Journal of advanced manufacturing and processing最新文献_第3页

Evaluation of two plumes jet plasma reactor for plasmolysis of H2O vapor and CO2 combinations – Optimization study 用于H2 O蒸汽和CO2组合等离子体裂解的双羽流喷射等离子体反应器的评估——优化研究

Journal of advanced manufacturing and processing Pub Date : 2023-04-05 DOI: 10.1002/amp2.10154

Wameath S. Abdul-Majeed, Qazi Nasir, Muzna H. Alajmi, Khaloud A. Almaqbali

引用次数: 0

Technoeconomic assessment of distillation heat transfer intensification using aeroelastically fluttering reeds 利用气动弹性摆动簧片强化精馏传热的技术经济评估

Journal of advanced manufacturing and processing Pub Date : 2023-02-05 DOI: 10.1002/amp2.10153

Miriam Blaine, Matthew J. Realff

{"title":"Technoeconomic assessment of distillation heat transfer intensification using aeroelastically fluttering reeds","authors":"Miriam Blaine, Matthew J. Realff","doi":"10.1002/amp2.10153","DOIUrl":"10.1002/amp2.10153","url":null,"abstract":"Dry cooling, where forced air is the heat transfer medium, is a preferable cooling method in arid locations lacking readily available process water. However, such locations often experience high ambient temperatures that limit the effectiveness of air cooling. The objective of this study is to quantify the economic and energetic benefits of heat transfer intensification via the implementation of aeroelastically fluttering reeds to the air-cooled condenser of a methanol distillation column. Condenser size and performance, regarding recovered methanol and required fan power, is evaluated across condenser operating temperatures (Tcond) from 60 to 62°C and heat transfer coefficients (U) Ubase–2Ubase for a range of inlet air temperatures based on ambient temperature data from Yuma, Arizona. Under typical design sizing, condenser capital cost was reduced by 6%–35% (1.3Ubase–2Ubase) and nominal methanol recovery was increased from 0.26% to 0.38% (Tcond = 62–60°C). At optimized condenser size, all enhanced U and Tcond pairs increase methanol recovery and reduce fan power costs compared to the optimal Ubase reference. Overall, using enhanced heat transfer to maintain condenser temperature under a wider range of inlet conditions, rather than to reduce operation temperature, produces more favorable performance. Methanol price is not a determining factor in which pairs are profitable. Analysis was repeated for a global warming scenario, revealing more valuable improvements under elevated temperatures. Energy savings from condenser improvement to a methanol production system are not significant with respect to an optimized conventional system. Unit economic and energetic incentives suggest implementation of fluttering reeds may be justified in other applications.","PeriodicalId":87290,"journal":{"name":"Journal of advanced manufacturing and processing","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41624143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Innovative Vaccine Packaging Technologies: perspectives on benefits and challenges of compact prefilled auto‐disable devices ( CPADs ) and polymer containers† 创新疫苗包装技术:对紧凑的预填充自动禁用装置(CPADs)和聚合物容器的好处和挑战的看法

Journal of advanced manufacturing and processing Pub Date : 2023-02-01 DOI: 10.1002/amp2.10152

S. Pagliusi, S. Jarrett, Rachel Park, Yudha Bramanti, Ravi Menon, C. Jarrahian, Collrane Frivold, Lingjiang Yang

引用次数: 1

Innovative vaccine packaging technologies: Perspectives on benefits and challenges of compact prefilled auto-disable devices and polymer containers 创新的疫苗包装技术：紧凑型预填充自动失效装置和聚合物容器的优势和挑战展望

Journal of advanced manufacturing and processing Pub Date : 2023-02-01 DOI: 10.1002/amp2.10152

Sonia Pagliusi, Stephen W. Jarrett, Rachel Park, Yudha Bramanti, Ravi Menon, Courtney Jarrahian, Collrane Frivold, Lingjiang Yang

{"title":"Innovative vaccine packaging technologies: Perspectives on benefits and challenges of compact prefilled auto-disable devices and polymer containers","authors":"Sonia Pagliusi, Stephen W. Jarrett, Rachel Park, Yudha Bramanti, Ravi Menon, Courtney Jarrahian, Collrane Frivold, Lingjiang Yang","doi":"10.1002/amp2.10152","DOIUrl":"https://doi.org/10.1002/amp2.10152","url":null,"abstract":"Vaccine packaging innovations have a potential impact on the supply chain, as well as acceptability and uptake by users. To better understand recent developments in packaging innovations, we assessed the benefits and challenges of compact pre-filled auto-disable devices (CPADs), polymer-based primary containers (or vials), and dual-chamber delivery devices. These packaging innovations have clear public health benefits related to ease of use, improved safety, supply logistics, and uptake enabling new vaccination opportunities. In addition, there seems to be high acceptability from users at country-level. However, uncertain costs including the impact on distribution and cold chain storage have hampered demand and consequently commercialization. For innovations to reach those who can benefit most, global stakeholders should place greater attention on new packaging technologies and assess the trade-offs between safety, coverage, uptake, ease of administration, wastage and costs.","PeriodicalId":87290,"journal":{"name":"Journal of advanced manufacturing and processing","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/amp2.10152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50116484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Refractive index as a process analytical technology to measure real time protein concentration for monitoring and control of commercial scale tangential flow filtration operations 折射率作为测量实时蛋白质浓度的过程分析技术，用于商业规模切向流过滤操作的监测和控制

Journal of advanced manufacturing and processing Pub Date : 2023-01-27 DOI: 10.1002/amp2.10151

Yik Lam, Devin McCann, Abdullah Loman, John Paul Smelko, Alex Brinkmann

{"title":"Refractive index as a process analytical technology to measure real time protein concentration for monitoring and control of commercial scale tangential flow filtration operations","authors":"Yik Lam, Devin McCann, Abdullah Loman, John Paul Smelko, Alex Brinkmann","doi":"10.1002/amp2.10151","DOIUrl":"10.1002/amp2.10151","url":null,"abstract":"Biological therapeutics are increasingly being formulated to high protein concentrations to decrease drug substance storage space and increase the flexibility of administration to patients. With the higher protein concentration targets comes added challenges to the downstream purification manufacturing process. Tangential flow filtration (TFF) operations are typically performed to reach target protein concentration. TFF operations for a given drug substance may include an Ultrafiltration and Diafiltration (UFDF) step, or a UFDF step followed by a single pass tangential flow filtration (SPTFF) step. Whether a TFF step achieves a target protein concentration is determined by at-line protein concentration measurements performed at the completion of a process step. If the measured protein concentration is outside the specified range, the unit operation may need to be restarted, reprocessing may need to be performed, or a batch may need to be terminated. Out of specification protein concentration measurements may be a result of the TFF operation or sample measurement. Increased viscosities associated with high concentration TFF operations pose added challenges to the TFF process and sample measurement. Implementation of an inline process analytical technology (PAT) to monitor real-time protein concentration during TFF operations has the potential to improve the accuracy of the operations in achieving target protein concentrations. This will result in improved process consistency and efficiency, increased operator confidence and decreased likelihood of batch failures. This paper studies the performance of a K-Patents PR-23 refractometer (Vaisala) as a PAT to monitor and control the UFDF and SPTFF unit operations of a commercial scale monoclonal antibody purification process.","PeriodicalId":87290,"journal":{"name":"Journal of advanced manufacturing and processing","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44020692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Advanced pharmaceutical manufacturing: A functional definition 先进制药:功能定义

Journal of advanced manufacturing and processing Pub Date : 2022-12-30 DOI: 10.1002/amp2.10150

Rodolfo J. Romañach, Torsten Stelzer, Eric Sanchez, Fernando Muzzio

{"title":"Advanced pharmaceutical manufacturing: A functional definition","authors":"Rodolfo J. Romañach, Torsten Stelzer, Eric Sanchez, Fernando Muzzio","doi":"10.1002/amp2.10150","DOIUrl":"10.1002/amp2.10150","url":null,"abstract":"The term “Advanced Pharmaceutical Manufacturing” (APM) has become an ubiquitous buzzword with deep potential policy implications. There is a real danger that APM will be seen as a general panacea for solving economic woes and drug shortages, devoiding it from specific meaning, and depriving the technical community of focus much needed for its development and implementation. This paper first discusses several semantic definitions of APM that have been proposed in the field. A functional definition of APM is then presented as: A system that is designed using predictive models, where automation minimizes human intervention while enabling closed loop process control and real time quality assurance, where performance has been optimized to maximize desired process goals, where flexible amounts of product with equivalent attributes can be manufactured, and where equivalent processes can be implemented at multiple locations to manufacture products with equivalent critical quality attributes. The proposed definition is presented to motivate discussion and elicit contributions from other stakeholders, and to contribute to the development of a consensus framework for design, development, implementation, and evaluation of APM.","PeriodicalId":87290,"journal":{"name":"Journal of advanced manufacturing and processing","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45944325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Resonant acoustic monitoring of damage in plug-screw feeders 螺塞馈线损坏的共振声监测

Journal of advanced manufacturing and processing Pub Date : 2022-12-12 DOI: 10.1002/amp2.10149

John Greenhall, Cristian Pantea, Troy Allen Semelsberger

{"title":"Resonant acoustic monitoring of damage in plug-screw feeders","authors":"John Greenhall, Cristian Pantea, Troy Allen Semelsberger","doi":"10.1002/amp2.10149","DOIUrl":"10.1002/amp2.10149","url":null,"abstract":"Plug-screw feeders are critical in many industrial processes for compressing slurry materials via a rotating plug-screw feeder. Over time, increasing plug-screw feeder wear will eventually lead to catastrophic mechanical failure. Early detection of the wear state can prevent unplanned catastrophic failures resulting in operational shut-downs, costly repairs, and most importantly the health and safety of workers. We present a theoretical basis for a noninvasive, in operando acoustic resonant technique to monitor the wear state of plug-screw feeders. The technique is based on tracking the resonant acoustic modes of the plug-screw feeder, which are sensitive to the plug-screw feeder geometry, material, and operating conditions. We implemented a multivariate polynomial model to estimate the plug-screw feeder wear state using multiple acoustic resonances by simulating the acoustic resonant modes for two categories of wear (tip and thread damage) that are common in plug-screw feeders. Fitting multiple resonances to the polynomial model, we demonstrate accurate estimation of the total mass loss, as well as characterization of the type of damage (i.e., tip vs. thread). Current approaches for monitoring plug-screw feeder wear rely on shutting down the operation and visually inspecting the plug-screw feeder. The presented acoustic technique offers a noninvasive, in operando measurement approach that mitigates unplanned catastrophic failures. The acoustic resonance technique presented in the paper has a broad range of industrial applications including the Pharmaceutical, Mining, Integrated Biorefineries (IBR), and Additive Manufacturing industries, to name a few.","PeriodicalId":87290,"journal":{"name":"Journal of advanced manufacturing and processing","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/amp2.10149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48140677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification of cardiac differentiation outcome, percentage of cardiomyocytes on day 10 of differentiation, for hydrogel-encapsulated hiPSCs 水凝胶包膜hipsc的心脏分化结果分类，分化第10天的心肌细胞百分比

Journal of advanced manufacturing and processing Pub Date : 2022-10-07 DOI: 10.1002/amp2.10148

Samira Mohammadi, Mohammadjafar Hashemi, Ferdous Finklea, Bianca Williams, Elizabeth Lipke, Selen Cremaschi

{"title":"Classification of cardiac differentiation outcome, percentage of cardiomyocytes on day 10 of differentiation, for hydrogel-encapsulated hiPSCs","authors":"Samira Mohammadi, Mohammadjafar Hashemi, Ferdous Finklea, Bianca Williams, Elizabeth Lipke, Selen Cremaschi","doi":"10.1002/amp2.10148","DOIUrl":"10.1002/amp2.10148","url":null,"abstract":"This study employed machine learning (ML) models to predict the cardiomyocyte (CM) content following differentiation of human induced pluripotent stem cells (hiPSCs) encapsulated in hydrogel microspheroids and to identify the main experimental variables affecting the CM yield. Understanding how to enhance CM generation using hiPSCs is critical in moving toward large-scale production and implementing their use in developing therapeutic drugs and regenerative treatments. Cardiomyocyte production has entered a new era with improvements in the differentiation process. However, existing processes are not sufficiently robust for reliable CM manufacturing. Using ML techniques to correlate the initial, experimentally specified stem cell microenvironment's impact on cardiac differentiation could identify important process features. The initial tunable (controlled) input features for training ML models were extracted from 85 individual experiments. Subsets of the controlled input features were selected using feature selection and used for model construction. Random forests, Gaussian process, and support vector machines were employed as the ML models. The models were built to predict two classes of sufficient and insufficient for CM content on differentiation day 10. The best model predicted the sufficient class with an accuracy of 75% and a precision of 71%. The identified key features including post-freeze passage number, media type, PF fibrinogen concentration, CHIR/S/V, axial ratio, and cell concentration provided insight into the significant experimental conditions. This study showed that we can extract information from the experiments and build predictive models that could enhance the cell production process by using ML techniques.","PeriodicalId":87290,"journal":{"name":"Journal of advanced manufacturing and processing","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43085907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Clean Energy Smart Manufacturing Innovation Institute (CESMII) Special Issue 清洁能源智能制造创新研究院特刊

Journal of advanced manufacturing and processing Pub Date : 2022-09-24 DOI: 10.1002/amp2.10146

Haresh Malkani, Prakashan Korambath

引用次数: 3

Thermal degradation of glycidyl esters in monoglycerides and mono- and diglyceride blends 缩水甘油酯在单甘油酯、单甘油酯和双甘油酯混合物中的热降解

Journal of advanced manufacturing and processing Pub Date : 2022-09-20 DOI: 10.1002/amp2.10147

Thomas Schmidt, Flemming Vang Sparsoe, Rico Bagger-Jørgensen, Thomas Norup From, Anna Kjaer Keskin, Rasmus Leth Miller

引用次数: 0