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Microbe Mentor:Career Activities at ASM Microbe 2016 微生物导师:ASM微生物2016的职业活动
Microbe (Washington, D.C.) Pub Date : 2016-05-01 DOI: 10.1128/MICROBE.11.223.1
L. Runyen-Janecky
{"title":"Microbe Mentor:Career Activities at ASM Microbe 2016","authors":"L. Runyen-Janecky","doi":"10.1128/MICROBE.11.223.1","DOIUrl":"https://doi.org/10.1128/MICROBE.11.223.1","url":null,"abstract":"In our second edition of a two-part series about Microbe 2016, we invited Dr. Laura Runyen-Janecky, Professor in the Department of Biology at the University of Richmond, to provide insight on how students and postdocs can navigate the careers activities at Microbe 2016. Here is what she had to say:","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63639599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infecting Pregnant Mice Disrupts Fetal Brain, Inducing Autism 感染怀孕小鼠扰乱胎儿大脑，诱发自闭症
Microbe (Washington, D.C.) Pub Date : 2016-05-01 DOI: 10.1128/MICROBE.11.194.1
Shannon Weiman
{"title":"Infecting Pregnant Mice Disrupts Fetal Brain, Inducing Autism","authors":"Shannon Weiman","doi":"10.1128/MICROBE.11.194.1","DOIUrl":"https://doi.org/10.1128/MICROBE.11.194.1","url":null,"abstract":"Infecting pregnant mice can activate immune responses that disrupt fetal brain development, causing autism spectrum disorder (ASD)-like syndrome in newborn mice, according to Gloria Choi of Massachusetts Institute of Technology in Cambridge, Mass., and her collaborators there and at several other institutions. The inflammatory cytokine IL-17a orchestrates that pathology, a finding with implications for preventive and therapeutic strategies if the mechanism in mice applies to humans, they say. Details appeared online 28 January 2016 in Science (doi: 10.1126/science.aad0314).","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63639094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reviews and Resources:Metabolism and Bacterial Pathogenesis: BOOKS 综述和资源:代谢和细菌发病机制:图书
Microbe (Washington, D.C.) Pub Date : 2016-05-01 DOI: 10.1128/MICROBE.11.227.2
G. Mora
{"title":"Reviews and Resources:Metabolism and Bacterial Pathogenesis: BOOKS","authors":"G. Mora","doi":"10.1128/MICROBE.11.227.2","DOIUrl":"https://doi.org/10.1128/MICROBE.11.227.2","url":null,"abstract":"I recently had the pleasure of reading this wonderful book. Metabolism and Bacterial Pathogenesis came at the right time, because I work on a human-exclusive pathogen for which some strains collected from patients are auxotrophic, making me wonder: how is it that a pathogen that is very effective at surviving in humans requires one of the very amino acids that is limiting in humans? Every chapter in this book, directly or indirectly, suggested to me that the answer I am looking for it may be very near, and what I have to do is to dig through some of the numerous references listed. These references are so limited that it made me recall the frequent editorial restrictions on references—clearly, the contributors were encouraged to freely discuss the details in depth. The contributors also suggest provocative and challenging new concepts, e.g. “pathometabolism.” This term encompasses the complex metabolic interactions between host and bacterial pathogen, concepts that could lead to novel antimicrobial therapeutics.","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1128/MICROBE.11.227.2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63639709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Setting Sail for the Future: In a fast-moving world, ASM has a big role to play to fulfill its mission of advancing and promoting the microbial sciences 为未来扬帆起航:在一个快速发展的世界中，ASM在实现其推进和促进微生物科学的使命方面发挥着重要作用
Microbe (Washington, D.C.) Pub Date : 2016-05-01 DOI: 10.1128/MICROBE.11.190.1
S. Bertuzzi
{"title":"Setting Sail for the Future: In a fast-moving world, ASM has a big role to play to fulfill its mission of advancing and promoting the microbial sciences","authors":"S. Bertuzzi","doi":"10.1128/MICROBE.11.190.1","DOIUrl":"https://doi.org/10.1128/MICROBE.11.190.1","url":null,"abstract":"It was with great excitement that I took the helm of the great ASM schooner as the new Chief Executive Officer at the beginning of January. It has been only a few months, but I would like to share my first impressions and the excitement that I feel.","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1128/MICROBE.11.190.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63639304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unsettling Case of Colistin-, Carbapenem-Resistant P. aeruginosa in Canada 令人不安的案例粘菌素，碳青霉烯耐铜绿假单胞菌在加拿大
Microbe (Washington, D.C.) Pub Date : 2016-04-01 DOI: 10.1128/MICROBE.11.146.1
D. Holzman
{"title":"Unsettling Case of Colistin-, Carbapenem-Resistant P. aeruginosa in Canada","authors":"D. Holzman","doi":"10.1128/MICROBE.11.146.1","DOIUrl":"https://doi.org/10.1128/MICROBE.11.146.1","url":null,"abstract":"The first North American instance of an individual infected with Pseudomonas aeruginosa that is resistant to colistin and also carries the resistance gene NDM-1 was documented last year, according to Johann Pitout of the Cumming School of Medicine at the University of Calgary in Calgary, Alberta, Canada, and his collaborators elsewhere in Canada and in South Africa. Importantly, that isolated case illustrates “the need for appropriate infection prevention and control measures and vigilant screening for carbapenem resistant gram-negative bacteria in patients with a history of travel to endemic areas, such as the Indian subcontinent,” they note. Details of appeared 11 January 2016 in Antimicrobial Agents and Chemotherapy (doi:10.1128/AAC.02591–15).","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63636293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small Things Considered 考虑到的小事
Microbe (Washington, D.C.) Pub Date : 2016-04-01 DOI: 10.1128/MICROBE.11.186.1
Brandon Kieft
{"title":"Small Things Considered","authors":"Brandon Kieft","doi":"10.1128/MICROBE.11.186.1","DOIUrl":"https://doi.org/10.1128/MICROBE.11.186.1","url":null,"abstract":"Though seawater looks uniform to our eyes, it is actually highly heterogeneous, containing vast amounts of microscopic particles, fluctuating chemical and nutri-ent gradients, and 1 billion or so diverse microbial organisms per liter. Turbu-lence, diffusion, thermal mixing, and currents add to the patchiness of ocean water, churning and stirring molecular-sized resources. Near the coastal oceans and in estuaries, especially at higher lati-tudes that have distinct seasons, varying sources of dissolved organic compounds make microgradients even more pro-nounced: during times of high river discharge, a coastal environment can become inundated with resources from washed-out terrestrial matter, often leading to phytoplankton blooms.","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1128/MICROBE.11.186.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63637644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carrying Antimicrobial Candidates across the Valley of Death: Key Milestones: Deciding to continue or when to halt development of seemingly promising antibiotic candidates is an iterative exercise 携带候选抗微生物药物跨越死亡之谷:关键里程碑:决定继续或何时停止看似有希望的候选抗生素的开发是一个反复的练习
Microbe (Washington, D.C.) Pub Date : 2016-04-01 DOI: 10.1128/microbe.11.155.1
J. Fox
{"title":"Carrying Antimicrobial Candidates across the Valley of Death: Key Milestones: Deciding to continue or when to halt development of seemingly promising antibiotic candidates is an iterative exercise","authors":"J. Fox","doi":"10.1128/microbe.11.155.1","DOIUrl":"https://doi.org/10.1128/microbe.11.155.1","url":null,"abstract":"What does a company need to do when a promising antimicrobial drug candidate turns up as part of a concerted research and development (R&D) program? First and foremost, said George Drusano of the University of Florida, Gainesville, “You need a hero to push the molecule forward.” However, if the molecule fails to meet critical milestones during that push forward, no matter how good it looked earlier, he added, “At some point, you need to put ‘old yeller’ down.”","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63636869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host microRNAs Help Regulate, Talk Back to the Gut Microbiome 宿主microrna帮助调节和回复肠道微生物群
Microbe (Washington, D.C.) Pub Date : 2016-04-01 DOI: 10.1128/microbe.11.148.1
C. Potera
{"title":"Host microRNAs Help Regulate, Talk Back to the Gut Microbiome","authors":"C. Potera","doi":"10.1128/microbe.11.148.1","DOIUrl":"https://doi.org/10.1128/microbe.11.148.1","url":null,"abstract":"Epithelial cells lining the gastrointestinal tracts of mice secrete microRNA molecules that can enter and switch on genes that alter the growth of certain types of bacteria in the gut, according to Howard Weiner and Shirong Liu at Brigham and Women's Hospital in Boston, Mass., and their collaborators. “It's a very basic finding, but it opens up an area of interaction between microRNAs and the gut microbiome that hasn't been known before,” Weiner says. “Our findings highlight microRNAs as a strategy for manipulation of the microbiome that may affect the health of the host.” Details appeared 13 January 2016 in Cell Host & Microbe (doi.org/10.1016/j.chom.2015.12.005).","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1128/microbe.11.148.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63636394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reviews and Resources:Lab Ref, Volume 1: a Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench: BOOKS 评论和资源:实验室参考，卷1:食谱手册，试剂，和其他参考工具在工作台使用:书籍
Microbe (Washington, D.C.) Pub Date : 2016-04-01 DOI: 10.1128/MICROBE.11.181.2
V. Casas
{"title":"Reviews and Resources:Lab Ref, Volume 1: a Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench: BOOKS","authors":"V. Casas","doi":"10.1128/MICROBE.11.181.2","DOIUrl":"https://doi.org/10.1128/MICROBE.11.181.2","url":null,"abstract":"As research scientists, some of our most prized possessions are the reference manuals that line our lab bookshelves. Volumes of general and specialized manuals, each with their contents of detailed background information, protocols, reagent and media recipes, reference tables, etc. They are the books we direct students to when they are designing experiments.","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1128/MICROBE.11.181.2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63636827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Viable but Nonculturable State for Bacteria: Status Update: This dormant form of bacteria was first appreciated in 1982; now skeptics recognize this state as a bacterial response to stress and a strategy for survival 细菌的存活但不可培养状态:状态更新:这种休眠形式的细菌在1982年首次被发现;现在怀疑论者认识到这种状态是细菌对压力的反应，也是一种生存策略
Microbe (Washington, D.C.) Pub Date : 2016-04-01 DOI: 10.1128/MICROBE.11.159.1
J. Oliver
{"title":"The Viable but Nonculturable State for Bacteria: Status Update: This dormant form of bacteria was first appreciated in 1982; now skeptics recognize this state as a bacterial response to stress and a strategy for survival","authors":"J. Oliver","doi":"10.1128/MICROBE.11.159.1","DOIUrl":"https://doi.org/10.1128/MICROBE.11.159.1","url":null,"abstract":"The notion of microorganisms living in a viable but nonculturable (VBNC) state originates from studies by Rita Colwell at the University of Maryland and her collaborators, whose focus was on Vibrio cholerae. Here, I summarize the early history of this field as well as some of the later studies on the genetics of the VBNC state, the role of quorum sensing in resuscitating dormant cells, and the effect global climate change is having on the spread and incidence of pathogenic vibrios. Much of this material was discussed during the symposium, “Healthy Waters, Healthy People: A Tribute to Rita Colwell,” convened during the 2015 ASM General Meeting in New Orleans, La.","PeriodicalId":87479,"journal":{"name":"Microbe (Washington, D.C.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1128/MICROBE.11.159.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63636918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
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