发布求助
文献互助 智能选刊 最新文献

Best Practice & Research Clinical Haematology最新文献

筛选
英文 中文
Transplantation and cellular therapy in acute leukemia 急性白血病的移植和细胞治疗
IF 2.1 4区 医学
Best Practice & Research Clinical Haematology Pub Date : 2023-09-01 DOI: 10.1016/j.beha.2023.101499
Michael Grunwald, Belinda Avalos, Edward Copelan
{"title":"Transplantation and cellular therapy in acute leukemia","authors":"Michael Grunwald, Belinda Avalos, Edward Copelan","doi":"10.1016/j.beha.2023.101499","DOIUrl":"10.1016/j.beha.2023.101499","url":null,"abstract":"","PeriodicalId":8744,"journal":{"name":"Best Practice & Research Clinical Haematology","volume":"36 3","pages":"Article 101499"},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10458632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The analysis of multiple outcomes, multiple variables and variables selection in hematopoietic cell transplantation studies 造血细胞移植研究的多结局、多变量及变量选择分析
IF 2.1 4区 医学
Best Practice & Research Clinical Haematology Pub Date : 2023-09-01 DOI: 10.1016/j.beha.2023.101478
Soyoung Kim , Xi Fang , Kwang Woo Ahn
{"title":"The analysis of multiple outcomes, multiple variables and variables selection in hematopoietic cell transplantation studies","authors":"Soyoung Kim ,&nbsp;Xi Fang ,&nbsp;Kwang Woo Ahn","doi":"10.1016/j.beha.2023.101478","DOIUrl":"10.1016/j.beha.2023.101478","url":null,"abstract":"<div><p>It is common to study time-to-event data in cancer research such as hematopoietic cell transplantation (HCT) for leukemia. The extensive work has been done for the univariate survival outcome, that is, one event type. However, in practice a subject is often exposed to multiple types of outcomes. In this article, we review various types of right-censored data with multiple outcome types including competing risks data, recurrent event data, and composite endpoints. We also provide hematopoietic cell transplantation data examples.</p></div>","PeriodicalId":8744,"journal":{"name":"Best Practice & Research Clinical Haematology","volume":"36 3","pages":"Article 101478"},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10477485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hodgkin lymphoma: Focus on evolving treatment paradigms 霍奇金淋巴瘤:关注不断发展的治疗范式
IF 2.1 4区 医学
Best Practice & Research Clinical Haematology Pub Date : 2023-08-17 DOI: 10.1016/j.beha.2023.101510
Joseph L. Roswarski , Dan L. Longo
{"title":"Hodgkin lymphoma: Focus on evolving treatment paradigms","authors":"Joseph L. Roswarski ,&nbsp;Dan L. Longo","doi":"10.1016/j.beha.2023.101510","DOIUrl":"https://doi.org/10.1016/j.beha.2023.101510","url":null,"abstract":"<div><p><span><span>Hodgkin lymphoma (HL) is a highly curable B-cell </span>malignancy<span> of germinal center origin. Biologically it is a </span></span>hematologic malignancy<span> that is highly dependent on the immune microenvironment and utilizes immune escape through upregulation of the programmed-death ligands on the neoplastic cells. Despite being highly curable, consensus is lacking nationally and internationally about the optimal approach to management, particularly in limited-stage disease. The addition of brentuximab vedotin<span> and checkpoint inhibitors for the management of HL has led to a rapidly changing treatment landscape. Further studies should be done to include these novel agents at all stages of disease to determine improvements in frontline cure rates and long-term toxicity.</span></span></p></div>","PeriodicalId":8744,"journal":{"name":"Best Practice & Research Clinical Haematology","volume":"36 4","pages":"Article 101510"},"PeriodicalIF":2.1,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91987019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytogenetics and genomics in pediatric acute lymphoblastic leukaemia 儿童急性淋巴细胞白血病的细胞遗传学和基因组学
IF 2.1 4区 医学
Best Practice & Research Clinical Haematology Pub Date : 2023-08-17 DOI: 10.1016/j.beha.2023.101511
Željko Antić , Jana Lentes , Anke K. Bergmann
{"title":"Cytogenetics and genomics in pediatric acute lymphoblastic leukaemia","authors":"Željko Antić ,&nbsp;Jana Lentes ,&nbsp;Anke K. Bergmann","doi":"10.1016/j.beha.2023.101511","DOIUrl":"https://doi.org/10.1016/j.beha.2023.101511","url":null,"abstract":"<div><p><span><span><span>The last five decades have witnessed significant improvement in diagnostics, treatment and management of children with </span>acute lymphoblastic leukaemia<span> (ALL). These advancements have become possible through progress in our understanding of the genetic and biological background of ALL, resulting in the introduction of risk-adapted treatment and novel therapeutic targets, e.g., </span></span>tyrosine kinase inhibitors for </span><em>BCR::ABL1</em><span>-positive ALL. Further advances in the taxonomy of ALL and the discovery of new genetic biomarkers and therapeutic targets, as well as the introduction of targeted and immunotherapies into the frontline treatment protocols, may improve management and outcome of children with ALL. In this review we describe the current developments in the (cyto)genetic diagnostics and management of children with ALL, and provide an overview of the most important advances in the genetic classification of ALL. Furthermore, we discuss perspectives resulting from the development of new techniques, including artificial intelligence (AI).</span></p></div>","PeriodicalId":8744,"journal":{"name":"Best Practice & Research Clinical Haematology","volume":"36 4","pages":"Article 101511"},"PeriodicalIF":2.1,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49716024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytogenetics and molecular genetics of myelodysplastic neoplasms 骨髓增生异常肿瘤的细胞遗传学和分子遗传学
IF 2.1 4区 医学
Best Practice & Research Clinical Haematology Pub Date : 2023-08-16 DOI: 10.1016/j.beha.2023.101512
Yi Ning , Yanming Zhang , Michael A. Kallen , Ashkan Emadi , Maria R. Baer
{"title":"Cytogenetics and molecular genetics of myelodysplastic neoplasms","authors":"Yi Ning ,&nbsp;Yanming Zhang ,&nbsp;Michael A. Kallen ,&nbsp;Ashkan Emadi ,&nbsp;Maria R. Baer","doi":"10.1016/j.beha.2023.101512","DOIUrl":"https://doi.org/10.1016/j.beha.2023.101512","url":null,"abstract":"<div><p>According to the 2022 World Health Organization (WHO) Classification (5th edition), the term myelodysplastic neoplasms (abbreviated MDS) has been introduced to replace myelodysplastic syndromes. MDS are a group of clonal hematopoietic stem cell<span><span> diseases<span> characterized by cytopenia(s), dysplasia<span><span> in one or more of lineages, ineffective hematopoiesis, and an increased risk of progression to </span>bone marrow failure or to </span></span></span>acute myeloid leukemia<span><span> (AML). Current NCCN guidelines and recent review articles have provided in depth discussion on the clinical diagnosis and management of MDS. This review will focus on discussion of the WHO and International Consensus Classification (ICC) updates on the role of cytogenetics and molecular genetics in the diagnosis and </span>risk stratification of MDS.</span></span></p></div>","PeriodicalId":8744,"journal":{"name":"Best Practice & Research Clinical Haematology","volume":"36 4","pages":"Article 101512"},"PeriodicalIF":2.1,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49734338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The presentation of results from studies in clinical haematology 临床血液学研究结果的介绍
IF 2.1 4区 医学
Best Practice & Research Clinical Haematology Pub Date : 2023-06-01 DOI: 10.1016/j.beha.2023.101472
Richard M. Szydlo
{"title":"The presentation of results from studies in clinical haematology","authors":"Richard M. Szydlo","doi":"10.1016/j.beha.2023.101472","DOIUrl":"10.1016/j.beha.2023.101472","url":null,"abstract":"<div><p>Research is based on trying to find answers to specific questions or to test hypotheses. Studies are thus undertaken to generate data which, with appropriate statistical methods, will help to determine the validity of the science under investigation. The aim of this paper is not to provide answers on which statistical methods to use, but will concentrate on suggesting the best ways of presenting the results of appropriately analysed data. And presentation is the key, because however well conducted and analysed a study may be, incorrect or inappropriate presentation of the findings will severely hamper its publication potential. With illustrative examples, the fundamentals required in the presentation of study objectives, population selection, description of characteristics and missing values, survival analyses, unadjusted analyses, multivariate regression models and matched pair analyses, are presented.</p></div>","PeriodicalId":8744,"journal":{"name":"Best Practice & Research Clinical Haematology","volume":"36 2","pages":"Article 101472"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9676581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunopathogenic mechanisms and modulatory approaches to graft-versus-host disease prevention in acute myeloid leukaemia 急性髓性白血病移植物抗宿主病预防的免疫致病机制和调节途径
IF 2.1 4区 医学
Best Practice & Research Clinical Haematology Pub Date : 2023-06-01 DOI: 10.1016/j.beha.2023.101475
Yifan Pang , Noa G. Holtzman
{"title":"Immunopathogenic mechanisms and modulatory approaches to graft-versus-host disease prevention in acute myeloid leukaemia","authors":"Yifan Pang ,&nbsp;Noa G. Holtzman","doi":"10.1016/j.beha.2023.101475","DOIUrl":"10.1016/j.beha.2023.101475","url":null,"abstract":"<div><p><span>Allogeneic haematopoietic stem cell transplantation<span> (HSCT) remains the only potential cure for intermediate to high-risk acute myeloid leukaemia<span><span> (AML). The therapeutic effect of HSCT is largely dependent on the powerful donor-derived immune response against recipient </span>leukaemia cells, known as graft-versus-leukaemia effect (GvL). However, the donor-derived immune system can also cause acute or chronic damage to normal recipient organs and tissues, in a process known as graft-versus-host disease (GvHD). GvHD is a leading cause of non-relapse mortality in HSCT recipients. There are many similarities and cross talk between the immune pathways of GvL and GvHD. Studies have demonstrated that both processes require the presence of mismatched </span></span></span>alloantigens<span> between the donor and recipient, and activation of immune responses<span> centered around donor T-cells, which can be further modulated by various recipient or donor factors. Dissecting GvL from GvHD to achieve more effective GvHD prevention and enhanced GvL has been the holy grail of HSCT research. In this review, we focused on the key factors that contribute to the immune responses of GvL and GvHD, the effect on GvL with different GvHD prophylactic strategies, and the potential impact of various AML relapse prevention therapy or treatments on GvHD.</span></span></p></div>","PeriodicalId":8744,"journal":{"name":"Best Practice & Research Clinical Haematology","volume":"36 2","pages":"Article 101475"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9767736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reducing barriers of access and care related to hematopoietic cell transplantation and cellular therapy: The mission-driven role of the national marrow donor program 减少与造血细胞移植和细胞治疗相关的获取和护理障碍：国家骨髓捐献者计划的使命驱动作用
IF 2.1 4区 医学
Best Practice & Research Clinical Haematology Pub Date : 2023-06-01 DOI: 10.1016/j.beha.2023.101480
Rafeek A. Yusuf , Jaime M. Preussler , Christa L. Meyer , Katie Schoeppner , Jennifer A. Sees Coles , Amber Ruffin , Meggan McCann , Steven M. Devine , Jeffery J. Auletta
{"title":"Reducing barriers of access and care related to hematopoietic cell transplantation and cellular therapy: The mission-driven role of the national marrow donor program","authors":"Rafeek A. Yusuf ,&nbsp;Jaime M. Preussler ,&nbsp;Christa L. Meyer ,&nbsp;Katie Schoeppner ,&nbsp;Jennifer A. Sees Coles ,&nbsp;Amber Ruffin ,&nbsp;Meggan McCann ,&nbsp;Steven M. Devine ,&nbsp;Jeffery J. Auletta","doi":"10.1016/j.beha.2023.101480","DOIUrl":"10.1016/j.beha.2023.101480","url":null,"abstract":"<div><p><span>The treatment of malignant and nonmalignant hematologic disorders continues to benefit from significant scientific advancement and progress in the use of hematopoietic </span>cell transplantation and cellular therapies. However, barriers associated with receiving these lifesaving treatments and care remain, which necessitate innovative approaches to overcome, so all persons in need can receive these therapies. This article reviews barriers to receiving hematopoietic cell transplantation and cellular therapies, and highlights novel approaches taken by the National Marrow Donor Program in reducing barriers for all patients in need.</p></div>","PeriodicalId":8744,"journal":{"name":"Best Practice & Research Clinical Haematology","volume":"36 2","pages":"Article 101480"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9676580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Diagnosis and management of mature B-cell lymphomas in children, adolescents, and young adults 儿童、青少年和年轻人成熟b细胞淋巴瘤的诊断和治疗
IF 2.1 4区 医学
Best Practice & Research Clinical Haematology Pub Date : 2023-06-01 DOI: 10.1016/j.beha.2023.101463
Stanton Goldman , Mitchell S. Cairo
{"title":"Diagnosis and management of mature B-cell lymphomas in children, adolescents, and young adults","authors":"Stanton Goldman ,&nbsp;Mitchell S. Cairo","doi":"10.1016/j.beha.2023.101463","DOIUrl":"10.1016/j.beha.2023.101463","url":null,"abstract":"<div><p><span><span>Mature B-cell lymphoma in children, adolescents and young adults comprises three major histological subtypes including in order of frequency Burkitt, germinal center diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma. The cure rate of the first two with aggressive short chemotherapy based on clinical grouping is ∼90% in resource rich countries. Recent data has shown that incorporation of </span>immune therapy has enhanced </span>event free survival<span> in advanced patients. Future studies will address the possibility of reducing the burden of chemotherapy by substitution of immune based therapies.</span></p></div>","PeriodicalId":8744,"journal":{"name":"Best Practice & Research Clinical Haematology","volume":"36 2","pages":"Article 101463"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9676579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Board / Aims & Scope 编委会/目标和范围
IF 2.1 4区 医学
Best Practice & Research Clinical Haematology Pub Date : 2023-06-01 DOI: 10.1016/S1521-6926(23)00052-X
{"title":"Editorial Board / Aims & Scope","authors":"","doi":"10.1016/S1521-6926(23)00052-X","DOIUrl":"https://doi.org/10.1016/S1521-6926(23)00052-X","url":null,"abstract":"","PeriodicalId":8744,"journal":{"name":"Best Practice & Research Clinical Haematology","volume":"36 2","pages":"Article 101491"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49812628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信