecting “I had no idea”, “I have heard of it”, or “I know very well”. Results: The study included a total of 125 participants with a history of cancer (75 females, 60%; 50 males, 40%), and their mean age was 52.05±11.50 years. We determined the validity and reliability of the questionnaire before analyzing participants' knowledge of exercise in cancer. Bartlett's test of sphericity and the Kaiser-Meyer-Olkin measure indicated that the data were appropriate for factor analysis (p<0.001). Factor analysis confirmed the structural validity of the questionnaire. Cronbach’s alpha was calculated as 0.963, implying reliable internal consistency. Subsequently, we analyzed participants’ answers to the questionnaire and observed that the response rate of “I know very well” ranged between 3.2% and 14.4% for different items. Conclusion: We prepared and validated a tool for the measurement of knowledge exercise i.e., patients diagnosed as having cancer. The sample size was calculated as five participants per item, that is 125 participants. The developed questionnaire can contribute to assess and improve knowledge of exercise among cancer patients.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49024144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Position Priority on Physiological Variables in Preterm Newborns Receiving Respiratory Support: Randomized Controlled Trial","authors":"Sultan Beşi̇ktaş, E. Efe","doi":"10.14235/bas.galenos.2021.6459","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.6459","url":null,"abstract":"ÖZ Objective: This study was designed to evaluate the effect of supine and prone position priority on oxygen saturation and heart rate in preterm newborns receiving respiratory support. Methods: This was a randomized controlled study. Preterm newborns who were aged <7 days, clinically stable and received respiratory support were included. The sample group consisted of 38 preterm newborns were divided into two groups by randomization according to position priority; Group 1 [supine/prone (S/P)], Group 2 [prone/supine (P/S)]. Results: In both prone and supine positions, the mean oxygen saturation of preterm newborns in Group 2 (P/S) was found to be significantly higher than those in Group 1 (S/P). It was determined that the mean heart rate of preterm newborns in Group 1 (S/P) in the supine position was significantly lower than in Group 2 (P/S). Conclusion: Giving the prone position first and then the supine position to preterm newborns receiving respiratory support increases oxygen saturation.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47718593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Anatomical Variations of AICA Loop be a Cause of Hearing Loss which can Affect the Laterality of Tinnitus Also?","authors":"E. TUNA YALÇINOZAN, Yasemin Küçükçiloğlu","doi":"10.14235/bas.galenos.2021.5843","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.5843","url":null,"abstract":"Objective: We aimed to reveal whether the vascular loop variations created by the antero-inferior cerebellar artery (AICA) in the cerebellopontine angle (CPA) and the internal acoustic canal (IAC) can be a cause, that can affect laterality of tinnitus and cause hearing loss. Methods: The data and the magnetic resonance imaging scans were collected retrospectively and 109 patients with tinnitus were included in the study. Data were recorded according to the patients’ duration and laterality of tinnitus, laterality, type and frequency of hearing loss ,contact type and extension of AICA with remarking the side of the vascular loop. Results: A statistically significant difference was found in between the left ear high frequency (HF) hearing loss (p=0.042) and extension type of the AICA. Also showed statistically significant results in between left sided tinnitus (p=0.030) and the Chavda classification. Besides the patients who had right sided tinnitus, was found to be in relation with the right sided contact type as the p value was 0.023. Conclusion: Our results suggest that AICA variations in CPA and IAC can cause HF hearing loss as well as particularly affect the side of tinnitus. Nevertheless, this relationship must be confirmed by more advanced audiological and imaging techniques.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45760313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Surgical Timing on Treatment Outcomes in Carpal Tunnel Syndrome","authors":"Fatih Durgut, E. Şahin, M. S. Akar, A. Özdemir, Şeyhmus Yiğit","doi":"10.14235/bas.galenos.2021.6714","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.6714","url":null,"abstract":"Objective: The purpose of this study is to assess and compare outcomes of two different timing surgery for moderately carpal tunnel syndrome (CTS). Methods: Eighty-eight patients who underwent early and late due to CTS were evaluated retrospectively. Patients with early surgery and late surgery were divided into two groups. Preoperative and postoperative visual analog scale (VAS) score and postoperative Boston Carpal Tunnel Questionnaire (BCTQ) scores of both groups were compared. Results: Preoperative and postoperative VAS scores were compared, there was a significant decrease in both groups. When BCTQ results of both groups were compared, the results of patients who underwent early surgery were statistically better. Conclusion: In conclusion, we think that early surgery is better clinically in patients with moderately CTS.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46419593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco: Its Conventional and Modern Dosage Forms in Medication","authors":"İmren Esentürk-Güzel, E. A. Yapar, R. Sindhu, Harnoor Kaur, Bilge Ahsen Kara","doi":"10.14235/bas.galenos.2021.6492","DOIUrl":"https://doi.org/10.14235/bas.galenos.2021.6492","url":null,"abstract":"Tobacco is one of the most planted products in worldwide and the whole Nicotiana tabacum L. plant, its leaves, flowers, seeds or roots, and individual chemical compounds have medicinal uses such as as sedative, diuretic, or expectorant. From the past to the present, tobacco has been used in various dosage forms including oral/ transdermal films, sublingual tablets, mouth/nasal spray, and inhaler. In addition, Tobacco is a very valuable plant with uses in medicine and bioengineering applications. In this review, it was aimed to give information about the tobacco plant and its medicinal uses and also the pharmaceutical dosage forms as well as novel delivery systems of nicotine compound of tobacco via comprehensively search method of the literature by using Pubmed, ScienceDirect, ISI Web of Knowledge, and Google Scholar databases for articles published in peer-reviewed journals from mostly 2016 to 2021. It is also aimed to draw attention to the pharmaceutical use of tobacco plant instead of potential harmful uses. In conclusion, there is need to be carried out new studies to enlighten the exact mechanisms of tobacco and its major compound of nicotine on other diseases such as schizophrenia, Parkinson’s disease, and prose memory and attention than smoking cessation therapy and evaluate its safety and develop more effective novel pharmaceutical dosage forms.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42091688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Current Adhesive Systems on Color Stability of Resin Composite","authors":"M. Ayar, Hafize Gamze Demi̇rbaş, Buse Kesgi̇n, Hatice Defne Burduroğlu","doi":"10.14235/bas.galenos.2022.09797","DOIUrl":"https://doi.org/10.14235/bas.galenos.2022.09797","url":null,"abstract":"ÖZ Objective: The adhesive systems which have an important place in modern dentistry can affect the color properties of final resin composite restorations. Therefore, the aim of the present study is to evaluate the influence of current adhesive systems on color, color stability and translucency of resin composites. Methods: Fifty disc-shaped microhybrid resin composite specimens were prepared. Resin composite discs were divided into five groups randomly according to adhesive system including a control group (n=10) (Clearfil Protect Bond, Adper EasyOne, Clearfil QuickBond and Tokuyama BondForce). Color and translucency measurements were performed with a clinical spectrophotometer at baseline, immediately after adhesive system application and after immersion in water for 30 days. For statistical analysis, paired-samples t-test, one-way analysis of variance (ANOVA) and Tukey’s post-hoc comparisons were used (p<0.05). Results: The adhesive application significantly changed the color (E*) of the resin composite discs regardless of the adhesive brand. Storage of the resin composite discs in water for 30 days caused significant color changes in the control group. Significant differences were found in color values of the Adper EasyOne and Clearfil Protect Bond groups after aging. surfaces of the discs were polished with 600-, 800-, 1,200-1,500-grit silicon carbide papers under water cooling. For distinction of the bottom and top sides of specimens, little notches were made with a dental bur on the edge of the bottom side of the composite discs. Final thicknesses of resin composite disks were measured by a digital caliper (1.2±0.1). Resin composite discs were kept in black bottles until color measurements were done. space by Conclusion: The adhesive systems may influence the final color of the restoration, however the adhesive systems tested in the study caused clinically acceptable discoloration at baseline and after aging.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42641353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Nanofiber Applications for Development of Phytopharmaceuticals","authors":"İmren Esentürk-Güzel, Lüceyn Abdo, Evren Alğın Yapar, Engin Esentürk, Derya Büyükkayhan, Rakesh K. Sindhu","doi":"10.14235/bas.galenos.2022.30502","DOIUrl":"https://doi.org/10.14235/bas.galenos.2022.30502","url":null,"abstract":"Herbal sources contain a variety of bio-actives, which are also called phytochemicals. Many of the herbal bio-actives have therapeutic effects and distinguished chemical properties that allow them favorable candidates for phytomedicines. The history of traditional herbal medicines, which are the precursors of phytopharmaceuticals, dates back to ancient times. Today, many of the officially approved and widely used medicines are produced by isolating active substances from herbal sources. Although traditional pharmaceutical dosage forms such as tablets, capsules, syrups, solutions, decoctions and ointments are still used today, problems related with the absorption, biotransformation and stability of phytochemicals reduces the efficacy, bioavailability and in some cases safety of herbal medicines. Also, conventional pharmaceutical dosage forms are often providing an immediate release of phytoconstituents. Besides the use of advanced drug delivery systems offer advantages to overcome mentioned problems, they also provide extended release with maximum efficacy associated with minimum side effects. Researches on development of herbal formulations by using novel drug delivery systems have gain attention and the use of nanotechnology-based a huge potential to improve in vivo simulated tests in drug development studies (9). Additionally, nanofibers play an important role in the field of regenerative medicine, which can recover important tissues such as heart, blood vessels, nerves, bones, cartilages, tendons, and joints. This is possible with the combination of 3D printing and electrospinning techniques to form biomimicking nanofiber scaffolds and patches loaded with stem cells (9,10). The unique specifications of nanofibers have made them widely used in treatment of different diseases such as infections, allergy, hypertension, rheumatic diseases, inflammatory autoimmune diseases, diabetes, intracranial aneurism, Alzheimer’s, cardiovascular diseases, gastrointestinal diseases, AIDS, and cancers (11,12). Mechanical properties of nanofibers such as high surface area-to-volume ratio, high porosity, amorphous structure, and flexibility of the nanofiber-based carrier systems to deliver herbal bio-actives through various drug application routes is overviewed.","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47644428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palliative Surgery in General Surgery Clinics","authors":"A. Akçakaya","doi":"10.14235/bas.galenos.2022.37029","DOIUrl":"https://doi.org/10.14235/bas.galenos.2022.37029","url":null,"abstract":"","PeriodicalId":8757,"journal":{"name":"Bezmialem Science","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45628346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}