Providing hematopoietic stem cell products from unrelated donors to the world: DKMS donor centers and DKMS Registry

IF 2.2 4区医学 Q3 HEMATOLOGY

Best Practice & Research Clinical Haematology Pub Date : 2024-03-01 DOI:10.1016/j.beha.2024.101541

Alexander H. Schmidt , Jürgen Sauter , Johannes Schetelig , Elke Neujahr , Julia Pingel

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引用次数: 0

Abstract

Allogeneic hematopoietic stem cell (HSC) transplantation is a curative therapy for many severe blood diseases. As many patients have no suitable family donor, large unrelated donor registries and donor centers have been established in many countries, along with an international system for the provision of unrelated donor HSC products. As an essential part of this system, DKMS operates donor centers in 7 countries with a total of 12.2 million donors and over 114,000 donations so far, and a multinational donor registry. In 2022, DKMS donors contributed 57.5% of all cross-border donations worldwide. In this review, we describe the international system for the provision of unrelated donor HSC products as well as tasks and responsibilities of donor registries and donor centers. We also discuss relevant aspects of DKMS donor centers, namely donor file composition, matching and donation probabilities and actual donations, and the unique multinational approach of the DKMS Registry.

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向全世界提供非亲属捐献者的造血干细胞产品：DKMS 捐赠者中心和 DKMS 登记处

异体造血干细胞（HSC）移植是治疗许多严重血液病的一种疗法。由于许多患者没有合适的家庭捐献者，因此许多国家建立了大型非亲属捐献者登记处和捐献中心，并建立了提供非亲属捐献者造血干细胞产品的国际系统。作为该系统的重要组成部分，DKMS 在 7 个国家运营着捐献中心，迄今已有 1.22 万名捐献者和超过 11.4 万例捐献，并建立了一个跨国捐献者登记册。2022 年，DKMS 捐赠者的捐赠量占全球跨境捐赠总量的 57.5%。在这篇综述中，我们介绍了提供非亲属捐献者造血干细胞产品的国际系统，以及捐献者登记处和捐献中心的任务和责任。我们还讨论了 DKMS 捐献中心的相关方面，即捐献者档案组成、配型和捐献概率、实际捐献情况以及 DKMS 登记处独特的跨国方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research Clinical Haematology 医学-血液学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.