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Preparation of 3-(alkylamino)imidazo[1,2-a]pyridine-2-carbaldehydes via Kornblum oxidation and unexpected ring-opening reactions of the corresponding alcohols under oxidative conditions. Kornblum氧化及相应醇的开环反应制备3-（烷基胺）咪唑[1,2-a]吡啶-2-乙醛
IF 2.7 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2026-05-19 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.58
Sandile J Mkhize, Memory Zimuwandeyi, Manuel A Fernandes, Amanda L Rousseau, Moira L Bode
{"title":"Preparation of 3-(alkylamino)imidazo[1,2-<i>a</i>]pyridine-2-carbaldehydes via Kornblum oxidation and unexpected ring-opening reactions of the corresponding alcohols under oxidative conditions.","authors":"Sandile J Mkhize, Memory Zimuwandeyi, Manuel A Fernandes, Amanda L Rousseau, Moira L Bode","doi":"10.3762/bjoc.22.58","DOIUrl":"10.3762/bjoc.22.58","url":null,"abstract":"<p><p>The first synthesis of 3-(alkylamino)imidazo[1,2-<i>a</i>]pyridine-2-carbaldehydes is reported. A Groebke-Blackburn-Bienaymé reaction between 2-aminopyridine derivatives, cyclohexyl isocyanide and glyoxylic acid in the presence of methanol and an acid catalyst gave the 2-ester derivatives that were reduced to give the corresponding alcohols. Mild Kornblum oxidation conditions, reaction in the presence of DMSO and NaHCO<sub>3</sub> under conventional or microwave heating to ≈100 °C, were applied to the bromides derived from these alcohols by treatment with PBr<sub>3</sub>, resulting in the desired aldehydes which successfully underwent reductive amination reactions with 2-chloroaniline. Alternative oxidation conditions such as PCC, IBX or <i>T. versicolor</i> laccase applied to the alcohols led only to oxidative ring-opening to give oxalamide derivatives, with no aldehyde being isolated.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"763-770"},"PeriodicalIF":2.7,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and biological evaluation of new brassinosteroid analogs with C-22 benzoate function. 具有C-22苯甲酸盐功能的新型油菜素内酯类似物的合成及生物学评价。
IF 2.7 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2026-05-18 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.57
María Núñez, Camila Escobar, Mario Párraga, Mauricio Soto, Luis Espinoza-Catalán, Katy Díaz, Andrés F Olea
{"title":"Synthesis and biological evaluation of new brassinosteroid analogs with C-22 benzoate function.","authors":"María Núñez, Camila Escobar, Mario Párraga, Mauricio Soto, Luis Espinoza-Catalán, Katy Díaz, Andrés F Olea","doi":"10.3762/bjoc.22.57","DOIUrl":"10.3762/bjoc.22.57","url":null,"abstract":"<p><p>The synthesis and structural characterization of new brassinosteroid (BR) analogs, in which substituents with different electronegativities and molecular sizes have been attached to a C-22 benzoate function, are described. The biological activities of all new compounds were evaluated by using the rice lamina inclination test (RLIT) and inhibition of root growth of <i>Arabidopsis thaliana</i>. The RLIT data is compared with those previously reported for two series of compounds having the same substitution pattern at C-22 but different structure in ring A. This comparison revealed that a 2α,3α-dihydroxy configuration is more active than a 3-carbonyl or 3β-hydroxy function in this ring. Additionally, the accumulation of the dephosphorylated form of the BES1 protein, which is part of the BRs signaling pathway and control their activity, has been evaluated as well. The results are analyzed in terms of BR analog's structure and compared with binding energies obtained from a docking study. In this way, it is intended to assess the effect of chemical structure on the initial and one intermediate step, and on the final plant response. Our results show that the binding of BR analogs to the active site, which initiate the signaling process, and dephosphorylation of BES1 depend on the structure of BR analogs in a similar way. However, the relationship between the BR analog's structure and the final plant response is different. The dependence on unknown factors which are able to activate or repress genes associated with growth and development is discussed.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"753-762"},"PeriodicalIF":2.7,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rongalite addition to dienones: diastereoselectivity in cyclic sulfone synthesis; stereochemical rationalization and prospects as a general conjugate nucleophile. 熔铝石加成二烯酮：环砜合成中的非对映选择性立体化学合理化及其作为一般共轭亲核试剂的前景。
IF 2.7 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2026-05-13 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.56
Melina Goga, Hao Zong, James Franco, Jazmine Prana, Rudolph Michel, Antonia Muro, Elana Rubin, Janet Brenya, Henk Eshuis, Magnus W P Bebbington
{"title":"Rongalite addition to dienones: diastereoselectivity in cyclic sulfone synthesis; stereochemical rationalization and prospects as a general conjugate nucleophile.","authors":"Melina Goga, Hao Zong, James Franco, Jazmine Prana, Rudolph Michel, Antonia Muro, Elana Rubin, Janet Brenya, Henk Eshuis, Magnus W P Bebbington","doi":"10.3762/bjoc.22.56","DOIUrl":"10.3762/bjoc.22.56","url":null,"abstract":"<p><p>A detailed experimental and computational study of the diastereoselectivity of cyclic sulfone synthesis by reaction of Rongalite with doubly electrophilic dienones is presented. Computational methods, including density functional theory, conformational search methods, and internal reaction coordinate methods, have been used to rationalize the diastereoselectivity of the reaction by transition-state modeling, and showcases the conformational subtleties of sulfur-containing rings. Extension of the original reaction to double intermolecular additions is also demonstrated along with a comparative study of Rongalite with the reactivity of other readily available sulfinate nucleophiles using competition and exchange experiments.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"742-752"},"PeriodicalIF":2.7,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of heterocycles based on azomethine ylides from α-amino acids (or amines) and carbonyl compounds. 以α-氨基酸（或胺类）和羰基化合物为原料合成亚甲酰基杂环化合物。
IF 2.7 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2026-05-13 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.55
Ekaterina V Berezhnaya, Alexander I Ponyaev, Vitali M Boitsov, Alexander V Stepakov
{"title":"Synthesis of heterocycles based on azomethine ylides from α-amino acids (or amines) and carbonyl compounds.","authors":"Ekaterina V Berezhnaya, Alexander I Ponyaev, Vitali M Boitsov, Alexander V Stepakov","doi":"10.3762/bjoc.22.55","DOIUrl":"10.3762/bjoc.22.55","url":null,"abstract":"<p><p>This review focuses on new directions in (3 + 2) cycloaddition of azomethine ylides to alkenes, resulting in the formation of fused or spiro-fused pyrrolidine derivatives with multiple chiral centers under high regio- and stereocontrol. Currently, strategies using azomethine ylides based on imino esters or α-amino acids with a variety of cyclic and acyclic carbonyl compounds dominate. Enantioselective (3 + 2) cycloaddition reactions of azomethine ylides obtained from imino esters, catalyzed by chiral Cu(I,II) and Ag(I) complexes, are widely used. Reactions using α-amino acids proceed, in most cases, without the use of catalysts, with high yields and high stereoselectivity. Electrophilic alkenes of various structures, (hetero)aromatic olefins and benzofulvenes, cyclic and acyclic unsaturated substrates, and fullerenes are useful dipolarophiles. This reaction method allows for the single-step creation of a wide variety of complex polyheterocyclic systems that may be useful for practical applications.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"705-741"},"PeriodicalIF":2.7,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-invasive and cytotoxic evaluation of a (+)-pinoresinol-based semisynthetic library against glioblastoma. （+）-松脂醇基半合成文库抗胶质母细胞瘤侵袭性及细胞毒性评价。
IF 2.7 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2026-05-11 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.54
Chen Zhang, Kah Yean Lum, Jonathan M White, Paul I Forster, Nicholas Booth, Sunita A Ramesh, Rohan A Davis
{"title":"Anti-invasive and cytotoxic evaluation of a (+)-pinoresinol-based semisynthetic library against glioblastoma.","authors":"Chen Zhang, Kah Yean Lum, Jonathan M White, Paul I Forster, Nicholas Booth, Sunita A Ramesh, Rohan A Davis","doi":"10.3762/bjoc.22.54","DOIUrl":"10.3762/bjoc.22.54","url":null,"abstract":"<p><p>The Australian endemic plant genus <i>Eremophila</i> has long been recognized for its unique chemical diversity, with numerous novel and bioactive compounds reported. In this study, we chemically investigated the seeds of <i>Eremophila maculata</i> for the first time, which led to the isolation and characterization of two known plant metabolites, (+)-salicifoliol and (+)-pinoresinol. Due to the reported biological properties of the lignan natural product (+)-pinoresinol and its high abundance from the seeds of <i>E. maculata</i>, we synthesized five analogues for biological evaluations. Preliminary cytotoxicity evaluations of the semisynthetic pinoresinol-based library against two human glioblastoma cell lines, U251MG and KNS42, showed (+)-4,4'-di(3,3-dimethylbutanoyl)pinoresinol had slight cytotoxicity at 10 µM. A transwell anti-invasive assay on the same compound showed a reduction in the invasion of adult U251MG cells by 50% and pediatric KNS42 cells by 30%, with IC<sub>50</sub> values of 0.26 and 0.40 µM, respectively.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"691-704"},"PeriodicalIF":2.7,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of depressin, cryptomeridiol and 4-epi-cryptomeridiol enabled by a terpenoid chiral pool-producing platform. 利用萜类手性池生成平台合成抑制素、隐甲二醇和4-外隐甲二醇。
IF 2.7 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2026-05-05 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.53
Yao Kong, Tao Wang, Chen Wang, Pengcheng Zhang, Yuanning Liu, Kaibiao Wang, Fen Liu, Hongli Jia, Zhengren Xu
{"title":"Synthesis of depressin, cryptomeridiol and 4-<i>epi</i>-cryptomeridiol enabled by a terpenoid chiral pool-producing platform.","authors":"Yao Kong, Tao Wang, Chen Wang, Pengcheng Zhang, Yuanning Liu, Kaibiao Wang, Fen Liu, Hongli Jia, Zhengren Xu","doi":"10.3762/bjoc.22.53","DOIUrl":"10.3762/bjoc.22.53","url":null,"abstract":"<p><p>Depressin (<b>1</b>) is a soft coral-derived diterpenoid containing the typical bicyclo[12.1.0]pentadecane casbane skeleton and a C5-keto group. Key strategies for the synthesis of depressin, as well as its casbene skeleton reported so far focused on the formation of the challenging 14-membered ring system. Cryptomeridiol (<b>2</b>) and 4-<i>epi</i>-cryptomeridiol (<b>3</b>) are two eudesmane-type sesquiterpene diols produced by a variety of different plants with broad biological activity. Most of the syntheses focused on the transformation of chiral pool substrates into their <i>trans</i>-6/6-fused ring system. We herein report the synthesis of compounds <b>1</b>-<b>3</b> by taking advantage of an expanded chiral pool strategy, in which the terpenoid skeletons including casbene (<b>4</b>) and germacrene A (<b>5</b>) were produced by an <i>Escherichia coli</i>-based heterologous host harboring the isopentenol utilization pathway and corresponding terpene cyclases. Two allylic oxidations of both C13 and C5 positions of the casbene skeleton followed by deoxygenation of C13 hydroxy group allowed the synthesis of compound <b>1</b> from <b>4</b> in nine steps. Selective acid-mediated 5,10-transannular cyclization of <b>5</b> followed by hydration reaction furnished both products <b>2</b> and <b>3</b> in two steps.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"683-690"},"PeriodicalIF":2.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13159238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing light energy with molecules. 利用光能和分子。
IF 2.7 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2026-05-04 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.52
Grace G D Han, Mogens Brøndsted Nielsen, Hermann A Wegner
{"title":"Harnessing light energy with molecules.","authors":"Grace G D Han, Mogens Brøndsted Nielsen, Hermann A Wegner","doi":"10.3762/bjoc.22.52","DOIUrl":"10.3762/bjoc.22.52","url":null,"abstract":"","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"680-682"},"PeriodicalIF":2.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13159346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using generative AI to transform peptide hits into small molecule leads. 利用生成式人工智能将肽点转化为小分子先导物。
IF 2.7 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2026-04-30 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.51
Joshua Mills, Yu Heng Lau
{"title":"Using generative AI to transform peptide hits into small molecule leads.","authors":"Joshua Mills, Yu Heng Lau","doi":"10.3762/bjoc.22.51","DOIUrl":"10.3762/bjoc.22.51","url":null,"abstract":"<p><p>There is a wealth of structural data on peptides that bind potential drug targets, serving as rich inspiration for designing small molecule inhibitors which can recapitulate key binding interactions while improving pharmacokinetic properties. With the rapid advancement of artificial intelligence capabilities including powerful generative models, there is significant potential for new AI-based tools to expedite the structure-based transformation of peptide hits into small molecule leads. In this Perspective, we highlight how AI-enabled prediction and design tools can potentially span the entire workflow from peptide to small molecule: target protein structure prediction, de novo peptide binder generation, diffusion models for generating novel small molecule scaffolds, and deep-learning predictors of binding affinity to rapidly triage candidates.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"672-679"},"PeriodicalIF":2.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13159291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoorganocatalytic trifluoromethylation of (het)arenes in green conditions. 绿色条件下（het）芳烃的光有机催化三氟甲基化。
IF 2.7 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2026-04-30 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.50
Egor N Boronin, Svetlana E Kaurkina, Milena M Svetlakova, Anton S Bolshakov, Maxim V Arsenyev, Vasilii F Otvagin, Alexey Yu Fedorov, Timothy Noël, Alexander V Nyuchev
{"title":"Photoorganocatalytic trifluoromethylation of (het)arenes in green conditions.","authors":"Egor N Boronin, Svetlana E Kaurkina, Milena M Svetlakova, Anton S Bolshakov, Maxim V Arsenyev, Vasilii F Otvagin, Alexey Yu Fedorov, Timothy Noël, Alexander V Nyuchev","doi":"10.3762/bjoc.22.50","DOIUrl":"10.3762/bjoc.22.50","url":null,"abstract":"<p><p>A sustainable photocatalytic protocol for the trifluoromethylation of (hetero)arenes is reported. The method operates under metal- and base-free conditions using an inexpensive and atom-efficient CF<sub>3</sub> source, trifluoroacetic anhydride, in ethyl acetate as a green solvent. An organic cyanoarene photocatalyst enables efficient CF<sub>3</sub> radical generation under blue-light irradiation, providing a broad range of trifluoromethylated arenes and heteroarenes. The reaction displays pronounced sensitivity to substituent patterns rather than electronic effects. Mechanistic investigations, including radical trapping, Stern-Volmer analysis, and DFT calculations, support a reductive quenching pathway involving photocatalyst-mediated reduction of TFAA. The protocol is amenable to scale-up, with continuous-flow operation delivering a significant increase in space-time yield, highlighting its potential for sustainable synthesis of CF<sub>3</sub>-containing molecules.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"662-671"},"PeriodicalIF":2.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13159295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advantages of PROTACs in achieving selective degradation of homologous protein families. PROTACs在实现同源蛋白家族选择性降解方面的优势。
IF 2.7 4区 化学
Beilstein Journal of Organic Chemistry Pub Date : 2026-04-27 eCollection Date: 2026-01-01 DOI: 10.3762/bjoc.22.49
Luxi Yang, Xinfei Mao, Jingyi Zhang, Jing Shu, Wenhai Huang, Xiaowu Dong, Yinqiao Chen, Mingfei Wu
{"title":"Advantages of PROTACs in achieving selective degradation of homologous protein families.","authors":"Luxi Yang, Xinfei Mao, Jingyi Zhang, Jing Shu, Wenhai Huang, Xiaowu Dong, Yinqiao Chen, Mingfei Wu","doi":"10.3762/bjoc.22.49","DOIUrl":"10.3762/bjoc.22.49","url":null,"abstract":"<p><p>Proteolysis-targeting chimeras (PROTACs) have emerged as a promising therapeutic modality and now represent an important addition to the toolkit of medicinal chemists. Compared with conventional small-molecule inhibitors, PROTACs exhibit notable advantages, particularly in achieving selectivity within highly homologous proteins. The ability to discriminate among members of such families holds broad implications for future disease treatment. In this review, we primarily summarize the advantages of PROTACs in conferring selectivity toward highly homologous proteins. This focus will provide a feasible strategy for developing PROTACs that selectively target highly homologous proteins and will ultimately support future therapeutic applications.</p>","PeriodicalId":8756,"journal":{"name":"Beilstein Journal of Organic Chemistry","volume":"22 ","pages":"628-661"},"PeriodicalIF":2.7,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13159260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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