Clinical neuroscience research最新文献_第2页

Analysis of Factors of Complications in Patients with Moyamoya Disease After Revascularization 烟雾病患者血运重建术后并发症因素分析

Clinical neuroscience research Pub Date : 2023-06-26 DOI: 10.26689/cnr.v1i1.5010

Qing-yue Xu

{"title":"Analysis of Factors of Complications in Patients with Moyamoya Disease After Revascularization","authors":"Qing-yue Xu","doi":"10.26689/cnr.v1i1.5010","DOIUrl":"https://doi.org/10.26689/cnr.v1i1.5010","url":null,"abstract":"Objective: In this study, the driving factors of complications in patients with moyamoya disease after revascularization are analyzed and discussed. Methods: A total of 1500 cases with moyamoya disease after revascularization in Yunan Shuifu People’s Hosptial and Beijing University of Chinese Medicine Third Affiliated Hospital from November 2017 to November 2022 were selected retrospectively, and they were divided into an observation group (with postoperative complications) and a control group (with no complications), resulting in 313 cases and 1187 cases in each group, respectively. Univariate and multivariate analysis were performed to screen out independent risk factors for complications in patients with moyamoya disease after revascularization. Results: Univariate analysis showed that the proportion of patients with cerebral ischemia, history of hypertension, and modified Rankin scale (mRs) score of 3-5 in the observation group were significantly higher than those in the control group. Complications were used as the dependent variable, and the indicators with statistically significant differences based on the univariate analysis were included as independent variables in the logistic regression analysis. The results showed that the first symptoms before operation were cerebral ischemia, history of hypertension, and mRs score of 3 to 5 were risk factors for complications in patients with moyamoya disease after revascularization, and there were significant differences in the data (OR = 1.781, 1.811, 1.859, all P < 0.05). Conclusion: Cerebral ischemia is the first symptom before operation, and history of hypertension and mRs score of 3 to 5 are all risk factors for complications in patients with moyamoya disease after revascularization. Therefore, clinical prevention should be strengthened, and corresponding treatment measures should be given in time to reduce the risk of postoperative complications in patients with moyamoya disease.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47041095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare Neurodegenerative Disease: Systematization of Nursing Care in Patients Affected by Huntington’s Disease 罕见神经退行性疾病:亨廷顿舞蹈病患者的系统化护理

Clinical neuroscience research Pub Date : 2023-05-24 DOI: 10.26689/cnr.v1i1.4967

Thamyris Lucimar Pastorini Gonçalves, Vivian Rodrigues Tadeus, Thaynara Naiane Castro Campello, Jamaira do Nascimento Xavier, Naime Ramos Oliveira, Lucas Benedito Fogaça Rabito, Bruna Daniella De Sousa de Lima, Gabriel Guembarski Flávio, Cristiano Lucas Menezes Alves, Andonai Krauze de França, Vivian Susi De Assis Canizares

引用次数: 0

Evaluation of Optic Nerve Sheath Diameter Measurement in the Management of Patients Admitted to the Emergency Department with Head Trauma 视神经鞘径测量在急诊科颅脑外伤患者管理中的应用价值

Clinical neuroscience research Pub Date : 2023-05-24 DOI: 10.26689/cnr.v1i1.4968

Özge Can, M. Ersel, S. Yalçınlı, F. K. Akarca

{"title":"Evaluation of Optic Nerve Sheath Diameter Measurement in the Management of Patients Admitted to the Emergency Department with Head Trauma","authors":"Özge Can, M. Ersel, S. Yalçınlı, F. K. Akarca","doi":"10.26689/cnr.v1i1.4968","DOIUrl":"https://doi.org/10.26689/cnr.v1i1.4968","url":null,"abstract":"Objective: Ultrasonographic measurements of optic nerve sheath diameter is associated with increased intracranial pressure. Intracranial pressure measurements are usually performed on critical areas or intensive care unit patients. The effect of ultrasonographic measurement of optic nerve sheath diameter in predicting pathology or the need for surgery in mild or moderate head trauma has not been evaluated. In our study, we compared ultrasonographic optic nerve sheath diameter measurements with cranial computed tomography (CT) findings and clinical outcomes of patients with head trauma. Materials and methods: Patients with head trauma admitted to the emergency department who were diagnosed with mild, moderate, and severe brain injury were selected for this retrospective study. The optic nerve sheath diameters were measured by ultrasonography. The findings were compared with the outcome and cranial tomography characteristics of the patients. Results: Of the 58 patients admitted to the emergency department with head trauma, mild traumatic brain injury was most common. Hospitalization or operation was required in 51.7% of the patients (30 patients). The mean optic nerve sheath diameter was 4.96 ± 1.02 mm (3.1–7.3 mm) on the right and 4.92 ± 1.02 mm (3.3–7.8) on the left. Optic nerve sheath diameter of 5 mm or more were statistically significant in predicting hospitalization, the presence of pathology, and increased intracranial pressure on cranial CT (P < 0.05). Conclusion: Optic nerve sheath diameters of patients with moderate and mild head trauma may provide information about the need for hospitalization or surgery and can be used as a triage criterion in determining the need for monitoring and follow-up and imaging priorities.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48359089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Sinapic Acid Provide Neuroprotection Against Cisplatin-Induced Toxicity in HT-22 Cells? 辛酸对HT-22细胞的顺铂毒性有神经保护作用吗?

Clinical neuroscience research Pub Date : 2023-05-24 DOI: 10.26689/cnr.v1i1.4984

Betül Çiçek, Sıdıka Genç

{"title":"Does Sinapic Acid Provide Neuroprotection Against Cisplatin-Induced Toxicity in HT-22 Cells?","authors":"Betül Çiçek, Sıdıka Genç","doi":"10.26689/cnr.v1i1.4984","DOIUrl":"https://doi.org/10.26689/cnr.v1i1.4984","url":null,"abstract":"Objective: The aim of this study was to explain the benefits and possible protective mechanisms of sinapic acid (SA) against cisplatin-induced oxido-inflammatory damage in HT-22 rat hippocampal cells by biochemical and molecular methods. Materials and methods: Sinapic acid (SA) was applied at different concentrations (100, 400, and 800 μM) before cisplatin treatment on HT-22 cells under in vitro conditions to elicit neuroprotective activity. Half an hour after SA treatment, 5.5 μM cisplatin was added to all wells except the control group and incubated for 24 hours. Cell viability was determined by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and cytotoxicity was determined by lactate dehydrogenase (LDH) assays. Oxidative stress was evaluated by total antioxidant capacity (TAC), catalase (CAT), glutathione reductase (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) assays. In addition, the effect of SA on Caspase-3 gene regulation in HT-22 cells was investigated by real-time PCR. Results: Cisplatin decreased cell viability by approximately 40% and increased LDH level in HT-22 cells. In SA-treated groups, cell viability increased and LDH level decreased dose-independently. SA showed neuroprotective activity by inhibiting the cytotoxic activity of cisplatin and increasing the antioxidant activity in cells. Similarly, Caspase-3, which was up-regulated by cisplatin, approached the control value upon SA administration. SA eliminated the neurotoxicity of cisplatin and significantly reduced cell death and oxidative stress. Conclusion: The results of this study indicate that SA protects HT-22 cells against cisplatin by inhibiting both the formation of oxidative stress and induction of cell apoptosis.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135090577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of Cognitive Improvement After Carotid Endarterectomy: Results of an Autopsy 颈动脉内膜切除术后认知改善的机制:尸检结果

Clinical neuroscience research Pub Date : 2023-05-24 DOI: 10.26689/cnr.v1i1.4966

K. Ogasawara

引用次数: 0

Is C-Reactive Protein an Indicator of Periodontal Risk? C反应蛋白是牙周病风险的指标吗？

Clinical neuroscience research Pub Date : 2023-04-20 DOI: 10.26689/cnr.v1i1.4032

Gisella Rojas González, Sandra de la Fuente

{"title":"Is C-Reactive Protein an Indicator of Periodontal Risk?","authors":"Gisella Rojas González, Sandra de la Fuente","doi":"10.26689/cnr.v1i1.4032","DOIUrl":"https://doi.org/10.26689/cnr.v1i1.4032","url":null,"abstract":"Periodontitis is a chronic, multifactorial, inflammatory disease caused by microorganisms and characterized by the progressive destruction of tooth-supporting tissue. In recent years, studies have shown a correlation and association between periodontitis and atherosclerotic cardiovascular disease, because both the disease has some similar risk factors and they produce an increase in plasma C-reactive protein (CRP) level. This protein has been attributed favorable characteristics as an inflammatory marker. This study was aimed to identify if there is any relationship between periodontitis and CRP values before starting periodontal treatment in a group of patients from the Faculty of Dentistry of the University of Costa Rica. Periodontal examinations were performed on 30 patients, and a blood sample was obtained from each patient to determine the P-CR concentration. The average P-CR was found to be 3.72mg/L (95%CI: 2.06–5.38), which is a moderate to severe risk marker. Fifty-four percent of the total patients had chronic generalized periodontal disease, with no significant difference between the different periodontal disease with gender (p=0.416) or age (p=0.477). Meanwhile, forty-three and three percent of the total patients had localized chronic periodontal disease, and gingivitis respectively. It was observed that the female gender showed a relatively higher cardiovascular risk compared to the opposite gender (p=0.640). In contrast, no statistically significant difference was found in the P-CR value by gender, age or the presence of other diseases, although it was higher in those with metabolic diseases (5.5mg/L) compared to those without (2.7mg/L).","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48891618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Antipsychotic Drugs on the Cardiac Function of Patients with Schizophrenia and Analysis of Echocardiogram Results 抗精神病药物对精神分裂症患者心功能的影响及超声心动图分析

Clinical neuroscience research Pub Date : 2023-03-28 DOI: 10.26689/cnr.v1i1.5032

J. Fan

{"title":"Effect of Antipsychotic Drugs on the Cardiac Function of Patients with Schizophrenia and Analysis of Echocardiogram Results","authors":"J. Fan","doi":"10.26689/cnr.v1i1.5032","DOIUrl":"https://doi.org/10.26689/cnr.v1i1.5032","url":null,"abstract":"Objective: To explore and analyze the effect of antipsychotic drug treatment on the cardiac function of patients with schizophrenia. Methods: From January 2021 to December 2022, 30 patients with schizophrenia were divided into three groups, group A (n = 10), group B (n = 10), and group C (n = 10), by random number table. Patients in group A were treated with risperidone, patients in group B were treated with quetiapine, and patients in group C were treated with aripiprazole. The Positive and Negative Syndrome Scale (PANSS) and Lowenstein Occupational Therapy Cognitive Assessment (LOTCA) scores, electrocardiogram results, and echocardiogram results were compared among the three groups. Results: There were no significant differences in PANSS and LOTCA scores among the three groups after treatment (P > 0.05). Electrocardiogram showed that the incidence of prolonged QT interval in group C was higher than that in groups A and B (P < 0.05); echocardiogram showed that the left ventricular ejection fraction (LVEF) and left ventricular end-diastolic volume (LVEDV) in group C were lower than those in group A and group B (P < 0.05). Conclusion: Risperidone, quetiapine, and aripiprazole can improve the symptoms and cognitive function in patients with schizophrenia. Aripiprazole has a greater impact on cardiac function, as evidenced on electrocardiogram and echocardiogram. Therefore, close monitoring must be done to ensure drug safety.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45449244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis and Discussion on the Effect of Early Rehabilitation on Motor Dysfunction in Patients with Acute Cerebral Infarction 早期康复治疗对急性脑梗死患者运动功能障碍的影响分析与探讨

Clinical neuroscience research Pub Date : 2023-03-10 DOI: 10.26689/cnr.v1i1.4969

Weisheng Sun

{"title":"Analysis and Discussion on the Effect of Early Rehabilitation on Motor Dysfunction in Patients with Acute Cerebral Infarction","authors":"Weisheng Sun","doi":"10.26689/cnr.v1i1.4969","DOIUrl":"https://doi.org/10.26689/cnr.v1i1.4969","url":null,"abstract":"Objective: To analyze the effect of early rehabilitation on motor dysfunction in patients with acute cerebral infarction. Methods: A total of 70 patients with acute cerebral infarction admitted to Suqian Zhongwu Hospital (our hospital) from January 2020 to December 2021 were selected as research subjects. The participants were divided into two groups through envelopes. The patients of the reference group (n = 35) received conventional treatment whereas the observation group underwent early rehabilitation and conventional treatment (n = 35). The scores of limb motor function (Fugl-Meyer Assessment [FMA]), functional independence (Barthel Scale), and Motor Assessment Scale (MAS) of the two groups were compared. Results: There was no significant difference between the scores of the two groups before treatment (P > 0.05); after early rehabilitation, the FMA and Barthel scale scores of the observation group were higher than those of the reference group, and the MAS scores of the observation group were also better than the reference group (P < 0.05). Conclusion: Early rehabilitation treatment on the basis of conventional treatment for patients with acute cerebral infarction can promote the recovery of motor function and improve the ability to perform daily activities of patients, thus it should be popularized.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44132985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disorders of Childhood Origin 童年起源障碍

Clinical neuroscience research Pub Date : 2018-12-07 DOI: 10.4324/9781315209227-9

L. Weyandt

引用次数: 0

Anxiety Disorder and Obsessive-Compulsive Disorder 焦虑障碍和强迫症

Clinical neuroscience research Pub Date : 2018-12-07 DOI: 10.4324/9781315209227-7

L. Weyandt

引用次数: 0