Journal of orthopedic research and therapy最新文献

{"title":"Surgical Complications of Idiopathic Scoliosis: Current Perspectives","authors":"H. H. A. Allah","doi":"10.29011/2575-8241.001193","DOIUrl":"https://doi.org/10.29011/2575-8241.001193","url":null,"abstract":"Despite the good results, however, spinal surgeries for Idiopathic Scoliosis is associated with compromises. Neurologic injury is the most severe complication and is, all things considered, the most dreaded since it can occur at either the intra-or post-operative stage. Additional complications include dural tears and ophthalmologic or fringe neuropathy, which can be caused by persistent positioning. All spine surgeons must be entirely familiar with all likely developments of complications, as well as proper control.","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69468161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyacrylamide Hydrogel Injection for Knee Osteoarthritis: A 6 Months Prospective Study","authors":"H. Bliddal, A. Overgaard, A. Hartkopp, J. Beier, P. Conaghan, M. Henriksen","doi":"10.29011/2575-8241.001188","DOIUrl":"https://doi.org/10.29011/2575-8241.001188","url":null,"abstract":"Objective: Intra-Articular (IA) injection of polyacrylamide hydrogel (PAAG) is a possible treatment for symptomatic Osteoarthritis (OA) of the knee. This study evaluated the efficacy and safety of a single injection of 6 ml intra-articular PAAG over 26 weeks. Methods: Open-label study in patients with symptomatic and radiographically confirmed knee OA . Primary outcome was change in WOMAC pain after 13 weeks. Secondary outcomes were WOMAC stiffness and function subscales, Patient Global Assessment of disease impact (PGA) and proportion of OMERACT-OARSI responders. Follow-up time points were 4, 13 and 26 weeks. Results: 49 patients (31 females) received PAAG, with 48 patients completing the 13 and 46 the 26 weeks assessments. Mean change in WOMAC pain after 13 weeks was -18.3 points [95% CI-23.4 to -13.3]; P<.0001 and at 26 weeks -20.8 points [95% CI -26.3 to -15.3]; P<0.0001 with similar benefits for WOMAC stiffness, physical function, and PGA. After 13 weeks 64.6% were OMERACT-OARSI responders and this was maintained at 26 weeks.. During the 13 weeks, 18 patients reported 23 adverse events, 13 of which were related to PAAG, none severe. Two serious adverse events, atrial fibrillation and gastrointestinal pain, were assessed as ‘not related’ to PAAG. Conclusions: PAAG can be delivered in a single 6 ml injection and this non-randomized trial in patients with knee OA demon-strated beneficial clinical effects at 13 and 26 weeks. No serious adverse events were seen with PAAG. These encouraging results need to be confirmed in controlled studies.","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69468073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hook Plate Fixation of Lateral one Third Clavicle Fracture with Coracoclavicular Ligaments Repair","authors":"","doi":"10.29011/2575-8241.001180","DOIUrl":"https://doi.org/10.29011/2575-8241.001180","url":null,"abstract":"","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69468170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Headless Screws for the Treatment of Type IV Capitellum Fractures in Adults","authors":"","doi":"10.29011/2575-8241.001178","DOIUrl":"https://doi.org/10.29011/2575-8241.001178","url":null,"abstract":"","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69468104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abraham Colles (1773-1843), Physician, Surgeon and Anatomist","authors":"","doi":"10.29011/2575-8241.001136","DOIUrl":"https://doi.org/10.29011/2575-8241.001136","url":null,"abstract":"","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69467492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Knee Arthroplasty in Patients with Fixed Flexion Contracture","authors":"Mohammed El-Sadek, Emad Abd-Elhady","doi":"10.29011/2575-8241.001179","DOIUrl":"https://doi.org/10.29011/2575-8241.001179","url":null,"abstract":"Background: soft tissues balancing and flexion knees deformity were difficulties’ in patients with advanced knee arthritis man aged by Total Knee Arthroplasty (TKA). Objectives: the purpose of our study was the evaluation of clinical and radiological results of patients with advanced primary Osteoarthritis knee with fixed flexion deformity. Patient & Method: prospective study of twenty five knees (twenty one patients unilateral and two patients bilateral) with primary Advanced OA with moderate to severe fixed flexion deformity with varus knee deformity in ten knees (varus range 15-25o). All patients were managed by primary TKA with appropriate soft tissues balancing from June, 2010 to July, 2018 in our university hospital. There were 9 male and 12 female with bilateral knee deformity in two female patients. They were classified into two groups, group I: patients with moderate flexion deformity (MF) with flexion deformity less than 30°, in 14 knees (56%) and group II: patients with severe flexion deformity (SF) with flexion more than 30° in 11 knees ( 44%). Metal augment in 7 knees long stem tibia in 4 cases 100 mm all was sacrificed PCL with posterior stabilized prosthesis. The patient’s clinical and radiological information were evaluated preoperative, Intraoperative and postoperative at a standard period and yearly follow up for two years. Results: We had no intraoperative complications in this study. Soft tissue release surgery and additional bone cuts were performed in group II. The mean age was 59±5.97 (range 48-71), mean flexion contracture deformity was 34±11.63 (range 20-60), mean preoperative ROM was 65±9.34 (range 45-80) and mean postoperative ROM was 99±932 (range 65-110). There was no difference between group I and group II postoperative ROM (112±10.23 and 115±9.2). In group I mean Knee Society Score (KSS) improved from 34 (0 to 71) to 88 (38 to 100) (p < 0.001) and the KSS Functional Score from 43 (0 to 70) to 86 (0 to 100). No knees required manipulations under anaethesia (MUA) and none of the knees had flexion instability. Group II mean Knee Society Score (KSS) improved from 28(0 to 56) to 85 (40 to 100) and the KSS Functional Score from 43 (0 to 70) to 84 (0 to 100). Two knees (8%) required manipulations under anaethesia (MUA) and none of the knees had flexion instability. We had no infection complication and no cases with patellar dislocation or subluxation seen in this study. Conclusion: Preoperative planning of the knees with severe flexion contracture managed by primary TKA with good soft tissues balancing can be performed successfully.","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69468132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Artificial Intelligence Improving the Quality Of Detection in Orthopaedic Imaging? A Systematic Review","authors":"","doi":"10.29011/2575-8241.001183","DOIUrl":"https://doi.org/10.29011/2575-8241.001183","url":null,"abstract":"","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69468184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-Scale Surface Modifications to Advance Current Treatment Options for Cervical Degenerative Disc Disease (CDDD).","authors":"Anne Yau,&nbsp;Ian Sands,&nbsp;Yupeng Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Degenerative Disc Disease (DDD) causes a nagging to severe back pain as well as numbing sensation to the extremities leading to loss of overall patients' height and weakness to leg muscles. Degenerative disc disease is often observed in aging patients as well as patients who have suffered from a back injury. Cervical Degenerative Disc Disease (CDDD) is a progressive condition that leads to the degeneration of the intervertebral discs supporting the cervical vertebral column. Anterior Cervical Interbody Fusion (ACIF) has been the longstanding treatment option for severe degenerative disc disease; however, ACIF presents various novel complications, necessitating numerous comparative device studies to reduce the negative effects of spinal fusion. Cervical disc arthroplasty, the recent focus of clinical attention, was one of the alternatives studied to mitigate the complications associated with vertebral fusion but presents its own disadvantages. These complications prompted further investigation and modifications that can be introduced into these devices. We will be discussing the nano-scale interactions between the implant and extracellular matrix play a crucial role in device integration and efficacy, providing an additional approach towards a device's overall success.</p>","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":"4 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946151/pdf/nihms-1576403.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25467982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin C in Cancer Therapeutics and Metastasis.","authors":"Dan Xi","doi":"10.29011/2575-8241.001127","DOIUrl":"10.29011/2575-8241.001127","url":null,"abstract":"<p><p>There have been significant increased publications of preclinical studies and clinical trials of vitamin C (ascorbate) on cancer therapeutics in the past a few years. In this communication reflecting my personal opinions, I will highlight the main points of current research status; discuss impacts of vitamin C on immune cell function and inflammation at tumor microenvironment, and tumor metastasis; and propose stimulating questions and direction for future research in this area.</p>","PeriodicalId":87310,"journal":{"name":"Journal of orthopedic research and therapy","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553485/pdf/nihms-1009972.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40551303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}