Interdisciplinary topics in gerontology最新文献_第4页

Organizing the geriatrician/oncologist partnership: one size fits all? Practical solutions. 组织老年病专家/肿瘤学家合作:一刀切?可行的解决方案。

Interdisciplinary topics in gerontology Pub Date : 2013-01-01 Epub Date: 2013-01-17 DOI: 10.1159/000343615

Holly M Holmes, Gilles Albrand

引用次数: 10

Geriatric oncology nursing: beyond standard care. 老年肿瘤护理:超越标准护理。

Interdisciplinary topics in gerontology Pub Date : 2013-01-01 Epub Date: 2013-01-17 DOI: 10.1159/000343610

Janine Overcash

引用次数: 6

Cancer vaccination at older age. 老年时接种癌症疫苗。

Interdisciplinary topics in gerontology Pub Date : 2013-01-01 Epub Date: 2013-01-25 DOI: 10.1159/000343596

Claudia Gravekamp

引用次数: 2

Frailty: a common pathway in aging and cancer. 虚弱:衰老和癌症的共同途径。

Interdisciplinary topics in gerontology Pub Date : 2013-01-01 Epub Date: 2013-01-17 DOI: 10.1159/000343586

Lodovico Balducci

引用次数: 37

Pharmacology of aging and cancer: how useful are pharmacokinetic tests?. 衰老和癌症的药理学:药代动力学试验有多有用?

Interdisciplinary topics in gerontology Pub Date : 2013-01-01 Epub Date: 2013-01-17 DOI: 10.1159/000343618

Stuart M Lichtman

{"title":"Pharmacology of aging and cancer: how useful are pharmacokinetic tests?.","authors":"Stuart M Lichtman","doi":"10.1159/000343618","DOIUrl":"https://doi.org/10.1159/000343618","url":null,"abstract":"The elderly comprise the majority of patients with cancer and are the recipients of the greatest amount of chemotherapy. Unfortunately, there is a lack of data to make evidence-based decisions with regard to chemotherapy. This is due to the minimal participation of older patients in clinical trials and that trials have not systematically evaluated chemotherapy. This chapter reviews the available information with regard to chemotherapy and aging. Due to the lack of prospective data, the conclusions and recommendations made are a consensus of the available information. Extrapolation of data from younger to older patients is necessary, particularly to those patients older than 80 years, for which data is almost entirely lacking. The classes of drugs reviewed include alkylators, antimetabolites, platinum compounds, anthracyclines, taxanes, purine analogues, antimicrotubule agents, camptothecins, and epipodophyllotoxins. Clinical trials need to incorporate an analysis of chemotherapy in terms of the pharmacokinetic and pharmacodynamic effects of aging. In addition, data already accumulated need to be re-analyzed by age to aid in the management of the older cancer patient.","PeriodicalId":87437,"journal":{"name":"Interdisciplinary topics in gerontology","volume":"38 ","pages":"104-23"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000343618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31314609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exercise for older cancer patients: feasible and helpful?. 老年癌症患者的运动:可行和有益?

Interdisciplinary topics in gerontology Pub Date : 2013-01-01 Epub Date: 2013-01-17 DOI: 10.1159/000343597

Heidi D Klepin, Supriya G Mohile, Shannon Mihalko

{"title":"Exercise for older cancer patients: feasible and helpful?.","authors":"Heidi D Klepin, Supriya G Mohile, Shannon Mihalko","doi":"10.1159/000343597","DOIUrl":"https://doi.org/10.1159/000343597","url":null,"abstract":"Older adults are at high risk for functional decline after a cancer diagnosis. Physiologic changes of aging which negatively impact body composition, strength, and fitness increase vulnerability to the development of short- and long-term disability when stressed with cancer burden and treatments. Treatment-associated physical disability impairs quality of life, limits therapeutic options, and contributes to the social and economic burden of cancer care in the elderly. Despite this, few clinical trials capture disability as an outcome or focus on whether it can be ameliorated in this population. Exercise has multiple positive effects on physical health and well-being in non-cancer elderly populations and holds promise as a supportive care intervention to improve physical function and symptoms during and after cancer treatments. The majority of studies supporting the positive benefits of exercise among cancer survivors have been performed in younger patients. Results from limited elderly-specific trials suggest that physical activity interventions are safe and effective in older cancer survivors, with prostate cancer survivors representing the best studied cohort of older persons with cancer. Many questions remain unanswered with respect to optimal timing, mode, intensity, and delivery of exercise interventions for older patients. While available data support the potential benefit of exercise for elders with cancer, recommendations will need to be individualized to optimize participation, safety, and efficacy.","PeriodicalId":87437,"journal":{"name":"Interdisciplinary topics in gerontology","volume":"38 ","pages":"146-57"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000343597","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31314613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Aging and cancer - addressing a nation's challenge. 老龄化和癌症——解决一个国家的挑战。

Interdisciplinary topics in gerontology Pub Date : 2013-01-01 Epub Date: 2013-01-17 DOI: 10.1159/000343575

Jeanne-Marie Bréchot, Martine Le Quellec-Nathan, Agnès Buzyn

{"title":"Aging and cancer - addressing a nation's challenge.","authors":"Jeanne-Marie Bréchot, Martine Le Quellec-Nathan, Agnès Buzyn","doi":"10.1159/000343575","DOIUrl":"https://doi.org/10.1159/000343575","url":null,"abstract":"The incidence of cancer will increase dramatically among elderly people in the 21st century. The first French National Cancer Plan (2003-2006) with the French Ministry of Health supported the creation of 15 pilot coordination units in oncogeriatrics (UPCOG) in 13 out of the 27 French regions. The second French National Cancer Plan (2009-2013) continues to support oncogeriatrics. Based on evaluation of the pilot experiment in 2010, requirement specifications for an oncogeriatric coordination unit were defined and rolled out nationwide. The following missions were set out: to adjust cancer treatment in elderly people and enable all elderly cancer patients to benefit from this oncogeriatric approach; to stimulate specific research in oncogeriatrics; to promote training of health professionals, and to promote information. The clinical use of a geriatric prescreening tool as a routine procedure needs to become more widespread. Lastly, recommendations for treatment strategies tailored to elderly persons with high-incidence cancer must be developed. Fifteen oncogeriatrics coordination units were founded since 2011, covering 11 regions. Roll-out continues in 2012.","PeriodicalId":87437,"journal":{"name":"Interdisciplinary topics in gerontology","volume":"38 ","pages":"158-64"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000343575","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31314614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Comprehensive geriatric assessment in oncology. 肿瘤学老年综合评估。

Interdisciplinary topics in gerontology Pub Date : 2013-01-01 Epub Date: 2013-01-17 DOI: 10.1159/000343608

Supriya G Mohile, Allison Magnuson

{"title":"Comprehensive geriatric assessment in oncology.","authors":"Supriya G Mohile, Allison Magnuson","doi":"10.1159/000343608","DOIUrl":"https://doi.org/10.1159/000343608","url":null,"abstract":"The incidence of cancer increases with advanced age and the majority of cancer deaths are in patients aged ≥ 65. The geriatric population is a heterogeneous group and a patient's chronologic age does not always correlate with underlying physiologic status. Oncologists need to be able to obtain information on physiologic and functional capacity in older patients in order to provide safe and effective treatment recommendations. The Comprehensive Geriatric Assessment (CGA) is a compilation of validated tools that predict morbidity and mortality in community-dwelling older adults. The various components of the CGA have also been shown to influence clinical decision-making and predict outcomes in older cancer patients. The combined data from the CGA can be used to stratify patients into risk categories to better predict their tolerance to treatment and risk for chemotherapy toxicity. However, the CGA is a comprehensive tool requiring significant time and training to perform. A variety of screening tools have been developed which may be useful in the general oncology practice setting to identify patients that may benefit from further testing and intervention. This chapter will review the components and predictive value of CGA in older cancer patients, with emphasis on how CGA can practically be incorporated into clinical practice.","PeriodicalId":87437,"journal":{"name":"Interdisciplinary topics in gerontology","volume":"38 ","pages":"85-103"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000343608","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31314608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Chronic mechanistic target of rapamycin inhibition: preventing cancer to delay aging, or vice versa?. 雷帕霉素抑制的慢性机制目标:预防癌症以延缓衰老，反之亦然。

Interdisciplinary topics in gerontology Pub Date : 2013-01-01 Epub Date: 2013-01-17 DOI: 10.1159/000343625

Zelton Dave Sharp, Tyler Jay Curiel, Carolina Becker Livi

{"title":"Chronic mechanistic target of rapamycin inhibition: preventing cancer to delay aging, or vice versa?.","authors":"Zelton Dave Sharp, Tyler Jay Curiel, Carolina Becker Livi","doi":"10.1159/000343625","DOIUrl":"https://doi.org/10.1159/000343625","url":null,"abstract":"Cancer and aging appear to be inexorably linked, yet approaches to ameliorate them in concert are lacking. Although not (easily) feasible in humans, years of preclinical research show that diet and growth factor restriction each successfully address cancer and aging together. Chronic treatment of genetically heterogeneous mice with an enteric formulation of rapamycin (eRapa) extended maximum lifespan of both genders when started in mid or late life. In part, cancer amelioration in treated mice suggested that long-term eRapa, like diet restriction, could be a pharmacological approach feasible for use in the clinic. We review the current understanding of the role of the mechanistic target of rapamycin (mTOR) in cancer and aging. We also discuss the tumor immune surveillance system, and the need for a better understanding of its responses to mTOR inhibitors. We also address the issue of the misperception that rapamycin is a potent immunosuppressant. Finally, we review the current state of mTOR inhibitors in the cancer clinic. Because of the burgeoning elderly population most at risk for cancer, there is a great need for our eRapa findings to be a proof of concept for the development of new and more comprehensive approaches to cancer prevention that are safe and also mitigate other deleterious effects of aging.","PeriodicalId":87437,"journal":{"name":"Interdisciplinary topics in gerontology","volume":"38 ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000343625","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31315169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Senescent cells and their secretory phenotype as targets for cancer therapy. 衰老细胞及其分泌表型作为癌症治疗的靶点。

Interdisciplinary topics in gerontology Pub Date : 2013-01-01 Epub Date: 2013-01-17 DOI: 10.1159/000343572

Michael C Velarde, Marco Demaria, Judith Campisi

{"title":"Senescent cells and their secretory phenotype as targets for cancer therapy.","authors":"Michael C Velarde, Marco Demaria, Judith Campisi","doi":"10.1159/000343572","DOIUrl":"https://doi.org/10.1159/000343572","url":null,"abstract":"Cancer is a devastating disease that increases exponentially with age. Cancer arises from cells that proliferate in an unregulated manner, an attribute that is countered by cellular senescence. Cellular senescence is a potent tumor-suppressive process that halts the proliferation, essentially irreversibly, of cells at risk for malignant transformation. A number of anti-cancer drugs have emerged that induce tumor cells to undergo cellular senescence. However, although a senescence response can halt the proliferation of cancer cells, the presence of senescent cells in tissues has been associated with age-related diseases, including, ironically, late-life cancer. Thus, anti-cancer therapies that can induce senescence might also drive aging phenotypes and age-related pathology. The deleterious effects of senescent cells most likely derive from their senescence-associated secretory phenotype or SASP. The SASP entails the secretion of numerous inflammatory cytokines, growth factors and proteases that can render the tissue microenvironment favorable for tumor growth. Here, we discuss the beneficial and detrimental effects of inducing cellular senescence, and propose strategies for targeting senescent cells as a means to fight cancer.","PeriodicalId":87437,"journal":{"name":"Interdisciplinary topics in gerontology","volume":"38 ","pages":"17-27"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000343572","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31315170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 99