Clinical neuroscience research最新文献

{"title":"Efficacy and Safety Evaluation of Levetiracetam + Oxcarbazepine in the Treatment of Patients with Epilepsy Secondary to Stroke","authors":"Yujing Huang, Zhenggang Wu","doi":"10.26689/cnr.v2i2.7445","DOIUrl":"https://doi.org/10.26689/cnr.v2i2.7445","url":null,"abstract":"Objective: To evaluate the therapeutic efficacy of levetiracetam (LEV) + oxcarbazepine (OXC) for post-stroke secondary epilepsy (PSE) in the elderly. Methods: 92 patients with PSE admitted to the hospital between July 2021 and July 2023 were selected. Random number table grouping was used, with 46 cases in the combination group, selecting LEV + OXC treatment; and 46 cases in the conventional group, selecting OXC treatment, comparing the treatment effect of the two groups. Results: The total effective rate of the combination group was higher than that of the conventional group, and the difference was statistically significant (P < 0.05). Before treatment, in the comparison of the epilepsy-related indexes and blood indexes between the groups, the difference was not statistically significant (P > 0.05). After treatment, the epilepsy-related indicators as well as blood indicators of the combination group were better than those of the conventional group, and the difference was statistically significant (P < 0.05). The adverse reaction rate of the combination group was lower than that of the conventional group, and the difference was statistically significant (P < 0.05). Conclusion: Implementing LEV + OXC therapy for PSE patients can enhance the effectiveness, improve the degree of epilepsy, regulate the blood indexes, and have high therapeutic safety.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Efficacy of the Quadruple-Limb Linkage Trainer Combined with Rehabilitation Training in Patients with Parkinson’s Disease","authors":"Le Wang, Yu Zhang, Sha Chang, Zhi Li, Xiaohui Wang","doi":"10.26689/cnr.v2i2.7649","DOIUrl":"https://doi.org/10.26689/cnr.v2i2.7649","url":null,"abstract":"Objective: This paper is an in-depth research that explores the effect of limb linkage training instruments combined with rehabilitation training on the treatment of Parkinson’s disease patients. Methods: 92 cases of Parkinson’s disease patients were randomly selected for analysis and research in the hospital from January 2023 to December 2023. 46 cases of the implementation of rehabilitation training intervention were named as the control group, and 46 cases of the implementation of the quadruple-limb linkage trainer combined with rehabilitation training intervention were named as the research group. The patients in the two groups were evaluated for their balance function, gait, quality of life, and get-up-and-walk time, respectively, after implementing the two different modes of intervention. Results: Balance function, gait, and quality of life were significantly improved in both groups, and the degree of improvement was significantly higher in the study group than in the control group. The get-up-and-walk time was shortened in both groups, and it was shorter in the study group (P < 0.05), which is of research value. Conclusion: Through the effective intervention of a limb linkage trainer combined with rehabilitation training, the method can effectively enhance the balance function and walking ability, and then significantly improve the quality of life of Parkinson’s disease patients, so it is worth using.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141817453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effectiveness and Efficiency of Minimally Invasive Craniotomy in the Treatment of Cerebral Hemorrhage","authors":"Yi Zhang","doi":"10.26689/cnr.v2i2.7444","DOIUrl":"https://doi.org/10.26689/cnr.v2i2.7444","url":null,"abstract":"Objective: To investigate the clinical effect of minimally invasive craniotomy in the treatment of patients with cerebral hemorrhage. Methods: 58 samples of patients with cerebral hemorrhage admitted to the hospital were extracted, and the enrollment time was from January 2023 to December 2023. The patients were grouped into an observation group (n = 29) and a control group (n = 29) by using the random draw method of the numerical table. Patients in the control group underwent traditional craniotomy, while patients in the observation group underwent minimally invasive craniotomy, comparing the clinical effectiveness rate, operation time, hematoma clearance rate, rebleeding rate, hospital stay, and various functional scores between the two groups. Results: The clinical efficiency of the observation group was higher than that of the control group (P < 0.05); the operation time and hospital stay of the observation group were lower than that of the control group (P < 0.05); there was no significant difference in the hematoma clearance rate and rebleeding rate of the two groups (P > 0.05); the neurological impairment score of the observation group was lower than that of the control group after the operation, and the Barthel index of daily living score, cognitive functioning score (HDS), dementia scale score of the observation group were lower than that of the control group (P > 0.05). Dementia scale scores (HDS) were higher than those of the control group (P < 0.05). Conclusion: Minimally invasive craniotomy is effective in the treatment of patients with cerebral hemorrhage, which can shorten the operation time and hospital stay, improve the recovery of neurological function and daily living ability, and is suitable to be promoted and applied in medical institutions.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141815847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Neurophysiological Features of Sensory Neuronopathy","authors":"Shuai Yan, Xin Liu, Luxuan Wang","doi":"10.26689/cnr.v2i2.7422","DOIUrl":"https://doi.org/10.26689/cnr.v2i2.7422","url":null,"abstract":"Objective: To improve the understanding of clinical and neurophysiological features of sensory neuronopathy and to achieve early diagnosis of the cause of sensory neuronopathy. Methods: This study retrospectively analyzed the clinical manifestations and neurophysiological features of 16 cases of sensory neuronopathy with a clear diagnosis. Results: The study subjects consisted of 6 males and 10 females, aged 42–71 years old, with a mean age of 55 years old. 10 cases were diagnosed with the sensation of walking on cotton, 4 cases complained of numbness and burning sensation in one or both hands, and 2 cases complained of weakness of the limbs. 4 cases had paraneoplastic sensory neuronopathy, 3 cases had autoimmune sensory neuronopathy, 2 cases had platinum-associated sensory neuronopathy, and 7 cases had idiopathic sensory neuronopathy. Sensory nerve action potentials were significantly reduced or lost in 16 patients, 12 cases were widespread in the limbs, and 4 cases were asymmetric. There was no obvious abnormality in motor nerve conduction. Conclusion: Sensory neuronopathies of various etiologies have common characteristic neurophysiological manifestations, and mastering the neurophysiological characteristics of sensory neuronopathies can lead to early identification of sensory neuronopathies.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141815574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Neurorehabilitation on the Motor Function and Independence Patients with Post-Stroke Hemiplegia","authors":"Chuan Sun","doi":"10.26689/cnr.v1i2.5253","DOIUrl":"https://doi.org/10.26689/cnr.v1i2.5253","url":null,"abstract":"Objective: To explore the effect of neurorehabilitation on the motor function and independence of patients with post-stroke hemiplegia. Methods: 62 stroke patients from August 2020 to August 2022 with hemiplegia were selected for this study. The patients were randomly divided into a study group (neurorehabilitation) and a control group (conventional rehabilitation). Gait changes, National Institutes of Health Stroke Scale (NIHSS), activities of daily living (BI index), motor function (Fugl-Meyer), quality of life (SF-36) and treatment satisfaction of both groups were compared. Results: The stride length (SL) and the fastest walking speed within 10 m (10 mMWS) of the research group were better than those of the control group (P < 0.05). The NIHSS, Barthel Index, Fugl-Meyer, SF-36, and other scores of the research group were better than those of the control group (P < 0.05). The treatment satisfaction of the study group was higher than that of the control group, P < 0.05. Conclusion: Neurorehabilitation is highly effective and feasible in improving walking speed, increasing stride length, and reducing nerve function damage in stroke patients with hemiplegia.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135581079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Effect of Aspirin and Clopidogrel in the Treatment of Cerebral Infarction and the Neurological Function of Patients","authors":"Weidong Wang","doi":"10.26689/cnr.v1i2.5227","DOIUrl":"https://doi.org/10.26689/cnr.v1i2.5227","url":null,"abstract":"Objective: To analyze the effective treatment options for cerebral infarction (CI). Methods: A total of 63 CI patients were selected and divided into a research group (32 cases, treated with aspirin combined with clopidogrel) and a control group (31 cases, treated with aspirin) by drawing lots, and the therapeutic effects of the prescription of both groups were compared. Results: After treatment, the functional scores, hemorheology indexes, quality-of-life scores and clinical effective rate of the study group were better than those of the control group (P < 0.05). Conclusion: Aspirin combined with clopidogrel has a significant impact on CI patients, and it can be fully promoted and applied in medical institutions.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135581077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Surgical Treatment on Endocrine Functional Hormone Indexes in Female Patients with Endocrine Disorders Caused by Sellar Region Tumors","authors":"Qinghuai Xu","doi":"10.26689/cnr.v1i2.5080","DOIUrl":"https://doi.org/10.26689/cnr.v1i2.5080","url":null,"abstract":"Objective: To explore, evaluate and analyze the effects of surgical treatment on endocrine functional hormone indexes in female patients with endocrine disorders caused by sellar region tumors. Methods: 600 female patients with endocrine disorders caused by sellar region tumors who were admitted to the Department of Neurosurgery of Yunan Shuifu People’s Hosptial and Beijing University of Chinese Medicine Third Affiliated Hospital from March 2018 to March 2023 were selected as the research subjects. The patients were divided into two groups, each consisting of 300 cases: the microscopic group received treatment via the microscopic transsphenoidal approach, while the endoscopic group underwent treatment through the neuroendoscopic transsphenoidal approach. The efficacy of both treatments and surgery-related indicators of the patients of both groups were compared. Besides, the endocrine functional hormone indicators, including estradiol (E2) and follicle-stimulating hormone (FSH) levels, were compared between the two groups before operation and 1 week after operation. Results: The efficacy of the treatment received by the endoscopic group was higher than that of the microscopic group, but the difference was not statistically significant (P > 0.05). The duration of operation and postoperative hospital stay of the endoscopic group were shorter than those of the microscopic group, and the intraoperative blood loss was less than that of the microscopic group, the differences were statistically significant (P < 0.05). The postoperative E2 and FSH levels of the two groups were higher than those before operation, and the E2 and FSH levels of the endoscopic group after treatment were higher than those of the microscopic group, and the difference was statistically significant (P < 0.05). Conclusion: The neuroendoscopic transsphenoidal approach for treating female patients with endocrine disorders caused by sellar region tumors proves to be more effective than the microscopic transsphenoidal approach. It enhances the levels of endocrine functional hormones and alleviates clinical symptoms, making it a promising approach worthy of wider adoption.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135581310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Efficacy of Neuroendoscopic Hematoma Evacuation in the Treatment of Chronic Subdural Hematoma and its Influence on the Neurological Function of Patients","authors":"Chun Dong, Jun Jia, Wei Meng","doi":"10.26689/cnr.v1i2.5284","DOIUrl":"https://doi.org/10.26689/cnr.v1i2.5284","url":null,"abstract":"Objective: To analyze the effect of neuroendoscopic hematoma evacuation on neurological function in patients with chronic subdural hematoma (CSDH). Methods: From September 2019 to September 2022, 113 patients with CSDH were selected and randomly divided into group A for neuroendoscopic hematoma evacuation and group B for soft channel drainage. The differences in neurological function of these two groups were compared. Results: Except for intraoperative blood loss and duration of surgery, all surgical indicators in group A were better than those in group B , P < 0.05. One month after operation, the neurological deficit (CSS) score in group A was lower than that in group B, and the quality of life (SF-36), activities of daily living (ADL) scores were higher than those in group B, with P < 0.05. 7 days after operation, the scores of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and other oxidative stress indicators were better than those in group B, P < 0.05; the complication rate in group A was lower than that in group B, with P < 0.05. Conclusion: Neuroendoscopic hematoma evacuation therapy can regulate oxidative stress indicators, improve nerve defects, and improve the outcome of CSDH patients.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135580773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Tirofiban Combined with Neurointerventional Therapy on Neurological Function of Patients with Acute Cerebral Infarction","authors":"Yongfei Jiang, Lesheng Wang, Wenze Li","doi":"10.26689/cnr.v1i2.5378","DOIUrl":"https://doi.org/10.26689/cnr.v1i2.5378","url":null,"abstract":"Objective: To analyze the effect of tirofiban combined with neurointerventional therapy on neurological function of patients with acute cerebral infarction. Methods: 70 patients with acute cerebral infarction admitted between January 2022 and January 2023 were selected as research objects, and patients were divided into control group (neurological interventional therapy) and experimental group (tirofiban combined with neurointerventional therapy) according to the computerized grouping method. The treatment outcomes of both groups were compared. Results: The efficacy of the treatment in the experimental group was 94.9%, which was significantly higher that of the control group control group at 77.14% (P < 0.05). Before treatment, there was no difference in the National Institutes of Health Stroke Scale and Barthel Index between the control group and the experimental group (P < 0.05); after treatment, the NIHSS score of the experimental group was lower than that of the control group, and the BI score was higher than that of the control group (P < 0.05). Before treatment, there was no difference in the levels of high-sensitivity C-reactive protein (hs-CRP) and neuron-specific enolase (NSE) between the control group and the experimental group (P < 0.05); after treatment, the levels of hs-CRP and NSE in the experimental group were lower than those in the control group (P < 0.05). Before treatment, there was no difference in the levels of carbon monoxide (CO), endothelin (ET), nerve growth factor (NGF), and myelin basic protein (MBP) between the control group and the experimental group (P < 0.05); after treatment, the levels of CO and NGF in the experimental group were higher than those in the control group, and the levels of ET and MBP were lower than those in the control group, with statistical significance (P < 0.05). Conclusion: Tirofiban combined with neurointervention is effective in treating acute cerebral infarction. It can not only control the development of the disease, but also improve the patients’ neurological function and the quality of life.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135581314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect Evaluation of Madopar Combined with Pramipexole in the Treatment of Parkinson’s Patients","authors":"Jianhua Liu, Chuanqi Wang, Yu Tan","doi":"10.26689/cnr.v1i2.5306","DOIUrl":"https://doi.org/10.26689/cnr.v1i2.5306","url":null,"abstract":"Objective: To analyze the clinical efficacy of Madopar combined with pramipexole in the treatment of Parkinson’s disease. Methods: This study was conducted from January 2021 to January 2023. This study involved 80 patients who were divided into two groups using a computerized randomization. The control group received pramipexole and the experimental group received both madopar and pramipexole. The treatment outcomes of these two groups were compared and analyzed. Results: The efficacy of the treatment received in the experimental group was 95.00%, which was higher than that of the control group (77.50%), whereas the total adverse reaction rate of the experimental group was 12.50%, which was lower than that of the control group, 35.00%; the difference was significant (P < 0.05). There was no difference in the levels of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), C-reactive protein (CRP), miR-124, miR-137, and Unified Parkinson’s Disease Rating Scale (UPDRS) total score (UPDRS Ⅱ, UPDRS Ⅲ, and UPDRS Ⅳ scores) between the control group and the experimental group (P > 0.05). After treatment, these indicators were significantly improved in the experimental group compared to the control group. Conclusion: Madopar combined with pramipexole in the treatment of Parkinson’s is both effective and safe. It delays the progression of the disease and has broad application prospects.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135580186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}