Acute cardiac care最新文献

{"title":"Is digoxin a breast cancer risk factor?","authors":"Shahla Masood","doi":"10.3109/17482941.2015.1066823","DOIUrl":"https://doi.org/10.3109/17482941.2015.1066823","url":null,"abstract":"Th e review of the literature regarding the association between digoxin and the development of breast cancer has remained controversial. Several observational studies have reported that the use of digoxin was associated with an increased risk of breast cancer. In a letter published in 1979, Stenkvist et al. (10) suggested that digoxin is associated with less aggressive breast tumor phenotypes and a lower risk of metastasis. Later, in 1999, the same investigators confi rmed their fi ndings in another report (11). Th is letter was followed by other reports, including two independent Danish studies that reported up to 30% increased breast cancer risk among digoxin users compared with non-users. However, these studies were limited by the inability to address the eff ects of confounding factors such as lifestyle-related risk factors and screening mammography (12 – 16). In order to overcome the above-mentioned shortcomings in these retrospective studies, Ahern et al., 2014 (17) studied the association of digoxin and breast cancer in the nurses ’ health study cohort. Th e authors in this study followed 90 202 post-menopausal women from 1994 – 2010, and assessed the incidence of breast cancer, overall and by their ER status, accounting for screening mammography and established breast cancer risk factors. It was found that digoxin use of less than four-years duration was associated with a 45% increased rate of breast cancer, compared with those women who did not use digoxin. Th is association was stronger for ER-positive tumors and had taken into account lifestyle risk factors and screening practices. In this study, it was noted that digoxin users were more likely to undergo screening mammography, and to be former users of postmenopausal hormones, and have similar reproductive history and rates of alcohol consumption. Th e suggested hypothesis from the observed association of digoxin use and increased incidence of ER-positive breast cancer stems from an estrogen-mimetic action of digoxin. It appears that digoxin acts through estrogen signaling pathways in promoting breast tumor growth. Th is hypothesis is supported by the fact that digoxin interacts with human estrogen receptors in vitro (18). Th is pattern is similar to those who have increased breast cancer risk due to exogenous hormone use. In addition, digoxin is associated with gynecomastia in males, an increased incidence of male breast cancer, and increased incidence of uterine cancer, a hormone sensitive malignancy (19 – 22). Acute Cardiac Care, 2015; 17: 29–31 Copyright © 2015 Informa UK, Ltd ISSN 1748-2941 print/ISSN 1748-295X online DOI: 10.3109/17482941.2015.1066823","PeriodicalId":87385,"journal":{"name":"Acute cardiac care","volume":"17 2","pages":"29-31"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/17482941.2015.1066823","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34079973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consequences of ventricular tachyarrhythmia in patients with a left ventricular assist device: Live recording in the ICU.","authors":"L Christian Napp, Tillmann Reinke, Fabio Ius, Jan D Schmitto, Axel Haverich, Johann Bauersachs","doi":"10.3109/17482941.2015.1084638","DOIUrl":"https://doi.org/10.3109/17482941.2015.1084638","url":null,"abstract":"A 64-year-old patient was admitted to the ICU with terminal heart failure due to ischemic cardiomyopathy. After medical recompensation the patient received minimal-invasive implantation of a left v...","PeriodicalId":87385,"journal":{"name":"Acute cardiac care","volume":"17 2","pages":"36-7"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/17482941.2015.1084638","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34079977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Florid peripheral stigmata of staphylococcus aureus infective endocarditis.","authors":"Kuan Leong Yew, Farah Razali","doi":"10.3109/17482941.2015.1066822","DOIUrl":"https://doi.org/10.3109/17482941.2015.1066822","url":null,"abstract":"","PeriodicalId":87385,"journal":{"name":"Acute cardiac care","volume":"17 2","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/17482941.2015.1066822","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34079974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bivalirudin use in patients undergoing percutaneous coronary intervention for acute myocardial infarction. Insights from the prospective, multi-centre EUROVISION registry.","authors":"U Limbruno,&nbsp;A Picchi,&nbsp;S Galli,&nbsp;K Huber,&nbsp;J Lipiecki,&nbsp;D Bernstein,&nbsp;E Deliargyris,&nbsp;P Anthopoulos,&nbsp;C Nienaber,&nbsp;M Hamon","doi":"10.3109/17482941.2014.944542","DOIUrl":"https://doi.org/10.3109/17482941.2014.944542","url":null,"abstract":"<p><strong>Background: </strong>The effectiveness of bivalirudin in patients undergoing percutaneous coronary intervention for acute myocardial infarction has been tested in clinical trials, but its use in a real-world scenario has never been reported.</p><p><strong>Methods: </strong>From the total number of patients enrolled in the EUROVISION registry, 678 subjects affected by ST-elevation myocardial infarction were selected and included in the analysis. Posology and usage patterns of bivalirudin, as evaluated by dose and time of drug bolus and infusion administered, were evaluated. The 30-day outcome has been assessed by efficacy and safety endpoints.</p><p><strong>Results: </strong>All patients received an initial intravenous bolus of bivalirudin (0.70±0.25 mg/kg) followed by an infusion (1.58±0.47 mg/kg/h; duration: 60 [30, 107] min) in 99.3% of cases. An additional bolus (0.49±0.06 mg/kg) was administered in 9.3% of patients. Bivalirudin infusion was prolonged after procedure in 62.2%. Death occurred in 2.1% of patients, non-fatal myocardial reinfarction in 0.3%, unplanned revascularization in 0.6% and non-fatal stroke in 0.4%. Acute stent thrombosis was not observed. Major bleeding occurred in 1.5% of patients.</p><p><strong>Conclusions: </strong>Bivalirudin usage in the setting of primary PCI provided excellent results in terms of 30-day outcome even in a real-world population.</p>","PeriodicalId":87385,"journal":{"name":"Acute cardiac care","volume":"16 4","pages":"127-31"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/17482941.2014.944542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32567791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistant hypertension and renal sympathetic denervation--what does the future hold?","authors":"Prashant Sharma,&nbsp;M Chadi Alraies","doi":"10.3109/17482941.2014.944537","DOIUrl":"https://doi.org/10.3109/17482941.2014.944537","url":null,"abstract":"<p><p>Hypertension is a major public health problem and despite adequate pharmacological treatment, blood pressure remains uncontrolled in a subset of patients with hypertension. Renal sympathetic denervation is a percutaneous catheter-based treatment for select patients with resistant hypertension. In this article, we discuss the development of this intervention, its role in patients with resistant hypertension and the need for guarded optimism in the future of device-directed renal sympathetic denervation.</p>","PeriodicalId":87385,"journal":{"name":"Acute cardiac care","volume":"16 4","pages":"132-3"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/17482941.2014.944537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32611508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent takotsubo syndrome in a patient with myotonic dystrophy 1.","authors":"Josef Finsterer,&nbsp;Claudia Stöllberger,&nbsp;Dita Demirtas,&nbsp;Martin Gencik,&nbsp;Irene Ohnutek,&nbsp;Anette Hornykewycz","doi":"10.3109/17482941.2014.944538","DOIUrl":"https://doi.org/10.3109/17482941.2014.944538","url":null,"abstract":"<p><strong>Objectives: </strong>Stress-induced cardiomyopathy (takotsubo-syndrome, TTS) and its recurrence have not been described in myotonic dystrophy-1.</p><p><strong>Case report: </strong>The patient was a 47-year-old female who was suspected to suffer from myotonic dystrophy-1 at 20 years of age, upon the typical clinical presentation and the electrophysiological findings. During weaning from general anesthesia for resectioning of a pelvic tumour she developed ventricular fibrillation, but was successfully resuscitated. During coronary angiography two days later she experienced recurrent QT-prolongation, torsades de pointes, and ventricular fibrillation, but was successfully resuscitated again each time. Echocardiography and electrocardiography were indicative of TTS, which was confirmed by normal findings on echocardiography and electrocardiography two months later. Ten months after the first TTS she developed dyspnea, leg edema, and anginal chest pain. Recurrence of TTS was diagnosed upon a typical electrocardiography and echocardiography findings. Shortly after onset of the second TTS, she unexpectedly died from sepsis.</p><p><strong>Conclusions: </strong>TTS may also occur in patients with myotonic dystrophy-1 induced by stress from surgery, respiratory insufficiency, or infection. In patients with myotonic dystrophy-1, takotsubo-syndrome may recur and may represent a previously unreported feature of cardiac involvement in myotonic dystrophy-1.</p>","PeriodicalId":87385,"journal":{"name":"Acute cardiac care","volume":"16 4","pages":"115-7"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/17482941.2014.944538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32567789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiology of sepsis-triggered takotsubo syndrome.","authors":"John E Madias","doi":"10.3109/17482941.2014.944543","DOIUrl":"https://doi.org/10.3109/17482941.2014.944543","url":null,"abstract":"pathetic nerves exert a damaging infl uence on the cardiomyocytes; (b) the sympathetic nerves are disrupted and thus they do not exert any stimulation on the cardiomyocytes, but the injurious infl uence on the cardiomyocytes is exerted by the noradrenaline spillover? (c) One wonders whether ‘ disrupted ’ sympathetic nerves secrete larger amounts of norepinephrine, except if the authors imply by ‘ disruption ’ of the sympathetic nerves an enhanced state of stimulation, with resultant increased norepinephrine secretion and spillover; (d) Do the authors imply ‘ cardiac sympathetic denervation ’ by ‘ cardiac sympathetic disruption ’ ? (e) Of course it is conceivable that a population of the cardiac sympathetic nerve terminals are partially disrupted, and non-functioning (partial cardiac sympathetic denervation), while other populations of such terminals are in a state of heightened function with intense stimulation of cardiomyocytes, and profuse nonadrenaline spillover. I will appreciate very much the response of the authors on the above.","PeriodicalId":87385,"journal":{"name":"Acute cardiac care","volume":"16 4","pages":"134"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/17482941.2014.944543","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32567790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombus straddling a patent foramen ovale.","authors":"Colin D Chue,&nbsp;Sohail Qaisar,&nbsp;Jerome Ment","doi":"10.3109/17482941.2014.944540","DOIUrl":"https://doi.org/10.3109/17482941.2014.944540","url":null,"abstract":"","PeriodicalId":87385,"journal":{"name":"Acute cardiac care","volume":"16 4","pages":"135"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/17482941.2014.944540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32567792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and survival to discharge of patients with STEMI between a PPCI-capable hospital and a non-PPCI hospital: a prospective observational study.","authors":"Irene Kritikou,&nbsp;Athanasios Chalkias,&nbsp;Anastasios Koutsovasilis,&nbsp;Theodoros Xanthos","doi":"10.3109/17482941.2014.944539","DOIUrl":"https://doi.org/10.3109/17482941.2014.944539","url":null,"abstract":"<p><strong>Introduction: </strong>Primary percutaneous coronary intervention (PPCI) is a key therapeutic method in the treatment of ST-elevation myocardial infarction (STEMI). We studied the characteristics and survival to discharge in STEMI patients who presented in a PPCI-capable hospital and a non-PPCI hospital.</p><p><strong>Patients and methods: </strong>This prospective observational study included 240 consecutive patients. One basic questionnaire was distributed along with an explanatory letter to the participants, who were followed until discharge from the hospital or death.</p><p><strong>Results: </strong>Of the 240 patients, 234 (97.5%) survived to hospital discharge. Only 6 (5%) patients who were initially presented to a non-PPCI hospital died after inter-facility transfer. Also, 36 (92.3%) of the 39 patients with an intervening time of over 90 min were admitted initially in a non-PPCI hospital. Although there was a statistically significant correlation between the type of the hospital and the delay from the onset of symptoms to PPCI (P=0.001), such correlation was not found between the delay PPCI and the outcome of the patients (P>0.05).</p><p><strong>Conclusion: </strong>Patients with STEMI may be transferred to a non-PPCI hospital due to the lack of prehospital triage. However, prompt inter-facility transfer results in good outcome.</p>","PeriodicalId":87385,"journal":{"name":"Acute cardiac care","volume":"16 4","pages":"118-22"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/17482941.2014.944539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32594175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful embolization of iatrogenic ruptured coronary artery using Onyx: a new technique.","authors":"I Asouhidou,&nbsp;V Katsaridis","doi":"10.3109/17482941.2014.944541","DOIUrl":"https://doi.org/10.3109/17482941.2014.944541","url":null,"abstract":"<p><p>Iatrogenic perforation of coronary artery is rare during percutaneous coronary intervention (PCI); however the complications are life-threatening. Patients in this clinical setting may be treated either by stent placement, closure of the perforation with fibrin glue or coils, or with emergency bypass surgery. Onyx, a new material that has been used successfully in cerebral arteries, represents a new and safe alternative. The advantage of Onyx is that it is easily injected through a microcatheter and it allows for a longer injection time having also the ability to reach difficult anatomical locations. We present the first case of successful embolization of a right coronary artery perforation during coronary angiography using Onyx.</p>","PeriodicalId":87385,"journal":{"name":"Acute cardiac care","volume":"16 4","pages":"123-6"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/17482941.2014.944541","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32575173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}