Savita Singh, Ineke van Herwijnen, Christian Phillips
{"title":"The management of lower urogenital changes in the menopause.","authors":"Savita Singh, Ineke van Herwijnen, Christian Phillips","doi":"10.1177/1754045313481536","DOIUrl":"https://doi.org/10.1177/1754045313481536","url":null,"abstract":"<p><p>Currently, 25% of women seek the advice of a medical professional for symptoms related to the menopause. However, with an increasingly ageing and medically aware population, it is likely this proportion will grow. The main symptoms related to the menopause are systemic vasomotor and localized urogenital symptoms. Numerous forms of estrogen have been used to alleviate these symptoms. Further problems that increase during the menopause include incontinence, pelvic organ prolapse and recurrent urinary tract infections. This article reviews the process by which estrogen affects the tissues of the urogenital tract, what symptoms occur during this period and what modalities of treatments are available.</p>","PeriodicalId":87478,"journal":{"name":"Menopause international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1754045313481536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31609941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Menopause internationalPub Date : 2013-06-01Epub Date: 2013-05-21DOI: 10.1177/1754045313487719
Joanne R Morling, Beverley Balkau, Sarah H Wild
{"title":"Diabetes in women: a life-course approach.","authors":"Joanne R Morling, Beverley Balkau, Sarah H Wild","doi":"10.1177/1754045313487719","DOIUrl":"https://doi.org/10.1177/1754045313487719","url":null,"abstract":"<p><p>The increasing prevalence of diabetes in combination with an aging population and increasing female longevity means that it is important to understand the effects of diabetes on women's health. Both type 1 and type 2 diabetes influence health outcomes throughout the life-course. This review article provides a summary of sex differences in diabetes epidemiology and covers specific aspects of the life-course in women including: the menarche, pregnancy and the menopause. It also discusses the associations with other conditions: cardiovascular disease, osteoporosis and cancer.</p>","PeriodicalId":87478,"journal":{"name":"Menopause international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1754045313487719","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31594141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Menopause internationalPub Date : 2013-06-01Epub Date: 2013-05-21DOI: 10.1177/1754045313488307
Sarah Gray
{"title":"Practice observed.","authors":"Sarah Gray","doi":"10.1177/1754045313488307","DOIUrl":"https://doi.org/10.1177/1754045313488307","url":null,"abstract":"‘‘I would be grateful if you could see this 50 year old woman in your clinic. She has a longstanding mood disorder. She describes herself as always being feisty and prone to extremes of mood and has often drunk to excess to blot out days when she feels bad. More recently her mood seems to have been more unstable resulting in antisocial behaviour, where she has been arrested, suicidal ideation and at other times is very over stimulated. Worsening of her mood has coincided with perimenopause and for a short while was on HRT which possibly seemed to improve matters. However there is a marked family history of breast cancer, her mother developed it in her 30’s and her sister had ovarian cancer at the age of 28. She has now been discharged from the family history clinic and screening there and is being screened by the NHS breast programme 3 yearly. She had a vaginal repair earlier this year. She is awaiting assessment by the mental health services. I would however be grateful for your input on the level of risk involved with HRT and what you feel the potential benefits are in her. Many thanks’’.","PeriodicalId":87478,"journal":{"name":"Menopause international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1754045313488307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31594143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Menopause internationalPub Date : 2013-06-01Epub Date: 2013-05-21DOI: 10.1177/1754045313487720
Ilaria Spoletini, Massimiliano Caprio, Cristiana Vitale, Giuseppe M C Rosano
{"title":"Androgens and cardiovascular disease: gender-related differences.","authors":"Ilaria Spoletini, Massimiliano Caprio, Cristiana Vitale, Giuseppe M C Rosano","doi":"10.1177/1754045313487720","DOIUrl":"https://doi.org/10.1177/1754045313487720","url":null,"abstract":"<p><p>Androgens are known to play a pivotal role in cardiovascular function. However, a definitive explanation as to how their impact differs between genders is yet to be provided. In this review, the existing studies on the link between androgens and cardiovascular disease have been analysed, with a particular focus on the gender-specific differences. Several studies agree that both direct and indirect effects of testosterone on cardiovascular function show a gender-related dimorphism. Consistently, men and women display different responses to androgen supplementation treatment. Post-menopausal women may particularly benefit from testosterone supplementation therapy. Future studies should further clarify the optimal dose and route of administration of testosterone, and more women should be included in clinical trials, in order to identify novel gender-specific targets, and finally to develop therapeutic strategies.</p>","PeriodicalId":87478,"journal":{"name":"Menopause international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1754045313487720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31594142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sitting is the problem, not just lack of exercise.","authors":"Simon Brown","doi":"10.1177/1754045313490905","DOIUrl":"https://doi.org/10.1177/1754045313490905","url":null,"abstract":"based on a circulating, covered plate that turns on its axis to present the various courses of the meal as visible portions. The plate and cover are an integral part of the airline tray – accommodating the cutlery and drinking vessels – which is easy to stack and store. The design (see front cover) also eliminates the lids and extra packaging which usually accompany airline meals. Commenting on this year’s Corus SPDA, Samantha Allison from Corus Packaging Plus remarks: ‘The SPDA is a chance for us to get together with the key players in the packaging supply chain, to exchange views and explore concepts outside the demands of day-to-day business practice. This year Corus redesigned the briefing pack, providing steel material samples and web based information. In addition our in-house design support desk, usually available to packaging designers, was made available to tutors and students to provide advice. Together with the brand owners and the D&AD we worked hard to bring the briefs to a new level of exploration. We appreciate the enthusiasm which the brand owners put into the SPDA briefs – for the real industry issues they set as challenges, but also recognising steel’s versatility as an answer to marketing and manufacturing needs that brand owners continually face.’ Further information is available at the Corus Packaging site www. corusspace.com or at www.dand.org.","PeriodicalId":87478,"journal":{"name":"Menopause international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1754045313490905","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31609939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Menopause internationalPub Date : 2013-03-01Epub Date: 2013-03-14DOI: 10.1177/1754045312472861
Cathy Green, Jacqueline Guest, Wee Ngu
{"title":"Long-term follow-up of women with genital lichen sclerosus.","authors":"Cathy Green, Jacqueline Guest, Wee Ngu","doi":"10.1177/1754045312472861","DOIUrl":"https://doi.org/10.1177/1754045312472861","url":null,"abstract":"<p><p>Genital lichen sclerosus (LS) is usually managed with potent topical corticosteroids. There is a small (<5%) increased risk of skin cancer and long-term follow-up is recommended. We audited patients discharged to the care of their general practitioner (GP) from our regional vulval clinic. Only 29% had seen their GP in the last 12 months; 53% self-examined; 48% were unaware of the need to report abnormalities immediately; 24.4% were unaware of the recommended duration of use of their 30 g tube of steroid and only 66.7% were aware of the risk of skin cancer. Further education of both LS patients and their family practitioners is required.</p>","PeriodicalId":87478,"journal":{"name":"Menopause international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1754045312472861","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31245281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Menopause internationalPub Date : 2013-03-01Epub Date: 2013-03-14DOI: 10.1177/1754045313478068
Edward Morris, Heather Currie
{"title":"Dwindling Drugs: is there anything we can do?","authors":"Edward Morris, Heather Currie","doi":"10.1177/1754045313478068","DOIUrl":"https://doi.org/10.1177/1754045313478068","url":null,"abstract":"","PeriodicalId":87478,"journal":{"name":"Menopause international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1754045313478068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31282481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The use of hormone therapy and its alternatives in women with a history of hormone dependent cancer.","authors":"Hashviniya Sekar, Tasneem Singhal, Debra Holloway, Janice Rymer","doi":"10.1177/1754045312473874","DOIUrl":"https://doi.org/10.1177/1754045312473874","url":null,"abstract":"<p><strong>Objective: </strong>Treating the effects of menopause in women with history of oestrogen-dependent cancers presents a clinical dilemma. Endocrine adjuvant agents like tamoxifen and other cancer treatments, often induce premature menopause. Vasomotor, psychological and somatic symptoms may be more severe in these women. The risk of hormone therapy (HT) and its efficacy must be balanced. Currently, there are no consensus guidelines for the management of these patients.</p><p><strong>Study design: </strong>This is a retrospective study carried out between 10/01/2011 and 27/01/2012 in a tertiary referral menopausal clinic.</p><p><strong>Main outcome measures: </strong>Data was collected about cancer type and treatment, symptoms, prior use of T, bone density analyses and menopause treatments.</p><p><strong>Results: </strong>590 patient records were scanned and 146 patients (24.7%) had a history of cancer. Of these, 45.9% were younger than 50 years old. 67.1% comprised breast cancer patients, of which 69.4% were on adjuvant endocrine agents. 24.7% consisted of gynaecological cancer patients who were predominantly treated with surgery in conjunction with adjuvant therapies. 90.4% of the women had at least one menopause-related symptom, vasomotor symptoms being most prevalent, followed by psychological and vaginal symptoms. Women used a variety of HT and non-HRT therapies for their symptoms. Of the 77 women who had a personal history of oestrogen receptor positive cancers, 19.5% chose to take HT in spite of it being contraindicated.</p><p><strong>Conclusions: </strong>Prescribing HT to women with a history of hormone dependent cancer remains controversial. Patient 'Quality of Life' must be considered. More research is required in this area.</p>","PeriodicalId":87478,"journal":{"name":"Menopause international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1754045312473874","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31231445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Menopause internationalPub Date : 2013-03-01Epub Date: 2013-03-14DOI: 10.1258/mi.2012.012027
Dianna Reed
{"title":"Qualitative enquiry into women's views of the specialist menopause service in Dundee and media coverage of hormone replacement therapy.","authors":"Dianna Reed","doi":"10.1258/mi.2012.012027","DOIUrl":"https://doi.org/10.1258/mi.2012.012027","url":null,"abstract":"<p><p>A qualitative study was undertaken via a questionnaire in a specialist menopause clinic in Dundee, to assess patient views of the service, their opinion of media coverage of hormone replacement therapy and whether their visit helped them reach an informed decision about using it. All women felt that they were given enough information and their concerns were addressed. Only 11% (3/28) of the women sampled viewed media coverage in a positive light.</p>","PeriodicalId":87478,"journal":{"name":"Menopause international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1258/mi.2012.012027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31231444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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