Tobacco: Its Conventional and Modern Dosage Forms in Medication

Tobacco is one of the most planted products in worldwide and the whole Nicotiana tabacum L. plant, its leaves, flowers, seeds or roots, and individual chemical compounds have medicinal uses such as as sedative, diuretic, or expectorant. From the past to the present, tobacco has been used in various dosage forms including oral/ transdermal films, sublingual tablets, mouth/nasal spray, and inhaler. In addition, Tobacco is a very valuable plant with uses in medicine and bioengineering applications. In this review, it was aimed to give information about the tobacco plant and its medicinal uses and also the pharmaceutical dosage forms as well as novel delivery systems of nicotine compound of tobacco via comprehensively search method of the literature by using Pubmed, ScienceDirect, ISI Web of Knowledge, and Google Scholar databases for articles published in peer-reviewed journals from mostly 2016 to 2021. It is also aimed to draw attention to the pharmaceutical use of tobacco plant instead of potential harmful uses. In conclusion, there is need to be carried out new studies to enlighten the exact mechanisms of tobacco and its major compound of nicotine on other diseases such as schizophrenia, Parkinson’s disease, and prose memory and attention than smoking cessation therapy and evaluate its safety and develop more effective novel pharmaceutical dosage forms.